Insights into Persian Gulf Beach Sand Mycobiomes: Promises and Challenges in Fungal Diversity.

Beach Sand Mycobiome is currently among the most important health challenges for viticulture in the world. Remarkably, the study of fungal communities in coastal beach sand and recreational waters remains underexplored despite their potential implications for human health. This research aimed to assess the prevalence of fungal species and the antifungal susceptibility profiles of fungi recovered from the beaches of the Persian Gulf and the Sea of Oman.

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018-2023).

Purpose: The incidence of Mucormycosis has increased during the last decades globally due to more patients being at risk for these life-threatening infections. Early diagnosis and proper selection of appropriate antifungal therapy are vital in enhancing patient outcomes. Mucorales species present a significant challenge due to their resistance to many drugs, so investigations for new therapies and strategies must be undertaken.

Pathogenicity Evaluation on Fluconazole-Resistant Candida auris Clade V in Murine Model.

Background: Candida auris, a medically multidrug-resistant fungal pathogen, has recently emerged as the primary one that poses a global public health threat. Although C. auris was first described in Japan, numerous cases of C.

Design and immunological evaluation of a multi-epitope vaccine candidate against incorporating MIC13, GRA1, and SAG1 antigens in BALB/c mice.

Toxoplasmosis, caused by the apicomplexan parasite , is a globally significant yet neglected disease that can cause serious clinical consequences in humans and extensive losses in the livestock industry. However, no effective vaccine has been provided for this parasite, so this study was designed to evaluate the immunogenicity of a chimeric multi-epitope antigen as a potential toxoplasmosis vaccine candidate in a murine model. The multi-epitope vaccine candidate, designed with bioinformatics tools, MGS: a chimera of MIC13, GRA1, and SAG1 antigens, was expressed in BL21 and purified by immobilized metal affinity chromatography using a His Ni-NTA column.

A fatal post-COVID-19 sino-orbital mucormycosis in an adult patient with diabetes mellitus: a case report and review of the literature.

Introduction: COVID-19 is associated with a broad spectrum of bacterial and fungal superinfections.

Case Presentation: We present a case of mucormycosis developing during post-COVID-19 therapeutic management. A 63-year-old diabetic female presented with COVID-19 and received combination therapy per institutional protocol, including dexamethasone, remdesivir, and ivermectin.

Deciphering Fluconazole Resistance in Candida auris clade V: The Role of Efflux Pump Gene Expression and Ergosterol Pathway Mutations.

Candida auris is an emerging multidrug-resistant yeast pathogen that poses a serious global health threat. In particular, fluconazole resistance is common in C. auris, posing challenges for treating invasive infections.

Characterization of COVID-19-Associated Candidemia Among Burn Patients.

Background: The emergence of COVID-19 has led to a significant public health crisis, and an increase in fungal infections, including candidemia. Candida species are frequently found in intensive care units (ICUs), and it is a common cause of death in many patients. The isolates were identified using polymerase chain reaction-restriction.

A Novel Niosomal Gel for Topical Delivery of Miltefosine Against Trichophyton indotineae Dermatophytosis in Animal Model.

Introduction: Dermatophytosis, a cutaneous fungal infection worldwide, is generally localised to the skin's superficial layers and keratinised structures. Although most agents are susceptible to current antifungal drugs available in clinical settings, frequent relapses and failures, especially in cases due to Trichophyton indotineae, have been frequently reported. Therefore, alternative targets and therapeutic approaches are highly required.

Prevalence of Fungal Infections in Pemphigus Patients: A Systematic Review and Meta-Analysis.

Background: Pemphigus is a life-threatening autoimmune disease characterised by blistering skin and/or mucous membranes. The present study aimed to determine the prevalence of fungal infections in the pemphigus population.

Methods: Different databases were searched to gain access to all studies on the prevalence of fungal infections published up to the 31st of May 2024.

Genetic diversity and antibiotic resistance patterns of Escherichia coli isolates causing septicemia: A phylogenetic typing and PFGE analysis.

Introduction: This study aims to analyze clinical isolates of E. coli causing septicemia across various phylogroups utilizing the PFGE method.

Materials And Methods: A total of 100 clinical isolates were collected.

Metabolic Patterns of Fluconazole Resistant and Susceptible Clade V and I.

, an emerging non- multidrug-resistant yeast, has become a significant cause of invasive candidiasis in healthcare settings. So far, data on the metabolites of in different clades are minimal, and no studies have focused on clade V metabolites. Therefore, Gas chromatography-mass spectrometry (GC-MS) was used for the metabolomic profiling of clade I compared with fluconazole-resistant and susceptible in clade V strains.

Multi-state evaluation of Candida infections in burn patients.

Background: Burn patients are at high risk of developing secondary invasive fungal infections due to their compromised skin barrier, extensive use of antibiotics, and immunosuppression.

Objectives: We investigated demographic characteristics and clinical factors associated with Candida infections in intensive care unit (ICU) burn patients, and the in vitro antifungal susceptibility of species of isolates.

Methods: A total of 353 burn patients admitted to three major ICUs of burn centers in Iran were evaluated between 2021 and 2023.

An Unusual High Prevalence of Cryptococcus (Naganishia) diffluens Colonization in Neonates Hospitalized in a Referral Neonatal Intensive Care Unit.

Background: Although the Candida species continue to be the most frequent colonizer of neonatal skin, a clear increase of colonization due to rare yeast-like fungi has been reported. In this study, we report an unusual high prevalence of Cryptococcus diffluens colonization in neonates admitted to the neonatal intensive care unit (NICU) over a 1-month period.

Methods: From January 2020 to June 2021, the study included all neonates who were admitted to the NICU of Bu Ali Sina Hospital at least 28 days old.

Molecular Epidemiology and Antifungal Susceptibility Profile in Nakaseomyces glabrata Species Complex: A 5-Year Countrywide Study.

Background: The current study aimed to identify Iranian Nakaseomyces (Candida) glabrata complex species in the clinical isolates and determine their antifungal susceptibility profile.

Methods: In total, 320 N. glabrata clinical isolates were collected from patients hospitalized in different geographical regions of Iran.

Molecular typing of a collection of Iranian clinical Trichophyton tonsurans isolates based on the non-transcribed spacer region of rDNA and antifungal susceptibility testing of the species.

Introduction: Wrestling, considered the national sport of Iran, has gained immense popularity among Iranians. Wrestlers frequently encounter skin conditions, with dermatophyte fungal infections, particularly tinea gladiatorum (TG), being a common issue. TG, caused by the Trichophyton genus, has emerged as a major health concern for wrestlers and other contact sport athletes worldwide.

Predominance of causing tinea capitis: A 12-year retrospective study in the north of Iran.

Background And Purpose: Among different clinical entities of dermatophytosis, tinea capitis (TC) is considered a major public health challenge in the world, especially in regions with poor health and low income. Therefore, this study aimed to provide a retrospective analysis of the patients suspected of TC who were referred to the medical mycology laboratory of Mazandaran, a northern province of Iran.

Materials And Methods: A retrospective analysis was performed on the patients suspected of TC who were referred to the medical mycology laboratory from July 2009 to April 2022.

Central nervous system Aspergillus quadrilineatus infection in a COVID-19 patient, a case report and literature review.

Background: Viral pneumonia such as COVID-19-associated aspergillosis could increase susceptibility to fungal super-infections in critically ill patients.

Methods: Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID-19-positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species.

A new record of isolated from paddy field soil in Iran: Phylogeny and antifungal susceptibility profiles.

Background And Purpose: species are ubiquitous environmental fungi, which are considered emerging agents that trigger disease in humans and animals. The present study aimed to determine strain isolated from paddy field soil samples using semi-selective media and evaluate its antifungal susceptibility profile.

Materials And Methods: Three paddy field soil samples were collected during an investigation for the isolation of species in Mazandaran province, Iran.

Onychomycosis due to Fusarium species in different continents, literature review on diagnosis and treatment.

Fusarium species are an emerging cause of onychomycosis, and the number of cases has dramatically increased in recent decades worldwide. This review presents an overview of the onychomycosis cases caused by Fusarium species and diagnosis and treatment that have been reported in the literature. The most common causative agent of onychomycosis is F.

Investigating intestinal parasitic infections with emphasis on molecular identification of and in north of Iran.

Currently, parasitic infections are one of the important health problems in the world, especially in developing countries. This study aims to investigate intestinal parasites with an emphasis on molecular identification through the analysis of mitochondrial and gene sequences of () and spp. in north of Iran.

Potential Inhibitory Effect of Miltefosine against Terbinafine-Resistant .

Several prolonged and significant outbreaks of dermatophytosis caused by , a new emerging terbinafine-resistant species, have been ongoing in India in recent years, and have since spread to various countries outside Asia. Miltefosine, an alkylphosphocholine, is the most recently approved drug for the treatment of both visceral and cutaneous leishmaniasis. Miltefosine in vitro activity against terbinafine-resistant and susceptible / species complex, including , is limited.