Beyond the Birds and Bees: Why Comprehensive Sexuality Education Is a Game-Changer for Everyone.

Comprehensive sexuality education (CSE) is a vital public health intervention that extends beyond basic biological facts to encompass emotional well-being, healthy relationships, and consent. This review explores the evolving landscape of sexuality education, examining diverse teaching methods, cultural and societal influences, and evidence-based strategies for effective implementation across all age groups and settings. By highlighting innovative practices, addressing persistent gaps and controversies, and advocating for inclusive models, this article positions sexuality education as a critical component of holistic health and public well-being, essential for fostering informed decision-making and promoting sexual rights globally.

Circulating MicroRNAs as diagnostic indicators in tuberculous Meningitis-A case -control study in North Indian population.

Purpose: Tuberculous meningitis (TBM), a severe and often fatal form of tuberculosis, showing high mortality and long-term neurological sequelae. Recent evidence suggests that microRNAs play a crucial role in TBM pathogenesis and may serve as potential biomarkers for diagnosis and disease progression.

Methods: Eight TBM patients and three healthy controls were recruited.

Assessing the utility of SISCOM and PISCOM in mapping the epileptogenic zone for epilepsy surgery: A comparative outcome-based study.

Intro: Ictal SPECT imaging stands out among non-invasive tools as the primary presurgical method for spatially defining the seizure network. Advanced image analysis methods like SISCOM and PISCOM improve the interpretation of SPECT images. However, research on their comparative utility, significance of their overlapping areas, and optimal z-scores for mapping/localizing the seizure onset zone is limited.

Ganglioside profiling in neuroblastoma.

Gangliosides play important roles in neuroblastoma research through their functions in adhesion, proliferation, and signalling. Researchers have quantified neuroblastoma cells to understand their importance and identify potential diagnostic targets. This study analyses methods for neuroblastoma cell ganglioside quantification.

Entero-Enteric Lumen Apposing Metal Stents (LAMS) for Biliary Access in Patients with Altered Anatomy.

Background And Aims: Biliary access in patients with Roux-en-Y hepaticojejunostomy, pancreaticoduodenectomy and duodenal switch can be challenging. Placement of an EUS guided lumen apposing metal stent (LAMS) between the small bowel and the afferent jejunal limb can create an entero-enteric conduit (EUS-EE), allowing for successful endoscopic access to the biliary tree for intervention. In this study, we aim to describe the safety and efficacy of EUS-EE for biliary access.

Rapid Thromboelastography Identifies Coagulopathy and Predicts Poor Outcomes in Severe Traumatic Brain Injury.

Introduction Traumatic brain injury (TBI) occurs when a force transmitted to the head or body results in neuropathologic damage and dysfunction. Approximately 25% of patients with TBI present with coagulopathy on admission, which is associated with increased mortality. Viscoelastic methods like rapid thromboelastography (r-TEG) and rotational thromboelastometry may be precise in identifying the coagulopathic changes in these patients.

Unraveling bioactive potential and production in through omics and machine learning modeling.

, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics. Thus, it is recognized as a valuable species of interest in the pharmaceutical and nutraceutical industries due to its important medicinal properties. Recent advances in omics technologies such as genomes, transcriptomics, proteomics, and metabolomics have considerably increased our understanding of the bioactives in .

Insurance claims estimation and fraud detection with optimized deep learning techniques.

Estimation and fraud detection in the case of insurance claims play a cardinal role in the insurance sector. With accurate estimation of insurance claims, insurers can have good risk perceptions and disburse compensation within proper time, while fraud prevention helps deter massive monetary loss from fraudulent activities. Financial fraud has done significant damage to the global economy, thus threatening the stability and efficiency of capital markets.

Transcriptome mapping of unfertilized pea flowers under high temperature: insights into gene regulatory networks genomics resources.

Heat stress is the most significant environmental constraint on pea production, and heat tolerance mechanisms are mediated through a variety of pathways. Pea (Pisum sativum L.) cultivar Arka Chaitra (AC) is considered a heat tolerant variety, whereas cultivar Matar Ageta (MA) is heat sensitive.

Facilitators and challenges of co-creating digital public health interventions: A Health CASCADE multi-case exploratory study.

Objectives: This study identifies facilitators and challenges in the co-creation of digital health interventions for public health.

Study Design: An exploratory multiple case study design was used to analyse three co-created digital health interventions.

Methods: Data were collected for three digital health interventions via expert interviews (n = 11), open-ended survey responses (n = 10), and project descriptions.

Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.

Background: Skin aging is a multifactorial process influenced by an individual's genetic predisposition, lifestyle choices, and environmental factors. This process leads to epidermal thinning, a reduction in collagen and elastin levels, and a decrease in skin suppleness. While aging cannot be entirely prevented, its effects can be mitigated through the application of appropriate skincare products.

Polyethylene microplastics disrupt focal adhesion kinase (FAK) signaling and sertoli cell metabolism, compromising blood-testis barrier function and spermatogenesis.

Polyethylene microplastics (PE-MPs), used extensively in personal care applications, are non-biodegradable pollutants with demonstrated bioaccumulation potential and toxicological relevance. Recent studies have detected microplastics in human semen and testicular tissues, raising concerns about their effect on male reproductive health. This study investigates the toxicological effects of orally administered polyethylene microplastics (PE-MPs) at 20 µg/mL, 200 µg/mL, and 2000 µg/mL doses in rats for 56 days, with a focus on disruption of the blood-testis barrier (BTB) and destabilization of ectoplasmic specialization (ES), both essential for normal spermatogenesis.

Synthesis of γ-Carbolines through Annulative Cyclization between Indolyl Azines and Alkynes under Rhodium Catalysis.

Functionalized carbolines play a crucial role in the discovery of bioactive compounds and functional materials. In this study, we report a Rh(III)-catalyzed annulative synthesis of γ-carbolines from indolyl azines and internal alkynes. Remarkably, indolyl azines can undergo N-N bond cleavage under the influence of a Rh(III) catalyst, yielding 2-fold ketimines, which demonstrates the atom economy of indolyl azines in catalytic C-H functionalizations.

Comparative evaluation of antimicrobial efficacy at the implant-abutment interface using gold and silver ion coatings - An in vitro study.

Aim: The aim of the study is to assess the antimicrobial efficacy at Implant-Abutment Interface (IAI) coated with metal ions (silver and gold) causing peri-implantitis, with the objective of comparing its antimicrobial properties.

Study Setting And Design: The study conducted is an in vitro experimental study.

Material And Methods: A total of 90 specimens 45 Titanium alloy discs substitute for Implant (Ti-6Al-4V, Grade V) and 45 Stainless Steel (315L SS) disc substitute for Abutment were serially ground, polished and cleaned to be coated with gold (Au) and silver (Ag) ions by sputtering technique which was later tested for antimicrobial efficacy by means of agar disk diffusion method with gram negative microorganisms causing peri-implantitis, the measurement of inhibition zone (ZOI) encircling each sample were taken and noted.

Habitat suitability and projecting distribution shifts of Himalayan Monal (Lophophorus impejanus) habitats across changing landscapes of the Indian Himalayan region.

The accelerated pace of climate change is altering the distribution of numerous taxa, including Himalayan Galliformes, which are highly sensitive to environmental changes due to their specialized habitat preferences. The Himalayan Monal (Lophophorus impejanus), a flagship species, relies on specific vegetation, microclimates, and elevations in IHR. This study uses Species Distribution Modeling (SDM) using MaxEnt to evaluate current (1980-2010) and future habitat suitability using the CMIP6 mpi-esm1-2 h model across three socioeconomic pathways.

Noise-induced vocal shifts in the Himalayan Monal (Lophophorus impejanus) vocal distribution in two different habitats.

Anthropogenic noise, an unexpected consequence of human activities, is disrupting the natural habitat of the Himalayan Monal and affecting its vocal communication. This study examines the impact of noise on the vocal frequency characteristics of this species across two distinct habitats, one exposed to anthropogenic noise and the other relatively undisturbed. Call parameters and noise variables were analyzed through quantile regression to understand how vocal behavior is influenced in different acoustic environments.

Evaluating the Outcomes and Safety of Underwater Ampullectomy Versus Traditional (Gas insufflation) Ampullectomy.

Background And Aims: Underwater endoscopic mucosal resection (UEMR) has shown promise in colorectal and non-ampullary duodenal polyps but remains understudied in ampullary lesions. This study aimed to compare underwater ampullectomy (UA) and traditional gas-insufflation ampullectomy (TA), hypothesizing UA would have improved en-bloc resection rates confirmed with negative histological margins and have shorter procedure times, with similar adverse events.

Methods: A retrospective cohort analysis was conducted for patients undergoing endoscopic ampullectomy (UA vs.

Prophylactic Rectal ESD (Endoscopic Submucosal Dissection) Defect Closure and Post-ESD Clinical Outcomes: An International Multi-Center Study (with Video).

Purpose: Prophylactic endoscopic submucosal dissection (ESD) defect closure has been suggested to reduce delayed adverse events (DAE) associated with ESD but the data are limited. We aim to study the effect of prophylactic rectal ESD defect closure on post-ESD outcomes.

Methods: An international multicenter retrospective cohort study was performed between 2016 and 2023 involving patients who underwent rectal ESD without intraprocedural perforations and had follow-up data available for at least 2 weeks post-ESD.

Elucidating the potential mechanism and therapeutic targets of chronic stress-induced muscle atrophy.

Skeletal muscle atrophy, while a long-standing health issue, is becoming more pressing concern in light of changing socioeconomic trends and current healthcare challenges. This shift reflects growing awareness of its widespread prevalence and significant impact on individual health. Demographic shifts like aging populations with rising sarcopenia rates, chronic diseases and sedentary lifestyles are major contributors.

A comprehensive and critical narrative review on movement disorders linked through dengue virus based infection.

Background: Dengue virus (DENV) has emerged as a significant cause of neurological complications, including movement disorders, which fall under the broader category of neurological manifestations associated with DENV infection. These disorders can have serious implications for patient's quality of life, especially in tropical and subtropical regions where dengue is endemic. The neurological complications of DENV, while less commonly recognized when compared to its classical features (like fever, haemorrhagic manifestations, or shock), are increasingly being reported thus warranting an exhaustive exploration.

Exploring the Effects of Novel Food Processing Methods on Food Proteins: A Review.

Novel food processing technologies, such as ohmic heating, ultrasonic heating, cold plasma, high-pressure processing (HPP), pulsed electric fields (PEFs), and enzymatic hydrolysis, have the ability to extend shelf life, improve quality, regulate the freshness of food products, and have diverse effects on food components, that is, protein, fat, and carbohydrates. Understanding the overall effects and mechanisms of these methods on food proteins from a multidimensional perspective is a core foundation for driving further innovations and advancements related to food protein modifications and their applications in the food industry. Therefore, this review aims to explore novel food processing technologies and their impacts on the particle size, structure, solubility, emulsion stability, foaming properties, and bioactivity of food protein, which affect the nutritional and functional properties of foods.

Distinct Selectivity of 2-Aryl Thioquinazolinones in the Sulfur Directing Rh(III)-Catalyzed Amidation Reaction.

Sulfur-directed C-H functionalization of N-heterocycles has emerged as an alternative solution to weakly coordinating carbonyl directing groups. In this study, we describe a sulfur-promoted Rh(III)-catalyzed C5 amidation of 4-thioquinazolinones using dioxazolones, yielding 5-amido-4-thioquinazolinones. The synthetic utility was demonstrated through a gram-scale experiment and synthetic modifications of the title compounds.

Unlocking the therapeutic potential of bioactive compounds in : a new frontier in natural medicine.

(Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of primary bioactive components, which include polysaccharides, triterpenoids, meroterpenoids, nucleotides, proteins, alkaloids, and sesquiterpenoids. These chemical components show a wide range of pharmacological effects, including immune modulation, cancer suppression, and neuroprotection.