Novel serum biomarker for powerfully predicting pediatric simple febrile seizures.

Objective: Current model or biomarkers are far from satisfactory to predict pediatric simple febrile seizures (SFS). This study aimed to explore novel serum biomarkers in children with SFS and analyze their clinical significance.

Methods: A total of 57 SFS children admitted to the pediatric ward of Jinhua Maternal and Child Health Hospital from June 2022 to October 2024 were enrolled as the observation group, 61 sepsis patients and 45 healthy children from the pediatric health clinic during the same period were included as the control groups.

Imaging monitoring of Balamuthia granulomatous amoebic encephalitis.

Balamuthia granulomatous amoebic encephalitis (GAE) is a rare and highly lethal infectious disease affecting the central nervous system, caused by the Balamuthia amoeba. This article reports the case of a child with normal immune function and no apparent epidemiological risk factors. In the initial stages, routine blood tests, cerebrospinal fluid cell tests, biochemical tests, and metagenomic next-generation sequencing (mNGS) were all normal.

Hypermethylation of Promoter Is a Biomarker Across 12 Cancer Types.

Aberrant DNA methylation is thought to be an early event in cancer development. Thus, identification of DNA methylation-based markers may provide valuable evidence in clinical decision-making. In this study, a DNA methylation dataset from 514 normal-tumor pairs is used to explore possible shared differentially methylated regions (DMRs) across 12 cancer types.