Development of a composite core collection from 5,856 Sesame accessions being conserved in the Indian National Genebank.

Objectives: A composite core collection (CCC) in sesame (Sesamum indicum L.) will help utilize genetic resources efficiently. This study reports, using genomics tools, a representative minimal set (CCC) that capture maximal genetic diversity from a set of 5,856 sesame accessions being conserved at the National Genebank (NGB) of the ICAR-NBPGR.

Society of cardiothoracic surgery in great Britain and Ireland guidance for adult mitral valve disease and interventions.

The Society of Cardiothoracic Surgery (SCTS) in Great Britain and Ireland provides comprehensive guidelines for the management of adult mitral valve disease, addressing both surgical and transcatheter interventions. These guidelines serve as a resource for healthcare professionals, supplementing existing clinical guidelines. They emphasize the evolving complexity of mitral valve disease management, influenced by the development of new technologies, ongoing research, and randomized trials.

Zinc Oxide Nanoplatelet-Coated Polypropylene Separators as a Bifunctional Tool for Enabling Dendrite-Free Lithium Metal Batteries: A Binder-Free Approach.

The commercialization of lithium metal as an anode is challenged by its poor electrochemical reversibility and short cycle life. Both issues stem from the fragile solid electrolyte interphase (SEI) and dendritic growth during continuous stripping-plating cycles. Here, we report ZnO-decorated polypropylene separators as a bifunctional tool to suppress or mitigate dendritic proliferation.

Computational and Experimental Insights on the Role of ZnO Nanoplatelets Coated Separator in Stabilizing Lithium Metal Anodes.

Severe interfacial instability, dendritic growth, poor reversibility, and compromised cycle life of lithium metal anode have limited its application as a potential anode. Herein, a lithiophilic ZnO-coated separator (ZnO-PP) is used to mitigate the interfacial instability by creating an artificial solid electrolyte interface (ASEI) in situ through the spontaneous reaction of ZnO with the lithium surface. The composite separator exhibited excellent wettability, high ionic conductivity, improved Li transference number, and exchange current density.

Tetrasubstituted imidazole-based multifunctional fluorophores: trace water detection and lipid droplet (LD) imaging studies.

Two tetrasubstituted imidazoles, denoted as TSIm-1 and TSIm-2, with flexible and rigid cores, respectively, displayed remarkable photophysical properties as well as aggregation-induced emission. TSIm-1 exhibited trace water detection in THF with an LOD of 0.03 wt%.

Nutritional profiling of horse gram through NIRS-based multi-trait prediction modelling.

Horse gram (Macrotyloma uniflorum (Lam.) Verd.) is an underutilised legume from the Indian subcontinent.

Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in .

Aurora kinase B, Ipl1 in , is a master regulator of cell division, required for checkpoint regulation, spindle assembly and disassembly, chromosome segregation, and cytokinesis. Decades of research employed ensemble averaging methods to understand its dynamics and function; however, the dynamic information was lost because of population-based averaging. Here, we use single-molecule imaging and tracking (SMIT) to quantify the recruitment dynamics of Ipl1 at the kinetochores and spindles in live cells.

Insights into early generation synthetic amphidiploid : a strategy to harness maximum parental genomic diversity for improving Indian mustard.

In India, amphidiploid (AABB, 2n=36) is a significant oilseed crop, but its small gene pool limits its ability to develop traits of higher breeding and economic value. Through interspecific hybridization from various lines of the progenitor species, resynthesized (RBJ) can provide breeders with additional resources for creating genetically diverse stress-tolerant and high-yielding cultivars. Three accessions and eight accessions were crossed in this study to develop 33 synthetic lines.

Retrospective Analysis of Dosimetric Comparison Between Intensity-Modulated Radiation Therapy and Volumetric-Modulated Arc Therapy in Patients With Esophageal Cancer.

Introduction Esophageal cancer is a significant global health concern, with high incidence and mortality rates, particularly in India, where it ranks among the top causes of cancer-related deaths. Radiotherapy plays a critical role in the treatment of advanced-stage esophageal cancer. This study aims to compare the dosimetric outcomes of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) to evaluate their efficacy and safety in managing mid-esophageal carcinoma.

A Fluorescent Probe Differentiates Apoptosis from Cysteine-Deprivation Ferroptosis through Imaging of Viscosity and Lipid Droplets.

Since death is an inevitable phenomenon, exploring cell deaths holds importance. During this process, the cellular microenvironment within cells such as pH, polarity, viscosity etc alter. One such microenvironment, viscosity elevates during different cell deaths.

Hybrid taguchi-grey relational analysis approach for optimizing cutter operational parameters in selective cauliflower harvesting.

Cauliflower is an important winter crop grown in India, its curds are rich in nutritional profile, containing valuable minerals and vitamins. However, cauliflower harvesting is mainly accomplished by hands, which is time-consuming and requires a high labour force. On the other hand, most developed cauliflower harvesters are once over or single pass type, which harvests all plants irrespective of their maturity.

Pyrene Based Schiff Base for Cascade Fluorescent "On-Off" Detection of Aluminium(III) and Fluoride Ions and its Applications in Live Cells Imaging.

An easy-to-prepare pyrene-based Schiff base PNZ was synthesized by condensing equimolar amount of 1-pyrenebutyric hydrazide with 2-hydroxy-naphthaldehyde, and employed as a fluorescent chemosensor for in-situ cascade detection of aluminium (Al) and fluoride (F) ions. In DMSO:HO (1 : 1, v/v), the weakly emissive PNZ showed a significant fluorescence enhancement at 455 nm selectively upon the addition of Al due to the complexation-induced formation of a pyrene excimer. Schiff base PNZ and Al formed a complex in 2 : 1 binding ratio with the estimated binding constants of K=9826.

Missense variant in PIGM associated with severe cystic encephalomalacia and portal vein thrombosis: Phenotypic and genotypic expansion of the glycosylphosphatidylinositol biosynthesis defect-1 (GPIBD1).

Glycosylphosphatidylinositols (GPIs) are a type of glycolipid responsible for anchoring many important proteins to the cell membrane surface. Defects in the synthesis of GPIs can lead to a group of multisystem disorders known as the inherited GPI deficiencies (IGDs). Homozygosity for the c.

Role of Serum Micro-RNA-122-5p Expression as a Circulatory Biomarker in People Having Both Knee Osteoarthritis and Osteoporosis: A Case-Control Study.

Background Although knee osteoarthritis (KOA) and osteoporosis (OP) manifest distinct pathophysiologies, they share numerous similarities. These health conditions are commonly found in older individuals, particularly among women. The objective of this study is to explore the expression of micro-RNA (miRNA) 122-5p (miR-122-5p) in people affected by both KOA and OP.

Sesame Genomic Web Resource (SesameGWR): a well-annotated data resource for transcriptomic signatures of abiotic and biotic stress responses in sesame (Sesamum indicum L.).

Sesame (Sesamum indicum L.) is a globally cultivated oilseed crop renowned for its historical significance and widespread growth in tropical and subtropical regions. With notable nutritional and medicinal attributes, sesame has shown promising effects in combating malnutrition cancer, diabetes, and other diseases like cardiovascular problems.

Double-digest restriction-associated DNA sequencing-based genotyping and its applications in sesame germplasm management.

Sesame (Sesamum indicum L.) is an ancient oilseed crop belonging to the family Pedaliaceae and a globally cultivated crop for its use as oil and food. In this study, 2496 sesame accessions, being conserved at the National Genebank of ICAR-National Bureau of Plant Genetic Resources (NBPGR), were genotyped using genomics-assisted double-digest restriction-associated DNA sequencing (ddRAD-seq) approach.

Efficacy of Bhramari pranayama and Om chanting on asthma control, quality of life, and airway inflammation in asthmatic children: an open-label randomized controlled trial.

Objectives: To explore the efficacy of combination of and chanting as an adjunct to standard pharmacological treatment on asthma control, quality of life, pulmonary function, and airway inflammation in asthmatic children.

Methods: Children ( = 110; 8-15 years) with uncontrolled or partly controlled asthma were recruited from the Pediatric Chest Clinic of All India Institute of Medical Sciences, New Delhi. Eligible participants were randomized to either home-based online and chanting plus standard treatment (YI + ST) group, or standard treatment (ST) alone group.

Agro-morphological and nutritional assessment of chenopod and quinoa germplasm-Highly adaptable potential crops.

Quinoa belongs to the family , a pseudo-grain having high nutritional value and is considered an underexploited vegetable crop with the potential to improve the nutritional security of millions. Therefore, assessing genetic diversity in germplasm to untap nutritional and site-specific adaptation potential would be of prime importance for breeders/researchers. The present study used 10 accessions of two species, that is, and .

Ratiometric fluorescent probes for pH mapping in cellular organelles.

The intracellular pH (pHi) in organelles, including mitochondria, endoplasmic reticulum, lysosomes, and nuclei, differs from the cytoplasmic pH, and thus maintaining the pH of these organelles is crucial for cellular homeostasis. Alterations in the intracellular pH (ΔpHi) in organelles lead to the disruption of cell proliferation, ion transportation, cellular homeostasis, and even cell death. Hence, accurately mapping the pH of organelles is crucial.

A Systematic Design and Synthesis of PET-based Fluorescent Probes for Monitoring pH During Mitophagy.

Mitochondria are the powerhouse of the cell and function at pH ∼8.0. Dysfunctions of mitochondria, includes mitochondrial damage, leading to pH alteration.

Role of cyclin D1 in glial tumors-A retrospective and observational study.

Aim: High-grade glial tumors remain as one of the most lethal malignancies. Cyclin D1 is expressed in some human malignancies and is the potential target of intervention. The present study aims to determine the relationship of cyclin D1 expression with other clinicopathological parameters.