NLRP12 decreases TRIM25-mediated HK2 degradation to promote glycolysis and H3K18la in gastric cancer.

Gastric cancer is the most common primary malignant tumor of the digestive system. Recent studies have shown that targeting tumor cell metabolic reprogramming is a key cancer treatment strategy. NLR family pyrin domain containing 12 (NLRP12) is related to innate immunity, inflammation and tumorigenesis, but its role in the progression of gastric cancer remains unclear.

miR-603 mediates thyroid cancer progression by inhibiting HACE1-Dependent YAP1 degradation.

This study delineates the regulatory role of MicroRNA-603 (miR-603) on the molecular dynamics of HACE1 and YAP1 in thyroid cancer (TC). Using a combination of bioinformatics, dual-luciferase reporter assays, and various cellular assays, we identified that miR-603 is significantly overexpressed in TC tissues and cells. Our investigations confirmed that miR-603 targets the 3'UTR of HACE1, suppressing its expression, which in turn affects the ubiquitination and stability of the YAP1 protein.

Electrical Manipulation of Field-Free Magnetization Switching Driven by Spin-Orbit Torque in Amorphous Gradient-MnSn.

Switching the magnetization without an assisted magnetic field is crucial for the application of spin-orbit torque (SOT) devices. However, the realization of field-free magnetization switching usually calls for intricate design and growth of heterostructure. In this study, it is found that the amorphous MnSn can generate a highly efficient spin current with a strong z-direction polarization component due to its spontaneous composition gradient, which switches the perpendicular magnetization in the absence of an external field.

Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study.

Background: Breast cancer, a major threat to women's health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression.

Methods: This study employed the two-sample Mendelian randomization (MR) approach to investigate the potential causal relationship between cathepsin levels and the risk of developing breast cancer.

Extracellular vesicle-mediated delivery of miR-766-3p from bone marrow stromal cells as a therapeutic strategy against colorectal cancer.

Objective: As colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths, understanding novel therapeutic mechanisms is crucial. This research focuses on the role of extracellular vesicles (EVs) from bone marrow stromal cells (BMSCs) in delivering miR-766-3p to CRC cells, targeting the MYC/CDK2 signaling axis.

Methods: Differentially expressed genes between BMSCs-EVs and CRC were identified using the Gene Expression Omnibus database.

Safety and cosmesis of gasless endoscopic thyroidectomy: a retrospective study.

Despite growing interest in gasless endoscopic unilateral thyroid lobectomy via the axillary approach, there are a lack of sufficient data on its safety and cosmetic outcomes. This retrospective study analysed the clinical outcomes and postoperative complications of 161 patients who underwent this surgery for thyroid cancer and nodules, with particular attention given to complications and patient satisfaction with cosmetic outcomes. All 161 patients (143 females, 18 males) successfully underwent the operation without conversion to open surgery.

Linearly Polarized Broadband Emission and Multiwavelength Lasing in Solution-Processed Quantum Dots.

A miniature laser with linear polarization is a long sought-after component of photonic integrated circuits. In particular, for multiwavelength polarization lasers, it supports simultaneous access to multiple, widely varying laser wavelengths in a small spatial region, which is of great significance for advancing applications such as optical computing, optical storage, and optical sensing. However, there is a trade-off between the size of small-scale lasers and laser performance, and multiwavelength co-gain of laser media and multicavity micromachining in the process of laser miniaturization remain as significant challenges.

Ratiometric fluorescent sensor with large pseudo-Stokes shifts for precise sensing and imaging of pH without interferential background fluorescence.

Endowing fluorescent pH sensors with large Stokes shifts promises to resolve interferential background fluorescence in practice, and yet few such method has been reported, owing to lack of luminescent materials with large Stokes shifts used in fluorescent sensors. Herein, we elaborately designed NaGdF:Ce@NaGdF:Nd@NaYF:Eu core-double shells (CDS) lanthanide-doped fluoride nanoparticles (LFNPs), employing Gd-mediated energy migration and interfacial energy transfer to realize intense red and NIR emissions under 254 nm irradiation, and pseudo-Stokes shifts of which reached up to striking 361 nm and 610 nm, respectively. The CDS LFNPs collaborated with absorption-based pH indicator bromocresol green to from a novel fluorescent sensor film, and employing low-cost dual chip RGB-NIR camera to precisely record luminescence signals.

Control of Compensation Temperature in CoGd Films through Hydrogen and Oxygen Migration under Gate Voltage.

Electrical control of magnetic properties is crucial for low-energy memory and logic spintronic devices. We find that the magnetic properties of ferrimagnetic CoGd can be altered through ionic liquid gating. Gate voltages manipulate the opposite magnetic moments in Co and Gd sublattices and induce a giant magnetic compensation temperature change of more than 200 K in Pt/CoGd/Pt heterostructures.

Luminescence, energy transfer, colour modulation and up-conversion mechanisms of Yb, Tm and Ho co-doped YMoO.

A series of novel up-conversion luminescent Yb/Ln (Tm, Ho, Tm/Ho)-doped YMoO (YMO) nanocrystals were synthesized using the sol-gel method. The consistent spherical morphology of the nanocrystals with different doping ratios was found to be profiting from the homogenisation and rapid agglomeration of the composition in the gel state and calcining process. The X-ray diffraction (XRD) and field-emission scanning electron microscope images were employed to confirm perfect crystallinity and uniform morphology.

Electrical Control of Magnetism through Proton Migration in FeO/Graphene Heterostructure.

Ion migration has direct and crucial bearing on the crystal lattice field, electron filling, orbital occupation and spin polarization, which in turn changes the physical properties. Electric field is an effective way to control ion migration, but it may include simultaneous movement of multiple ions and increase the complexity of the system. Therefore, controllable and selective single ion migration with an unambiguous mechanism is highly desired.

Inner filter effect between upconversion nanoparticles and Fe(ii)-1,10-phenanthroline complex for the detection of Sn(ii) and ascorbic acid (AA).

Dual-function and multi-function sensors can use the same material or detection system to achieve the purpose of detection of two or more substances. Due to their high sensitivity and specificity, dual-function and multi-function sensors have potential applications in many fields. In this article, we designed a dual-function sensor to detect Sn(ii) and ascorbic acid (AA) based on the inner filter effect (IFE) between NaYF:Yb,Er@NaYF@PAA (UCNPs@PAA) and Fe(ii)-1,10-phenanthroline complex.

Rational designing of oscillatory rhythmicity for memory rescue in plasticity-impaired learning networks.

In the brain, oscillatory strength embedded in network rhythmicity is important for processing experiences, and this process is disrupted in certain psychiatric disorders. The use of rhythmic network stimuli can change these oscillations and has shown promise in terms of improving cognitive function, although the underlying mechanisms are poorly understood. Here, we combine a two-layer learning model, with experiments involving genetically modified mice, that provides precise control of experience-driven oscillations by manipulating long-term potentiation of excitatory synapses onto inhibitory interneurons (LTP).

A Critical Role for γCaMKII in Decoding NMDA Signaling to Regulate AMPA Receptors in Putative Inhibitory Interneurons.

CaMKII is essential for long-term potentiation (LTP), a process in which synaptic strength is increased following the acquisition of information. Among the four CaMKII isoforms, γCaMKII is the one that mediates the LTP of excitatory synapses onto inhibitory interneurons (LTP). However, the molecular mechanism underlying how γCaMKII mediates LTP remains unclear.

Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression.

Introduction: Breast cancer metastasis is the main cause of cancer-related death in women worldwide. Current therapies have remarkably improved the prognosis of breast cancer patients but still fail to manage metastatic breast cancer. Here, the present study was set to explore the role of microRNA (miR)-660 from tumor-associated macrophages (TAMs) in breast cancer, particularly in metastasis.

HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.

Background: Ubiquitously expressed transcript (UXT) is a prefoldin-like protein. It was reported that UXT played vital role in several cancer types. However, functional role of UXT in breast cancer need further investigation.

MiR-200c promotes papillary thyroid cancer cell proliferation, migration, and invasion by downregulating PTEN.

MiR-200c has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-200c remain uncovered papillary thyroid cancer (PTC). The expression level of miR-200c was evaluated in PTC tissues using RT-qPCR.

Excitation-transcription coupling via synapto-nuclear signaling triggers autophagy for synaptic turnover and long-lasting synaptic depression.

For network rewiring and information storage in the brain, late phase long-term synaptic depression (L-LTD) requires the long-lasting reorganization of cellular resources. We found that activation of GRIN/NMDAR recruits transcription-dependent autophagy for synaptic turnover to support L-LTD. Activity-dependent CRTC1 synapto-nuclear translocation increases nuclear CRTC1 that competes with FXR for binding to CREB; this in turn enhances the direct binding between CRTC1-CREB and macroautophagy/autophagy gene promoters.

Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD.

Cellular resources must be reorganized for long-term synaptic plasticity during brain information processing, in which coordinated gene transcription and protein turnover are required. However, the mechanism underlying this process remains elusive. Here, we report that activating N-methyl-d-aspartate receptors (NMDARs) induce transcription-dependent autophagy for synaptic turnover and late-phase long-term synaptic depression (L-LTD), which invokes cytoplasm-to-nucleus signaling mechanisms known to be required for late-phase long-term synaptic potentiation (L-LTP).

Warm white-light emitting silica films prepared using lead-free double perovskite QDs.

Lead-free double perovskite has attracted widespread attention due to its good stability and non-toxicity. In this work, Cs2AgxNa1-xInCl6 quantum dots were synthesized via a thermal injection method using non-toxic precursors. Based on the wide spectrum of self-bound excitons, the quantum dots achieved white light emission.

Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons.

Mental experiences can become long-term memories if the hippocampal activity patterns that encode them are broadcast during network oscillations. The activity of inhibitory neurons is essential for generating these neural oscillations, but molecular control of this dynamic process during learning remains unknown. Here, we show that hippocampal oscillatory strength positively correlates with excitatory monosynaptic drive onto inhibitory neurons (E→I) in freely behaving mice.

Fluorescence resonance energy transfer between NH-NaYF:Yb,Er/NaYF@SiO upconversion nanoparticles and gold nanoparticles for the detection of glutathione and cadmium ions.

Dual-functional nanosensors based on small molecule regulation can be widely used due to their simplicity, high sensitivity and selectivity. Herein, glutathione (GSH) calibrated dual-functional system for GSH and cadmium ions (Cd) detection based on fluorescence resonance energy transfer (FRET) between NH-NaYF:Yb,Er/NaYF@SiO upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) is designed. Unmodified AuNPs are easy to aggregate in high-salt solution and thereby quenching the red emission of UCNPs.

Fluorometric determination of antioxidant capacity in human plasma by using upconversion nanoparticles and an inner filter effect mechanism.

The balance between free oxygen radicals and antioxidant defense systems is usually assessed by an antioxidant capacity assay. A rapid and sensitive antioxidant capacity assay is described here. It is making use of NaYF:Yb/Er@NaYF core-shell upconversion nanoparticles (UCNPs) and potassium permanganate (KMnO).

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory.

Learning and memory depend on neuronal plasticity originating at the synapse and requiring nuclear gene expression to persist. However, how synapse-to-nucleus communication supports long-term plasticity and behavior has remained elusive. Among cytonuclear signaling proteins, γCaMKII stands out in its ability to rapidly shuttle Ca/CaM to the nucleus and thus activate CREB-dependent transcription.

UV Light Illumination Can Improve the Sensing Properties of LaFeO₃ to Acetone Vapor.

The synthesized LaFeO₃ nanocrystalline sensor powders show positive response to sensing acetone vapor at 200 °C. The responses to acetone vapor (at 0.5, 1, 2, 5, 10 ppm) are 1.