Publications by authors named "Bingxin Lu"
Chromosomal instability (CIN) is pervasive in human tumours and often leads to structural or numerical chromosomal aberrations. Somatic structural variants (SVs) are intimately related to copy number alterations but the two types of variant are often studied independently. Additionally, despite numerous studies on detecting various SV patterns, there are still no general quantitative models of SV generation.
View Article and Find Full Text PDFThe cation transport pump is a critical process in the realm of organismal energy utilization and acquisition. In this study, a TpPa-SO/TiO-CN nanochannel membrane is fabricated to emulate the energy-consuming ion pump mechanism of V-ATPase. The channels exhibit ion rectification properties, excellent cation selectivity due to negatively charged TpPa-SO groups, while the TiO-CN heterojunction acted as the light-harnessing component for counter-gradient ion transport, enabling light-driven cation pumping through their synergistic effect.
View Article and Find Full Text PDFBackground: Adipose stem cells (ADSCs) have garneVred increasing attention for their potential to treat diabetes mellitus erectile dysfunction (DMED), but the underlying molecular mechanisms remain unclear. The aim of this study was to identify and investigate the key cytokines and mechanisms by which ADSCs improve erectile function in DMED rats.
Methods: We performed in vivo and in vitro assays, including rat erectile function assessment, cell co-culture, cytokine microarray screening and co-immunoprecipitation to investigate the role of ADSCs in improving erectile function in DMED rats.
Cancer phylogenetic inference using copy number alterations detected from DNA sequencing data.
Cancer Pathog Ther
January 2025
Cancer is an evolutionary process involving the accumulation of diverse somatic mutations and clonal evolution over time. Phylogenetic inference from samples obtained from an individual patient offers a powerful approach to unraveling the intricate evolutionary history of cancer and provides insights that can inform cancer treatment. Somatic copy number alterations (CNAs) are important in cancer evolution and are often used as markers, alone or with other somatic mutations, for phylogenetic inferences, particularly in low-coverage DNA sequencing data.
View Article and Find Full Text PDFMicrobial sulfate reduction leads to the formation of various chalcophile trace metal sulfides, thereby immobilizing chalcophile trace metals in sediments. Iron/sulfate-reducing bacteria (ISRB) are ubiquitous in soils and sediments, its ability to reduce Fe(III) (oxyhydr)oxides and biogeochemical significance have attracted much attention. This research investigated the effect of the goethite and ISRB induced S cycle on cadmium mobility.
View Article and Find Full Text PDFArticle Synopsis
- The mining and use of rare earth elements (REEs) like cerium (Ce) have increased their concentration in the environment, particularly in soil.
- This study examines how Ce ions influence the formation and properties of hexagonal birnessite (HB), which is important for oxidizing and immobilizing arsenite (As(III)).
- Findings show that Ce alters HB's structure, improving its ability to remove As(III) from water, especially at lower concentrations, but the effectiveness declines at higher As levels due to changes in manganese (Mn) oxidation states.
Article Synopsis
- Senescence is a significant risk factor for liver fibrosis, and Sirtuin 1 (SIRT1) may play a key role in its development, particularly in aged rats exposed to carbon tetrachloride (CCl).
- The study found that SIRT1 levels were decreased in fibrotic liver tissues, leading to increased NLRP3 inflammasome activity and p53/p21 pathway activation, which were associated with inflammation and cell aging.
- Overexpressing SIRT1 through adenoviral vectors was shown to reverse these effects by deacetylating HnRNP U, ultimately reducing liver fibrosis in senescent hepatocytes.
Article Synopsis
- Ovarian high-grade serous carcinoma (HGSC) begins in the fallopian tube, with precursor cells called p53 signatures developing into more advanced lesions (STIC) that lead to invasive cancer and metastasis in the body.
- Research revealed that late-stage HGSC samples have a higher ploidy (genomic content) compared to early-stage samples, suggesting significant genetic changes occur throughout the disease's progression.
- Analyzing tissue samples from patients, the study found that alterations in ploidy happen early in the cancer's development, indicating these genetic changes could be key to understanding the progression of HGSC from its initial formations to more advanced stages.
High-performance osmotic energy harvesting enabled by the synergism of space and surface charge in two-dimensional nanofluidic membranes.
J Colloid Interface Sci
November 2024
Article Synopsis
- Researchers are exploring 2D nanochannels for capturing osmotic energy but face challenges in power generation due to ion flux and selectivity issues.
- A new type of composite membrane made from montmorillonite and cellulose nanofibers significantly improves ion transport and generates about 16.57 W/m, outperforming existing systems.
- The study highlights how the combination of space charge and surface charge enhances osmotic energy conversion, providing useful insights for developing more efficient clean energy technologies.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a dangerous type of cancer that is different inside each tumor, making it hard to treat.
- Researchers studied over 600 samples from 123 patients to understand how this cancer develops and progresses.
- They discovered that the most aggressive cells in a tumor are the best way to predict how well a patient will do, not just by looking at how different the tumor cells are from each other.
Article Synopsis
- The study investigates the relationship between air pollution, particularly fine particulate matter (PM), biological aging, and the risk of developing liver cirrhosis, finding a significant association.
- It involved a case-control design with 100 liver cirrhosis patients and matched controls, using machine learning to estimate PM concentrations and algorithms to assess biological age.
- The results suggest that biological aging partially mediates the risk of liver cirrhosis related to PM exposure, indicating that slowing the aging process could help reduce this risk.
Article Synopsis
- Researchers are exploring biomimetic nanochannels for osmotic energy conversion, but current devices have limited power output due to low light-induced currents and energy efficiency.
- A new design combines ZnO and N719 on anodic aluminum oxide to improve cation selectivity and ion transport, achieving a significant power density of ≈18.49 W/m².
- The study highlights how the heterojunction interfaces enhance exciton production and improve energy conversion efficiency, opening doors for better energy solutions using biomimetic technologies.
Article Synopsis
- Phylogenetic trees that utilize copy number profiles from a patient’s multiple samples can enhance our understanding of how cancer evolves.
- A new method called CNETML has been developed, which uses maximum likelihood to infer phylogenies, including tree topology, node ages, and mutation rates from these copy number data.
- Simulations indicate that CNETML performs effectively, and when applied to real data, it aligns with past findings while also revealing new early copy number events worth exploring.
Article Synopsis
- The study investigates the early stages of tumor formation, focusing on the genetic inactivation of TP53 in gastric organoids, which mimics human pre-cancerous conditions.
- Researchers used experimental evolution over two years to observe how TP53 loss led to genetic changes and aneuploidy, common in gastric cancers.
- Findings suggest that the initial stages of tumor development show predictable patterns, indicating potential strategies for early detection and prevention of aggressive tumors.
Article Synopsis
- * The TpDB COFs are made using a layer-by-layer self-assembly method at room temperature, which is eco-friendly and allows for easy assembly onto a substrate.
- * The newly developed TpDB-HPAN membrane features increased open-circuit voltage and outstanding energy harvesting capabilities, making it a cost-effective option for future energy conversion applications.
Article Synopsis
- * Researchers created an artificial ionic rectifier bridge using anodic aluminum oxide and a light-responsive polymer, allowing control of ion current with UV and visible light.
- * The findings enhance our understanding of ion transport and open new possibilities for intelligent ion devices that can better integrate with biological systems.
Article Synopsis
- * A study involving 67 patients with hepatocellular carcinoma (HCC) revealed that while genetic variations remained stable across different cancer stages, phenotypic variations quickly increased, especially in stage II patients, often showing multiple transcriptomic subtypes within a single tumor.
- * The findings indicate that phenotypic ITH is a critical factor for predicting patient outcomes and explains why single-target therapies are often ineffective in HCC, stressing the need for more comprehensive studies on phenotypic evolution in various cancers.
Article Synopsis
- * A new covalent organic polymers membrane is developed, boasting high mechanical strength and stability for up to one month under harsh conditions.
- * Using a sol-gel approach, this membrane can easily be produced in a large size (26 × 26 cm) and achieves a maximum output power density of 6.21 W/m², showing promise for future applications.
Article Synopsis
- Lead and cadmium are harmful to health, so a new adsorbent material called BUT-VER, made from functionalized vermiculite, was developed to remove these metals from water.
- The study optimized various factors affecting the adsorption process and found that the adsorption data matched well with a pseudo-second-order model, indicating efficient removal.
- BUT-VER demonstrated over 99% removal efficiency in real river water within one hour and maintained high efficacy over multiple regeneration cycles, suggesting it's a practical and cost-effective solution for cleaning contaminated water.
Article Synopsis
- Viral suppressors of RNA silencing (VSRs) help viruses like the tomato zonate spot virus (TZSV) evade plant defenses, and the TZSV NSs protein was identified as a strong VSR.
- The study showed that TZSV NSs interacts with the plant protein NbSGS3, a key player in RNA silencing, which enhances the severity of symptoms caused by another virus, potato virus X (PVX).
- Results indicated that TZSV NSs reduces the levels of NbSGS3 in plant cells via cellular processes like ubiquitination and autophagy, revealing a new way TZSV undermines plant antiviral defenses.
Article Synopsis
- * Researchers identified 38 PgrAQP genes in the pomegranate genome, categorizing them into five subfamilies and noting their evolution influenced by whole-genome duplication and purifying selection.
- * Analysis showed that specific PgrAQP genes are linked to water accumulation in seed coats, with higher expression levels potentially aiding in the development of the juicy edible flesh of pomegranates.
Sandwich "Ion Pool"-Structured Power Gating for Salinity Gradient Generation Devices.
ACS Appl Mater Interfaces
July 2021
Article Synopsis
- Nanoconfinement ion transport, akin to biological ion channels, has garnered interest for applications in energy conversion and nanofluidic diodes, with a focus on improving rectification performance through various asymmetries.
- This research introduces an "ion pool"-structured nanofluidic diode made from an anodic aluminum oxide (AAO) membrane sandwiched between ZIF-8 and WO, achieving a high rectification ratio of 192 by effectively concentrating ions within the ion pool.
- The device is pH-responsive and shows exceptional ion selectivity, enabling it to function as a power gating device in salinity gradient harvesting by switching between On and Off states, leading to significantly enhanced performance compared to traditional membranes
Article Synopsis
- The study focuses on how genetic diversity in tumors arises, particularly the formation and spread of karyotype alterations in human tumors at a single-cell level.
- Researchers developed a method called 3D Live-Seq that combines live imaging of tumor organoids and whole-genome sequencing to track changes in tumor cells over generations.
- Findings show that karyotype changes occur rapidly and can either happen gradually through multiple cell divisions or emerge suddenly from a single division, highlighting the complex evolution of tumor genomes.
Kinetic Process of an Alkaline Earth Metal Ion Transmembrane through ZIF-8.
J Phys Chem Lett
June 2021
Article Synopsis
- The transport of molecules and ions is influenced by the confinement effect of biological ion channels, which have very small pores (angstrom-sized).
- The study focuses on comparing the potassium channel's structure and ZIF-8’s intrinsic pores, highlighting their similarities.
- A glass/ZIF-8 hybrid membrane was created to study ion transport using electrochemical methods, revealing that ion transport behaves according to Arrhenius principles, where ionic charge and size are significant factors.