Self-assembly of dipolar crystals from magnetic colloids.

We study the self-assembly of magnetic colloids using the Stockmayer (SM) model characterized by short-range Lennard-Jones interactions and long-range dipole-dipole interactions. Using molecular dynamics simulations, we design cooling protocols that yield perfectly assembled single-domain magnetic crystals. We identify cooling rates at which the system transforms from an amorphous glass to a crystal, where magnetic ordering promotes crystalline order.

Development of a composite core collection from 5,856 Sesame accessions being conserved in the Indian National Genebank.

Objectives: A composite core collection (CCC) in sesame (Sesamum indicum L.) will help utilize genetic resources efficiently. This study reports, using genomics tools, a representative minimal set (CCC) that capture maximal genetic diversity from a set of 5,856 sesame accessions being conserved at the National Genebank (NGB) of the ICAR-NBPGR.

Green synthesis of ZnO nanoparticles using and zinc nitrate precursor: a dual-functional material for water purification and antibacterial applications.

This study presents an eco-friendly, bio-engineered approach for synthesizing zinc oxide nanoparticles (ZnO NPs) using pod (-pod) extract, offering a sustainable alternative for environmental remediation and antimicrobial applications. X-ray diffraction (XRD) analysis confirms the wurtzite crystalline phase, with an average particle size of 20.87 nm.

Expanding horizons of cancer immunotherapy: hopes and hurdles.

Background: Tumor displays various forms of tumor heterogeneity including immune heterogeneity that allow cancer cells to survive during conventional anticancer drug interventions. Thus, there is a strong rationale for overcoming anticancer drug resistance by employing the components of immune cells. Using the immune system to target tumor cells has revolutionized treatment.

Comparative and Studies of Novel Zinc/Tin Metal Coordinates Bearing BRCA-1 Mimetics on WTp53 and MTp53 Proteins.

Purpose: This study compares the activity of BRCA-1 mimetics on WTp53 (wild-type p53 protein) and MTp53 (mutated-type p53 protein) proteins, examining the impact of TP53 mutations in breast cancer. p53 activators can be a new insight and synthesis of effective compounds for the treatment of cancer. The project contributes to the growing body of research on p53 activators and provides new insights into the design and synthesis of effective compounds for the treatment of cancer.

Two-stage assembly of patchy ellipses: From bent-core particles to liquid crystal analogs.

We investigate the two-dimensional behavior of colloidal patchy ellipsoids specifically designed to follow a two-step assembly process from the monomer state to mesoscopic liquid-crystal phases via the formation of the so-called bent-core units at the intermediate stage. Our model comprises a binary mixture of ellipses interacting via the Gay-Berne potential and decorated by surface patches, with the binary components being mirror-image variants of each other-referred to as left-handed and right-handed ellipses according to the position of their patches. The surface patches are designed so as in the first stage of the assembly the monomers form bent-cores units, i.

Phase separation of a magnetic fluid: Asymptotic states and nonequilibrium kinetics.

We study self-assembly in a colloidal suspension of magnetic particles by performing comprehensive molecular dynamics simulations of the Stockmayer (SM) model, which comprises spherical particles decorated by a magnetic moment. The SM potential incorporates dipole-dipole interactions along with the usual Lennard-Jones interaction and exhibits a gas-liquid phase coexistence observed experimentally in magnetic fluids. When this system is quenched from the high-temperature homogeneous phase to the coexistence region, the nonequilibrium evolution to the condensed phase proceeds with the development of spatial as well as magnetic order.

Accelerated inertial regime in the spinodal decomposition of magnetic fluids.

Furukawa predicted that at late times, the domain growth in binary fluids scales as () ∼ , and the growth is driven by fluid inertia. The inertial growth regime has been highly elusive in molecular dynamics (MD) simulations. We perform coarsening studies of the ( = 3) Stockmayer (SM) model comprising of magnetic dipoles that interact long-range dipolar interactions as well as the usual Lennard-Jones (LJ) potential.

Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade.

Background: Highest incidence of oral cancer is reported in India with reduced survival rate in the advanced stages due to lack of effective biomarkers. Therefore, it is essential to develop novel biomarkers for the better management of this disease. In the current study, TNFAIP8/TIPE protein family comprising of four proteins is explored for its role in oral cancer.

Orai-1 and Orai-2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF-κB signalling.

Despite remarkable progress in understanding and treating oral cancer (OC), it still remains one of the life-threatening diseases and predominant cancers in the world. Therefore, deciphering the molecular mechanisms of this disease would help us to develop highly efficacious therapies. Multiple lines of evidence suggest that calcium and its dysregulation play significant role in the development of various cancers.

TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade.

Lung cancer represents the most common cause of cancer deaths in the world, constituting around 11.6% of all new cancer cases and 18.4% of cancer-related deaths.

Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.

Protein kinase B (Akt) plays a very significant role in various cancers including oral cancer. However, it has three isoforms (Akt1, Akt2, and Akt3) and they perform distinct functions and even play contrasting roles in different cancers. Therefore, it becomes essential to evaluate the isoform-specific role of Akt in oral cancer.

Assessment of topsoil contamination in an urbanized interfluve region of Indo-Gangetic Plains (IGP) using magnetic measurements and spectroscopic techniques.

The magnetic susceptibility (MS) measurements are used for rapid and cost-effective soil surveys and for accessing heavy metal contamination worldwide. In the sub-Himalayan plains of India, nearly 6.05 × 10 km area of most the fertile land occurs as interfluve of Late Quaternary age between the two major glacier-fed rivers (Ganga and Yamuna).

Formononetin reverses established osteopenia in adult ovariectomized rats.

Objective: Formononetin (Formo) prevents ovariectomy (Ovx)-induced bone loss in rats. However, there are no reports on the curative effects of Formo. The objective of this study was to investigate the ability of Formo in restoring trabecular microarchitecture and promoting new bone formation in osteopenic rats.

One step synthesis of 2-hydroxymethylisoflavone and their osteogenic activity.

An efficient one step synthesis of new 2-hydroxymethylisoflavone is reported. A series of deoxybenzoin was subjected to cyclization with glyoxal in the presence of basic condition (KOH/EtOH) to afford the 2-hydroxymethyl isoflavone. The structures of compounds 5a-g were confirmed by NMR experiments including (1)H, (13)C, HMBC, HSQC and COSY.