Exploring key developmental phases and phase-specific genes across the entirety of anther development in maize.

Anther development from stamen primordium to pollen dispersal is complex and essential to sexual reproduction. How this highly dynamic and complex developmental process is controlled genetically is not well understood, especially for genes involved in specific key developmental phases. Here we generated RNA sequencing libraries spanning 10 key stages across the entirety of anther development in maize (Zea mays).

Effect of miR124a on collageninduced arthritis in mice and the underlying mechanisms.

Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease. MicroRNA has been shown to play an important role in RA. MicroRNA-124a (miR-124a) has anti-proliferative and anti-inflammatory effects in RA fibroblast synovial cells.

Influencing Factors of International Students' Anxiety Under Online Learning During the COVID-19 Pandemic: A Cross-Sectional Study of 1,090 Chinese International Students.

Objective: We conducted the following cross-sectional study to comprehensively assess the anxiety among Chinese international students who studied online during the COVID-19 pandemic and its influencing factors.

Methods: Questionnaires were distributed through "Sojump," and a total of 1,090 valid questionnaires were collected. The questionnaire was divided into two parts: general situation and anxiety assessment of students.

leaf extracted and incorporated polycaprolactone/polyvinylpyrrolidone electrospun microfibers for antibacterial application.

is a valuable reforestation conifer and traditional medicinal plant. In order to retain the physiological and pharmacological activities of the plant and obtain a fibrous material with better antibacterial properties, a mixed solvent of dichloromethane and ,'-dimethylformamide was used to obtain the leaf extracts, and leaf extract (ScLE)-loaded PCL/PVP microfibers were successfully fabricated by electrospinning. The whole preparation process was carried out at room temperature to avoid deterioration of active ingredients.

Simultaneous Prediction of Wheat Yield and Grain Protein Content Using Multitask Deep Learning from Time-Series Proximal Sensing.

Wheat yield and grain protein content (GPC) are two main optimization targets for breeding and cultivation. Remote sensing provides nondestructive and early predictions of yield and GPC, respectively. However, whether it is possible to simultaneously predict yield and GPC in one model and the accuracy and influencing factors are still unclear.

The effect of anger on pedestrian avoidance in a simulated driving task.

Studies of the influence of emotions on driving behaviour have produced contradictory conclusions. This confusion is related to two factors: emotional arousal and driving tasks. The purpose of this study is to explore the effects of anger and happiness on the driving behaviour of drivers who encounter a pedestrian-crossing event on an unmarked road, which requires strategic and behavioural choices.

The effect of automation trust tendency, system reliability and feedback on users' phishing detection.

As a new intrusion method in the security field, phishing poses an enormous threat to network security and personal privacy. Thus, improving the level of network security and preventing phishing are a matter of great concern to both the state and researchers. A 2 (automation trust tendency) *2 (system reliability level) *2 (feedback) between-subjects design was adopted to study the impact of individual characteristics and system features on phishing detection.

DMRA: Depth-Induced Multi-Scale Recurrent Attention Network for RGB-D Saliency Detection.

In this work, we propose a novel depth-induced multi-scale recurrent attention network for RGB-D saliency detection, named as DMRA. It achieves dramatic performance especially in complex scenarios. There are four main contributions of our network that are experimentally demonstrated to have significant practical merits.

Age-related GSK3β overexpression drives podocyte senescence and glomerular aging.

As life expectancy continues to increase, clinicians are challenged by age-related renal impairment that involves podocyte senescence and glomerulosclerosis. There is now compelling evidence that lithium has a potent antiaging activity that ameliorates brain aging and increases longevity in Drosophila and Caenorhabditis elegans. As the major molecular target of lithium action and a multitasking protein kinase recently implicated in a variety of renal diseases, glycogen synthase kinase 3β (GSK3β) is overexpressed and hyperactive with age in glomerular podocytes, correlating with functional and histological signs of kidney aging.

Building on endogenous lipid mediators to design synthetic receptor ligands.

Large numbers of diverse biologically active molecules are produced from phospholipids, the constituents of biological membranes. Indeed, many lipid-derived ligands, which can undergo inter-transformation between one and another by certain kinases or enzymes, bind to protein receptors such as G-protein-coupled receptors, and serve to regulate multiple biological processes through a variety of signaling pathways. Thus, lipid mediators are likely involved in a synergistic regulatory network, and dysfunction of this network may result in diseases.

Microalgae tolerant of boron stress and bioresources accumulation during the boron removal process.

Boron (B) industry and consuming produce large amounts of B-containing wastewater. Low tolerance of microorganisms and plants resulted in the biological removal of B was limited. Microalgae show high adaptability in adverse environments.

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma.

Background: Infectious agents can reprogram or "train" macrophages and their progenitors to respond more readily to subsequent insults. However, whether such an inflammatory memory exists in type 2 inflammatory conditions such as allergic asthma was not known.

Objective: We sought to decipher macrophage-trained immunity in allergic asthma.

iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis.

Background: Approximately 30% of patients with rheumatoid arthritis (RA) respond poorly to combination therapy of multiple drugs. The molecular mechanisms of different responses to methotrexate + leflunomide + infliximab therapy in patients with RA were explored in this study.

Methods: Infliximab was administered to patients with RA whose disease activity score was higher than 5.

Xp11.2 Translocation Renal Cell Carcinoma With Rearrangement: Distinct Morphological Features and Prognosis With Different Fusion Partners.

Background: Renal cell carcinoma (RCC) associated with Xp11.2 translocation/ gene fusion is a rare and new subtype of RCC and was classified by the WHO in 2004. Since then, multiple 5' fusion partners for have been reported; however, the impact of individual fusion variant on specific clinicopathologic features of Xp11.

[Isolation and identification of cholesterol-degrading intestinal bacteria by culturomics and evaluation of their functions].

High cholesterol is one of the important factors inducing cardiovascular and cerebrovascular diseases. Drug therapy is the main method for reducing cholesterol, but has the disadvantages such as high cost and side effects. Studies have shown that intestinal bacteria play important roles in cholesterol metabolism.

Modified osteotomy for treatment of forearm deformities (Masada IIb) in hereditary multiple osteochondromas: a retrospective review.

Purpose: Approximately 30% of patients with hereditary multiple osteochondromas (HMO) have forearm deformity and dysfunction. The aim of this retrospective study was to review our experience with the surgical treatment of children with HMO and Masada IIb forearm deformities.

Methods: Data of eight children treated for HMO Masada IIb forearm deformity at our hospital between 2015 and 2019 were collected from the hospital records and retrospectively reviewed.

High genetic diversity in Plasmodium falciparum isolates among Chinese migrant workers returnee from Africa.

Malaria is one of the most important parasitic diseases that causes a serious public health problem. The genetic diversity of malaria parasites may affect malaria transmission and malaria control strategies. In China, imported malaria was significantly increased in recent years, among which numerous migrant workers were infected with Plasmodium falciparum from Africa.

Chemical compositions and pharmacological activities of natural musk (Moschus) and artificial musk: A review.

Ethnopharmacological Relevance: Natural musk (Moschus), derived naturally from male musk deer (Moschus berezovskii Flerov, Moschus sifanicus Przewalski, or Moschus moschiferus Linnaeus), has long been an important component of traditional Chinese medicine (TCM), and was used as resuscitation, blood circulation, and collateral drainage. detumescence and pain relief. Artificial musk was researched and applied into TCM as natural musk being as unsustainable resources.

Exploring the performance of click and slide gestures on large in-vehicle touch screens.

Because of the operation distractions created by large in-vehicle touch screens, it is necessary to explore the influence of the locations at which clicking and sliding gestures are performed on driving safety and operation performance. This study conducted two experiments to identify an easy operation area. In experiment 1, the influence of control size and control position on click offsets was discussed.

The Relationship Between WeChat Use by Chinese Urban Older Adults Living Alone and Their Subjective Well-Being: The Mediation Role of Intergenerational Support and Social Activity.

Purpose: WeChat is China' biggest social media platform. In addition to instant messaging, it has a great many useful functions that can help Chinese citizens adapt to an increasingly digitized society. This study aimed to examine the effect of WeChat use on the subjective well-being (SWB) of Chinese older adults living alone, and how the effect could occur.

XGBLC: an improved survival prediction model based on XGBoost.

Motivation: Survival analysis using gene expression profiles plays a crucial role in the interpretation of clinical research and assessment of disease therapy programs. Several prediction models have been developed to explore the relationship between patients' covariates and survival. However, the high-dimensional genomic features limit the prediction performance of the survival model.

Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in multidrug-resistant cancer cells through activation of PERK/eIF2α/ATF4 pathway.

After decades of research, multidrug resistance (MDR) remains a huge challenge in cancer treatment. In this study, the cytotoxic of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide (MCC1734) has been investigated towards multidrug-resistant cancer cell lines. MCC1734 exerted cytotoxicity on cell lines expressing different mechanisms of drug resistance (P-glycoprotein, BCRP, ABCB5, EGFR, p53 knockout) to a different extent.

Exploring Seasonal and Circadian Rhythms in Structural Traits of Field Maize from LiDAR Time Series.

Plant growth rhythm in structural traits is important for better understanding plant response to the ever-changing environment. Terrestrial laser scanning (TLS) is a well-suited tool to study structural rhythm under field conditions. Recent studies have used TLS to describe the structural rhythm of trees, but no consistent patterns have been drawn.