Prognostic Value of Myocardial T1 Mapping and Extracellular Volume Fraction in Heart Failure: A Meta-Analysis.

Background: Heart failure (HF) is a global health burden. Myocardial fibrosis is a crucial promotor in HF progression which can be characterized noninvasively by cardiac magnetic resonance T1 mapping.

Objectives: This study aims to systemically evaluate the prognostic value of myocardial T1 mapping and extracellular volume fraction (ECV) covering the entire spectrum of HF through a meta-analysis.

Risk stratification and outcomes in diabetes mellitus patients with preserved ejection fraction: a cardiac MRI study.

Background: Patients with diabetes mellitus (DM) have a significantly increased risk of developing heart failure (HF), which exacerbates adverse cardiovascular outcomes. Limited data are available on the prognostic value of cardiac MRI in DM. We aimed to evaluate the association between MRI-derived strain analysis and adverse outcomes in DM patients at different heart failure (HF) stages.

Phenotypic stratification and prognostic value of cardiac magnetic resonance in non-dilated left ventricular cardiomyopathy.

Background: Non-dilated left ventricular cardiomyopathy (NDLVC), characterised by non-ischaemic scar/fatty replacement or isolated systolic dysfunction without dilatation, lacks validated risk stratification tools. We aimed to define cardiac magnetic resonance (CMR)-based phenotypes and evaluate their association with clinical outcomes.

Methods: In 515 patients with NDLVC (mean age 45 (16) years), three phenotypes were classified by CMR: late gadolinium enhancement (LGE+)/H- (LGE with preserved left ventricular ejection fraction (LVEF), n=130), LGE-/H+ (hypokinesia without LGE, n=226) and LGE+/H+ (LGE with reduced LVEF, n=159).

Physician-guided deep learning model for assessing thymic epithelial tumor volume.

Purpose: The Response Evaluation Criteria in Solid Tumors (RECIST) relies solely on one-dimensional measurements to evaluate tumor response to treatments. However, thymic epithelial tumors (TETs), which frequently metastasize to the pleural cavity, exhibit a curvilinear morphology that complicates accurate measurement. To address this, we developed a physician-guided deep learning model and performed a retrospective study based on a patient cohort derived from clinical trials, aiming at efficient and reproducible volumetric assessments of TETs.

Tubulin tyrosine ligase variant perturbs microtubule tyrosination, causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes.

Hypertrophic cardiomyopathy (HCM) is a hereditary heart condition characterized by either preserved or reduced ejection fraction without any underlying secondary causes. The primary cause of HCM is sarcomeric gene mutations, which account for only 40%-50% of the total cases. Here, we identified a pathogenic missense variant in tubulin tyrosine ligase (TTL p.

State-of-the-art review:Cardiac magnetic resonance imaging in primary cardiac tumors.

Cardiac tumors are very rare and their diagnosis and treatment remain challenging. Cardiac magnetic resonance imaging is considered the gold standard for noninvasive diagnosis because of its larger field of view, excellent tissue contrast, multiplanar imaging, and the unique ability to differentiate between different tissue features. CMR can effectively identify cardiac non-neoplastic and neoplastic mass, as well as benign and malignant tumors.

Right Ventricular Strain Improves Cardiac MRI-based Prognostication in Heart Failure with Preserved Ejection Fraction.

Background Right ventricular (RV) function is an independent predictor of clinical status and prognosis in multiple cardiovascular diseases; however, the prognostic value of RV strain in patients with heart failure with preserved ejection fraction (HFpEF) remains largely unknown. Purpose To determine the associations between RV strain variables derived from cardiac MRI feature tracking and adverse outcomes in patients with HFpEF. Materials and Methods This retrospective study included patients with HFpEF who underwent cardiac MRI from January 2010 to December 2018.

Towards Phenotyping Characteristics and Mechanism of Conduction Delay in Patients With Nonischemic Heart Failure With Reduced Ejection Fraction: Insights From Cardiac Magnetic Resonance Imaging.

Background: Considering that 30% to 40% of patients do not benefit from cardiac resynchronization therapy implantation, it is insufficient to evaluate patients with heart failure with reduced ejection fraction solely based on QRS duration and morphology for guiding cardiac resynchronization therapy decisions and prognosis. A crucial step in addressing this issue is conducting a comprehensive pathophysiological assessment to understand the mechanisms underlying dyssynchrony and inefficient cardiac contraction. This study aims to utilize cardiac magnetic resonance imaging to explore underlying pathophysiological impairments in patients with heart failure with reduced ejection fraction with different QRS morphologies, seeking to identify better indicators for clinical assessment.

Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT.

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT). Palifermin, a recombinant N-truncated keratinocyte growth factor (KGF), protects epithelial tissues, including the thymus and gut. Although high-dose KGF prevents GVHD in preclinical models, lower doses of palifermin were ineffective in humans.

Prognosis and Risk Stratification in Dilated Cardiomyopathy With LVEF≤35%: Cardiac MRI Insights for Better Outcomes.

Background: Current guidelines recommend implantable cardioverter defibrillators for the primary prevention of sudden cardiac death (SCD) in patients with dilated cardiomyopathy with left ventricular ejection fraction (LVEF)≤35%. However, its effectiveness is hindered by the inability to reliably discriminate between the risk of SCD and competing death of heart failure deterioration, thereby limiting its clinical utility. We aimed to refine the SCD risk stratification model based on cardiac magnetic resonance imaging for patients with dilated cardiomyopathy with LVEF≤35%.

Status of cardiovascular magnetic resonance in clinical application and scientific research: a national survey in China.

Background: Cardiovascular magnetic resonance (CMR) is rapidly expanding in China, yet comprehensive national data on its clinical application and research status are limited. This study aims to evaluate the current landscape of CMR across the country.

Methods: An electronic survey was conducted targeting the following two groups: physicians trained at the Fuwai Fellowship Program and members of the Chinese Society of Radiology.

Prognostic Value of Myocardial Parametric Mapping in Patients with Acute Myocarditis: A Retrospective Study.

Purpose To investigate the prognostic value of T1 mapping, extracellular volume fraction (ECV), and T2 mapping in a large cohort of patients with acute myocarditis. Materials and Methods This retrospective study included patients with acute myocarditis who underwent cardiac MRI (3.0 T) between March 2016 and October 2022.

Myocardial Abnormalities Across the AHA/ACC Stages of Heart Failure in Patients With Diabetes.

Background: Cardiac magnetic resonance imaging (CMR) could serve as a robust tool for comprehensive evaluation of early changes across heart failure (HF) stages classified by the American Heart Association/American College of Cardiology guideline in diabetes mellitus (DM).

Objectives: The authors aimed to explore phenotypic imaging features characterizing DM participants at different HF stages by CMR.

Methods: DM participants with preserved ejection fraction who underwent CMR examination between January 2020 and December 2021 were evaluated.

Synthesis, spectroscopic, computational, molecular docking, antidiabetic(in vitro & in vivo) DNA and BSA interaction studies of ruthenium(II) carboxylate complexes.

The ruthenium compounds have been known to have the wide range of potential applications as anticancer, antibacterial and anti-diabetic etc. The ligand substitutions play a vital role in enhancing the pharmacological and biological activities. In the present study, three ruthenium-metal based complexes, designated as (I-III), were synthesized and characterized employing element analysis, FTIR and HNMR.

Active left atrial ejection fraction as a non-invasive marker in pulmonary hypertension secondary to heart failure.

Background: Patients with pulmonary hypertension (PH) secondary to left heart failure (HF) exhibit a complex pathophysiological profile and poor prognosis. Left atrial (LA) function is pivotal in the progression of this disease, yet its predictive significance remains exclusive. This study aimed to explore the predictive capability of LA metrics in this population and compare them with other common predictors.

AuAgCu trimetallic nanoparticles based alloy: an advanced electrocatalyst for hydrogen evolution reaction in alkaline media.

Hydrogen production cost-effective electrochemical water splitting is one of the most promising approaches to confront the energy crisis and to obtain clean fuels with high energy density. To address this concern, herein, we developed a simple one-step synthesis method for creating an AuAgCu trimetallic alloy using aspirin as a capping agent. This alloy shows potential for efficient electrocatalyst for hydrogen evolution reaction.

Assessment of growth, reproduction, and vermi-remediation potentials of Eisenia fetida on heavy metal exposure.

Heavy metal pollution is a significant environmental concern with detrimental effects on ecosystems and human health, and traditional remediation methods may be costly, energy-intensive, or have limited effectiveness. The current study aims were to investigate the impact of heavy metal toxicity in Eisenia fetida, the growth, reproductive outcomes, and their role in soil remediation. Various concentrations (ranging from 0 to 640 mg per kg of soil) of each heavy metal were incorporated into artificially prepared soil, and vermi-remediation was conducted over a period of 60 days.

Heart Failure with Normal Natriuretic Peptide Levels and Preserved Ejection Fraction: A Prospective Clinical and Cardiac MRI Study.

Purpose To describe the clinical presentation, comprehensive cardiac MRI characteristics, and prognosis of individuals with predisposed heart failure with preserved ejection fraction (HFpEF). Materials and Methods This prospective cohort study (part of MISSION-HFpEF [Multimodality Imaging in the Screening, Diagnosis, and Risk Stratification of HFpEF]; NCT04603404) was conducted from January 1, 2019, to September 30, 2021, and included individuals with suspected HFpEF who underwent cardiac MRI. Participants who had primary cardiomyopathy and primary valvular heart disease were excluded.

Smartphone-assimilated colorimetric sensor for sub-nanomolar emamectin detection via KA30 capped silver nanoparticles in food, bio-fluids and water samples.

In this report, we firstly synthesized nitro calix [4] resorcinarene compound (referred as KA30) and characterized it though proton (H) nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI-MS) and Fourier Transform Infra-red (FTIR) spectroscopy. KA30 was applied as functionalizing agent for the formation of silver nanoparticles (KA30-AgNPs). These NPs were confirmed as highly selective and extremely sensitive colorimetric sensor for ultra-low level detection of emamectin (EMA) as a novel report.

UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease.

Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide (CP). Results revealed that while both result in corneal recrudescence, only UV-B irradiation results in rHSK.

Long-term outcomes prediction in diabetic heart failure with preserved ejection fraction by cardiac MRI.

Objectives: We aimed to explore imaging features including tissue characterization and myocardial deformation in diabetic heart failure with preserved ejection fraction (HFpEF) patients by magnetic resonance imaging (MRI) and investigate its prognostic value for adverse outcomes.

Materials And Methods: Patients with HFpEF who underwent cardiac MRI between January 2010 and December 2016 were enrolled. Feature-tracking (FT) analysis and myocardial fibrosis were assessed by cardiac MRI.

Cryo-EM research in India.

To celebrate the 50th anniversary of Cell Press and the Cell special issue focusing on structural biology, we want to highlight the rapid progress of cryo-EM related research in India in this collection of Voices. We have asked structural biologists to introduce their research and the national cryo-EM facilities throughout the country.