M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis.

Macrophage infiltration was closely associated with inflammatory injury of podocytes in diabetic nephropathy (DN), while how macrophages affected podocytes remained not entirely clear. Here, we not only investigated the relationship between macrophages and high glucose (HG)-treated podocytes, but the underlying mechanisms were also explored. Transmission electron microscopy, nanoparticle tracking analysis, and western blot of CD9, CD63, CD81, and Calnexin were performed to identify exosomes; QRT-PCR was performed to detect AFAP1-AS1 expression; Western blot was performed to examine NLRP3, Cleaved caspase-1, and GSDMD-N protein levels; Immunofluorescence was performed to assess co-localisation of NLRP3 and ASC; ELISA was performed to detect IL-18 and IL-1β levels; Cytotoxicity LDH Assay Kit was performed to detect LDH level; RNA pulldown was performed to determine the interaction of AFAP1-AS1 and EZH2; ChIP was employed to determine the interaction of EZH2 and H3K27me3 in the NLRP3 promoter region.

Deciphering the Role of Lattice Selenium in Electrocatalytic Self-Reconstruction for Boosting Alkaline Hydrogen Evolution.

Cathode reconstruction is equally crucial for water electrolysis, yet it has received less attention than anode. Lattice selenium (Se) doping is an effective strategy to improve hydrogen evolution reaction (HER) of metal-based electrocatalysts in cathodes, but many fundamental questions concerning the actual role of Se on the active species as well as catalytic kinetics remain to be clarified, especially in those electrocatalytic self-reconstruction systems. Here, we showcase the accelerated two-stage structural evolution of Se-doped cobalt phosphide (Se-CoP) during alkaline HER by operando X-ray absorption spectroscopy and powder X-ray diffraction, combined with high-resolution transmission electron microscopy (HRTEM) analysis.

Pretreatment CALLY index as promising novel biomarker in the prediction of surgical and oncological outcomes in esophageal cancer: a multi-center retrospective cohort study.

Background: Esophageal cancer (EC) is a global health challenge with high mortality rates. The traditional TNM staging system is limited in its ability to provide accurate prognostic predictions. This study aimed to investigate the utility of the C-reactive protein-albumin-lymphocyte (CALLY) index in the evaluation of mid- to long-term outcomes in patients undergoing esophagectomy.

Astragaloside IV ameliorates Parkinson's disease by inhibiting TLR4/NF-κB-dependent neuroinflammation.

Astragaloside IV (AS-IV) is a bioactive compound derived from Radix Astragali, a traditional Chinese herb widely used as a dietary supplement to enhance immune function. Modern pharmacological studies have demonstrated that AS-IV exhibits anti-inflammatory and immunomodulatory properties. In this study, we investigated the effects of AS-IV on motor dysfunction, microglial polarization, and immune regulation mechanisms in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) mouse model.

Co-Implementing Optimized Volmer and Heyrovsky Reactions in Hydrogen Production via Composite Active Sites on Electron-Withdrawing Carriers.

The trade-off of the Volmer reaction for *H formation and the Heyrovsky/Tafel Reaction for *H desorption is a crucial challenge in alkaline hydrogen evolution reaction (HER). Thus, aside from the conventional construction of bifunctional active sites to accelerate the water dissociation step, the electronic retrimming of each metal site is also non-negligible. Herein, an efficient HER electrocatalyst combining Pt single-atoms and Pt nanoparticles on the etched boron nitride (eBN) coated carbon nanotube (Pt-eBN@CNT) is synthesized, where both the Volmer and Heyrovsky steps are promoted by the synergistic adsorption of the composite active sites and the electron-withdrawing effect of eBN carrier, respectively.

Post-oxidation of all-organic electrocatalysts to promote O-O coupling in water oxidation.

Covalently bonded metal-free electrocatalysts exhibit significant potential for sustainable energy technologies, yet their performances remain unsatisfactory compared with metal-based catalysts. Herein, we propose an all-organic electrocatalyst, MEC-2, that conforms to the infrequent oxide path mechanism in alkaline oxygen evolution reaction through post-oxidation modification. MEC-2 achieves an intrinsic overpotential of 257.

Multiscale Structural Regulation of Energy Storage Properties and Their Mechanism of the (1 - ) (BiNa)SrTiO-Ca(MgTa)O Ceramics.

Ceramic dielectric capacitors have gained significant attention due to their ultrahigh power density, current density, and ultrafast charge-discharge speed. However, their potential applications have been limited by their relatively low energy storage density. Researchers have employed various approaches to enhance their energy storage density.

Urea Complexation for Docosahexaenoic Acid Enrichment from Crypthecodinium cohnii Oil: Using Water as the Urea Solvent.

Based on the observation that urea, water, and ethyl esters (EE) can form gypsum-like mixtures, this study explored the feasibility of employing water as a solvent for urea in the urea complexation method to enrich n-3 polyunsaturated fatty acids with docosahexaenoic acid (DHA)-containing ethyl esters (DHA- EE) from Crypthecodinium cohnii as the material. Under the conditions of a urea/DHA-EE ratio of 3, a water/DHA-EE ratio of 0.75, a mixing temperature of 65℃, and a cooling temperature of 20℃, a concentrate containing over 90% DHA was achieved.

Mendelian randomization study of the relationship between blood and urine biomarkers and lung cancer.

Introduction: Identifying suitable biomarkers is crucial for exploring the pathogenesis, early screening, and therapeutic monitoring of lung cancer. This study aims to analyze comprehensively the associations between lung cancer and biomarkers in blood and urine.

Methods: Bidirectional two-sample Mendelian randomization (MR) was used to evaluate the potential causal relationships between blood and urine biomarkers and lung cancer.

Preoperative localization of pulmonary nodules by electromagnetic navigation bronchoscopy combined with methylene blue injection.

Background: Electromagnetic navigation bronchoscopy (ENB) can help to accurately locate pulmonary nodules using a minimally invasive approach. This study sought to evaluate the clinical efficacy and safety of dye marking localization under the guidance of ENB followed by surgery.

Methods: A retrospective analysis was performed of 61 patients who underwent ENB localization using methylene blue dye marking before surgery at Shanghai General Hospital from October 2021 to February 2022.

[Retracted] LOXL1‑AS1 promotes thymoma and thymic carcinoma progression by regulating miR‑525‑5p‑.

Following the publication of the above article, a concerned reader drew to the Editor's attention that certain of the cell invasion assay data featured in Figs. 2G and H, 5M and N, and 9K and L, and the tumor images shown in Fig. 6B, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to , or were under consideration for publication at around the same time (some of which have been retracted).

Study onanddegradation of polydioxanone weaving tracheal stents.

The appropriate degradation characteristics of polydioxanone (PDO) are necessary for the safety and effectiveness of stents. This study aimed to investigate the degradation of PDO weaving tracheal stents (PW stents)and. The degradation solution of(SAU),(ECO),(PAE), and control (N) were prepared, and the PW stents were immersed for 12 weeks.

Discovery and validation of combined biomarkers for the diagnosis of esophageal intraepithelial neoplasia and esophageal squamous cell carcinoma.

Early diagnosis and intervention of esophageal squamous cell carcinoma (ESCC) can improve the prognosis. The purpose of this study was to identify biomarkers for ESCC and esophageal precancerous lesions (intraepithelial neoplasia, IEN). Based on the proteomic and genomic data of esophageal tissue including previously reported data, up-regulated proteins with copy number amplification in esophageal cancer were screened as candidate biomarkers.

Management of deep sacral and ischial pressure injuries with free-style local perforator flaps: A D+P+DPD model.

Background: Previous reports on the treatment of sacral and ischial pressure injuries have not provided clear algorithms for surgical therapies. The objective of this study was to establish a reconstruction algorithm to guide the selection of an ideal free-style perforator flap that can be tailored to the defect in question.

Methods: We used 23 perforator flaps to reconstruct 14 sacral and 8 ischial defects in 22 patients over 5 years.

Iron-doping-induced formation of Ni-Co-O nanotubes as efficient bifunctional electrodes.

The rational design of earth-abundant and efficient electrocatalysts to replace precious metal-based materials is highly anticipated for overall water splitting. Herein, NiCoO electrocatalysts with different Fe doping amounts (Fe-NCO, = 1, 2, 3) were synthesized by a low-temperature chemical method. It was interesting to find that the doping of Fe induced the formation of NiCoO nanotube arrays by modulating the Fe content.

Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells.

Background: Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 2 (APOBEC2) is associated with nucleotide alterations in the transcripts of tumor-related genes which are contributed to carcinogenesis. Expression and prognosis value of APOBEC2 in stomach adenocarcinoma (STAD) remains unclear.

Methods: The APOBEC2 gene alteration frequency of STAD and APOBEC2 gene expression in STAD and normal tissues were investigated in cBioportal and GEPIA, respectively.

Evaluating personalized circulating tumor DNA detection for early-stage lung cancer.

Circulating tumor DNA (ctDNA) has been widely used as a minimally invasive biomarker in clinical routine. However, a number of factors such as panel design, sample quality, patients' disease stages are known to influence ctDNA detection sensitivity. In this study, we systematically evaluated common factors associated with the variability of ctDNA detection in plasma and investigated ctDNA abundance in bronchoalveolar lavage (BAL).

Electronic Effect Promoted Visible-Light-Driven CO-to-CO Conversion in a Water-Containing System.

The design of unsaturated nonprecious metal complexes with high catalytic performance for photochemical CO reduction is still an important challenge. In this paper, four coordinatively unsaturated Co-salen complexes - were explored in situ using -phenylenediamine derivatives and 5-methylsalicylaldehyde as precursors of the ligands in -. It was found that complex , bearing a nitro substituent (-NO) on the aromatic ring of the salen ligand, exhibits the highest photochemical performance for visible-light-driven CO-to-CO conversion in a water-containing system, with TON and CO selectivity values of 5300 and 96%, respectively.

Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis.

PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular mechanisms remain incompletely understood. Herein, we show that PRMT1 plays a critical role in RNA alternative splicing, with a preference for exon inclusion. PRMT1 methylome profiling identifies that PRMT1 methylates the splicing factor SRSF1, which is critical for SRSF1 phosphorylation, SRSF1 binding with RNA, and exon inclusion.

Effect of modulation by adsorption and doping on the quantum capacitance of borophene.

Electric double-layer supercapacitors (EDLCs) have attracted much attention in the energy storage field due to their advantages such as high output power, long service life, safety and high efficiency. However, their low energy density limits their application. Aiming at the problem of the low energy density of EDLCs, improving quantum capacitance () of electrode materials is an effective strategy.

Estrogen-Induced LncRNA, LINC02568, Promotes Estrogen Receptor-Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis Mechanisms.

Endocrine therapy is the frontline treatment for estrogen receptor (ER) positive breast cancer patients. However, the primary and acquired resistance to endocrine therapy drugs remain as a major challenge in the clinic. Here, this work identifies an estrogen-induced lncRNA, LINC02568, which is highly expressed in ER-positive breast cancer and functional important in cell growth in vitro and tumorigenesis in vivo as well as endocrine therapy drug resistance.

Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer.

Background: Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in breast cancer.

Methods: The GEPIA2 database was used to evaluate the expression and survival of NNMT mRNA and DKK1 mRNA of breast cancer. Then an immunohistochemical study was carried out on 374 cases of breast tissue to identify the protein expression and significance of NNMT and DKK1.

Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer.

Purpose: To identify specific novel genes that could be used as diagnostic and prognostic factors in papillary thyroid carcinoma (PTC).

Methods: Screening of differential genes by RNA sequencing (RNA-Seq) in normal thyroid, Hashimoto's thyroiditis, PTC combined with Hashimoto's thyroiditis and PTC tissues. The genes QPCT, SCEL and TNFRSF12A were selected by qRT-PCR and immunohistochemical pre-experiments.