Curcumin-loaded nanoscale coordination polymers for ROS scavenging and anti-inflammatory therapy in atherosclerosis.

The progression of atherosclerosis (AS) is marked by escalating chronic inflammation and oxidative stress within the arterial wall, which heightens the risk of plaque rupture and subsequent acute ischemic cardiovascular and cerebrovascular events. Conventional anti-inflammatory and antioxidant therapies, however, are often limited by modest efficacy and potential side effects. Here, we synthesized iron-curcumin coordination polymers (Fe-Cur CPs) coordinated by trivalent iron ions and the natural product curcumin (Cur).

Single-Atom Enzymes: From Evolutionary Insights, Precision Engineering to Breakthroughs in Biomedical Applications.

Single-atom enzymes (SAEs), integrating the catalytic efficiency of single-atom catalysts with enzymatic functions, represent a paradigm shift in biomedicine. Comprising natural enzymes, mimic enzymes, and single-atom nanozymes, SAEs leverage isolated metal atoms as catalytic centers. Natural enzymes, evolved over billions of years, feature monoatomic active sites for precise biocatalysis under physiological conditions.

Soil and litter emission sources as important contributors to ozone production from volatile organic compounds in island tropical forests.

While studies have confirmed that volatile organic compounds (VOCs) emitted directly by tropical island forest vegetation significantly influence ozone (O) production and climate change through atmospheric oxidation processes, the environmental effects of long-neglected soil and litter emission sources as key potential contributors to VOCs, particularly their driving mechanisms in near-surface O pollution formation, remain understudied. This investigation combines field observations with machine learning models to investigate the emission characteristics, sources, and contributions of VOCs from tropical island forests to O and secondary organic aerosol (SOA) formation. The results reveal discrepancies between traditional ozone formation potential (OFP) estimates and machine learning-based assessments.

Universal Albumin Drugs-Cored Spherical Nucleic Acid (ad-SNA) Platform for Targeted Drug Delivery.

Albumin-based drug delivery system, exemplified by FDA-approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor-targeting capability, leading to low efficacy and systemic side effects on healthy cells in applications. Here, we report a general method for modification of albumin drugs by aptamer coating shell that are hydrophobically inserted into the albumin surface, for constructing albumin drugs-cored spherical nucleic acid (adSNA).

Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy Through Copper Overload and Glutathione Depletion.

Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by its dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) with a nucleosome-like structure to improve tumor cuproptosis therapy by exploiting mitochondrial copper overload and GSH depletion.

Enzyme Core Spherical Nucleic Acid That Enables Enhanced Cuproptosis and Antitumor Immune Response through Alleviating Tumor Hypoxia.

Cuproptosis, a copper-dependent cell death process, has been confirmed to further activate the immune response and mediate the immune resistance. However, hypoxic tumor microenvironment hampers cuproptosis sensitivity and suppresses the body's antitumor immune response. Herein, we have successfully immobilized and functionalized catalase (CAT) with long single-stranded DNA containing polyvalent CpG sequences through rolling circle amplification (RCA) techniques, obtaining an enzyme-cored spherical nucleic acid nanoplatform (CAT-ecSNA-Cu) to deliver copper ions for cuproptosis.

A Single-Atom Manganese Nanozyme Mn-N/C Promotes Anti-Tumor Immune Response via Eliciting Type I Interferon Signaling.

Tumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are a new type of nanozyme with incredible catalytic efficiency. Here, a single-atom manganese (Mn)-N/C nanozyme is constructed.

A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction.

Severe systemic inflammation following myocardial infarction (MI) is a major cause of patient mortality. MI-induced inflammation can trigger the production of free radicals, which in turn ultimately leads to increased inflammation in cardiac lesions (i.e.

Influences of offshore background wind on the formation of sea-land breeze and the characteristics of pollutant diffusion.

The formation of sea-land breeze (SLB) is primarily affected by background wind and temperature difference between the sea and nearby land. Because the intensity of sea breeze is significantly stronger than that of land breeze, land breeze may result in more accumulated pollutants under the condition of offshore background wind (OBW) than under the condition of no OBW in coastal areas. The formation process of sea-land breeze and the dispersion trajectory and accumulation effect of pollutants are studied under different velocities of OBW with the same sea-land temperature difference by employing computational fluid dynamics (CFD).

[Indoor Formaldehyde and Benzene Series in Shanghai Residences and Their Associations with Building Characteristics and Lifestyle Behaviors].

From March 2013 to December 2014, we on-site inspected indoor concentrations of formaldehyde and a benzene series in 454 children's bedrooms that were decorated earlier than one year before our inspection. Large differences existed in the formaldehyde and benzene-series concentrations among individual bedrooms. Bedrooms that were inspected in winter had significantly higher concentration of formaldehyde than bedrooms that were inspected in other seasons (<0.