Study on the Self-Healing Performance of Polyurethane/Graphene Oxide-Modified Asphalt Based on Dynamic Disulfide Bonds.

In this study, an investigation on using polyurethane/graphene oxide (PU/GO) containing disulfide bonds as a modifier to improve the self-healing ability of asphalt was conducted. PU/GO with different GO contents were synthesized and modified asphalt with different PU/GO dosages (2%, 4%, 6%, 8%) were also prepared. The effect of GO contents on the mechanical and self-healing properties of PU/GO was explored and the impacts of PU/GO contents on the basic properties and self-healing properties of asphalt were also investigated.

Sustainable Synthesis of 3-Acylmethylated Coumarins via Photoredox Catalytic Radical Addition/Cyclization in Aqueous Media.

A photoredox catalytic cascade radical reaction for the addition/cyclization of arylalkynoates with α-bromoketones in water at room temperature has been developed, offering a green and efficient approach for synthesizing 3-acylmethylated coumarins. This method eliminates the need for conventional organic solvents, phase-transfer catalysts, and excess oxidants, ensuring operational simplicity and environmental sustainability. The reaction is scalable, accommodates a broad array of substrates with outstanding tolerance for functional groups, and offers a versatile route to biologically valuable coumarins.

microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.

Background: Inflammation is the most common cause of kidney damage, and inflammatory responses in a number of diseases are mediated by microRNA-338-3p (miR-338-3p). However, there are only a few reports which described the regulation of miR-338-3p in human proximal tubular cells. The goal of this study was to see how miR-338-3p affected lipopolysaccharide (LPS)-caused inflammatory response in HK-2 cells.

Circ-BICC1 Knockdown Alleviates Lipopolysaccharide (LPS)-Induced WI-38 Cell Injury Through miR-338-3p/MYD88 Axis.

Circular RNAs (circRNAs) play important roles in human diseases, including infantile pneumonia. In this article, we aimed to investigate the functions of circ-BICC1 in lipopolysaccharide (LPS)-induced injury of WI-38 cells. Quantitative real-time polymerase chain reaction (qRT-PCR) assay was performed for the levels of circ-BICC1, BICC1, microRNA-338-3p (miR-338-3p), and myeloid differentiation primary response 88 (MYD88).

Clinical and Immunological Characteristics of Patients With Adenovirus Infection at Different Altitude Areas in Tibet, China.

Background: The severities of human adenovirus (HAdV) infection are diverse in different areas of Tibet, China, where a large altitude span emerges. Serious consequences may be caused by medical staff if the clinical stages and immunological conditions of patients in high-altitude areas are misjudged. However, the clinical symptoms, immunological characteristics, and environmental factors of HAdV infection patients at different altitude areas have not been well described.

Assessing Consumer Preference for Overpackaging Solutions in E-Commerce.

The emergence of e-commerce and express delivery services has significantly transformed business operations and consumer shopping experience. However, the resulting problem of packaging waste, particularly from overpackaging, poses serious challenges to environmental sustainability and human health. Existing research has proposed many solutions from various perspectives, but very few have considered the acceptability and consumer preference for these proposals.

[Clinical efficacy of interactive group sandplay versus individual sandplay in the treatment of preschool children with autism spectrum disorder].

Objective: To study the clinical efficacy of interactive group sandplay versus individual sandplay in the treatment of preschool children with autism spectrum disorder (ASD).

Methods: A total of 80 ASD children, aged 4-6 years, were enrolled and randomly divided into experimental and control groups, with 40 children in each group. The children in the experimental group joined group sandplay with normal children at a ratio of 1: 3, and those in the control group were treated with individual sandplay.

[Clinical effect of integrated sandplay therapy in children with Asperger syndrome].

Objective: To study the clinical effect of integrated sandplay therapy in preschool children with Asperger syndrome (AS).

Methods: A total of 44 preschool children with AS were randomly divided into an experimental group and a control group, with 22 children in each group. The children in the control group were given routine training, and those in the experimental group were given integrated sandplay therapy in addition to the routine training.

The evaluation of basic fibroblast growth factor and fibroblastic growth factor receptor 1 levels in saliva and serum of patients with salivary gland tumor.

Basic fibroblast growth factor (FGF2) is a well-known endothelial mitogen that regulates endothelial cell proliferation, migration, differentiation, and survival. In the present study, we investigated the levels of FGF2 and fibroblastic growth factor receptor 1 (FGFR1) in saliva and serum of patients with salivary gland tumors. Saliva and serum samples were collected from 43 patients with salivary gland tumors and 40 healthy volunteers.