Risk factors of thoracolumbar fascia injury for patients with Parkinson's disease and construction of a nomogram model.

Background: Thoracolumbar fascia injury (TLFI) is common in Parkinson's disease (PD) patients; however, the related risk factors are still controversial, and few studies have focused on clinical prediction models for TLFI. The aim of this study was to investigate the risk factors for TLFI in patients with PD and construct a clinical nomogram prediction model.

Methods: The clinical data of 351 patients with PD from October 2019 to September 2022 were retrospectively analyzed.

[Clinical Analysis of Supral-abyrinthine Cholesteatoma and Literature Review].

To evaluate surgical strategies and clinical outcomes in supra-labyrinthine cholesteatoma management, providing evidence-based guidance for therapeutic decision-making. Seven patients with supra-labyrinthine cholesteatoma in our hospital from 2021 to 2023 were enrolled in this study. The clinical manifestations, imaging findings, and surgical outcomes of patients were retrospectively analyzed.

SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress.

Aims: SERCA2, one of the P-type pumps encoded by gene ATP2A2, is the only calcium reflux channel of the endoplasmic reticulum (ER) and participates in maintaining calcium homeostasis. The present study was designed to explore SERCA2 expression pattern in auditory hair cells and the possible mechanism underlying the effects of SERCA2 on cisplatin-induced ototoxicity.

Main Methods: The SERCA2 expression pattern in cochlea hair cells and HEI-OC1 cells was measured by Western blot (WB) and immunofluorescence staining.

Selection of a Surgical Approach for Middle Ear Cholesteatoma Based on the Fusion Images of Non-Echo Planar Diffusion-Weighted MRI and CT.

Purpose: This study aimed to explore the ability of fusion images of non-echo planar diffusion-weighted magnetic resonance imaging (non-EPI-DWI MRI) and computed tomography (CT) to accurately locate cholesteatoma and plan the surgical approach.

Methods: In the first part, 41 patients were included. Their CT images and non-EPI DWMRI images were fused.

AdipoRon reduces cisplatin-induced ototoxicity in hair cells:possible relation to the regulation of mitochondrial biogenesis.

AdipoRon (AR) can exert antidiabetic and anti-inflammatory effects by maintaining mitochondrial structure and function. The present study was designed to explore whether AR protects the auditory cells from cisplatin-induced damage and, if so, to probe the possible mechanisms underlying its action on this type of cells. Cell viability and apoptosis in House Ear Institute-Organization of Corti 1 (HEI-OC1 cells) and mouse cochlea hair cells (HCs) were detected by CCK8 and immunofluorescence.

Otomastoiditis Caused by A Case Report and Literature Review.

usually infects people with impaired immune status and usually manifests in the lungs. Otomastoiditis caused by Nocardia infection is extremely rare, with only 4 cases reported to date. This report describes a case of otomastoid infection in an immunocompetent patient.

Notch signaling pathway plays a critical role in chemotherapeutic drug-induced vestibular injury.

The vestibule of the inner ear is susceptible to certain chemotherapeutic agents in clinical practice. Therefore, it is of great significance to discover molecular pathways and targets that can protect the vestibule from chemotherapeutic drugs. The Notch signaling pathway is closely related to hair cell regeneration in the inner ear.

A New Case of Endoscopic Resection of a Chorda Tympani Schwannoma.

Chorda tympani schwannoma is a very rare tumor, with only 12 reported cases in the English literature. There are few reports on the diagnosis of chorda tympani schwannoma, and it is easily misdiagnosed. At present, surgery is recognized as a treatment for chorda tympani schwannoma.

Reliability, internal consistency, and concurrent validity of a modified version of the dynamic gait index in people with vestibular disorders.

Background: People with vestibular disorders often have abnormalities in gait and balance. The Dynamic Gait Index (DGI) is a relatively effective clinical gait measure that has been validated for use in patients with vestibular disorders. The modified version of the DGI (M-DGI) is based on the original DGI.

Pseudo-Benign Paroxysmal Positional Vertigo: A Retrospective Study and Case Report.

Pseudo-benign paroxysmal positional vertigo (pseudo-BPPV) is a specific type of vestibular migraine disguised as benign paroxysmal positional vertigo, which is characterized by recurrent different types of positional and atypical positional vertigo with migraine features. It is easy to be misdiagnosed with BPPV at the first visit, which means that the ideal therapeutic effects are not achieved. Twenty-five cases of pseudo-BPPV with frequent changing positional vertigo were retrospected and the following key features help to identify the disease: recurrent positional and atypical positional vertigo, migrainous accompanying symptoms or migraine history, mild or indistinctive headaches, with or without impaired vestibular function, ineffective for simply reposition.

Characteristics and prognosis of idiopathic sudden sensorineural hearing loss in aged people: a retrospective study.

Few studies focused on the prognosis of sudden sensorineural hearing loss (ISSHL) of aged people. The aim of this study is to analyze the characteristics, treatment, and prognostic factors of ISSHL in aged people. A total of 278 patients diagnosed of ISSHL in aged people from 2014 to 2019 were retrospectively analyzed.

Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis.

Objective: To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL), we prospectively analysed the Lipid-lowering therapy Group (LLTG) data compared with Control Group (CG) data to determine the effects of Lipid intervention on the prognosis of sudden hearing loss.

Design: A prospective, non-randomized study.

Setting: Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.

Gαi Proteins are Indispensable for Hearing.

Background/aims: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound.

Temporospatial expression and cellular localization of VGLUT3 in the rat cochlea.

Vesicular glutamate transporter 3 (VGLUT3) plays an important role in hearing, and VGLUT3 knockout mice are deaf. However, the mechanisms whereby VGLUT3 exerts its effects in the cochlea are not well established. Elucidating the developmental and aging dynamics of VGLUT3 localization and expression in the cochlea would aid a functional understanding of auditory glutamatergic transmission.

Petrosquamosal sinus in the temporal bone as a cause of pulsatile tinnitus: a radiological detection.

We report a newly evidenced cause of venous pulsatile tinnitus--the petrosquamosal sinus in the temporal bone. We also present the case of a 45-year-old woman who presented with an incapacitating objective pulsatile tinnitus in the left ear for 10 years. The radiology evidenced a petrosquamosal sinus in the air cells of the left temporal bone.

Sigmoid sinus diverticulum and pulsatile tinnitus: analysis of CT scans from 15 cases.

Background: Although the imaging features of sigmoid sinus diverticulum induced pulsatile tinnitus (PT) have been presented in some extent, detailed imaging findings still have not been systematically evaluated and precise diagnostic radiographic criteria has not been established.

Purpose: To examine the computed tomography (CT) characteristics of sigmoid sinus diverticulum accompanied with PT.

Material And Methods: Fifteen PT patients with sigmoid sinus diverticula proven by surgery were recruited after consenting.

Cochlear implant challenges encountered in tuberculous otitis media.

Tuberculous otitis media (TOM) is rare in ENT department, and is frequently misdiagnosed as otitis media. Thus early systemic treatment is very important for TOM. We reported a case report with TOM to highlight development of the disease and difficulties in clinical treatment in late stage of TOM.