Alternative polyadenylation and metabolic profiling in young panicle development of hybrid rice and its parents.

Alternative polyadenylation (APA) is a widespread post-transcriptional regulatory mechanism in eukaryotes that modulates gene expression by generating transcript variants. The development of young panicles in rice is a critical stage that determines grain number and weight. However, the regulatory mechanisms and inheritance patterns of APA during this process remain poorly understood.

Current approaches to overcome the limit of TRAIL-based treatment in colorectal cancer: From fusion protein to nano-delivery platform.

Colorectal cancer (CRC), one of common malignancies, ranks second in cancer-related mortality worldwide. Despite advances in targeted therapy and immune therapy, patients with metastatic CRC have poor 5-year survival, which is approximately 14%. Multiple investigations are underway with the aim to improve outcome of this cohort.

Analysis of risk factors for perioperative hyperamylasemia in kidney transplant recipients.

Background: Perioperative hyperamylasemia has been observed in several kidney transplant recipients (KTRs) at our center. However, there are currently no published reports on this observation. This study aimed to identify the risk factors associated with perioperative hyperamylasemia in KTRs.

Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning.

Acute bipyridine herbicide poisoning poses a significant clinical challenge due to the lack of an effective antidote, with CNS damage leading to particularly poor outcomes. This retrospective study included 189 patients with acute bipyridine poisoning, with a median age of 39 years. Among them, 33.

A utero-pelvic fistula and pelvic-parasitic myoma by hysteroscopic resection of a recurrent submucosal myoma: a case report.

Background: The occurrence of a uterine fistula combined with parasitic myoma formation is rare. We report a case involving a utero-pelvic fistula and a pelvic-parasitic myoma following hysteroscopic resection of a recurrent submucosal myoma.

Case Presentation: A 37-year-old woman who had undergone surgery for laparoscopic myomectomy of large uterine fibroids presented with abnormal uterine bleeding (AUB) for over 6 months and 4 years ago.

The association between altitude and cerebral small vessel disease burden in the Tibetan population: a cross-sectional study.

Cerebral small vessel disease (CSVD) is a major neurovascular contributor to stroke and cognitive impairment, yet its interaction with chronic high-altitude adaptation remains poorly understood. This first neuroimaging investigation examined 499 Tibetan natives residing at 2000-4800 m using 3 T MRI to quantify CSVD burden and to assess its association with residential altitude. Multivariable logistic regression, treating altitude as both a continuous variable (per 500 m increment) and a categorical variable (mid-high [2000-3500 m] vs.

Morroniside ameliorates experimental autoimmune encephalomyelitis by regulating gut microenvironment, immune balance, and NF-κB neuroinflammatory pathway.

Multiple sclerosis (MS) is a chronic disease characterized by demyelination and neuroinflammation in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is a classic animal model for MS. Existing therapeutic drugs for MS have limitations such as high cost, significant side effects, and the inability to reverse nerve damage.

Machine Learning and Experimental Validation Reveal MYH11 as a Novel Prognostic Biomarker and Therapeutic Target in Bladder Cancer.

Introduction: Bladder cancer (BCa) is one of the top ten most common cancers, yet its underlying mechanisms remain unclear. This study aimed to explore the potential molecular mechanisms of BCa using multi-omics and single-cell analysis.

Methods: First, differential analysis of transcriptome data related to BCa from public databases was performed, and a risk model was then developed using 101 different machine learning algorithms to determine prognostic genes, followed by independent prognostic analysis to construct a nomogram.

Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and emotional disturbances. The amygdala is an important connectivity structure in the brain and is responsible for emotional responses. 5-HT is involved in various neurodevelopmental processes in the brain.

Study pressure and self harm in Chinese primary school students: the effect of depression and parent-child relationships.

Background: Self-harm has become a significant and increasing global problem in children and adolescents. In this study, we tested a moderated mediation model to examine the impact of study pressure and depression, and one protective factor, good parent-child relationship, on self harm.

Methods: A self-report Questionnaire survey was conducted among 33,285 primary school students from 3rd-6th grade (mean age = 10.

Resistance mechanism of Abies beshanzuensis under heat stress was elucidated through the integration of physiological and transcriptomic analyses.

Elevated temperatures significantly impaired the normal growth and development of plants. This study combined physiological and transcriptomic analyses to explore the potential mechanisms of response to heat stress in Abies beshanzuensis M. H.

Pien Tze Huang plus entecavir improves hepatic fibrosis in Chinese patients with chronic hepatitis B.

Background: Pien Tze Huang (PTH), a well-established traditional Chinese medicine compound, has exhibited anti-hepatic fibrosis properties both in vitro and in vivo animal models, but the randomized clinical trials to evaluate anti-hepatic fibrosis efficacy of PTH are deficient. Chronic hepatitis B (CHB) is a leading cause of hepatic fibrosis in China. Although antiviral therapies have demonstrated significant effectiveness in arresting the progression of fibrotic disease, complete regression of established fibrosis is limited to only a subset of treated patients.

Imaging monitoring of Balamuthia granulomatous amoebic encephalitis.

Balamuthia granulomatous amoebic encephalitis (GAE) is a rare and highly lethal infectious disease affecting the central nervous system, caused by the Balamuthia amoeba. This article reports the case of a child with normal immune function and no apparent epidemiological risk factors. In the initial stages, routine blood tests, cerebrospinal fluid cell tests, biochemical tests, and metagenomic next-generation sequencing (mNGS) were all normal.

Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism.

Background: As a core personality trait closely linked to mental health outcomes, psychoticism warrants particular attention in adolescent populations. The association between elevated psychoticism levels and self-harm ideation and behaviors (SIB) remained insufficiently characterized, especially regarding specific risk profiles. This study aims to delineate SIB characteristics and identify risk factors among adolescents with high psychoticisme.

Preoperative donor urinary UDP-Glc as an independent risk factor for delayed graft function.

Background: Expanded criteria donors (ECD) have the potential to greatly increase the donor organ pool but pose a higher risk of delayed graft function (DGF) post-transplantation. Uridine diphosphate-glucose (UDP-Glc) plays a significant role in extracellular signaling related to tissue damage and retains stability for detection. Donor urinary UDP-Glc level may be an appropriate and effective biomarker for predicting DGF.

MNMO: discover driver genes from a multi-omics data based-multi-layer network.

Motivation: Cancer as a public health problem is driven by genomic variations in "cancer driver" genes. The identification of driver genes is critical for the discovery of key biomarkers and the development of personalized therapy.

Results: We propose a prediction method MNMO: a multi-layer network model based on multi-omics data.

Development of a clinical prediction model for acute myocarditis using coronary computed tomography angiography-based radiomics.

Background: Both acute myocarditis patients and normal cohort usually present with normal coronary computed tomography angiography (CCTA) performance, and the performance of CCTA radiomics on the prediction for myocarditis is still unclear. This study aims to build a clinical prediction model for acute myocarditis using CCTA-based radiomics.

Methods: A total of 215 consecutive patients from the Affiliated Jinhua Hospital, Zhejiang University School of Medicine (Center 1) and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (Center 2) who underwent CCTA and were diagnosed as normal or acute myocarditis were enrolled.

SLAMF7-expressing B cells as crucial mediators in the pathogenesis of rheumatoid arthritis-interstitial lung disease.

The regulatory factors involved in rheumatoid arthritis (RA) complicated with interstitial lung disease (ILD) (RA-ILD) remain unknown. Due to the cross-sectional nature of our study, our aim was to explore the role of the signalling lymphocytic activation molecule family (SLAMF) in RA-ILD by analysing synovial and lung samples from the Gene Expression Omnibus, animal models, and clinical samples.We collected peripheral blood mononuclear cells from patients for flow cytometry analysis of B cells, SLAMF1 protein, and SLAMF7 protein.

Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer.

Bladder cancer (BLCA) is a common malignant tumor whose pathogenesis has not yet been fully elucidated. This study analyzed prognostic genes in BLCA by integrating transcriptomics and proteomics data, and established prognostic models, aiming to offer novel insights for BLCA therapy. Transcriptomic, proteomic, and protein acetylation sequencing were conducted on six BLCA tumor tissues and six paraneoplastic tissue samples.

More complex anti-predator behaviors develop with age in Chinese water deer fawns.

An anti-predator strategy increases the fitness of the prey itself, in which vigilance behavior plays an important role. Numerous studies have explored the correlation between prey age and the level of vigilance towards an approaching predator. However, limited studies have delved into the development of vigilant behaviors, much less the vigilant decision-chains.

In Operando Raman Spectroscopy Reveals Li-Ion Solvation in Lithium Metal Batteries.

Inhomogeneous lithium (Li) deposition and unstable solid electrolyte interphase are the main causes of short cycle life and safety issues in Li metal batteries (LMBs). Developing a 3D structured matrix current collector and novel electrolyte are feasible strategies to tackle these issues. Ether-based electrolytes are widely used in LMBs.

Multiparametric cardiovascular magnetic resonance in patients with myocarditis with consecutive follow-up and a comparison between non-COVID-19 and COVID-19-associated myocarditis.

Background: The pattern of myocardial injury and dysfunction development during follow-up is unclear in patients with myocarditis. This study aims to explore the developmental pattern of myocardial injury and cardiac dysfunction during the follow-up of myocarditis by cardiac magnetic resonance (CMR) and differences in short-term follow-up CMR performance between patients with coronavirus disease 2019 (COVID-19)-associated myocarditis (CAM) and non-COVID-19-associated myocarditis (NCAM).

Methods: Data of patients with clinically diagnosed myocarditis who underwent follow-up CMR were retrospectively collected.

Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in mice by activating TLCA/TGR5 pathway.

Diabetic kidney disease (DKD) is a severe diabetic microvascular complication featured by chronic low-grade inflammation. Roux-en-Y gastric bypass (RYGB) surgery has gained importance as a safe and effective surgery to treat DKD. Bile acids significantly change after RYGB, which brings a series of metabolic benefits, but the relationship with the improvement of DKD is unclear.