Relationship between coronary artery calcification and plaque vulnerability, a qualitative and quantitative optical coherence tomography study.

Background: Coronary artery calcification (CAC) is an established hallmark of advanced atherosclerosis. The detailed relationship between CAC and plaque vulnerability remains incompletely understood. We aim to investigate the relationship between calcification burden, calcification patterns, and plaque instability features.

Nurse-Led Design and Evaluation of a Retractable Safety Needle for Injection Safety.

Objective: Needlestick injuries remain a significant source of bloodborne pathogen exposure in clinical settings, contributing to healthcare-associated infections among nurses. Existing safety devices rely on user compliance or administrative controls, which are insufficient under real-world pressures. This study evaluates the infection control potential of a nurse-designed retractable safety needle (RSN), developed to structurally reduce exposure risk through substitution-level engineering, as defined by the NIOSH Hierarchy of Controls.

Oral contrast-enhanced ultrasonographic features and radiomics analysis to predict NIH risk stratification for gastrointestinal stromal tumors.

Objective: To evaluate the value of oral contrast-enhanced ultrasonography and radiomics analysis in predicting the National Institutes of Health (NIH) staging of gastrointestinal stromal tumors (GISTs).

Methods: A retrospective cohort study was conducted on 204 patients presenting with GISTs in Tianjin Medical University Cancer Institute and Hospital from January 2020 to January 2023. The clinical profiles, oral contrast-enhanced ultrasonography (CEUS), and endoscopic ultrasound (EUS) imaging data were collected.

Electrocardiographic and clinical predictors for in-hospital mortality in patients with acute myocardial infarction caused by left main coronary artery occlusion.

The data on prediction for early mortality in patients with acute myocardial infarction (AMI) caused by total left main (LM) occlusion are limited. We aim to evaluate predictors for early mortality in these extremely high-risk patients. In this retrospective study, all consecutive patients with total occlusive LM-AMI were included between January 1997 and October 2023.

The relationships between inflammatory biomarkers, plaque characteristics, and macrophage clusters in coronary plaque: a quantitative assessment of macrophages based on optical coherence tomography.

Background: Quantitative assessment of macrophage accumulation is appealing in evaluating plaque inflammation. In optical coherence tomography (OCT) imaging, local macrophage clusters may be a feasible marker for macrophage quantification.

Methods: 404 patients presenting with acute coronary syndrome who underwent OCT evaluation were included.

The Evaluation of a Porcine Circovirus Type 2 (PCV2) Intradermal Vaccine Against a PCV2 Field Strain.

Porcine circovirus type 2 (PCV2) has a major impact on swine productivity. Vaccines are used to aid in control and mitigate production losses. We investigated the protection provided by an intradermal PCV2 vaccine against a field strain in Taiwan.

Carbon footprint analysis and emission reduction pathways of Bogie frame manufacturing process in Urban Rail Transportation.

It is significant for the carbon emission reduction of bogie frame (BF) to establish a standardized carbon footprint accounting method for BF manufacturing and to analyze the carbon emissions of different materials, different production stages, and different functional constituent parts. This study is based on the theory of life cycle assessment (LCA), combined with the carbon emission factor method, to account for the carbon footprint and formulate emission reduction measures for the entire manufacturing process of BF. The results show that the carbon footprint of each BF produced is 3115.

C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter-mediated doxorubicin resistance.

Osteosarcoma is an aggressive bone malignancy with a high propensity for drug resistance and metastasis, leading to poor clinical outcomes. This study investigates the role of core 1 β1,3-galactosyltransferase 1 (C1GALT1) in osteosarcoma, focusing on its implications in chemoresistance. Our findings reveal that high expression of C1GALT1 is associated with advanced stages, adverse overall survival, and increased recurrence rates.

Integrated study of hydrochemistry, quality and risk to human health of groundwater in the upper reaches of the Wulong River Basin.

Groundwater, a vital source of water supply, is currently experiencing a pollution crisis that poses a significant risk to human health. To understand the hydrochemical formation mechanisms, quality and risk to human health of groundwater in the upper reaches of the Wulong River basin, 63 sets of groundwater samples were collected and analyzed. A combination of mathematical statistics, correlation analysis, Gibbs diagram, ion ratio, and cation exchange were comprehensively employed for hydrochemical analysis, and further water quality index (WQI) and human health risk assessment were conducted.

[Analysis on Spatial Variability of Hydrochemical Characteristics and Control Factors of Jinan Baotu Spring Area].

To understand the karst groundwater hydrochemical characteristics and ion sources of the Jinan Baotu Spring area, this study focused on the three functional zones as an indirect recharge area, direct recharge area, and discharge area. Through water sample collection and testing, the spatial variability of groundwater chemical characteristics in different functional zones and the formation mechanism were analyzed using hydrochemistry parameter statistics, multivariate statistics, self-organizing map, hydrochemistry graphical analysis, ion ratios, and other methods, guided by the theory of groundwater flow system and combined with regional physical geography and hydrogeological conditions. The results showed that： the groundwater of each functional zone was alkaline as is typical in the dissolution of carbonate minerals.

Prediction of clear cell renal cell carcinoma ≤ 4cm: visual assessment of ultrasound characteristics versus ultrasonographic radiomics analysis.

Objective: To investigate the diagnostic efficacy of the clinical ultrasound imaging model, ultrasonographic radiomics model, and comprehensive model based on ultrasonographic radiomics for the differentiation of small clear cell Renal Cell Carcinoma (ccRCC) and Renal Angiomyolipoma (RAML).

Methods: The clinical, ultrasound, and contrast-enhanced CT(CECT) imaging data of 302 small renal tumors (maximum diameter ≤ 4cm) patients in Tianjin Medical University Cancer Institute and Hospital from June 2018 to June 2022 were retrospectively analyzed, with 182 patients of ccRCC and 120 patients of RAML. The ultrasound images of the largest diameter of renal tumors were manually segmented by ITK-SNAP software, and Pyradiomics (v3.

Evaluating ChatGPT's Performance in the EU*US eHealth Work Foundational Curriculum Using the HITCOMP Self-Assessment Quiz.

This study investigated the performance of OpenAI's Chat Generative Pre-trained Transformer (ChatGPT) in responding to the EU*US eHealth Work Foundational Curriculum. This curriculum, a collaborative effort between European and U.S.

Comparing Artificial Intelligence-Based Versus Conventional Endotracheal Tube Monitoring Systems in Clinical Practice.

Endotracheal tube dislodgement is a common patient safety incident in clinical settings. Current clinical practices, primarily relying on bedside visual inspections and equipment checks, often fail to detect endotracheal tube displacement or dislodgement promptly. This study involved the development of a deep learning, artificial intelligence (AI)-based system for monitoring tube displacement.

Nursing Informatics Research: A Bibliometric Analysis from 1989 to 2023.

Nursing informatics has evolved rapidly since its inception. Despite its growth, there remains a gap in comprehensive bibliometric analyses of the field's development and themes. The study aimed to provide an overview of the evolution and current status of nursing informatics by conducting a bibliometric analysis of the literature from 1989 to 2023.

O-GlcNAcylation regulates long-chain fatty acid metabolism by inhibiting ACOX1 ubiquitination-dependent degradation.

Background: Cold as a common environmental stress, causes increased heat production, accelerated metabolism and even affects its production performance. How to improve the adaptability of the animal organism to cold has been an urgent problem. As a key hub of lipid metabolism, the liver can regulate lipid metabolism to maintain energy balance, and O-GlcNAcylation is a kind of important PTMs, which participates in a variety of signaling and mechanism regulation, and at the same time, is very sensitive to changes in stress and nutritional levels, and is the body's "stress receptors" and "nutrient receptors".

Experimental and theoretical insight into carbamazepine degradation by chlorine-based advanced oxidation processes: Efficiency, energy consumption, mechanism and DBPs formation.

Chlorine has been widely used in different advanced oxidation processes (AOPs) for micropollutants removal. In this study, different chlorine-based AOPs, namely medium pressure (MP) UV/chlorine, low pressure (LP) UV/chlorine, and in-situ chlorination, were compared for carbamazepine (CBZ) removal efficiency, energy consumption, and disinfection by-products (DBPs) formation. All three processes could achieve nearly 100% CBZ removal, while the reaction time needed by in-situ chlorination was double the time required by UV/chlorine processes.

FT3/FT4 Enhances Risk Assessment in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Based on GRACE 2.0 Score.

Little is known about the association between the free triiodothyronine/free thyroxine (FT3/FT4) ratio and clinical outcomes in euthyroid patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI). A total of 1448 euthyroid patients with NSTE-ACS who underwent PCI were included in this prospective study. Multivariate Cox regression analysis revealed that there was a significantly increased risk of stroke (hazard ratio [HR] 11.

Early versus late delayed percutaneous coronary intervention in elderly patients with ST-segment elevation myocardial infarction.

Background And Objective: There are a substantial proportion of elderly patients with ST-segment elevation myocardial infarction (STEMI) miss the optimal time window (12 h from symptom onset) of primary percutaneous coronary intervention (PCI). For these patients, the ideal timing of delayed PCI remains undetermined. Therefore, this study compared the clinical outcomes of early versus late delayed PCI in elderly patients with STEMI.

Intergenerational Esthetic Co-Creation Program for Promotion of Community Creative Aging.

The world is facing rapid global aging. Global countries are concerned about the development of aging societies and related topics ranging from successful, healthy, and active aging in the past to the current creative aging (CA) perspective. However, in-depth research on applying esthetics to promote community CA in Taiwan is lacking.