Article Synopsis
- - Oxytocin and its receptor (OXTR) play crucial roles in managing social behaviors and cognitive functions in the brain, influencing various intracellular signaling pathways.
- - The effectiveness of oxytocin is closely tied to OXTR's regulation and expression, which may vary due to genetic and epigenetic factors.
- - Recent research highlights how changes in OXTR gene methylation and polymorphism are linked to psychiatric disorders like autism, emphasizing the need for further understanding of these relations.
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Article Abstract
Oxytocin and its target receptor (oxytocin receptor, OXTR) exert important roles in the regulation of complex social behaviors and cognition. The oxytocin/OXTR system in the brain could activate and transduce several intracellular signaling pathways to affect neuronal functions or responses and then mediate physiological activities. The persistence and outcome of the oxytocin activity in the brain are closely linked to the regulation, state, and expression of OXTR. Increasing evidence has shown that genetic variations, epigenetic modification states, and the expression of OXTR have been implicated in psychiatric disorders characterized by social deficits, especially in autism. Among these variations and modifications, OXTR gene methylation and polymorphism have been found in many patients with psychiatric disorders and have been considered to be associated with those psychiatric disorders, behavioral abnormalities, and individual differences in response to social stimuli or others. Given the significance of these new findings, in this review, we focus on the progress of OXTR's functions, intrinsic mechanisms, and its correlations with psychiatric disorders or deficits in behaviors. We hope that this review can provide a deep insight into the study of OXTR-involved psychiatric disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159063 | PMC |
| http://dx.doi.org/10.3389/fncel.2023.1164796 | DOI Listing |
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