Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer.

Purpose: Phototherapy has remarkable advantages in cancer treatment, owing to its high efficiency and minimal invasiveness. Indocyanine green (ICG) plays an important role in photo-mediated therapy. However, it has several disadvantages such as poor stability in aqueous solutions, easy aggregation of molecules, and short plasma half-life.

Antibody functionalized curcuma-derived extracellular vesicles loaded with doxorubicin overcome therapy-induced senescence and enhance chemotherapy.

Conventional cancer treatments often induce a sustained DNA damage response (DDR) in tumor cells, leading to therapy-induced senescence (TIS), characterized by permanent cell cycle arrest and resistance to apoptosis. These senescent cells secrete senescence-associated secretory phenotypes (SASP), which can promote tumor progression and create an immunosuppressive microenvironment. This study introduces a novel approach to enhance chemotherapy efficacy by using functionalized curcuma-derived extracellular vesicles (DR5-CNV/DOX) to target and eliminate senescent tumor cells and inhibit their SASP.

A Novel Ginsenoside-Transforming α-L-Rhamnosidase from : Screening, Characterization and Application.

Despite the rapid advancement of glycosidase biotechnology, ginsenoside-transforming rhamnosidases remain underexplored due to a lack of research. In this study, we aimed to bridge this gap by evaluating eight putative rhamnosidases for their ability to transform ginsenosides. Among them, a novel rhamnosidase (C118) from was identified as being efficient at hydrolyzing ginsenoside Re.

Investigation of the emission and leaching behavior of characteristic heavy metals in sintered bricks prepared from oil-based drill cutting residues.

Oil-based drill cutting residues (OBDCR) are hazardous waste generated by the thermal desorption of oil-based drill cuttings. Recently, the utilization of OBDCR as building materials has attracted extensive attention, but the environmental risks during preparation and long-term usage remained unclear. In this study, OBDCR with a 40 % (wt.

AML cell-derived exosomes suppress the activation and cytotoxicity of NK cells in AML via PD-1/PD-L1 pathway.

Exosomes are bilayer lipid bodies and contain a variety of bioactive molecules such as proteins, lipids, and nucleic acids, and so forth. Exosomes derived from solid tumors may play critical roles in tumor development and immune evasion. However, the underlying effects of tumor-derived exosomes on immune function in modulating intercellular crosstalk within the bone marrow niche during acute myeloid leukemia (AML) development and immune evasion remain largely elusive.

Dual-targeting of tumor cells and subcellular endoplasmic reticulum AgPPIX-based Janus nanoparticles for photodynamic/immunotherapy against TNBC.

Triple-negative breast cancer (TNBC) is known for its strong invasiveness, high recurrence rates, and poor prognosis. Heme oxygenase-1 (HO-1) is closely related to tumor invasion, metastasis, recurrence and formation of tumor immunosuppression. The expression of HO-1 is high in TNBC and low in normal tissues.

Emission and distribution characteristics of PCDD/Fs during the co-processing of various solid wastes in coal-fired boilers in China.

The advancement of co-processing solid wastes in coal-fired boilers is significant for waste recycling and contributes to the sustainable development of the coal-fired power industry. However, concerns over the emission of dioxins during co-processing have prompted a comprehensive investigation into the dioxin emission properties. In this study, the PCDD/F emission concentrations of seven coal-fired boilers, including three pulverized coal boilers and four circulating fluidized bed boilers were examined.

Field-tested innovation: Sustainable utilization of secondary alumina dross for flash setting admixtures production.

Secondary alumina dross (SAD) has emerged as an alternative to bauxite in the production of flash setting admixtures (FSA), a critical admixture in shotcrete. However, the presence of hazardous components has hampered its large-scale adoption. This study conducted field tests at an FSA factory, utilizing SAD as the primary raw material, to evaluate the feasibility and environmental risks.

Emission characteristics of dioxin during solid waste co-processing in the Chinese cement industry.

Development of co-processing technology in the cement industry in China is important for environmentally sound disposal and recycling of waste, and contributes to sustainable development of the cement industry. However, dioxin pollution could negatively affect promotion of this technology. Therefore, it is necessary to study the emission characteristics of dioxins in cement kilns.

CD93 promotes acute myeloid leukemia development and is a potential therapeutic target.

CD93 is a transmembrane receptor belonging to the Group XIV C-Type lectin family. It is expressed in a variety of cellular types such as monocytes, neutrophils, platelets, microglia, and endothelial cells. CD93 has been reported to play important roles in cell proliferation, cell migration, and tumor angiogenesis.

Novel Split Intein-Mediated Enzymatic Channeling Accelerates the Multimeric Bioconversion Pathway of Ginsenoside.

Cascade reaction systems, such as protein fusion and synthetic protein scaffold systems, can both spatially control the metabolic flux and boost the productivity of multistep enzymatic reactions. Despite many efforts to generate fusion proteins, this task remains challenging due to the limited expression of complex enzymes. Therefore, we developed a novel fusion system that bypasses the limited expression of complex enzymes via a post-translational linkage.

Effects of increasing chlorine concentration in feedstock on the emission and distribution characteristic of dioxins in circular fluidized bed boiler.

Field studies were conducted to study the emission and distribution characteristics of dioxins by elevating the chlorine concentration in feedstock in a circular fluidized bed boiler. The concentration and total equivalent quantity of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in all flue gas, electrostatic ash, bag filter ash, and bottom ash samples under blank condition (i.e.

Heavy metal and metalloid emissions during co-processing of waste in a sintering kiln: Migration characteristics in the kiln and long-term leaching from bricks.

Heavy metals (HMs) in mixed hazardous waste can be volatilized in the kiln for preparing sintered bricks, which greatly increases the environmental risk. In this study, the volatilization, transformation, and leaching of HMs from bricks were evaluated. Field tests and laboratory leaching experiments were carried out.

Dual-Responsive multifunctional "core-shell" magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy.

Ferroptosis is a newly found promising cell death pathway, which bypasses apoptosis and overcomes multidrug resistance of tumor. In this study, acid and redox dual-responsive multifunctional magnetic nanoparticles loading with Sorafenib (Sor), namely FMMHG/Sor, were prepared for tumor ferroptosis therapy. FeO nanoparticles as the core provided sufficient iron ion for ferroptosis and magnetic targeting.

Ginsenoside Rh2 mitigates doxorubicin-induced cardiotoxicity by inhibiting apoptotic and inflammatory damage and weakening pathological remodelling in breast cancer-bearing mice.

Objectives: There are presently a few viable ways to reduce cardiotoxicity of doxorubicin (Dox). The combination of chemotherapy agents with natural compounds delivers greater efficacy and reduces adverse effects in recent researches for cancer treatment. Here, we examined the potential effect of ginsenoside Rh2 on a Dox-based regimen in chemotherapy treatment.

Synergistic antimicrobial activity of ε-polylysine, chestnut extract, and cinnamon extract against .

A mixed natural preservative composed of ε-polylysine (ε-PL), chestnut 70% ethanol extract (NE), and cinnamon hydrothermal extract (CW), was investigated for the reduction of . The minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) of seven natural extracts were investigated against a cocktail of three strains of (ATCC 25923, ATCC 33591, and ATCC 33594). Three important factors (ε-PL, NE, and CW) were selected by using the Plackett-Burman (PB) design for the response surface model ( < 0.

Multifunctional "ball-rod" Janus nanoparticles boosting Fenton reaction for ferroptosis therapy of non-small cell lung cancer.

Ferroptosis is a newly found cell death mechanism, which could bypass apoptosis and reverse multidrug resistance of tumors. However, efficient induction of tumor ferroptosis remains a challenge. In this study, multifunctional "ball-rod" Janus nanoparticles (FTG/L&SMD) were constructed for non-small cell lung cancer (NSCLC) ferroptosis treatment.

The fate of heavy metals in the co-processing of solid waste in converter steelmaking.

The improper disposal of large amounts of solid waste (SW) has led to serious ecological and environmental problems, especially heavy metal (HM) pollution. Converter steelmaking has the potential to co-process SW, but the distribution of heavy metals (HMs) during converter steelmaking is unclear. In this study, the effects of smelting temperature and slag alkalinity on the distribution of typical HMs in the SW of steel samples, steel slag, and the gas phase were investigated in a specially-made induction furnace.

Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer.

Breast cancer is the most common malignant tumor in women. Researchers have found that the combined use of multiple methods to treat tumors is a promising strategy. Here, we have developed a biomimetic nano-platform PDA@MB for tumor targeted photothermal therapy (PTT) combined with chemotherapy.

Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy.

The treatment efficiency of the Fenton reaction is expected to be greatly restricted due to problems such as inefficient delivery of Fenton catalysis, limited HO concentration and uneven tumour tissue. Accurate photothermal therapy (PTT) could improve the efficiency of Fenton catalysis to some extent by raising the temperature. However, the heat shock response (HSR) of tumour cells caused by PTT and Fenton reaction would attenuate the treatment effect.

A field study of dioxins during co-processing of hazardous waste in multicomponent slurry gasifier.

A field test was conducted to study the emission and distribution characteristics of dioxins during co-processing of hazardous waste in a multicomponent slurry gasifier (MCSG). The toxicity equivalent concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in all exhaust gas, waste water, and solid waste under both blank condition (i.e.

Functionalized PDA/DEX-PEI@HA nanoparticles combined with sleeping-beauty transposons for multistage targeted delivery of CRISPR/Cas9 gene.

CRISPR/Cas9 system has been used as the most powerful gene editing tool for precision medicine and advanced gene therapy. However, its wide applications are limited by the poor biosafety of lentivirus delivery vectors though with high-efficiency transduction. To construct a safer vector and promote genome integration, the CRISPR/Cas9 gene is cloned into a plasmid-based non-viral safe vector Sleeping-Beauty (SB) transposon in this study to obtain pT2SpCas9.

Ca/calmodulin-dependent Protein Kinases in Leukemia Development.

Ca/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated.

Field-scale study of co-processing dichlorodiphenyltrichloroethane-contaminated soil in a cement kiln.

Persistent organic pollutants in soil are not readily degraded in the short term. The utilization of co-processing solid waste in cement kilns has received increasing attention in recent years. Co-processing may be a good way of disposing of dichlorodiphenyltrichloroethane-contaminated soil (CS).

Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy.

B lymphoblastic leukemia (B-LL) is a clonal hematopoietic stem cell neoplasm derived from B-cell progenitors, which mainly occurs in children and adolescents and is one of the main causes of death from malignant tumors in this population. The surface marker CD19 is specifically expressed on the membrane of most malignant B-cells, which is widely used as a marker of B-LL antigen-specific immunotherapy. In this study, mesoporous titanium dioxide nanoparticles (MTNs)-based antibody drug delivery system was designed for B-LL treatment.