Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study.

Background: Colorectal cancer (CRC) is increasingly prevalent among young adults (<50 years) in China, a demographic that has been historically underrepresented in clinical studies. While most patients with CRC are aged ⩾65 years, this age group is also underrepresented in trials, highlighting the need for a better understanding of treatment outcomes in both younger and older populations. A recent phase IV trial evaluating the safety of fruquintinib in Chinese patients with metastatic CRC (mCRC) showed a manageable profile.

Estimating Radicle Length of Germinating Elm Seeds via Deep Learning.

Accurate measurement of seedling traits is essential for plant phenotyping, particularly in understanding growth dynamics and stress responses. Elm trees ( spp.), ecologically and economically significant, pose unique challenges due to their curved seedling morphology.

Endovascular treatment should be cautiously considered for acute vertebrobasilar artery occlusion patients with National Institutes of Health Stroke Scale score <7.

Background: The efficacy of endovascular treatment (EVT) for acute vertebrobasilar artery occlusion (VBAO) with mild severity remains controversial. This study aimed to determine whether a threshold of stroke severity exists at which the efficacy of EVT changes in acute VBAO patients.

Methods: A retrospective cohort study including patients with acute VBAO from 65 stroke centers in China (December 2015 to June 2022) was conducted.

Mitoxantrone liposome-based MEA regimen for treatment mixed lineage leukemia-rearranged acute myeloid leukemia: a case series.

Background: Acute myeloid leukemia (AML) harboring mixed lineage leukemia () rearrangement typically presents with high malignancy, poor remission rates, susceptibility to relapse, and a dismal prognosis. For these patients, achieving rapid remission followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important strategy, underscoring the importance of choosing the initial induction regimen. Mitoxantrone liposome (L-MIT) is a modified drug formulation that enhances anti-tumor activity and reduces toxicity.

Global, Regional, and National Burden of Ischaemic Stroke Attributed to High Fasting Plasma Glucose: An Analysis of Data From 1990 to 2021.

Background: The role of high fasting plasma glucose (HFPG) in ischaemic stroke (IS) has become increasingly prominent. Our study aimed to assess the global and regional distribution of the burden of IS attributable to HFPG (IS-HFPG) and to predict the disease burden of IS-HFPG to 2041.

Methods: This study extracted the data on the burden of IS-HFPG, including the number and age-standardized rate of deaths and disability-adjusted life years (DALYs) from the Global Burden of Disease Study (GBD) 2021.

Tryptophan metabolism and the intestinal microbiota: Implications for inflammatory bowel disease.

Tryptophan metabolism exerts a pivotal influence on inflammatory bowel disease (IBD) involving intestinal microbiota. Tryptophan (Trp) undergoes several metabolic processes that result in the formation of several bioactive compounds, such as 5-hydroxytryptamine (5-HT), kynurenine (KYN), and indole analogs, and these metabolites have significant roles in maintaining intestinal health and modulating immune function. The components and ability of the intestinal microbiota affect the metabolic balance of tryptophan, and dysbiosis may lead to disorders of tryptophan metabolism, which may exacerbate the condition of IBD.

PAR2 regulates proliferation, migration of lung cancer and chemotherapy sensitivity by involving PTEN pathway.

Background: Protease-activated receptor 2 (PAR2) is associated with tumor growth and metastasis. Here we examined the functions of PAR2 on growth, migration, invasion and chemosensitivity using both lung cancer cells and human lung cancer tissue.

Methods: The effect of PAR2 on growth of lung cancer cells was examined by MTT assay.

Development and validation of a prognostic staging system for primary plasma cell leukemia.

Background: The existing risk models for multiple myeloma (MM) are suboptimal for the stratification of patients with primary plasma cell leukemia (pPCL), a rare and peculiar MM. In this study, we aimed to develop a staging system for pPCL defined as the presence of ≥ 5% circulating plasma cells (CPC) according to the new diagnostic criteria, utilizing one of the largest series of patients with pPCL.

Methods: This multicenter retrospective study included 340 patients with pPCL (the training cohort) from 25 centers nationwide in China.

Assessment of influential factors and risk area prediction of scrub typhus in Gannan region, China, based on ecological niche modelling and geographical detector.

This study sought to define the potential infection risk zone of scrub typhus in Gannan and investigate the factors that contribute to this risk zone. Based on the distribution data of scrub typhus cases and environmental factors in Gannan from 2015-2021, a maximum entropy ecological niche modelling was employed to forecast potential risk areas in the region. The influence of each environmental factor on the risk was quantified using a geographical detector.

Efficacy of 2-undecanol produced by KM2501-1 in controlling .

Unlabelled: Root-knot nematodes (RKNs) are notoriously challenging to control because of their broad host spectrum and swift proliferation. Consequently, there is an urgent need to develop safe and effective nematicides. Microorganisms and their metabolites have the potential to control RKNs safely and effectively.

Burden of ischemic stroke attributable to high low-density lipoprotein cholesterol in China from the global burden of disease study 2021.

High low-density lipoprotein cholesterol are a significant risk factor for ischemic stroke. This study aims to analyze the burden of disease and temporal trends of ischemic stroke attributable to high LDL-C (IS-hLDL-C) in China, thereby providing a scientific basis for the development of effective prevention and intervention strategies. This study extracted the age-standardized mortality rates (ASMRs) and age-standardized disability-adjusted life years rates (ASDRs) of IS-hLDL-C from the global burden of disease (GBD) 2021.

Evaluating amide proton transfer imaging for improved glioma assessment: implications for RANO 2.0 criteria.

Objectives: The updated RANO 2.0 criteria acknowledge the limitations of conventional MRI in distinguishing tumour progression (TP) from pseudoprogression (PsP) after surgery. Advanced imaging techniques, such as amide proton transfer (APT) imaging, further validating its integration into the RANO 2.

Exploring the Causal Link Between Systemic Lupus Erythematosus and Stroke Risk Through Mendelian Randomization Study.

Introduction: Observational studies have indicated an association between systemic lupus erythematosus (SLE) and stroke. However, the genetic causality of this association remains incompletely understood. This study utilizes Mendelian randomization (MR) to investigate the potential causal relationship between SLE and the risk of stroke.

Carbon neutral spatial zoning and optimization based on land use carbon emission in the qinba mountain region, China.

Amid global climate change, the pursuit of low-carbon development has become a unified international goal. The Qinba Mountain region plays an important role in maintaining China's ecological security, making spatial zoning tailored for carbon neutrality vital for local sustainable development. Using land use and socioeconomic data from 2000 to 2020 for 81 county-level units, a carbon neutral spatial zoning framework was developed, considering natural, economic, ecological and land resource factors.

Single-center clinical efficacy analysis of 16 cases of primary light chain cardiac amyloidosis including stage IIIb patients.

Objective: To investigate the clinical efficacy of daratumumab versus bortezomib in patients with systemic light chain amyloidosis (pAL) with cardiac involvement, particularly those at stage IIIb.

Methods: Retrospective analysis of 16 AL patients with cardiac involvement, two groups of patients received treatment primarily with bortezomib and daratumumab, respectively. The hematologic remission rate, cardiac response rate, survival and adverse reactions of the two groups were analyzed.

Prediction of monthly occurrence number of scrub typhus in Ganzhou City, China, based on SARIMA and BPNN models.

Scrub typhus poses a serious public health risk globally. Forecasting the occurrence of the disease is essential for policymakers to develop prevention and control strategies. This study investigated the application of modelling techniques to predict the occurrence of scrub typhus and establishes an early warning system aimed at providing a foundational reference for its effective prevention and control.

Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study.

Background: Previous studies have confirmed the significant role of cathepsins in the development of neurodegenerative diseases. We aimed to determine whether genetically predicted 10 cathepsins may have a causal effect on Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) study using publicly available data from genome-wide association study (GWAS) to assess the causal associations between 10 cathepsins and three neurodegenerative diseases, including AD, PD, and ALS.

Quantitative fluorescent detection of tetracycline in animal-derived foods using quantum dots.

Tetracycline (Tc) antibiotics, a class of synthetically produced broad-spectrum antimicrobial drugs, have been widely used in animal husbandry, leading to their widespread presence in animal-derived foods. However, misuse, overuse, and non-compliance with withdrawal periods in animal farming have resulted in excessive Tc residues in these foods, which can cause various adverse reactions in humans, induce bacterial resistance, and pose a significant threat to public health. Consequently, the detection of Tc antibiotic residues in animal-derived food has become a critical issue.

Nematodes exposed to furfural acetone exhibit a species-specific vacuolar H-ATPase response.

Furfural acetone (FAc) is widely used as an additive by the food industry, as well as an intermediate in several fine chemical industries. Its nematicidal activity against the free-living model organism Caenorhabditis elegans and the parasitic nematode Meloidogyne incognita are well known, but its molecular mechanism of action remains unclear. To deep this subject, we performed 48-h lethal tests on eight nematode species, encompassing free-living, plant-parasitic, and animal-parasitic nematodes.

Evaluation of the effect of full-process blood glucose management on T2DM cataract patients based on visual electrophysiology and OCTA.

To investigate the difference in preoperative retinal function in patients with type 2 diabetes cataract (DC) without obvious retinopathy and to explore the clinical application of full blood glucose management for improving the postoperative vision in DC patients. This was a retrospective analysis in which we estimated the changes in visual electrophysiology (N75, P100, photopic flash electroretinogram(FERG), and scotopic FERG, paraoptic retinal nerve fibre layer thickness (pRNFL) and paraoptic radial capillary network blood flow density (ppVD) of type 2 diabetes (T2DM) patients at different phases of disease progression along with fasting blood glucose (FBG) and glycosylated haemoglobin (HbAlC) levels before and after DC surgery at Ziyang Central Hospital from January 2020 to December 2022. Additionally, trends in the above data throughout the entire process of glucose management intervention were examined.

Systemic immune inflammation index and risk of stroke: a cross-sectional study of the National Health and Nutrition Examination Survey 2005-2018.

Background: The incidence of stroke has increased globally, resulting in medical expenditures and social burdens over the past few decades. We aimed to explore the relationship between systemic immune inflammatory index (SII) and stroke using the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018.

Methods: Based on NHANES data, 902 stroke patients and 27,364 non-stroke patients were included in this study.

An overview of systematic reviews of acupuncture for Parkinson's disease.

Background: Many systematic reviews (SRs) have reported the efficacy of acupuncture in improving Parkinson's disease (PD), but the quality of evidence is unknown. Therefore, it is necessary to comprehensively summarize and objectively evaluate the evidence of acupuncture for PD.

Methods: Seven databases were searched to retrieve SRs on the acupuncture for PD.