Integrative taxonomy uncovers four novel species of Drawida Michaelsen, 1900 (Clitellata: Moniligastridae) revealing untapped earthworm diversity in India.

Background: The earthworm fauna of India remains inadequately documented, despite its pivotal ecological importance, and there is a pressing need to address this gap. Recognizing this lack of comprehensive documentation, the present study was undertaken to explore and characterize the diversity in previously under-surveyed regions. During systematic surveys in Madhya Pradesh (Central India) and Manipur (North-Eastern India), four novel species of the genus Drawida Michaelsen, 1900 were discovered: D.

Peri-Implant Esthetics in Focus: Comparing Anodized Titanium and Zirconium Dioxide Abutments in a Randomized Clinical Trial.

Objective: Achieving optimal esthetics remains challenging due to limited comparative evidence between pink-anodized titanium and zirconium dioxide abutments. The objective of this clinical study was to evaluate the optical outcomes of pink-anodized titanium and zirconium dioxide abutments in the esthetic region.

Methods: Twenty-two subjects with an edentulous site in the maxillary esthetic region with a tooth present mesially and distally were selected for implant surgery along with hard and soft tissue augmentation.

Comparative Analysis of Shear Bond Strength between Orthodontic Brackets Adhered Using Self-Etching Adhesives and Conventional Adhesives.

Background: The strength of the connection between orthodontic brackets and the enamel is a major factor in the outcome of orthodontic therapy. Bonding methods have changed a lot, and self-etching primers are becoming more and more common because of their easy process.

Materials And Methods: Two sets of 40 removed human premolars (n = 20) were randomly assigned.

COMPARING THE EFFICACY OF OSSEODENSIFICATION OVER CONVENTIONAL DRILLING TECHNIQUE ON IMPLANT STABILITY AND BONE DENSITY IN LOW BONE DENSITY SITES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Purpose Of The Research: To assess the efficacy of osseodensification (OD) over conventional drilling technique (CD) on implant stability and bone density in low bone density sites.

Materials And Methods: An electronic and manual search were conducted to analyze the effect of OD over CD technique on implant stability and bone density in human-based randomized controlled trials (RCTs) and nonrandomized controlled trials (NRCTs). The risk of bias was assessed using (RoB 2.

Ultrawide implants for immediate molar extraction socket versus standard diameter fixtures in healed alveolar ridges of missing molars, one-year postloading evaluation: A randomized controlled trial.

Background: This randomized split-mouth study aimed to evaluate the feasibility of ultrawide immediate implants in fresh extraction sockets of nonrestorable molars. The comparison was made with standard-diameter implants placed in healed ridges of missing molars. After 1 year of functional loading, both groups were assessed for crestal bone changes, implant stability, and soft-tissue remodeling.

Three Novel Species of Earthworms of Genus Metaphire Sims and Easton, 1972 from Manipur, India.

The systematics of pheretimoids have been hindered by limited diagnostic traits and extensive homoplasy. This study utilized an integrative taxonomic approach, combining morpho-anatomical traits and mitochondrial COI data, to delineate species and clarify phylogenetic relationships among Indian pheretimoids. Three new species of Metaphire (Megascolecidae) were identified: Metaphire manipurensis Tiwari & Yadav sp.

RNA Pol-II transcripts in nucleolar associated domains of cancer cell nucleoli.

We performed a comparative study of the non-ribosomal gene content of nucleoli from seven cancer cell lines, using identical methods of purification and analysis. We identified unique chromosomal domains associated with the nucleolus (NADs) and genes within these domains (NAGs). Four cell lines have relatively few NAGs, which appears mostly transcriptionally inactive, consistent with literature.

In vitro Antibiofilm Activity-directed In silico Identification of Natural Products Targeting Bacterial Biofilm Regulators SarA and LasR.

Background: Antibiofilm agents serve as an essential tool in the fight against antibiotic resistance, and natural products provide a promising source for potential drug leads.

Objective: This study investigates the activity of twenty Bangladeshi medicinal plants against Staphylococcus aureus and Pseudomonas aeruginosa biofilms and predicts the interactions of selected phytochemicals from five of the best performing plants with the active sites of transcriptional regulatory proteins SarA of S. aureus and LasR of P.

Navigating liver cancer: Precision targeting for enhanced treatment outcomes.

Cancer treatments such as surgery and chemotherapy have several limitations, including ineffectiveness against large or persistent tumors, high relapse rates, drug toxicity, and non-specificity of therapy. Researchers are exploring advanced strategies for treating this life-threatening disease to address these challenges. One promising approach is targeted drug delivery using prodrugs or surface modification with receptor-specific moieties for active or passive targeting.

Medically responsive amyloidogenic giant sellar-parasellar prolactinoma.

Background: Giant prolactinomas are rare; among them, the amyloidogenic variant, prolactinomas with extensive spherical amyloid deposits, are rare, with only 30 cases reported with recommendations of surgical management contrary to the routine prolactinoma's medical management.

Case Description: We report here a case of giant amyloidogenic prolactinoma in a 32-year-old male patient who had a very atypical presentation in terms of clinical, radiological, and pathological features and responded to dopamine agonist therapy like a normal prolactinoma.

Conclusion: Amyloidogenic giant prolactinomas are rare.

Anthelmintic screening of Bangladeshi medicinal plants and related phytochemicals using in vitro and in silico methods: An ethnobotanical perspective.

Ethnopharmacological Relevance: Infections caused by parasitic worms or helminth continue to pose a great burden on human and animal health, particularly in underdeveloped tropical and subtropical countries where they are endemic. Current anthelmintic drugs present serious limitations and the emergence of drug resistance has made it increasingly challenging to combat such infections (helminthiases). In Bangladesh, medicinal plants are often used by indigenous communities for the treatment of helminthiases.

Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach.

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Approximately, around 2% to 3% percent of the general population experience symptoms of OCD over the course of their lifetime. OCD can lead to economic burden, poor quality of life, and disability.

Role of pattern recognition receptors in sensing .

is one of the major invasive intracellular pathogens causing most deaths by a single infectious agent. The interaction between host immune cells and this pathogen is the focal point of the disease, Tuberculosis. Host immune cells not only mount the protective action against this pathogen but also serve as the primary niche for growth.

Chebulinic Acid: An Incipient Anticancer Agent.

Background: ) comprising chebulinic acid as its principle active constituent is used to cure various diseases. and chebulinic acid are used as antimicrobial, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, antimutagenic, radioprotective, cardioprotective, antiproliferative, antiarthritic, anticaries, and so on.

Objective: The objective of this current study is to give an overview of the recent literature and patents of and chebulinic acid including methods of its isolation/extraction and their application in the prevention of various cancers and other diseases.

Nanoconstructs for theranostic application in cancer: Challenges and strategies to enhance the delivery.

Nanoconstructs are made up of nanoparticles and ligands, which can deliver the loaded cargo at the desired site of action. Various nanoparticulate platforms have been utilized for the preparation of nanoconstructs, which may serve both diagnostic as well as therapeutic purposes. Nanoconstructs are mostly used to overcome the limitations of cancer therapies, such as toxicity, nonspecific distribution of the drug, and uncontrolled release rate.

Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves.

Ethnopharmacological Relevance: Callicarpa arborea Roxb. is widely used as traditional medicine especially by the tribal people of Bangladesh in the management of wide range of ailments. In addition to Bangladesh, the leaves of this plant is utilized as a remedy to various painful and inflammatory conditions including rheumatism, toothache and stomachache in other countries of Indian subcontinent.

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis.

Diterpenes and their derivatives have many biological activities, including anti-inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory-derived products have been demonstrated for antiarthritic activities. This study summarizes the literature about diterpenes and their derivatives acting against rheumatoid arthritis (RA) depending on the database reports until 31 August 2021.

Pesticidal Activity of Sundarban Mangrove Plant Extracts against Pests and Identification of Active Constituents Using LC-MS.

Plants act as a rich source of novel natural pesticides. In the backdrop of the recent revival of interest in developing plant-based insecticides, this study was carried out to investigate the pesticidal activity of Sundarban mangrove plants. A total of nine different plant parts from five plants, namely, , , , and , were extracted with methanol and tested for insecticidal activity against two common stored product pests and using direct contact feeding deterrent wafer disc method.

Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb Colocasia gigantea and molecular docking study against COX-II enzyme.

Ethnopharmacological Relevance: Consumable herbs play a basic part in sustenance and human health. Traditionally, Colocasia gigantea Hook (Araceae) is used to treat fever, infection, wounds healing, drowsiness, tuberculosis, stomach problems etc. AIM OF THE STUDY: The study aspired to identify bioactive compounds, to evaluate anti-inflammatory and analgesic potentials of edible herb C.

Genomic properties of allamanda leaf mottle distortion virus, a new begomovirus from golden trumpet (Allamanda cathartica) in India.

Golden trumpet (Allamanda cathartica) plants were observed to exhibit mottling and distortion symptoms on leaves. The genome of an associated begomovirus (Al-K1) was amplified by rolling-circle amplification, cloned, and sequenced. The viral genome consisted of two circular ssDNA molecules, and the organization of the ORFs was similar to those of DNA-A and DNA-B components of bipartite begomoviruses.

Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats.

is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis.

The evolution of built-up areas in Ghana since 1975.

We use high resolution satellite data on the proportion of buildings in a 250x250 meter cell to study the evolution of human settlement in Ghana over a 40 year period. We find a strong increase in built-up area over time, mostly concentrated in the vicinity of roads, and also directly on the coast. We find strong evidence of agglomeration effects both in the static sense-buildup in one cell predicts buildup in a nearby cell-and in a dynamic sense-buildup in a cell predicts buildup in that cell later on and an increase in buildup in nearby cells.

Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm.

Date palm () plays a vital role in ethnomedicinal practices in several parts of the world. There are over 2000 cultivars of date palm that differ in chemical composition and extent of bioactivity. The present study was undertaken to comparatively evaluate the antioxidant potential of three cultivars of date palm (Ajwah, Safawy and Sukkari) from Saudi Arabia and analyze their phenolic constituents in order to draw a rationale for their activity.