Part-Wise Graph Fourier Learning for Skeleton-Based Continuous Sign Language Recognition.

Sign language is a visual language articulated through body movements. Existing approaches predominantly leverage RGB inputs, incurring substantial computational overhead and remaining susceptible to interference from foreground and background noise. A second fundamental challenge lies in accurately modeling the nonlinear temporal dynamics and inherent asynchrony across body parts that characterize sign language sequences.

Comparative Effectiveness and Safety of Adalimumab, Secukinumab, and Upadacitinib in Psoriatic Arthritis: A Prospective Cohort Study Based on PARWCH Cohort.

Psoriatic arthritis (PsA) is a chronic inflammatory disease, with prevalence among psoriasis patients ranging from 6% to 42% across populations. Although targeted therapies such as adalimumab (ADA), secukinumab (SEC), and upadacitinib (UPA) have demonstrated efficacy in randomized controlled trials, real-world head-to-head comparisons remain limited. This study aimed to compare the real-world effectiveness and safety of ADA, SEC, and UPA in PsA patients.

Integrative population pharmacokinetic modeling of two BCMA-targeted and one CD19-targeted CAR-T therapies using full Bayesian inference with a student's t-based M3 censoring approach for robust handling of outliers and BLQ data.

Background: Chimeric antigen receptor (CAR) T-cell therapies represent a novel class of adoptive immunotherapies characterized by dynamic in vivo expansion, contraction, and long-term persistence. These unique kinetic properties distinguish CAR-T therapies from traditional small-molecule and biologic agents and pose significant challenges for pharmacometric modeling, particularly due to high interindividual variability, frequent outliers, and a large proportion of concentrations below the lower limit of quantification (BLQ).

Objective: In this study, we developed and applied an integrated Bayesian population pharmacokinetic (PopPK) modeling framework to evaluate and compare the cellular kinetics of three CAR-T therapies: liso-cel (CD19-targeted), and ide-cel and orva-cel (both BCMA-targeted).

Demographic characteristics and disease severity associated with IgA/IgG deposition patterns in autoimmune bullous diseases: a cohort study based on a registry database.

Background: Direct immunofluorescence (DIF) microscopy is the gold standard for diagnosing autoimmune bullous diseases (AIBDs), but the clinical significance of IgA and IgG co-deposition was unclear.

Objective: Investigate the demographic differences and disease severity among different IgG/IgA deposition patterns in DIF.

Methods: We conducted a retrospective cohort study based on a registry database that analyzed demographic data, involvement sites, and immunofluorescence patterns of patients with DIF biopsy.

Autoimmune Bullous Disease Combined With Acquired Hemophilia A: A Systematic Review and Case Analysis.

Autoimmune bullous diseases (AIBDs) are rare, chronic conditions characterized by blisters and erosions on the skin and mucous membranes. Acquired hemophilia A (AHA) is a rare bleeding disorder in which autoantibodies target coagulation factor VIII, often associated with other autoimmune diseases. However, the simultaneous occurrence of AIBD and AHA is rare, with limited understanding of their combined impacts.

Albumin nanocomplex of BCL-2/xL inhibitor reduced platelet toxicity and improved anticancer efficacy in myeloproliferative neoplasm and lymphoma.

The clinical application of BCL-2/xL inhibitors for cancer treatment is limited by the on-target thrombocytopenia. Although APG-1252 was designed to mitigate this issue, platelet toxicity at higher doses in clinical trials restricts dose escalation for greater efficacy. We have developed albumin nanocomplexes of APG-1252 (Nano-1252) to reduce platelet toxicity while improving drug efficacy through enhancing drug delivery to lymphoid organs.

SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity through B Cell Antigen Presentation.

Current neoantigen cancer vaccines activate T cell immunity through dendritic cell/macrophage-mediated antigen presentation. It is unclear whether incorporating B cell-mediated antigen presentation into current neoantigen vaccines could enhance CD4/CD8 T cell immunity to improve their anticancer efficacy. We developed SARS-CoV-2 B cell epitope-guided neoantigen peptide/mRNA cancer nanovaccines (BTVax) to improve anticancer efficacy by enhancing tumor-specific CD4/CD8 T cell antitumor immunity through B cell-mediated antigen presentation.

Population Pharmacokinetics of Orvacabtagene Autoleucel, an Autologous BCMA-Directed Chimeric Antigen Receptor T-cell Product, in Patients with Relapsed/Refractory Multiple Myeloma.

Purpose: Orvacabtagene autoleucel (orva-cel; JCARH125), a chimeric antigen receptor T-cell therapy targeting B-cell maturation antigen, was evaluated in patients with relapsed/refractory multiple myeloma in the EVOLVE phase I/II study (NCT03430011). We applied a modified piecewise model to characterize orva-cel transgene kinetics and assessed the impact of various covariates on its pharmacokinetics (PK).

Experimental Design: The population PK analysis included 159 patients from the EVOLVE study.

Long-term straw returning increased soil aggregation and aggregate associated organic carbon fractions in a paddy soil.

Despite the well-documentation of the effects of straw returning on soil structural stability and fertility, its long-term impacts on profile aggregate size composition and organic carbon (OC) fractions remain poorly investigated. To address this research gap, the present nine-year field trial explored the co-effects of straw returning and chemical fertilization on soil total OC (TOC), dissolved OC (DOC), resistant OC (ROC), easily oxidative OC (EOC), as well as soil aggregate size composition of different soil depths (0-15, 15-30, and 30-50 cm) in a paddy field, East China. To do so, four different treatments were set up, including no straw returning plus no fertilization (CK), conventional fertilization (F), straw returning plus conventional fertilization (SF), and straw returning plus 80 % conventional fertilization (SDF).

Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission by Promoting B/CD 4 T Cell Crosstalk.

Current cancer vaccines using T cell epitopes activate antitumor T cell immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 T cell crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) to achieve long-term tumor remission by promoting B/CD4 T cell crosstalk. The topographic features of ACNVax were achieved using an iron nanoparticle core attached with an optimal number of gold nanoparticles, where the clusters of HER2 B/CD4 T cell epitopes were conjugated on the gold surface with an optimal intercluster distance of 5-10 nm.

Two-stage hydrothermal oxygenation for efficient removal of Cr(VI) by starch-based polyporous carbon: Wastewater application and removal mechanism.

Cr(VI) is of concern because of its high mobility and toxicity. In this work, a two-stage hydrothermal strategy was used to activate the O sites of starch, and by inserting K-ion into the pores, starch-based polyporous carbon (S-PC) adsorption sites was synthesized for removal of Cr(VI). Physicochemical characterization revealed that the O content of the S-PC reached 20.

Exploring Transformer Model in Longitudinal Pharmacokinetic/Pharmacodynamic Analyses and Comparing with Alternative Natural Language Processing Models.

There remains a substantial need for a comprehensive assessment of various natural language processing (NLP) algorithms in longitudinal pharmacokinetic/pharmacodynamic (PK/PD) modeling despite recent advances in machine learning in the space of quantitative pharmacology. We herein investigated the application of the transformer model and further compared the performance among several different NLP models, including long short-term memory (LSTM) and neural-ODE (Ordinary Differential Equation) in analyzing longitudinal PK/PD data using virtual data containing three different regimens. Results suggested that LSTM and neural-ODE, along with their respective variants provide a strong performance when predicting from training-included (seen) regimens, albeit with slight information loss for training-excluded (unseen) regimens.

Effects of Straw Returning and New Fertilizer Substitution on Rice Growth, Yield, and Soil Properties in the Chaohu Lake Region of China.

Recently, replacing chemical fertilizers with straw returning and new fertilizers has received considerable attention in the agricultural sector, as it is believed to increase rice yield and improve soil properties. However, less is known about rice growth and soil properties in paddy fields with the addition of different fertilizers. Thus, in this paper, we investigated the effects of different fertilizer treatments, including no fertilization (CK), optimized fertilization based on the medium yield recommended fertilizer amount (OF), 4.

The efficacy and safety of low-dose rituximab in the treatment of pemphigus vulgaris: a cohort study.

Background: Rituximab (RTX) is considered the first-line treatment for pemphigus vulgaris (PV), which is a B-cell-mediated acquired autoimmune disease. However, no consensus on the optimum dosage has been achieved.

Objectives: To investigate the efficacy and safety of low-dose RTX (a single infusion of 500 mg) for the treatment of PV, a cohort study was conducted for patients with PV, along with a 12-month follow-up following the administration of RTX.

Ultrasound-based detection of inflammatory changes for early diagnosis and risk model construction of psoriatic arthritis.

Objectives: PsA is the most prevalent coexisting condition associated with psoriasis. Early-stage PsA patients always present unspecific and subtle clinical manifestations causing delayed diagnosis and leading to unfavourable health outcomes. The application of US enables precise identification of inflammatory changes in musculoskeletal structures.

Fault Detectability of Asynchronous Switched Boolean Networks: A Set Reachability Approach.

This article addresses the fault detectability problem of asynchronous switched Boolean networks, which is focused on whether occurrence of the faults would have an impact on the outputs of the considered network. By applying the semi-tensor product method, the asynchronous switching scheme of the considered system is converted into multiple switching signals. Based on them, an augmented system is established to transform the fault detectability issue of the original system into a set reachability problem.

Enhancement of Cr(VI) adsorption on lignin-based carbon materials by a two-step hydrothermal strategy: Performance and mechanism.

Cr(VI) is a carcinogenic heavy metal that forms an oxygen-containing anion, which is difficult to remove from water by adsorbents. Here, industrial alkali lignin was transformed into a Cr(VI) adsorbent (N-LC) by using a two-step hydrothermal strategy. The characterization results of the adsorbent showed that O and N were uniformly distributed on the surface of the adsorbent, resulting in a favorable morphology and structure.

Effects of continuous straw returning on bacterial community structure and enzyme activities in rape-rice soil aggregates.

Straw returning is an effective management measure to improve or maintain soil fertility in agricultural ecosystems. This study investigated the effects of straw returning combined with compound fertilizer on the bacterial community, enzyme activities, and soil nutrients' contents in a rape-rice rotation soil aggregates. To do so, a 5-year field trial (November 2016 to October 2021) was carried out in a paddy soil with three treatments: no straw + no fertilization (CK), compound fertilizer (F), and straw returning + compound fertilizer (SF).

[Effects of Continuous Straw Returning with Chemical Fertilizer on the Carbon Pool and Crop Yield of Rice-Rape Rotation Soils].

According to the positioning experiment of straw returning in the continuous field 7a, the effects of straw returning combined with chemical fertilizer on soil total organic carbon (TOC), dissolved organic carbon (DOC), particulate organic carbon (POC), labile organic carbon (LOC), carbon pool management index (CPMI), and crop yield in farmland soil profiles (0-20, 20-50, and 50-80 cm) in the Chaohu Lake area were studied. There were four treatments:no straw returning+no fertilization (CK), conventional fertilization (F), straw returning+conventional fertilization (SF1), and straw returning+80% conventional fertilization (SF2). The changes in soil total organic carbon and component content, CPMI, and rape rice yield in different soil layers were analyzed.

Feasibility and preclinical efficacy of CD7-unedited CD7 CAR T cells for T cell malignancies.

Chimeric antigen receptor (CAR)-mediated targeting of T lineage antigens for the therapy of blood malignancies is frequently complicated by self-targeting of CAR T cells or their excessive differentiation driven by constant CAR signaling. Expression of CARs targeting CD7, a pan-T cell antigen highly expressed in T cell malignancies and some myeloid leukemias, produces robust fratricide and often requires additional mitigation strategies, such as CD7 gene editing. In this study, we show fratricide of CD7 CAR T cells can be fully prevented using ibrutinib and dasatinib, the pharmacologic inhibitors of key CAR/CD3ζ signaling kinases.