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The present work aimed to evaluate the influence of a training programme on energy expenditure (EE), cost of transport (COT, cardiac beats to move the body mass during exercise) and metabolic power (Pmet) in young Purebred Lusitano horses used in dressage. With this purpose, nine male horses, ~4 years old, were evaluated before (M1) and after 6 weeks (M2) of a training programme that included 40-80 min of preparatory dressage exercises, 6×/week, individually adjusted. In M1 and M2, the animals were examined in a dressage field test (DFT), when heart rate (HR) and respiratory rate (RR), body temperature (BT) and blood lactate were recorded. In DFT, the horses used a cardiac monitor (Polar H10) for calculation using the formulas: EE (J/kg/min) = 0.0566 × HR, COT = (HR-HR)/kg/m × 10 and Pmet (beats/min/kg) = (HR - 35)/min/kg. The training led to a significant reduction in EE (799.9 vs. 682.8 J/min; p = 0.037) and COT (0.73 vs. 0.59 bpm/kg/m × 10; p = 0.042), without change in Pmet. Furthermore, a significant increase in peak of speed was observed (5.81 vs. 7.36 m/s; p = 0.0161). It was possible to conclude that the proposed training protocol led to greater efficiency in locomotion costs, with lower EE and COT values.
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http://dx.doi.org/10.1111/jpn.14134 | DOI Listing |
JCO Glob Oncol
May 2025
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Purpose: Breast cancer remains a significant public health challenge globally, as well as in India, where it is the most frequently diagnosed cancer in females. Significant disparities in incidence, mortality, and access to health care across India's sociodemographically diverse population highlight the need for increased awareness, policy reform, and research.
Design: This review consolidates data from national cancer registries, global cancer databases, and institutional findings from a tertiary care center to examine the epidemiology, clinical challenges, and management gaps specific to India.
J Am Chem Soc
September 2025
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
The direct cross-coupling of unactivated alkyl halides with aryl or heteroaryl partners remains a fundamental challenge in synthetic chemistry due to their inertness and propensity for side reactions. Herein, we report a transition-metal-free electrochemical halogen-atom transfer strategy that enables efficient alkyl radical cross-coupling via convergent paired electrolysis. In this system, anodically generated α-aminoalkyl radicals mediate the activation of alkyl iodides, while aryl/heteroaryl aldehydes or nitriles undergo cathodic reduction to afford persistent ketyl radical anions or aryl radical anions.
View Article and Find Full Text PDFBrain
September 2025
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, 13005 Marseille, France.
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions.
View Article and Find Full Text PDFClin Rehabil
September 2025
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
ObjectiveTo adapt and modify the successful SIESTA (Sleep for Inpatients: Empowering Staff to Act) sleep-promoting hospital protocol to an acute stroke rehabilitation setting.DesignThis study utilized a mixed methods design, involving qualitative surveys and interviews. Needs assessment and staff interviews informed the development of the adapted protocol, SIESTA-Rehab.
View Article and Find Full Text PDFPLoS One
September 2025
Emergency Department, Peking University Third Hospital, Beijing, China.
Introduction: Triage is an essential strategy to mitigate crowding and guarantee patients' safety in emergency departments. To improve the quality of triage in emergency departments, Nurses should be equipped with the necessary competencies. Therefore, this review aims to synthesize available evidence on the competency elements required for triage nurses in emergency departments and to identify factors that influence their competency development.
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