BRIDGE-DS study: evaluating the effectiveness and safety of dapagliflozin/sitagliptin combination in type 2 diabetes mellitus patients with heart failure.

Background: Co-occurrence of type 2 diabetes mellitus (T2DM) and heart failure (HF) elevates the risk of morbidity and mortality. Recent research emphasizes treatment strategies that go beyond glycemic control to enhance heart function.

Aim: To assess the effectiveness and safety of the fixed-drug combination of dapagliflozin and sitagliptin (FDC D/S) in T2DM patients with HF.

Self-Reported Bruxism, Masticatory Muscle Pain, Psychological Profile and Bowel Symptoms: A Retrospective Study.

Aim: To investigate associations between self-reported bruxism, masticatory muscle pain and bowel symptoms, and their relationship to the 9 dimensions of the Symptom Checklist-90- Revised (SCL-90-R).

Methods: Data from 3 separate validated questionnaires - Bowel Symptom Questionnaire (BSQ) to classify bowel status, Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) to determine self-reported bruxism and masticatory muscle pain on palpation, and SCL-90-R for psychometric assessment were collected for each patient. BSQ used the Rome II criteria to identify the presence or absence of bowel symptoms but did not analyse sub-sets of bowel symptoms.

CRISPR/Cas9: efficient and emerging scope for Brassica crop improvement.

CRISPR/Cas9 revolutionizes Brassica crop improvement by enhancing yield, quality, and stress resistance, providing a precise and versatile tool for genetic and agronomic advancements. The rapidly advancing CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9) technologies are being employed in both diploid and polyploid species of Brassica for gene functions and precise genetic improvements. CRISPR/Cas technology has sparked significant attention among the scientific community due to its affordability, precision, and effectiveness compared to other genome editing techniques.

Insights into early generation synthetic amphidiploid : a strategy to harness maximum parental genomic diversity for improving Indian mustard.

In India, amphidiploid (AABB, 2n=36) is a significant oilseed crop, but its small gene pool limits its ability to develop traits of higher breeding and economic value. Through interspecific hybridization from various lines of the progenitor species, resynthesized (RBJ) can provide breeders with additional resources for creating genetically diverse stress-tolerant and high-yielding cultivars. Three accessions and eight accessions were crossed in this study to develop 33 synthetic lines.

α-Amylase inhibitory potential of dihydropyrano coumarins: In silico and DFT analysis.

Unlabelled: Coumarin derivatives are one of the naturally occurring bioactive molecule. Dihydropyrano coumarins are one of the medicinally important derivatives of coumarin which have been reported to exhibit various bioactivity. However, there are no reports on their antihyperglycemic activities.

Reappraisal of anatomical diversity of lateral circumflex femoral artery with its substantial clinical applicability: cadaveric study.

Studies reveal variations in the in the origin, number, and branching patterns of the lateral circumflex femoral artery (LCFA). The present study aimed to document such variations and their potential clinical applicability. Thirty-two femoral triangles of 16 embalmed adult human cadavers were dissected to investigate the variation in the origin, number, and branching patterns of LCFA.

COVID-19 outbreak… journey of dental care workers: A systematic review.

The conditions of health-care professionals including dental fraternity have been extremely affected during the COVID-19 pandemic. Dental care workers have suspended all routine dental activities with the fear of transmission of the virus from aerosol-generating dental procedures. They have also stood with medical care professionals as frontline warriors because of the exponentially overburdened of the COVID-19-positive patients worldwide.

Indexing Resilience to Heat and Drought Stress in the Wild Relatives of Rapeseed-Mustard.

Wild species are weedy relatives and progenitors of cultivated crops, usually maintained in their centres of origin. They are rich sources of diversity as they possess many agriculturally important traits. In this study, we analysed 25 wild species and 5 U triangle species of for their potential tolerance against heat and drought stress during germination and in order to examine the early seedling stage.

Strategies for utilization of crop wild relatives in plant breeding programs.

Crop wild relatives (CWRs) are weedy and wild relatives of the domesticated and cultivated crops, which usually occur and are maintained in natural forms in their centres of origin. These include the ancestors or progenitors of all cultivated species and comprise rich sources of diversity for many important traits useful in plant breeding. CWRs can play an important role in broadening genetic bases and introgression of economical traits into crops, but their direct use by breeders for varietal improvement program is usually not advantageous due to the presence of crossing or chromosome introgression barriers with cultivated species as well as their high frequencies of agronomically undesirable alleles.

Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements.

Introduction: Vitamin D has been shown to play a vital role in bone mineral homeostasis by stimulating the intestinal absorption of calcium and phosphate. The critical role of Vitamin D in bone metabolism triggered the need to evaluate the effect of Vitamin D deficiency and hence replacement of the same on osseointegration of dental implants. This prospective study evaluated the crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements.

Occlusal-based planning for dental rehabilitation following segmental resection of the mandible and maxilla.

Reconstruction of the maxilla and mandible incorporating a dental prosthesis supported by dental implants is a complex process but has tremendous benefit to patient rehabilitation following ablative procedures. This study presents a protocol that can be used to aid other institutions to provide the highest standard of reconstruction.

Ectopic breast tissue lesion in axilla: Cytology report of two cases.

Ectopic breast tissue (EBT) predominantly seen along the primitive embryonic milk lines that extend from axilla to groin. Axillary breast tissue is one of the common variant of EBT seen in 2% to 6% of women. Phyllodes tumour in EBT is uncommon.

Steroid Cell Tumour of Ovary - A Rare Case Report.

Steroid cell tumours of the ovary are uncommon sex- hormone secreting tumours characterized by a steroid cell proliferation. The incidence of steroid cell tumour of the ovary is only 0.1% of all ovarian tumours.

Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation: A Potential Marker for Prematurity and Retinopathy.

Purpose: To present the association between mutations affecting the Wnt-signaling receptor protein (FZD4), inherited vitreoretinopathies, and retinopathy of prematurity (ROP).

Design: Retrospective analysis of prospective samples at a tertiary referral center.

Participants: Patients referred to our practice for management of a variety of pediatric vitreoretinopathies were offered participation in an ophthalmic biobank (421 participants with vitreoretinopathies were included in this study).

Retentiveness of various luting agents used with implant-supported prosthesis: an in vitro study.

Desired retrievability of cemented implant-supported fixed prosthesis makes the retentive strength of cementing agents an important consideration. The aim of the study was to evaluate the retentiveness of purposely designed implant cement and compare its retentiveness with dental cements that are commonly used with implant systems. Ten implant analogs were embedded in auto-polymerizing acrylic resin blocks and titanium abutments were attached to them.

Evaluation of accuracy of casts of multiple internal connection implant prosthesis obtained from different impression materials and techniques: an in vitro study.

Movement of impression copings inside the impression material using a direct (open tray) impression technique during clinical and laboratory phases may cause inaccuracy in transferring the 3-dimensional spatial orientation of implants intraorally to the cast. Consequently, the prosthesis may require corrective procedures. This in vitro study evaluated the accuracy of 3 different impression techniques using polyether and vinyl polysiloxane (VPS) impression material to obtain a precise cast for multiple internal connection implants.

Outcomes and predictive factors in bilateral macular holes.

Purpose: To evaluate the incidence, risk factors, outcomes, and visual prognosis in patients with bilateral macular holes repaired surgically with indocyanine green (ICG)-assisted internal limiting membrane (ILM) peeling in our population.

Design: Retrospective, multisurgeon, nonrandomized, noncomparative case series.

Participants: Eighty-two patients were identified who underwent bilateral macular hole surgery with ILM peeling without other vision-limiting pathologic features.

Retentiveness of various luting agents used with implant-supported prostheses: a preliminary in vitro study.

The aim of this preliminary in vitro study was to compare the retentiveness of a luting agent designed for use with dental implants to luting agents designed for use with tooth-retained restorations. The following luting agents were tested: (1) implant cement, (2) resin-bonded zinc oxide-eugenol cement, (3) zinc phosphate cement, (4) zinc polycarboxylate cement, and (5) glass-ionomer cement. After cementation, each sample was subjected to a pull-out test using a universal testing machine, and the loads required to remove the crowns were recorded.

Reconstruction of Exenterated Orbit using Combined Surgical and Prosthetic Approach.

Reconstruction of an exenterated orbit remains a challenge. Orbital prostheses are nowadays are made of silicone elastomers. A major limitation with silicone orbital prostheses is their relatively short life span.