Single nucleus RNA sequencing profile analysis to reveal cell type specific common molecular drivers of Parkinson's disease and therapeutic agents.

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by progressive motor and cognitive decline, leading to long-term disability and significantly impacting quality of life. While PD research has traditionally focused on dopaminergic neurons in the substantia nigra (SN), emerging evidence also suggests glial involvement in disease progression. So, this study explored PD-associated key genes from neuronal and glial cell types to uncover pathogenetic mechanisms and potential therapeutics by employing single-nucleus RNA sequencing (snRNA-seq) data from the accession number GSE184950.

Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.

Nipah virus (NiV) causes a severe neurological disease in humans. The first NiV outbreak, in Malaysia, involved pig-to-human transmission, that resulted in significant economic losses to the local pig industry. Despite the risk NiV poses to pig-dense regions, no licensed vaccines exist.

Technology Addiction: Effects of Electronic Games and Social Media Use on Academic Performance and Symptoms of Psychiatric Disorders Among School-Age Adolescents.

Background And Aims: There is conflicting research regarding the negative effects of electronic gaming and addictive social media use on psychological disorders and academic achievement. Therefore, we aimed to examine the association between social media use and electronic gaming addiction with depression and academic achievement.

Methods: This investigation is cross-sectional.

Unveiling the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-inflammatory effect of three leafy green vegetables: , , and .

This study investigates the phytochemical composition, and biological properties of methanol and ethanol extracts from , , and , emphasizing their bioactive potential in food chemistry. Among the extracts, the methanol extract of showed the highest phenolic (94.41 ± 1.

Modeling impacts of climate-induced yield variability and adaptations on wheat and maize in a sub-tropical monsoon climate - using fuzzy logic.

Climate change is causing more frequent and extraordinary extreme weather events that are already negatively affecting crop production. There is a need for improved climate risk assessment by developing smart adaptation strategies for sustainable future crop production. This study aims to assess yield impacts of extreme temperatures and rainfall variability on wheat, and winter and summer season-planted maize in northwestern Bangladesh.

Novel mannose-binding snail mucus lectins from Lissachatina fulica exhibited antimicrobial, antitumor and insecticidal activities.

Lectins are carbohydrate-binding proteins with diverse biological functions, particularly their roles in innate immunity through the recognition of pathogen-associated molecular patterns and mediation of non-specific immune responses. This study investigates the bioactivities of mucus lectins derived from Lissachatina fulica (LFLs). The LFLs were purified using ion exchange chromatography and analyzed for toxicity, antimicrobial, antioxidant, antitumor, and insecticidal properties.

Herd immunity and prevention in HPV transmission with exogenous reinfection.

Cervical cancer is a major global health concern, primarily caused by human papillomavirus (HPV), which spreads through unsafe sexual contact. Natural immunity often fails to provide full protection, permitting exogenous reinfection, which plays a key role in the persistence and transmission of HPV. This paper presents and analyzes a deterministic mathematical model of HPV transmission, incorporating exogenous re-infection.

Breast Cancer Knowledge and Self-Examination Practices Among University Female Students in Dinajpur, Bangladesh: A Cross-Sectional Study.

Background And Aims: Breast cancer (BC) is the most common cancer among women worldwide, with increasing incidence rates in developing countries, including Bangladesh. Understanding BC awareness and self-examination practices among young women is essential for enhancing early detection and prevention efforts. This study aims to assess BC awareness, knowledge of risk factors, and the practice of breast self-examination (BSE) among female university students in Dinajpur District, Bangladesh.

The Mediating Role of Humor in Relation With COVID-19 Fear, Anxiety and Depression of Bangladeshi People: A Cross-Sectional Study.

Background And Aims: The coronavirus (COVID-19) outbreak induced fear and worry, which has been linked to a higher risk of mental health problems. A sense of humor may function by assisting in the reappraisal of threats or by making fear, anxiety, and depression less threatening. However, little attention was paid to its roles.

Dynamics of computational waveform: A study of bifurcation, chaos, and sensitivity analysis.

This study delves into the extraction of solutions for the fractional-order that describes wave circulation in space-time fractional low-pass electrical transmission (LPET) lines and Drinfel'd-Sokolov-Wilson (DSW) equations. Leveraging the Sardar-subequation scheme, by applying a simple linear fractional transformation, the model equations are transformed into an ordinary differential equation. The use of the Sardar-subequation technique produces a diverse range of traveling waveform for the governing equations.

Synergistic Effects of Pediococcus pentosaceus E24-168 and Exercise on Obesity-Related Dysfunctions and Anxiety in High-Fat Diet-Induced Obese Mice.

Obesity is a global health crisis associated with various metabolic and psychological dysfunctions, which requires a comprehensive therapeutic approach. This study aimed to assess the combined effects of Pediococcus pentosaceus E24-168 and exercise on obesity-related dysfunctions and anxiety in mice with high-fat diet (HFD)-induced obesity. Swiss Albino male mice were divided into five groups: control, HFD, HFD with exercise (HFD + Ex), HFD with Pediococcus pentosaceus E24-168 (HFD + PP), and HFD with both exercise and Pediococcus pentosaceus E24-168 (HFD + Ex + PP).

Socioeconomic inequalities in disability prevalence and health service use in Bangladesh.

Research on the relationship between socioeconomic status (SES), the prevalence of disability, and the use of healthcare services by people with disabilities is limited. The aim of this study is to identify socioeconomic predictors of disability and examine the utilization of healthcare services among people with disabilities in Bangladesh. We used the first national representative, the National Household Survey on Persons with Disabilities (NSPD) 2021 survey data.

Genome-wide identification and in-silico characterization of phytopathogenic Taf14 gene in Fusarium oxysporum fungus, and fungicide repurposing.

Background: Phytopathogenic fungi cause global agricultural damage of around 40%, for which there is an economic loss of more than $200 billion annually. F. oxysporum is one of the top five phytopathogenic fungi worldwide, which is extremely resistant to high temperatures and antiseptic chemicals.

Co-curricular engagement, moral quotient, and pro-environmental behaviors of university students in Bangladesh.

Background: The continuous degradation of the environment requires us to change our current poor eco-friendly behaviors towards more pro-environmental actions. Hence, it is essential to understand the factors promoting pro-environmental behaviors (PEBs). To this end, this study was designed to investigate the relationship between moral quotient (MQ) and PEBs mediated by the sense of obligation of university students engaged in co-curricular activities.

Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations.

Early studies have shown that erythrocytes have caspase-3 and caspase-8 and are capable of dying through an apoptotic-like cell death triggered by Ca ionophores. This cell death is associated with apoptosis-like morphological signs, including cell shrinkage, membrane blebbing, and phosphatidylserine externalization. To emphasize that mature erythrocytes don't have the apoptotic mitochondrial machinery and distinguish this unique cell death modality from apoptosis, it was named "eryptosis".

Green-synthesized magnetite-maghemite nanocomposites for the removal of lead and cadmium from water: competitive adsorption behavior and mechanism studies.

The environment and human health are at risk when industrial waste leaks into aquatic environments. Green-synthesized magnetite-maghemite nanocomposites (GSMMNs) were developed in this study as bio-synthesized adsorbents for removing heavy metals from water. The XRD, TEM, FT-IR, SEM-EDS, BET, VSM, and XPS analyses characterized the nanocomposites.

Emerging pollutants in pharmaceutical and personal care product industrial effluents: Characterization and their environmental impacts.

This study aimed to assess emerging pollutants and heavy metals (HMs) in pharmaceuticals and personal care products (PPCPs), industrial effluents, and their environmental impacts using several indices. The mean HM concentrations for pharmaceutical and personal care product (PCP) effluents were in the order of Fe > Ni > Cr > Mn > Pb > Zn > Cu > Cd and Cu > Mn > Cr > Fe > Zn ≥ Pb > Ni > Cd, respectively, where Cr, Ni, Pb, and Cd concentrations for pharmaceutical effluent and Cr, Mn, and Cd for PCP effluent exceeded their accepted limits set by the Department of Environment, Bangladesh 2019. The values of chemical oxygen demand (COD) for PCP effluent were found to be much higher in all seasons, while these values for pharmaceutical effluent slightly exceeded the permissible limits of the Bangladesh Environmental Conservation Rules 2023 in two seasons.

Short birth spacing and its impact on maternal and child health in India with urban-rural variation: An epidemiological study using the National Family Health Survey Data.

Background: Maintaining an appropriate gap between childbirths is essential for promoting the health of both the mother and the child. This practice lowers the risk of adverse maternal and child health outcomes. Inadequate birth spacing is a multifaceted issue linked to increase infant mortality and has the potential to impact the health and demographic landscape of the nation.

Insomnia, Pain, and Pain-Related Dysfunctional Beliefs About Sleep among Patients with Cancer.

Purpose: We explored the reliability and validity of the Pain-related Beliefs and Attitudes about Sleep (PBAS) scale among patients with cancer. Further, we compared the usability of the PBAS scale with that of the Cancer-related Dysfunctional Beliefs and Attitudes about Sleep-14 (C-DBAS-14) among patients with cancer.

Materials And Methods: The medical records of 252 patients with cancer who visited the Sleep Clinic from August 1, 2023 to June 30, 2024 were retrospectively analyzed.

Extremely Low Doses of CpG Oligodeoxynucleotides From Streptococcus thermophilus LacZ Strongly Induce CXCL5 in Macrophages.

Infectious diseases pose significant challenges to livestock production, compromising animal health and reducing economic productivity. To address these challenges, CpG-oligodeoxynucleotides (CpG-ODNs) have emerged as promising immunomodulators that stimulate the innate immune system through Toll-like receptor 9 (TLR9), offering a potential strategy for enhancing disease resistance in livestock. This study examined MsST, a class B CpG-ODN derived from Streptococcus thermophilus, a representative lactic acid bacterium widely used in yogurt production, and its role in modulating CXCL5 expression in macrophages.

Microplastic pollution in the marine environment: Sources, impacts, and degradation.

Microplastics (MPs) are tiny particles derived from plastic, and their high fragmentation poses a significant threat to the marine environment. MPs can originate from various sources, such as primary or secondary sources as well as internal or external sources. However, in marine environments, MPs mainly enter from external sources, such as plastic waste, debris from land-based activities, tourism, shipping, and atmospheric deposition.

Comparative study of the glucose and trehalose addition on the extenders for goat sperm liquid storage.

Objectives: The objective of this study was to assess the effects of varying glucose and trehalose concentrations on tris-citric acid-egg yolk-fructose (TCEF) diluents for the short-term cold storage of goat semen.

Materials And Methods: The semen sample was collected, unwashed, and divided into the following groups: control (TCEF without glucose and trehalose), TCEF + glucose (75, 150 mm), and TCEF + trehalose (75, 150 mm). Each experimental sperm group (sperm concentration: 9 × ×10/ml) was kept at 4°C in a refrigerator.

Computational design and cheminformatics profiling of omeprazole derivatives for enhanced proton pump inhibition of potassium-transporting ATPase alpha chain 1.

Proton pump inhibitors are essential for treating moderate-to-severe gastroesophageal reflux, peptic ulcers, esophagitis, and related conditions by increasing gastric pH and inhibiting hydrogen ion discharge into the stomach. However, prolonged use may lead to adverse effects along with reduced efficacy. Our research investigates the strategic modification of omeprazole (OMP) derivatives to improve their binding affinity to targeted proteins, thereby enhancing their chemical reactivity, stability, and toxicity profiles.

Computational profiling of anti-inflammatory phytochemicals targeting 5-LOX and COX-2 pathways: PASS prediction, molecular docking and ADMET analysis.

This study computationally evaluates six phytochemicals (piperine, ardisiaquinone A, genistein, cianidanol, liquiritigenin, and rosmarinic acid) for their anti-inflammatory potential targeting 5-LOX and COX-2 pathways. PASS prediction analysis revealed that all phytochemicals, except piperine, met the threshold for significant anti-inflammatory activity (Pa > Pi and Pa ≥0.5).

Enhancing cadmium stress resilience in rice seedlings via Bacillus pseudomycoides: modulation of heavy metal transporters and physiological responses for sustainable agriculture.

Heavy metal contamination, particularly cadmium pollution, is a critical environmental concern that poses a serious threat to sustainable agriculture. Our study examined the impact of Bacillus pseudomycoides (Bp) on enhancing rice seedling growth, metabolism, stress tolerance, and reducing cadmium accumulation, with potential applications for mitigating heavy metal toxicity and promoting sustainable agriculture. A 50-min seed inoculation with Bp resulted in the greatest enhancements in seed emergence rate, seedling vigor, germination capability, plant stature, dry weight, and relative water content.