Major depressive disorder detection via temporal-frequency-spatial transformer with sub-domain knowledge alignment using EEG.

Major Depressive Disorder (MDD) is a common mental illness that seriously jeopardizes the physical and mental health of patients. Accurate detection of MDD is crucial for treatment. Currently, there are significant differences in the EEG signals of each MDD patient, leading to lower accuracy of cross-subject MDD detection.

Phosphorylation enhanced OTUD3 deubiquitination ARID3A promotes the progress of cholangiocarcinoma.

Cholangiocarcinoma (CCA) is a highly heterogeneous group of malignant tumors with different molecular etiologies and clinical manifestations. Post-translational modifications (PTM) such as ubiquitination and phosphorylation are widely involved in the progression of CCA. Our aim was to elucidate the effect of the deubiquitinating enzyme OTU domain-containing protein 3 (OTUD3) on the molecular pathogenesis of CAA.

Effective Dose of Epidural Hydromorphone for Analgesia Following Caesarean Section in Using Modified Dixon Sequential Method.

Background: A single dose of epidural hydromorphone has been suggested as an alternative method for providing analgesia after caesarean section (CS). Nevertheless, the optimal dosage of epidural hydromorphone for postoperative pain relief following CS has yet to be determined.

Methods: This trial included 30 singleton primiparous women undergoing scheduled caesarean delivery, who were recruited to determine doses of epidural hydromorphone using the modified Dixon sequential method.

[Temporal and Spatial Variations of Soil Organic Carbon and the Influencing Factors in Shaanxi Province in Recent 30 Years].

Soil organic carbon （SOC） variation is a significant indicator for the soil quality dynamic and global carbon cycle. Therefore, it is necessary to study the regional temporal and spatial distribution of SOC pool and the influencing factors. In this study, a total of 540 soil data and environmental variables were collected from Shaanxi Province during a 30-year period from 1985 to 2015, and univariate analysis of variance and path analysis were used to explore the temporal and spatial distribution characteristics of SOC content and the influencing factors of SOC change.

Magnetized bentonite modified rice straw biochar: Qualitative and quantitative analysis of Cd(II) adsorption mechanism.

Industrialization has caused a significant global issue with cadmium (Cd) pollution. In this study, Biochar (Bc), generated through initial pyrolysis of rice straw, underwent thorough mixing with magnetized bentonite clay, followed by activation with KOH and subsequent pyrolysis. Consequently, a magnetized bentonite modified rice straw biochar (FeO@B-Bc) was successfully synthesized for effective treatment and remediation of this problem.

A novel intronic variant causing aberrant splicing identified in two deaf Chinese siblings with enlarged vestibular aqueducts.

Objective: We aimed to evaluate the genotype-phenotype relationship in two Chinese family members with enlarged vestibular aqueduct (EVA).

Methods: We collected blood samples and clinical data from each pedigree family member. Genomic DNA was isolated from peripheral leukocytes using standard methods.

Keystone taxa of phoD-harboring bacteria mediate alkaline phosphatase activity during biochar remediation of Cd-contaminated soil.

Phosphorus (P)-modified biochar can efficiently remediate cadmium (Cd)-contaminated soil. However, the mechanisms of responses of alkaline phosphatase (ALP) and phoD-harboring microorganisms, which are notably sensitive to Cd and P, are not clear during the remediation process. In this study, apple (Malus domestica) tree branches were co-pyrolyzed with tripotassium phosphate (KPO) to prepare P-modified biochar, which was used to remediate Cd-soil contaminated soil collected near a mine site.

Phosphorus acquisition strategies of wheat are related to biochar types added in cadmium-contaminated soil: Evidence from soil zymography and root morphology.

Biochar application for the remediation of cadmium (Cd)-contaminated soils may result in a relative deficiency of phosphorus (P) due to the disruption of soil nutrient balance. However, the P acquisition strategies of plants in such situation are still unclear. In this study, analyses on soil zymography and root morphology were combined for the first time to investigate the effects of pristine and P-modified biochars from apple tree branches on the P acquisition strategies of wheat under Cd stress.

Reliability and validity of the Chinese version of the kiddie-schedule for affective disorders and schizophrenia-present and lifetime version DSM-5 (K-SADS-PL-C DSM-5).

Background: As the Diagnostic and Statistical Manual of Mental Disorders fifth version (DSM-5) was published, the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version (K-SADS-PL) was modified to adapt the new version (K-SADS-PL DSM-5). We translated it to Chinese (K-SADS-PL-C DSM-5) and described its reliability and validity.

Methods: A total of 154 groups of 6 to 18-year-old children and their guardians were included.

Deficit of perineuronal net induced by maternal immune activation mediates the cognitive impairment in offspring during adolescence.

Maternal immune activation (MIA) during pregnancy is considered a risk factor for neurodevelopment in the offspring, resulting in behavioral abnormalities. Furthermore, adolescence is a vulnerable period for developing different psycho-cognitive deficits. Here, we aimed to observe the cognitive consequences of prenatal MIA exposure in adolescents and explored the underlying mechanisms.

Endoscopic Management of Recurrent Maxillary Sinus Ameloblastoma in a Child With Autism Spectrum Disorder: A Case Report.

Ameloblastomas are slow-growing, aggressive odontogenic epithelial tumors that originate from the jawbone. One of the most easily relapsing maxillofacial tumors, ameloblastomas mainly occur in the mandibular molar area and ascending branch, although they can occasionally occur in the nasal cavity and paranasal sinuses. A 14-year-old child with autism spectrum disorder underwent sinus computed tomography (CT) under anesthesia.

Efficient removal of Cd(II) by phosphate-modified biochars derived from apple tree branches: Processes, mechanisms, and application.

Phosphate (P)-modified biochar is a good material for cadmium (Cd) immobilization, and the pore-forming effect of potassium ions (K) can favor the P loading on biochar. However, few studies have been done specifically on Cd(II) removal by composites of potassium phosphates with biochar, and the removal potential and mechanisms are not clear. Herein, apple tree branches, a major agricultural waste suitable for the development of porous materials, were pyrolyzed individually or together with KHPO, KHPO·3HO, or KPO·3HO to obtain biochars to remove Cd(II), denoted as pristine BC, BC-1, BC-2, and BC-3, respectively.

Anatomical dimensions of the lumbar dural sac predict the sensory block level of continuous epidural analgesia during labor.

Background: The anatomical dimensions of the lumbar dural sac determine the sensory block level of spinal anesthesia; however, whether they show the same predictive value during continuous epidural anesthesia (CEA) remains undetermined. We designed the present study to verify the efficacy of the anatomical dimensions of the lumbar dural sac in predicting the sensory block level during labor analgesia.

Methods: A total of 122 parturients with singleton pregnancies requesting labor analgesia were included in this study.

The interplay of labile organic carbon, enzyme activities and microbial communities of two forest soils across seasons.

Soil labile organic carbon (LOC) responds rapidly to environmental changes and plays an important role in carbon cycle. In this study, the seasonal fluctuations in LOC, the activities of carbon-cycle related enzymes, and the bacterial and fungal communities were analyzed for soils collected from two forests, namely Betula albosinensis (Ba) and Picea asperata Mast. (Pa), in the Qinling Mountains of China.

Next-generation sequencing identifies rare pathogenic and novel candidate variants in a cohort of Chinese patients with syndromic or nonsyndromic hearing loss.

Background: Hearing loss (HL) is a common sensory disorder in humans characterized by extreme clinical and genetic heterogeneity. In recent years, next-generation sequencing (NGS) technologies have proven to be highly effective and powerful tools for population genetic studies of HL. Here, we analyzed clinical and molecular data from 21 Chinese deaf families who did not have hotspot mutations in the common deafness genes GJB2, SLC26A4, GJB3, and MT-RNR1.

Surface properties and suspension stability of low-temperature pyrolyzed biochar nanoparticles: Effects of solution chemistry and feedstock sources.

Intensive application of biochar requires better understanding of their environmental behaviors such as stability, fate, and mobility. The release of bulk biochar into biochar nanoparticles (NPs) may bring risks because of their potential flowing into downstream water bodies with nutrients/containments attached. Low-temperature pyrolyzed biochars, namely fruit tree branch biochar of 350/450/550 °C (FB350, FB450 and FB550), corn straw biochar of 350 °C (CB350) and peanut straw biochar of 350 °C (PB350), were produced, and their NPs were extracted.

The mutation frequencies of GJB2, GJB3, SLC26A4 and MT-RNR1 of patients with severe to profound sensorineural hearing loss in northwest China.

Objective: To expose the spectrum and frequency of GJB2, GJB3, SLC26A4 and MT-RNR1 in northwest China and to investigate the underlying causative genes in patients without common mutations.

Methods: We analyzed the mutation screening results of GJB2, GJB3, SLC26A4 and MT-RNR1 in 398 unrelated severe-to-profound probands with bilateral, symmetrical sensorineural hearing loss. Subsequently, we selected 10 probands with a significant family history of inherited hearing loss (HL) that did not have the above four common gene mutations to perform next-generation sequencing (NGS) of 139 known deafness genes, followed by co-segregation analysis of all available family members.

[Effects of Biochar Application on Soil Microbial Nutrient Limitations and Carbon Use Efficiency in Lou Soil].

Soil microbial metabolism is vital for nutrient cycling and stability of an ecosystem. To elucidate the long-term effects of biochar application on nutrient limitations and carbon use efficiency (CUE) of soil microbial metabolisms, biochars pyrolyzed at 450℃ from trunks and branches of fruit trees under an oxygen-limited condition were mixed with the top Lou soils (0-20 cm) with application amounts of 0, 20, 40, 60, and 80 t·hm in 2012. Corn-wheat rotation was carried out afterwards for seven years.

Postoperative intensity-modulated radiation therapy reduces local recurrence and improves overall survival in III-N2 non-small-cell lung cancer: A single-center, retrospective study.

Purpose: To determine the postoperative effects of radiotherapy (PORT) on the local recurrence-free survival (LRFS) and overall survival (OS) of stage III-N2 non-small-cell lung cancer (NSCLC).

Materials And Methods: 183 patients with resected stage III-pN2 NSCLC from Hunan Cancer Hospital between 2013 and 2016 were divided into two groups for postoperative chemotherapy (POCT) (n = 105) or combination chemotherapy and radiotherapy (POCRT) (n = 78). The LRFS and OS were compared and the factors affecting local recurrence were illustrated in these two groups.

[Impact of Biochar on Soil Bulk Density and Aggregates of Lou Soil].

The effect of biochar on the bulk density and aggregate stability of Lou soil was evaluated and compared after biochar was applied for 2 years and 5 years through a field-positioning experiment. Five biochar amounts were applied in this study, as follows:0 t·hm (B), 20 t·hm (B), 40 t·hm (B), 60 t·hm (B), and 80 t·hm (B). The biochar was produced by pyrolysis of stems and branches from fruit trees at the temperature of 450℃ with limited oxygen apply.

[Remediation Effects of Different Composite Materials on Cadmium-Contaminated Farmland Soil].

A pot experiment was conducted to study the application effects of three composite materials, namely SC (lime:organic compound fertilizer=2:3), LS (ferrous sulfate:lime=1:1) and LB (ferrous sulfate:biochar in combinations of 1:1, 1:2, 1:3, 1:4 and 1:5), on soil Cd bioavailability, Cd cumulative distribution in different wheat organs, and wheat yield. The results indicated that:① Addition of composite materials all significantly decreased the soil available Cd content by 50.2%-81.