Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: ) comprising chebulinic acid as its principle active constituent is used to cure various diseases. and chebulinic acid are used as antimicrobial, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, antimutagenic, radioprotective, cardioprotective, antiproliferative, antiarthritic, anticaries, and so on.
Objective: The objective of this current study is to give an overview of the recent literature and patents of and chebulinic acid including methods of its isolation/extraction and their application in the prevention of various cancers and other diseases.
Methods: Present research and patents highlighting the anti-cancer potential of and chebulinic acid have been studied and discussed keeping in view the scientific novelty and impact.
Results: Both and chebulinic acid are currently being explored for their anticancer potential and . They are either incorporated alone or in combination with other plants or drugs to show their activity and many clinical trials are also going on various potentials of the plant and chebulinic acid. Novel extraction techniques are also explored and patented. Efforts are being made to improve the bioavailability by developing Novel herbal drug delivery systems of the plant extract or chebulinic acid itself.
Conclusion: Anti-cancer potential of and chebulinic acid may be well established by promising clinical trials and may open new interventions in various tumors. Clinical trials in conjunction with standard therapies are required to explore and validate the actual potential of T. chebula and chebulinic acid respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1574892819666230821110429 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy.
J Ethnopharmacol
August 2025
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:
Ethnopharmacological Relevance: Euphorbia fischeriana (EF), an herb used in ethnomedicine for cancerous ascites, particularly in Inner Mongolian practices, is limited by severe enterotoxicity. Traditionally, co-decoction with Terminalia chebula (TC) mitigates this toxicity, but the underlying mechanism is unknown, hindering its rational clinical development.
Aim Of The Study: To elucidate the molecular mechanism by which TC detoxifies EF, providing a scientific basis for developing safer EF-based therapies against malignant ascites.
Production of Envelope Protein-Based Virus-like Particles of DENV‑2 in and Investigation of Their Binding Interactions with Gallic Acid Derivatives of Glucose as Potential Drug Candidates.
ACS Omega
August 2025
Department of Biophysics, University of Delhi South Campus, Benito Juarez Road, South Moti Bagh, New Delhi 110021, India.
Perennial endemics of mosquito-borne dengue infection affect millions of lives across tropical and subtropical regions every year. Factors like the Earth's rising temperature, climate change, and lack of dengue-specific drugs and vaccines have led to a significant surge in these infections, warranting urgent efforts to develop new antidengue agents. The dengue virus (DENV) envelope exposes approximately 90 E (envelope) protein dimers on its surface, making it a potent target for drug discovery and vaccine development.
View Article and Find Full Text PDFStudy on the astringent mechanism of .
Food Chem X
July 2025
School of Pharmacy, Chengdu Medical College, Chengdu 610500, PR China.
(CF) is commonly used to make juice, porridge, and also as dietary supplements owing to anti-inflammatory and antioxidant activities. However, astringency affects the palatability and compliance. During taste masking, it is essential to identify astringent mechanism to balance masking needs and efficacy maintenance.
View Article and Find Full Text PDFAmidated xanthan gum-coated gastroretentive beads for controlled release of chebulinic acid solid dispersions.
Carbohydr Res
August 2025
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India. Electronic address:
This study investigates the usefulness of chemically modified xanthan gum (XG), a natural polysaccharide known for its mucoadhesive and swelling characteristics, in gastroretentive drug delivery systems. XG was modified through amidation using triethanolamine in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as a coupling agent. The resulting amidated xanthan gum (AXG) exhibited significantly improved physicochemical properties, including reduced hydrophilicity, enhanced thermal stability, and increased crystallinity, as confirmed by FTIR, DSC, XRD, and ^1H NMR analyses.
View Article and Find Full Text PDFVirtual Screening of Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and In Vitro Validation.
Molecules
April 2025
Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Guangzhou 510650, China.
The transcription factor erythroid 2-related factor 2 (Nrf2) is a central regulator of cellular defense mechanisms against oxidative stress and inflammation. Keap1 (Kelch-like ECH-associated protein 1) regulates Nrf2 activity by ubiquitination-mediated cytoplasmic retention, thereby suppressing its nuclear translocation and subsequent transcriptional activation of genes encoding phase II detoxifying enzymes. Using a structure-based virtual screening approach, we screened ~16,000 natural compounds to identify Keap1-Nrf2 PPI inhibitors.
View Article and Find Full Text PDF