Ginsenoside Rh2 alleviates inflammatory response and enhances motor function recovery in spinal cord injury mice via the ROS/MAPK14 signaling pathway.

Background: Inhibiting inflammation in nervous system is a vital part of treating for spinal cord injury (SCI). Compounds originating from plants can decrease the damage in the spinal cord for recovering the function of nerve and interrupting the inflammatory reaction. 20(S)-Ginsenoside Rh2 (G-Rh2) from Panax ginseng is an anti-inflammatory property inhibiting the expression of MAPK14 protein by enabling the MAPK pathway.

Design, synthesis, and biological evaluation of Pamicogrel derivatives as potential antiplatelet agents.

According to the bioisosterism principle and activity substructure splicing strategy, new pamicogrel derivatives were designed, synthesized, and evaluated for their antiplatelet aggregation activities in vitro. Bioassay results showed that compound SZ displayed superior in vitro antiplatelet aggregation activities induced by Arachidonic Acid (AA) and Collagen (COL) with the IC values of 3.44 and 2.

The current status of early nursing for emergency pancreatitis and analysis of factors influencing prognosis: A retrospective study.

This study is to investigate the incidence of pain and the influencing factors of prognostic complications in early admission care of pancreatitis in the emergency department patients. This provides a basis for clinical nursing management and prognosis improvement. Hundred patients with acute pancreatitis admitted to the tertiary hospital between January 2021 and December 2023 were selected according to the inclusion and exclusion criteria.

Development and validation of a prediction model for hypoproteinemia after traumatic spinal cord injury: A multicenter retrospective clinical study.

A multicenter retrospective analysis of conventionally collected data. To identify the potential causes of hypoproteinemia after traumatic spinal cord injury (TSCI) and provide a diagnostic model for predicting an individual likelihood of developing hypoproteinemia. Hypoproteinemia is a complication of spinal cord injury (SCI), an independent risk factor for respiratory failure in elderly patients with SCI, and a predictor of outcomes in patients with cervical SCI.

Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy.

Valproic acid (VPA) is a primary medication for epilepsy, yet its hepatotoxicity consistently raises concerns among individuals. This study aims to establish an automated machine learning (autoML) model for forecasting the risk of abnormal increase of transaminase levels while undergoing VPA therapy for 1995 epilepsy patients. The study employed the two-tailed T test, Chi-square test, and binary logistic regression analysis, selecting six clinical parameters, including age, stature, leukocyte count, Total Bilirubin, oral dosage of VPA, and VPA concentration.

Development and validation of a risk nomogram to estimate risk of hyponatremia after spinal cord injury: A retrospective single-center study.

Objective: This study aimed to establish a nomogram-based assessment for predicting the risk of hyponatremia after spinal cord injury (SCI).

Design: The study is a retrospective single-center study.

Participants: SCI patients hospitalized in the First Affiliated Hospital of Guangxi Medical University.

Superior hydrogen performance of formed carbon modified MgH composites.

The MgH-carbonic combustion product of the anthracene (CCPA) composite was synthesized by hydrogen combustion and mechanically ball-milled method to simultaneously achieve confinement by the formed amorphous carbon. The amorphous carbon derived from the carbonic combustion product of anthracene in the MgH-CCPA composite led to a significant increase in hydrogen sorption characteristics. The onset dehydrogenation temperature for the MgH-CCPA composite was reduced to 589 K, which was 54 K less than that of pure milled MgH.

Systematically Investigating the Pharmacological Mechanism of in the Treatment of Spinal Cord Injury by Network Pharmacology and Experimental Verification.

Objective: This study aimed to explore the molecular mechanism of (MG) in spinal cord injury (SCI) by network pharmacology analysis.

Methods: We searched for potential active MG compounds using the TCMSP database and the BATMAN-TCM platform. The Swiss target prediction database was used to find MG-related targets and the targets of SCI from the CTD, GeneCards, and DrugBank databases.

Functional analyses of two interferon-stimulated gene 15 (ISG15) copies in large yellow croaker, Larimichthys crocea.

In this study, we conducted functional analyses for two ISG15 homologues of Larimichthys crocea (LcISG15-1 and LcISG15-2). Our results of qRT-PCR showed that both LcISG15-1 and LcISG15-2 were significantly changed in head kidney and peripheral blood, after poly (I:C) stimulation. Western blot analyses with prepared polyclonal antibodies suggested that LcISG15-1 and LcISG15-2 both could be secreted by primary head kidney lymphocytes into the extracellular milieu.

Design and synthesis of novel benzimidazole-iminosugars linked a substituted phenyl group and their inhibitory activities against β-glucosidase.

A series of novel benzimidazole-iminosugars linked a (substuituted) phenyl group on benzene ring of benzimidazole 5(a-p) and 6(a-p) have been rationally designed and conveniently synthesized through Suzuki coupling reaction in high yields. All compounds have been evaluated for their inhibitory activities against β-glucosidase (almond). Six compounds 5d, 6d, 6e, 6i, 6n, and 6p showed more significant inhibitory activities with IC values in the range of 0.

[Intraoperative IPC combined with 3M warming instrument to prevent lower extremity deep venous thrombosis in patients undergoing proximal femoral anti rotation intramedullary nailing].

Objective: To explore the effect of intermittent pneumatic compression(IPC) combined with 3M thermometer on the prevention of deep venous thrombosis(DVT) in patients with femoral intertrochanteric fracture.

Methods: From March 2016 to August 2019, 127 patients with femoral intertrochanteric fractures who underwent proximal femoral nail antirotation(PFNA) were retrospectively analyzed. They were divided into two groups according to different methods of thrombus prevention and treatment.

Efficacy and safety of free medial plantar flap in repair of the high-voltage electrical burns in hands.

Purpose: The purpose of this work was to validate the efficacy and safety of free medial plantar flap in repair of hand wounds resulted from high-voltage electrical burn.

Methods: 22 patients with high-voltage electrical burn wounds were retrieved between July 2016 and July 2018 in the Affiliated Zhengzhou Central Hospital of Zhengzhou University. All the wounds were the entrance of high-voltage electrical current.

Effects of enteral nutrition with parenteral glutamine supplementation on the immunological function in septic rats.

The aim of the present study was to investigate the effects of enteral nutrition (EN) with parenteral glutamine (GLN) supplementation on inflammatory response, lymphatic organ apoptosis, immunological function and survival in septic rats by caecal ligation and puncture (CLP). Male rats were randomly assigned into two experimental groups and two sham CLP control groups (n 10 per group). After CLP or sham CLP model and nutrition programme were completed, the GLN concentrations of plasma and tissues and several indices of immunological function including serum Ig content, circulating lymphocyte number, the CD4:CD8 ratio, the neutrophil phagocytosis index (NPI), the organ index and apoptosis of thymus and spleen, and plasma cytokine levels were determined.

[Comparative study of four alkaloids contents and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province].

Objective: To compare the contents of four alkaloids and antitussive activities of Stemona tuberosa from different habitats of Guangxi Province.

Methods: The HPLC separation was performed on a Merck Purospher STAR RP18 (250 mm x 4. 6 mm, 5 µm) column by gradient elution using 0.