The Role of Influencers and Echo Chambers in the Diffusion of Vaccine Misinformation: Opinion Mining in a Taiwanese Online Community.

Background: Prevalence and spread of misinformation are a concern for the exacerbation of vaccine hesitancy and a resulting reduction in vaccine intent. However, few studies have focused on how vaccine misinformation diffuses online, who is responsible for the diffusion, and the mechanisms by which that happens. In addition, researchers have rarely investigated this in non-Western contexts particularly vulnerable to misinformation.

Digitalization, Psychological Well-Being, and the Third-Level Digital Divide: Survey Study During the COVID-19 Pandemic in China.

Background: While rapid digitalization has helped society cope with the uncertainty of the COVID-19 pandemic, will it bring health equity to the digitally disadvantaged? Limited studies have explored how individuals' digital activities may impact their psychological well-being during the pandemic and whether these effects vary across different sociodemographic groups.

Objective: This study aims to examine how individuals' digital activities influence their psychological well-being and whether socioeconomic status moderates the relationship between digitalization and mental health.

Methods: This study was based on a sample of 2170 residents surveyed in Hubei, the early epicenter of the pandemic in China, between March 23 and April 9, 2020.

RXR modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKK-AMPK axis.

Hepatic stellate cells (HSCs) are the primary fibrogenic cells in the liver, and their activation plays a crucial role in the development and progression of hepatic fibrosis. Here, we report that retinoid X receptor-alpha (RXR), a unique member of the nuclear receptor superfamily, is a key modulator of HSC activation and liver fibrosis. RXR exerts its effects by modulating calcium/calmodulin-dependent protein kinase kinase (CaMKK)-mediated activation of AMP-activated protein kinase-alpha (AMPK).

Assessment of influential factors and risk area prediction of scrub typhus in Gannan region, China, based on ecological niche modelling and geographical detector.

This study sought to define the potential infection risk zone of scrub typhus in Gannan and investigate the factors that contribute to this risk zone. Based on the distribution data of scrub typhus cases and environmental factors in Gannan from 2015-2021, a maximum entropy ecological niche modelling was employed to forecast potential risk areas in the region. The influence of each environmental factor on the risk was quantified using a geographical detector.

Comparative evaluation of moutan pods and moutan barks by HPLC-DAD-ESI-MS/MS technique.

To evaluate the development and application of a kind of oil peony by chromatographic analysis of the main active components of the waste moutan pods (MP).The methods adopted in this paper, firstly, the quality evaluation method of MP is established by HPLC-DAD-ESI-MS/MS; The second is to compare the types and contents of the main active components of moutan barks (Chinese Pharmacopoeia, MB) with those of the medicinal parts of peony used in oil. HPLC fingerprint method for the extract of moutan pods (EMP) was established.

Prediction of monthly occurrence number of scrub typhus in Ganzhou City, China, based on SARIMA and BPNN models.

Scrub typhus poses a serious public health risk globally. Forecasting the occurrence of the disease is essential for policymakers to develop prevention and control strategies. This study investigated the application of modelling techniques to predict the occurrence of scrub typhus and establishes an early warning system aimed at providing a foundational reference for its effective prevention and control.

Association between short-term exposure to meteorological factors on hospital admissions for hemorrhagic stroke: an individual-level, case-crossover study in Ganzhou, China.

Background: Hemorrhagic stroke (HS) is associated with significant disability and mortality. However, the relationship between meteorological factors and hemorrhagic stroke, as well as the potential moderating role of these factors, remains unclear.

Methods: Daily data on HS, air pollution, and meteorological conditions were collected from January 2015 to December 2021 in Ganzhou to analyze the relationship between meteorological factors and HS admissions.

Dose-dependent effects of hydroquinone on liver injury and lipid dysregulation based on SCD1/AMPK signaling pathway in C57BL/6 mice.

Hydroquinone (HQ) is extensively utilized in various industrial applications and as a dermatological agent; however, its metabolic processes and toxicological effects, particularly in the liver, remain insufficiently understood. This study aimed to investigate the impact of different doses of HQ on liver injury and lipid metabolism in C57BL/6 mice, with a specific focus on the SCD1/AMPK signaling pathway. We administered HQ at doses of 0, 12.

The effect of short-term exposure to air pollution on the admission of ischemic stroke and its interaction with meteorological factors.

Objectives: The aim of this study was to investigate the associations, potential effects, and interactions between short-term exposure to air pollution and the risk of ischemic stroke (IS).

Study Design: An ecological study.

Methods: Daily data on IS incidents, air pollution, and meteorological conditions were collected from 2017 to 2021 in Gannan.

Hospitalized children with influenza A before, during and after COVID-19 pandemic: a retrospective cohort study.

Context: Since the outbreak of COVID-19 in late 2019, the transmission dynamics and clinical presentation patterns of influenza A (Flu A) virus have undergone changes.

Objectives: This article conducted a comparative analysis in clinical characteristics and laboratory results of pediatric patients with Flu A before, during, and after the COVID-19 pandemic.

Methods: The medical records of 885 children hospitalized with Flu A virus infection at a tertiary hospital in Guangdong Province, China, were retrospectively analyzed.

TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma.

Purpose: Terminal nucleotidyltransferase 5A (TENT5A), recently predicted as a non-canonical poly(A) polymerase, is critically involved in several human disorders including retinitis pigmentosa, cancer and obesity. However, the exact biological role of TENT5A in hepatocellular carcinoma (HCC) has not been elucidated.

Methods: The transcription level of TENT5A and clinical correlation were analyzed using the LIRI-JP cohort, the TCGA-LIHC cohort, and clinical tissue samples of HCC patients in our laboratory.

Sex-Based Differences in the Risk of Contrast-Induced Nephropathy and Clinical Outcomes in Patients Undergoing Coronary Angiography and/or Percutaneous Coronary Intervention.

There is still controversial or limited evidence on whether sex differences exist in clinical characteristics, the risk of contrast-induced nephropathy (CIN), and other clinical outcomes of patients who received coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). The aim of this study was to characterize the effect of sex on clinical characteristics and outcomes of patients undergoing CAG and/or PCI. A total of 3,340 consecutive patients undergoing CAG and/or PCI from May 2017 to December 2022 were assessed in this retrospective study.

Hospitalized children with COVID-19 infection during large outbreak of SARS-CoV-2 Omicron strain: a retrospective study in Chaozhou, Guangdong, China.

Objective: We aimed to investigate the clinical findings of hospitalized paediatric COVID-19 patients by the end of 2022.

Method: All confirmed children with COVID-19 infection admitted into Chaozhou Central Hospital during the COVID-19 outbreak from 19 December 2022 to 1 February 2023 were included. Detailed clinical data of those children were evaluated retrospectively.

Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China.

Background: SARS-CoV-2 infection is described as asymptomatic, mild, or moderate disease in most children. SARS-CoV-2 infection related death in children and adolescents is rare according to the current reports. COVID-19 cases increased significantly in China during the omicron surge, clinical data regarding pediatric critical patients infected with the omicron variant is limited.

Resurgence of influenza A after SARS-CoV-2 omicron wave and comparative analysis of hospitalized children with COVID-19 and influenza A virus infection.

Context: The highly infectious Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused large-scale transmission from Dec 2022 to Feb 2023 in China. After this event, a remarkable surge of influenza A (Flu A) occurred from March to May 2023, especially in pediatric patients.

Objectives: This study aimed to investigate the differences between pediatric patients infected with COVID-19 Omicron and Flu A virus.

Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province.

The prevalence of G6PD deficiency has not been reported in Yangjiang, a western city in Guangdong province. This study aims to investigate the molecular characteristics of G6PD deficiency in this region. Blood samples were collected from adults at a local hospital to screen for G6PD deficiency.

Replication of previous autism-GWAS hits suggests the association between and and autism in the Han Chinese population.

Background: Autism is a severe neurodevelopmental disorder characterized by social interaction deficits, impairments in communication, and restricted and repetitive stereotyped behavior and activities. Family and twin studies suggested an essential role of genetic factors in the etiology of autism spectrum disorder (ASD). Also, other studies found and () might be involved in brain development and susceptible to ASD.

Exploring the effects and interactions of meteorological factors on the incidence of scrub typhus in Ganzhou City, 2008-2021.

Background: Scrub typhus poses a substantial risk to human life and wellbeing as it is transmitted by vectors. Although the correlation between climate and vector-borne diseases has been investigated, the impact of climate on scrub typhus remains inadequately comprehended. The objective of this study is to investigate the influence of meteorological conditions on the occurrence of scrub typhus in Ganzhou City, Jiangxi Province.

Mechanisms and markers of malignant transformation of oral submucous fibrosis.

Oral submucous fibrosis (OSF) is a chronic premalignant disease associated with betel quid chewing. Epidemiological studies indicate that there are approximately 5 million individuals suffering from OSF worldwide, with a concerning malignancy transformation rate of up to 4.2 %.

Prevalence of Hypertension and Associated Factors among Residents Aged ≥18 Years in Ganzhou, China: A Cross-Sectional Study.

Background: Reliable epidemiologic data on the present burden of hypertension are needed in developing region-specific strategies since previous studies have suggested that China is lagging in risk factor management.

Objective: The study aimed at exploring the prevalence of hypertension and its associated factors among adult residents in Ganzhou, China. .

UHPLC-MS/MS-based central carbon metabolism unveils the biomarkers related to colon cancer.

Even though colon cancer ranks among the leading causes of cancer mortality, early detection dramatically increases survival rates. Many studies have been conducted to determine whether altered metabolite levels may serve as a potential biomarker of cancer that affects key metabolic pathways. The goal of the study was to detect metabolic biomarkers in patients with colon cancer using liquid chromatography-mass spectrometry (LC-MS).

The clinical characteristics of COVID-19 omicron variant infection in pregnant women and their neonates.

Objective: The objective of this study was to analyze the clinical characteristics of pregnant women infected with the COVID-19 omicron variant and their neonates during the outbreak in Guangdong province, China.

Methods: The clinical data of pregnant women infected with the COVID-19 omicron variant and their neonates were retrospectively collected from two hospitals in Guangdong province. Information recorded included age of mother, date of birth, sex, weight at birth, mode of delivery, gestational age, feeding mode, Apgar score, signs, medical records, underlying comorbidities and laboratory results.