Preyssler Polyoxometalate Supported Transition Metal Bipyridine Coordination Complexes.

We have synthesized two Preyssler-type polyoxometalate ({NaPWO})-based compounds [{Co(CHN)}{Co(CHN)}HNaPWO]·24HO () and [{Cu(CHN)}(CHN)NaPWO]·6HO () by solvothermal synthesis. The crystal structure of compound consists of Preyssler polyoxometalate (POM) coordinated to {Co(2,2'-bpy)} (bpy = 2,2'-bipyridine, CHN) complex and two uncoordinated {Co(2,2'-bpy)} complexes. The molecular structure of compound consists of four {Cu(2,2'-bpy)} complexes coordinated to terminal oxygens of Preyssler polyanion and three 2,2'-bipyridinium cations.

Alginate-based NPs for targeted ovarian cancer therapy: Navigating current progress and biomedical applications.

Ovarian cancer continues to be one of the most lethal gynecological malignancies, with earlier symptoms that are frequently subtle, resulting in detection at late stages. Although there are several traditional treatments, patients do not respond well to them owing to serious side effects. Alginate, a polysaccharide extracted from brown seaweed (a natural polymer), has gained significant attention as an ideal biopolymer for developing drug delivery systems because of its nontoxicity, biodegradability, and ease of manipulation.

Selective steroid receptor modulators, degraders and PROTACs: Therapeutic strategies in management of endocrine-related cancers.

Endocrine-related disorders are highly prevalent globally, affecting millions of people. Such diseases are multifactorial in origin and are influenced by the complex interplay of genetics, lifestyle, and environmental factors. Recurring disruptions in the endocrine homeostasis can lead to a cascade of endocrine-related cancers.

Human microRNA miR-197-3p positively regulates HIV-1 virion infectivity through its target DDX52 by stabilizing Vif protein expression.

MicroRNAs are a part of the integral regulatory mechanisms found in eukaryotic cells that help in maintaining cellular homeostasis by modulating the expression of target genes. However, during stress conditions like viral infection, the expression profile of the microRNAs change, thereby directly modulating the expression of viral genes and/or indirectly targeting the virus by regulating the host genes. The present study intends to identify previously uncharacterized cellular microRNAs, which are significantly modulated upon HIV-1 infection.

Fermentative production of vitamin B by and and its promising health benefits: A review.

Cobalamin, generally known as vitamin B, is a crucial component required for humans in several physiological processes. It has been produced from sources that are derived from animals, making it difficult for vegetarians and vegans to consume the recommended amount each day. The importance of vitamin B in red blood cell production, DNA synthesis, and brain processes has been highlighted.

Production of biodegradable food packaging from mango peel via enzymatic hydrolysis and polyhydroxyalkanoates synthesis: A review on microbial intervention.

The rising environmental problem of plastic packaging waste has led to the development of sustainable alternatives, particularly for food packaging. Polyhydroxyalkanoates (PHAs) are biodegradable, thermoplastic polyesters. They are employed in the production of various products, including packaging films.

Unveiling the Health Promising Benefits of Processed Foods Derived from Underutilized Edible Plants: A Review.

Wild food plants (WFPs) grow naturally and are essential components of the diet and conventional food chain. These plants are underutilized despite being nutritious and highly bio-active compounds. Wild food consumption has declined over the last generation owing to life-style changes and lower availability, and it is still consumed by marginalized communities.

Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication.

Viral infections can cause Endoplasmic Reticulum (ER) stress due to abnormal protein accumulation, leading to Unfolded Protein Response (UPR). Viruses have developed strategies to manipulate the host UPR, but there is a lack of detailed understanding of UPR modulation and its functional significance during HIV-1 infection in the literature. In this context, the current article describes the protocols used in our laboratory to measure ER stress levels and UPR during HIV-1 infection in T-cells and the effect of UPR on viral replication and infectivity.

HIV-1 replication requires optimal activation of the unfolded protein response.

Several human diseases including viral infections activate the unfolded protein response (UPR) due to abnormal accumulation of unfolded/misfolded proteins. However, UPR modulation and its functional relevance in HIV-1 infection lack comprehensive elucidation. This study reveals that HIV-1 activates IRE1, PERK, and ATF6 signaling pathways of UPR.

Mitotic genome-bookmarking by nuclear hormone receptors: A novel dimension in epigenetic reprogramming and disease assessment.

Arrival of multi-colored fluorescent proteins and advances in live cell imaging has immensely contributed to our understanding of intracellular trafficking of nuclear receptors and their roles in gene regulatory functions. These regulatory events need to be faithfully propagated from progenitor to progeny cells. This is corroborated by multiple converging mechanisms that include histone modifications and lately, the phenomenon of 'mitotic genome-bookmarking' by specific transcription factors.

Photochemical and gas adsorption studies of Keggin polyoxometalate functionalized porous melamine terephthaldehyde material.

A compound containing a microporous melamine-terephthaldehyde framework is protonated by grinding with acetic acid, resulting in a mesoporous protonated melamine-terephthaldehyde network. The Keggin polyanion [PMoO] is then immobilized into this protonated melamine-terephthaldehyde network through a solid-state reaction. The polyanion interacts with the protonated microporous organic network through electrostatic interaction.

Extraction and Encapsulation of Phytocompounds of Poniol Fruit via Co-Crystallization: Physicochemical Properties and Characterization.

Poniol () has beneficial health effects due to its high polyphenolic and good antioxidant activity content. This study aimed to encapsulate the Poniol fruit ethanolic extract to the sucrose matrix using the co-crystallization process and analyze the physicochemical properties of the co-crystalized product. The physicochemical property characterization of the sucrose co-crystallized with the Poniol extract (CC-PE) and the recrystallized sucrose (RC) samples was carried out through analyzing the total phenolic content (TPC), antioxidant activity, loading capacity, entrapment yield, bulk and traped densities, hygroscopicity, solubilization time, flowability, DSC, XRD, FTIR, and SEM.

Exploiting the bioactive properties of essential oils and their potential applications in food industry.

Fruits are an abundant source of minerals and nutrients. High nutritional value and easy-to-consume property have increased its demand. In a way to fulfil this need, farmers have increased production, thus making it available for consumers in various regions.

Light-induced dissolution and concomitant crystallization of a Keggin-type polyoxometalate mimicking a naturally occurring phenomenon.

A suspension of a yellow polycrystalline compound [PPh][PMoO] in -methylformanilide (NMF) (in which it is not soluble), on irradiation with sunlight, initiates dissolution its reduction followed by its crystallization leading to the isolation of single crystals of compound [PPh][PMoMoO]·3CH(CH)NCHO (1). Compounds [PPh][PMoO]·1.75 CH(CH)NCHO (2) and [PPh][PMoO]·2CH(CH)NCHO (3), each containing an oxidized Keggin anion, are obtained at two different temperatures when the corresponding mother liquor is kept in the dark.

Incidence and Correlates of Early Cognitive Impairment following Intracerebral Haemorrhage.

Objectives: To determine the incidence of early cognitive impairment following intracerebral haemorrhage.

Methods: A total of 30 adult patients (>18 years) with intracerebral hemorrhage were enrolled in the study. Demographic profile, clinical and radiological profile of the patients was noted.

Vaccines for the prevention of diarrhea due to cholera, shigella, ETEC and rotavirus.

Background: Diarrhea is a leading cause of mortality in children under 5 years along with its long-term impact on growth and cognitive development. Despite advances in the understanding of diarrheal disorders and management strategies, globally nearly 750,000 children die annually as a consequence of diarrhea.

Methods: We conducted a systematic review of the efficacy and effectiveness studies.

Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering.

The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity.

Chitosan scaffolds containing silicon dioxide and zirconia nano particles for bone tissue engineering.

A scaffold harboring the desired features such as biodegradation, biocompatibility, porous structure could serve as template for bone tissue engineering. In the present study, chitosan (CS), nano-scaled silicon dioxide (Si) and zirconia (Zr) were combined by freeze drying technique to fabricate a bio-composite scaffold. The bio-composite scaffold (CS/Si/Zr) was characterized by SEM, XRD and FT-IR studies.

Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering.

In this study, a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver particles (CS/nHAp/nAg) was developed by freeze drying technique, followed by introduction of silver ions in controlled amount through reduction phenomenon by functional groups of chitosan. The scaffolds were characterized using SEM, FT-IR, XRD, swelling, and biodegradation studies. The testing of the prepared scaffolds with Gram-positive and Gram-negative bacterial strains showed antibacterial activity.