Fine mapping and candidate gene analysis of the major QTL qSW-A03 for seed weight in Brassica napus.

Seed weight is a determining factor for improving rapeseed productivity. In the present study, a high-density genetic map was constructed via genome resequencing in an RIL population derived from a cross of two rapeseed varieties, ZS11 and DL704, with great differences in thousand-seed weight (TSW). A total of 1,306 bins involving 1,261,526 markers were used to construct the bin map.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer.

Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed DNA methylation of colorectal cancer (CRC) cells following treatment with proteasome inhibitors, and investigated the underlying mechanism of DNA methylation changes and the biological effects on CRC cells. We established that inhibition of proteasome leads to significant alterations in DNA methylation profile in CRC by suppressing the synthesis of DNA methyltransferases (DNMTs).

Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology.

In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients.

Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection.

Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H.

Genome-wide association study and protein network analysis for understanding candidate genes involved in root development at the rapeseed seedling stage.

Root system is essential for plants to absorb water and nutrients. The root related traits are complex quantitative traits and regulated by genetic control. Here, we used two association mapping panels to perform a genome-wide association study (GWAS) on seven root related traits in Brassica napus at the seedling stage and obtained 27 SNP loci significantly associated with the phenotypes.

QTL Mapping of Seed Glucosinolate Content Responsible for Environment in .

Glucosinolates (GSLs) are a major class of secondary metabolites. The content of seed GSL is largely regulated by environments in rapeseed (). However, the genetic control of seed GSL content responsible for environment in has been poorly understood.