Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing.

Multi-tissue regeneration remains a critical clinical challenge due to the lack of solutions that can replicate the hierarchical heterogeneity of such complex interfaces. While biofabrication approaches, such as extrusion-based, allow replicating robust, biomimetic, and layered designs, constructs are usually hindered by inadequate phase/layer integration, poor filler dispersion, and mismatched rheological and mechanical performances. This study introduces an ink engineering strategy as a solution for integrating natural-based nanocomposites in multi-tissue regenerative approaches.

Characterization of the Population, Treatment Patterns, and Outcomes of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor Mutation (EGFRm): A Retrospective Cohort Study from IPO Porto.

Most patients with non-small-cell lung cancer (NSCLC) present with advanced/metastatic disease at diagnosis, and molecular profiling is critical in guiding treatment decisions. This retrospective cohort study aimed to characterize EGFR mutations (EGFRm) in advanced/metastatic NSCLC patients, treatment patterns, and real-world outcomes. Adults diagnosed between 2018 and 2021 and treated at a Comprehensive Care Center were included.

The untapped potential of vaginal microbiome diagnostics for improving women's health.

Microbiome research has expanded rapidly over the past 15 years; however, the primary focus has been on the gut microbiome. Although understudied, the vaginal microbiome holds significant potential to improve women's health. In this paper, we describe the current clinical diagnostic techniques utilised in women's health and examine their drawbacks and limitations.

Emerging Trends in Active Packaging for Food: A Six-Year Review.

The development of active food packaging has evolved rapidly in recent years, offering innovative solutions to enhance food preservation and safety while addressing sustainability challenges. This review compiles and analyzes recent advancements (2019-2024) in release-type active packaging, focusing on essential oils, natural extracts, and phenolic compounds as active agents. Primarily plant-derived, these compounds exhibit significant antioxidant and antimicrobial activities, extending shelf life and enhancing food quality.

Extension of Poultry Meat Shelf Life Using L. Leaf Extracts as a Natural Preservative.

Food additives are used to prevent food spoilage and extend its shelf life. However, concerns regarding the potential health implications associated with some synthetic additives have prompted research efforts aimed at identifying natural alternatives, such as plant extracts. L.

Coping with Ineffective Overlap in Multilocus Phylogenetics.

Missing data is a long standing issue in phylogenetic inference, which often results in high levels of taxonomic instability, obscuring otherwise well supported relationships. Multiple approaches have been developed to deal with the negative effects of ineffective overlap on tree resolution, often by identifying taxa for removal. Here we repurpose a heuristic method developed to identify unstable taxa in morphological data matrices, concatabominations, and combine it with a novel gene-tree jackknifing on matrix representation of trees to identify candidates for targeted sequencing.

Round Cell Sarcoma: A Challenging Diagnosis.

Sarcomas are malignant tumors of mesenchymal origin that can occur throughout the body. Among these, undifferentiated round cell sarcomas are rare, aggressive tumors, often affecting young adults and presenting diagnostic challenges. We report the case of a 22-year-old female who presented with persistent chest pain and progressive respiratory distress.

A Strange Case of Fever: Hematopyometra As the Initial Presentation of Endometrial Adenocarcinoma.

Pyometra is a rare condition involving the accumulation of purulent material within the uterine cavity, typically affecting postmenopausal women. Clinical presentation varies and may be silent, but can include fever, abdominal pain, and vaginal discharge. In this case, we report a 62-year-old woman presenting with prolonged constitutional symptoms and fever, ultimately diagnosed with a large hematopyometra secondary to endometrial adenocarcinoma.

A 6-Week Training Protocol Reduces Energy Consumption in Young Lusitano Horses Used in Dressage.

The present work aimed to evaluate the influence of a training programme on energy expenditure (EE), cost of transport (COT, cardiac beats to move the body mass during exercise) and metabolic power (Pmet) in young Purebred Lusitano horses used in dressage. With this purpose, nine male horses, ~4 years old, were evaluated before (M1) and after 6 weeks (M2) of a training programme that included 40-80 min of preparatory dressage exercises, 6×/week, individually adjusted. In M1 and M2, the animals were examined in a dressage field test (DFT), when heart rate (HR) and respiratory rate (RR), body temperature (BT) and blood lactate were recorded.

Enhancing human gut health: Global innovations in dysbiosis management.

The microbiota, comprising all the microorganisms within the body, plays a critical role in maintaining good health. Dysbiosis represents a condition resulting from an imbalance or alteration of the microbiota. This study comprehensively investigates the patent literature on dysbiosis over the past 20 years.

Acute Pericarditis as an Initial Presentation of Neoplastic Disease: A Case Report.

Acute pericarditis is the most common pericardial disease, presenting with varied manifestations and potentially indicative of systemic disease. A 56-year-old male with a history of hypertension, dyslipidemia, type 2 diabetes, and a former smoker presented with chest pain relieved by leaning forward, fever, elevated inflammatory markers, and electrocardiographic changes consistent with acute pericarditis. Initial treatment with acetylsalicylic acid and colchicine resulted in a favorable clinical response with improvement in inflammatory markers.

Advances in active packaging using natural biopolymers and fruit by-products for enhanced food preservation.

The development of biodegradable active food packaging materials enriched with bioactive compounds derived from plant sources and agro-industrial by-products, such as fruit peels, has gained significant attention as a sustainable alternative to conventional packaging. These materials offer functional benefits, including antimicrobial and antioxidant properties, which enhance food preservation while reducing environmental impact. This review provides a comprehensive analysis of biopolymers, particularly polysaccharides and proteins, as matrices for active packaging systems.

Ipomoea carnea Jacq. ameliorates formalin-induced paw inflammation in rats through modulation of oxidative and inflammatory pathways.

Ipomoea carnea Jacq. (I. carnea) belongs to Convolvulaceae family, that is being for the management of pain and inflammation.

Ludwig's Angina in a Pediatric Patient: A Case Report.

Ludwig's angina (LA) is a life-threatening, rapidly progressive infection of the submandibular, sublingual, and submental spaces, often caused by odontogenic infections. We report the case of an eight-year-old previously healthy girl who developed LA following untreated dental caries. She presented with a four-day history of odontalgia, left hemifacial edema, and trismus.

Assessing the efficacy of washing methods in reducing multi-pesticide residues in Brown, milled long, and milled basmati Rice.

Pesticides are vital for protecting crops from diseases but pose risks to human health and the environment, requiring careful evaluation. This study examines pesticide residues in rice and strategies for their removal. Brown, long-milled, and basmati-milled rice samples were spiked with 121 pesticides from different categories (e.

Rapid screening of fumonisins in maize using near-infrared spectroscopy (NIRS) and machine learning algorithms.

Fumonisins occurrence in maize represents a significant global challenge, impacting economic stability and food safety. This study evaluates the potential of near-infrared (NIR) spectroscopy combined with chemometric algorithms to detect fumonisins in maize. For fumonisin B1 (FB1) and B2 (FB2) levels were developed predictive NIR models using partial least squares (PLS) and artificial neural networks (ANN).

From waste to wellness - what women want: insights into patient perspectives on topical vaginal estrogen applicators and environmental considerations.

Objective: Environmental consciousness and the role of plastic waste are increasing. Topical vaginal estrogen prescription can be prescribed with one reusable plastic applicator or multiple single-use plastic applicators. User preference about the role of plastic in personal healthcare is not fully understood.

Validation of an HPLC-MS/MS method for the quantification of pesticide residues in Rice and assessment of the washing effect.

Unlabelled: A method was validated to determine 121 pesticide residues (carbamates, organophosphates, organochlorines, and pyrethroids) in rice samples, following the guidance document SANTE/11312/2021v2. QuEChERS method was selected for pesticide extraction, and the extract was analyzed by HPLC-MS/MS. The methodology demonstrated precision and accuracy, with recovery rates ranging from 70 % to 119 %.

A Case of Native Valve Infective Endocarditis and Bacteremia Due to Streptococcus cristatus.

Infective endocarditis is a severe infection affecting the inner lining of the heart chambers and valves, often preceded by bacteremia and frequently caused by organisms from the commensal oral flora, including . However, remains an uncommon causative agent. We present the case of a 68-year-old male with a history of dyslipidemia, severe aortic insufficiency, and mild mitral insufficiency who presented with a two-week history of fever without other symptoms.

Magneto-Enzymatic Microgels for Precise Hydrogel Sculpturing.

The inclusion of hollow channels in tissue-engineered hydrogels is crucial for mimicking the natural physiological conditions and facilitating the delivery of nutrients and oxygen to cells. Although bio-fabrication techniques provide diverse strategies to create these channels, many require sophisticated equipment and time-consuming protocols. Herein, collagenase, a degrading agent for methacrylated gelatin hydrogels, and magnetic nanoparticles (MNPs) are combined and processed into enzymatically active spherical structures using a straightforward oil bath emulsion methodology.

Human Chorionic Membrane-derived Tunable Hydrogels for Vascular Tissue Engineering Strategies.

One of the foremost targets in the advancement of biomaterials to engineer vascularized tissues is not only to replicate the composition of the intended tissue but also to create thicker structures incorporating a vascular network for adequate nutrients and oxygen supply. For the first time, to the best of current knowledge, a clinically relevant biomaterial is developed, demonstrating that hydrogels made from the human decellularized extracellular matrix can exhibit robust mechanical properties (in the kPa range) and angiogenic capabilities simultaneously. These properties enable the culture and organization of human umbilical vein endothelial cells into tubular structures, maintaining their integrity for 14 days in vitro without the need for additional polymers or angiogenesis-related factors.

How are agitated patients dealt with in internal medicine departments?

Background: Studies on agitation in internal medicine departments are scarce, especially regarding how doctors and nurses act in these situations. The objective of this study was to clarify how agitation is dealt with in these departments.

Methods: This prospective observational study was performed in the internal medicine departments of four Portuguese hospitals.

Comparative Analysis of Maize Physico-Chemical Parameters and Mycotoxin Levels in Dual Environments.

Maize ( L.) stands as a vital staple food globally, holding significant nutritional and economic value. However, its susceptibility to mycotoxin contamination under stressful environmental conditions poses a considerable concern.