A low resistance circular diverter tee based on an improved random forest model.

Local components are prevalent in building transmission and distribution systems, and their resistance can significantly increase a system's operating energy consumption. This paper takes a tee as an example and proposes a novel resistance reduction method for building transmission and distribution systems that utilizes an improved random forest model. Unlike existing studies on local component resistance reduction that rely on trial-and-error empirical methods, this study introduces a posterior optimization approach that can obtain a global optimal solution within a given range.

Study on the influencing mechanisms of obstacles on dust lifted by shock waves after tunnel blasting.

Understanding the influence mechanisms by which obstacles affect the dust lifting process resulting from shock waves after tunnel blasting requires clarifying the influence of obstacles on the spatiotemporal evolution characteristics of shock waves and the interaction mechanisms between obstacles and dust layers at different spatial positions. Using compressible flow numerical simulations, a gas-solid two-phase flow model was established to simulate shock wave evolution influenced by obstacles and their interactions with the dust layer at different tunnel locations. Compared with conditions without obstacles, when the dust layer is situated upstream of the obstacle, the shock wave reflection and the obstruction by the obstacle create an upstream enhanced dust lift (UEDL) mechanism.

Estimation of Wind Speed Based on Schlieren Machine Vision System Inspired by Greenhouse Top Vent.

Greenhouse ventilation has always been an important concern for agricultural workers. This paper aims to introduce a low-cost wind speed estimating method based on SURF (Speeded Up Robust Feature) feature matching and the schlieren technique for airflow mixing with large temperature differences and density differences like conditions on the vent of the greenhouse. The fluid motion is directly described by the pixel displacement through the fluid kinematics analysis.

Parametric modeling study for blown-dust secondary pollution and optimal ventilation velocity during tunnel construction.

Tunnel construction often relies on drilling and blasting. High dust pollution is one of the primary problems of drilling and blasting construction. The level of secondary blown dust pollution caused by ventilation matches that of dust pollution caused by drilling construction.

A new model based on gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts prognostic outcome after curative resection of solitary hepatocellular carcinoma.

Background: This study intends to explore the potential clinical value of gamma-glutamyl transpeptidase to platelet ratio (GPR) and the new multi-factor scoring model for recurrence and prognosis prediction in solitary HCC patients who received radical resection.

Methods: This study retrospectively analyzed 295 HCC patients after curative resection. According to the Receiver Operating Characteristic (ROC) curve, the optimal cut-off value of GPR for predicting prognosis of HCC after resection was determined.

Adaptive Wall-Based Attachment Ventilation: A Comparative Study on Its Effectiveness in Airborne Infection Isolation Rooms with Negative Pressure.

The transmission of coronavirus disease 2019 (COVID-19) has presented challenges for the control of the indoor environment of isolation wards. Scientific air distribution design and operation management are crucial to ensure the environmental safety of medical staff. This paper proposes the application of adaptive wall-based attachment ventilation and evaluates this air supply mode based on contaminants dispersion, removal efficiency, thermal comfort, and operating expense.

Temporal variation of airborne fungi in university library rooms and its relation to environmental parameters and potential confounders.

Indoor airborne fungi have been associated with adverse human health effects. Therefore, it is important to understand the causes of underlying variation in airborne fungi in indoor environments. This study consequently aimed to investigate the association between indoor fungi with temporal variation, environmental parameters, and potential confounders over 10 months in four library rooms using Andersen samplers.

Research on a personalized targeted air supply device based on body movement capture.

Unlike general ventilation, personalized ventilation can improve thermal comfort and conserve energy based on individual differences. It can also provide every individual the ability to control fresh air exposure and ensure good indoor air quality. However, determining how to improve air supply efficiency while avoiding a draft sensation is still a difficult question.

On-site investigation of the concentration and size distribution characteristics of airborne fungi in a university library.

It is important to investigate fungal air quality in libraries because they represent a complex indoor environment. The aim of the study was to quantitatively investigate airborne fungal contamination levels based on field measurements in autumn and winter in four selected library rooms (compact stack, lending room, reading room, study room) in a university library building, as well as the effects of several factors on the culturability of airborne fungi. Airborne fungal levels varied by room, with the highest fungal levels in the reading room (634 ± 275 CFU/m) and the lowest in the lending room (486 ± 177 CFU/m).

A Pilot Study of RSK4 Expression in Patients with Human Non-Small Cell Lung Carcinoma.

Background: Lung cancer represents the leading cause of cancer deaths worldwide, with non-small cell lung carcinoma (NSCLC) comprising the most common type of lung cancer.

Objective: The aim of this pilot study was to ascertain RSK4 expression at both the gene and protein level in normal and cancerous tissue of patients with NSCLC.

Methods: From January 2015 to December 2015, a total of forty patients diagnosed with NSCLC who underwent surgery were recruited into this study.

Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells.

IFN-γ-induced PD-L1 expression represents the existence of tumor-specific T cells, which predicts high-response rate to anti-PD-1/L1 therapy, but loss-of-function of IFN signals (e.g., JAK mutation) induces adaptive immune resistance in patients with low-response rate.

The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC and .

Hypermethylation of tumor suppressor genes (TSGs) promoters by DNA methyltransferase (DNMT) can be observed in almost all cancers which represent a hallmark of carcinogenesis, including lung cancer. DNMT inhibitors (e.g.

Hypermethylation of ATP-binding cassette B1 (ABCB1) multidrug resistance 1 (MDR1) is associated with cisplatin resistance in the A549 lung adenocarcinoma cell line.

Development of multiple drug resistance has been attributed to the overexpression of the ATP-binding cassette B1 (ABCB1) gene. In this study, the major purpose was to assess the expression and methylation levels of ABCB1 in human lung adenocarcinoma and to reveal the relationship between these processes and acquisition of cisplatin (DDP) resistance in the human cancer cell line A549. Methylation and expression levels of the ABCB1 gene ABCB1 in clinical human lung tissue were assessed using bisulphite sequencing, reverse transcription real-time PCR (RT -PCR) and Western blot methods.

Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.

Our previous study showed DNMT1 is up-regulated in esophageal squamous cell carcinoma (ESCC), which is associated with methylation of tumor suppressors. In the current study, we investigate the role of DNMT1 in ESCC. We found silencing DNMT1 inhibited proliferation, metastasis and invasion of three different ESCC cells, K150, K410 and K450.

Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.

DNA methylation is an epigenetic DNA modification catalyzed by DNA methyltransferase 1 (DNMT1). The purpose of this study was to investigate DNMT1 gene and protein expression and the effects of methylation status on tumor suppressor genes in human non-small cell lung cancer (NSCLC) cell lines grown in vitro and in vivo Human lung adenocarcinoma cell lines, A549 and H838, were grown in vitro and inoculated subcutaneously into nude mice to form tumors and were then treated with the DNA methylation inhibitor, 5-aza-2'-deoxycytidine, with and without treatment with the benzamide histone deacetylase inhibitor, entinostat (MS-275). DNMT1 protein expression was quantified by Western blot.

Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma is one of the most common malignancies in the world. Studies have confirmed that there are many genes abnormally hypermethylated in esophageal squamous cell carcinoma. The objective is to detect methylation of the RASSF1A gene promoter and the expression of the DNA methyltransferase 1 (DNMT1) protein in esophageal cancer tissue and discuss their relationship with esophageal squamous cell carcinoma.

Surgical treatment of an endobronchial lipoma obstructing the right upper bronchus: Imaging features with pathological correlation.

Endobronchial lipomas are rare benign unusual tumors of the respiratory tract. We describe a 65-year-old Chinese man with a history of cough due to an endobronchial tumor. The endobronchial biopsy was not excisional and was unable to evaluate the whole tumor.

[Experimental study of myocardial protective effect of cardiac arrest versus beating heart during open heart surgery].

Objective: To investigate the myocardial protective effects of beating heart versus heart arrest in goats undergoing open heart surgery with cardiopulmonary bypass (CPB).

Methods: Eighteen healthy and homologous goats were randomly divided into three groups: groupI (n=6), with intermittent cold crystalloid cardioplegia; group II (n=6), with continuous warm blood cardioplegia; group III (n=6), with beating heart. Animals in group II and group III were operated with mild hypothermic CPB.