Publications by authors named "Guodong Wu"

Radial tears in the body of the meniscus occur quite often in clinical practice. Because of the concentration of stress, lack of resistance to external forces, and poor blood supply in this area, healing is more difficult compared with other types of tears. As a result, some physicians may perform meniscectomy, which can lead to rapid joint degeneration and osteoarthritis.

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Background: Processed Aconiti Kusnezoffii Radix (Aconiti kusnezoffii Radix Preparata, Zhicaowu) and Retz. (Hezi) are a classic herb pair in Mongolian medicine, where Hezi mitigates Zhicaowu's hepatotoxicity. Despite extensive studies on their detoxification effects, the role of cytochrome P450 (CYP450) modulation remains unclear.

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Ataxia telangiectasia mutated (ATM) blockage can induce apoptosis in ovarian cancer. However, the molecular mechanisms underlying this process remain poorly understood. In this study, ovarian cancer cells (SKOV3) were treated with an ATM inhibitor (KU60019) for 24 hours, and the fold changes of DGAT1 and hsa-miR-1273g-3p were quantified by real-time quantitative polymerase chain reaction (RT-qPCR).

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Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self-tolerance loss, causing tissue damage. Standard treatments targeting late-stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.

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Developing efficient adsorbents for removal of organic pollutants and heavy metals is essential for environmental protection. In this study, a series of GO/UiO-66-(OH) composites were synthesized and characterized using XRD, FT-IR, and SEM, confirming enhanced thermal stability, reduced aggregation, and maintained crystallinity of UiO-66-(OH) due to GO incorporation. Batch adsorption experiments showed that GO increased the adsorption capacity, with GO-8/UiO-66-(OH) achieving 324.

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Renal fibrosis (RF), characterized by excessive deposition of extracellular matrix leading to tissue damage and scar formation, represents a refractory disease and a pivotal pathological basis for the progression to end-stage renal disease. The pathogenesis of RF is intricate, prominently implicating multiple key signaling pathways, including adenosine monophosphate-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), transforming growth factor-β1/small mother against decapentaplegic (TGF-β1/Smad), toll-like receptor 4/nuclear factor kappa B (TLR4/NF-κB), wingless integrated/β-catenin (Wnt/β-catenin), hypoxia-inducible factor-1α (HIF-1α), Hedgehog, and mitogen-activated protein kinase (MAPK). The current Western medical practices primarily rely on supportive and replacement therapies, which are often costly and suboptimal in efficacy.

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Flexible wearable devices and solar flexible units often use thermally sensitive organic materials as substrates, which are prone to thermal damage during the bonding process in 3D packaging, leading to chip deformation or failure. Multicomponent solders, with well-designed multicomponent metallic elements, exhibit unique low-melting-point characteristics. The application of low-temperature multicomponent solders in electronic packaging can significantly reduce bonding temperatures and minimize thermal damage to chips.

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Multiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS.

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Background: Gut microbes have been used to predict CRC risk. Fecal occult blood test (FOBT) has been recommended for population screening of CRC.

Objective: To analyze the effects of fecal occult blood test (FOBT) on gut microbes.

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The synergistic effect of CNT and three-dimensional N-doped graphene foam (3DNG) on improving corrosion resistance of zinc-reinforced epoxy (ZRE) composite coatings was studied in this work. Although CNT itself was demonstrated to be effective to promote the anti-corrosion performance of the ZRE coating, the incorporation of additional 3DNG leads to further enhancement of its corrosion resistance under the synergistic effect of the hybrid carbon nanofillers with different dimensions. Both the content of the carbonaceous fillers and the ratio between them affected the performance of the coating.

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Traditional tissue engineering strategies focus on geometrically static tissue scaffolds, lacking the dynamic capability found in native tissues. The emerging field of 4D bioprinting offers a promising method to address this challenge. However, the requirement for consistent exogenous supplementation of growth factors (GFs) during tissue maturation poses a significant obstacle for in vivo application of 4D bioprinted constructs.

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Article Synopsis
  • - The growing success of Transformers in machine learning is generating interest in its application to remote sensing (RS), but research is limited by the lack of large labeled datasets and data variability across platforms.
  • - The study introduces a multi-modal fusion mechanism (MGSViT) that combines multispectral (MS) and synthetic aperture radar (SAR) data using a pre-trained ViT model and gated fusion units for improved feature extraction.
  • - Results indicate that this new method surpasses existing algorithms in classification tasks, demonstrating its effectiveness in multi-modal data fusion for remote sensing applications.
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Background: Pregnancy-induced hypertension remains one of the important types of diseases that affect maternal and infant outcomes; prenatal and perinatal ultrasound examination is an important tool for evaluating fetal development. So, this study aimed to explore the clinical value of applying fetal heart quantification (fetal HQ) measuring left ventricular global longitudinal strain (LVGLS) and left ventricular ejection fraction (LVEF) in mid-to-late fetuses to predict neonatal complications in patients with gestational hypertension.

Methods: A retrospective summary of 146 pregnant women with gestational hypertension diagnosed from August 2020 to October 2023 into JinHua Maternal and Child Health Care Hospital was performed.

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Lung ischemia-reperfusion injury (IRI) stands as the primary culprit behind primary graft dysfunction (PGD) after lung transplantation, yet viable therapeutic options are lacking. In the present study, we used a murine hilar clamp (1 h) and reperfusion (3 h) model to study IRI. The left lung tissues were harvested for metabolomics, transcriptomics, and single-cell RNA sequencing.

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Article Synopsis
  • Scientists learned that a protein called YTHDF3 helps cancer cells in non-small cell lung cancer (NSCLC) avoid attacks from the immune system.
  • When YTHDF3 levels are high, it stops CD8 T cells (a type of immune cell) from fighting the cancer effectively.
  • This study shows that targeting YTHDF3 may help boost the immune system's ability to fight lung cancer, providing ideas for new treatments.
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Magnesium hydroxide, as a green inorganic flame-retardancy additive, has been widely used in polymer flame retardancy. However, magnesium hydroxide is difficult to disperse with epoxy resin (EP), and its flame-retardancy performance is poor, so it is difficult to use in flame-retardant epoxy resin. In this study, an efficient magnesium hydroxide-based flame retardant (MH@PPAC) was prepared by surface modification of 2-(diphenyl phosphine) benzoic acid (PPAC) using a simple method.

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Broadband photodetectors have attracted much attention due to their multispectral response properties and show great potential in the fields of optical sensing, multispectral imaging, and optical communications. Palladium telluride (PdTe) is highly competitive in broadband detection due to its tunable bandgap and nonlinear optical properties. However, the low response speed hinders further improvement in the performance of PdTe-based broadband photodetectors.

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Objective: It was previously believed that atherosclerotic (AS) plaque starts to develop from the intima and that intraplaque vasa vasorum (VV) hyperplasia promotes adventitial VV (AVV) hyperplasia. However, recent studies have shown that arterial AVV hyperplasia precedes early intimal thickening, suggesting its possible role as an initiating factor of AS. To provide further insight into this process, in this study, we examine the evolution of AAV and VV development in a preclinical model of early AS with longitudinal ultrasound imaging.

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Leucine-rich α2-glycoprotein-1 (LRG1) is overexpressed in various cancers, including non-small cell lung cancer (NSCLC), but its role in NSCLC cell metastasis is not well understood. In this study, NSCLC cell exosomes were analyzed using different techniques, and the impact of exosomal LRG1 on NSCLC cell behavior was investigated through various assays both in vitro and in vivo. The study revealed that LRG1, found abundantly in NSCLC cells and exosomes, enhanced cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).

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Ethnopharmacological Relevance: Ginkgo biloba leaf and seed have been traditionally used in ancient China for the treatment of cough and asthma. However, there is limited literature available on the anti-COPD effects and mechanisms of Ginkgo biloba.

Aims Of The Study: The aim of this study was to comprehensively investigate the therapeutic potential of ginkgo extracts in COPD through a combination of in vivo and in vitro functional experiments.

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Background: We sought to create a system to evaluate the physical fitness of outstanding Chinese male boxers that included an evaluation index, fitness level criteria, and modeling. This system was then used to assess athletes' physical fitness and development.

Methods: Documentation, expert interviews, questionnaires, measurements, and statistical analyses were used in this study.

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Objective: Arterial adventitial vasa vasorum (AVV) plays an important role in the occurrence and development of atherosclerotic (AS) disease. AS is a systemic disease, and plaque is not only a local vascular event, but also occurs at multiple sites throughout the vascular bed. Currently, effective anti-AVV therapies are lacking.

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Background: The lower limbs play a key role to develop the linear momentum for hitting power in effective boxing. The knee extensor and flexor strength guarantees the dynamic stability of boxers. The insufficient extensor strength of the lower extremities causes compensation during flexion resulting in movement errors or damage to knee joint muscles.

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