Evaluating the Outcomes and Safety of Underwater Ampullectomy Versus Traditional (Gas insufflation) Ampullectomy.

Background And Aims: Underwater endoscopic mucosal resection (UEMR) has shown promise in colorectal and non-ampullary duodenal polyps but remains understudied in ampullary lesions. This study aimed to compare underwater ampullectomy (UA) and traditional gas-insufflation ampullectomy (TA), hypothesizing UA would have improved en-bloc resection rates confirmed with negative histological margins and have shorter procedure times, with similar adverse events.

Methods: A retrospective cohort analysis was conducted for patients undergoing endoscopic ampullectomy (UA vs.

Peroral endoscopic myotomy as an emergent treatment in hospitalized patients with esophageal motility disorders.

Background And Aims: The role of peroral endoscopic myotomy (POEM) as an emergent treatment for hospitalized patients with esophageal motility disorders and acute feeding incapacity is not well established. This study evaluates the effectiveness and safety of POEM as an inpatient intervention for this group.

Methods: This retrospective multicenter study included patients aged ≥18 years who were hospitalized for severe symptoms of esophageal motility disorders and underwent emergent POEM during the same admission at 17 international centers from March 2012 to January 2024.

A Rare Presentation of a Rare Disease: Oropharyngeal Dysphagia as The Main Manifestation of Myasthenia Gravis.

Oropharyngeal dysphagia is defined as the inability or difficulty to initiate swallowing. It has a wide array of etiologies including structural and neurologic diseases. Myasthenia gravis (MG) is a rare autoimmune condition caused by antibodies against the post-synaptic membranes of the neuromuscular junction, leading to fatigable weakness of skeletal muscles.