Overcoming barriers to referral for CAR T-cell therapy in patients with non-Hodgkin aggressive B-cell lymphomas: A Delphi consensus.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of aggressive B-cell non-Hodgkin lymphoma, particularly in relapsed/refractory large B-cell lymphoma and mantle cell lymphoma. Despite its transformative potential, significant challenges persist in optimizing patient identification and referral pathways to ensure timely and equitable access. This expert consensus, developed through the Delphi methodology, analyzes key barriers to the referral process and proposes structured solutions to enhance collaboration between referring treatment centers (RTCs) and qualified treatment centers (QTCs).

Calcification of the elastic component: the impact on the cardiovascular system.

In the cardiovascular system, elastic fibres exert a fundamental role providing the long-range elasticity required for physiological functions. Elastic fibres are complex in composition and structure containing, in addition to elastin, a wide range of matrix components, such as microfibrillar proteins, calcium-binding proteins and glycosaminoglycans. Changes in composition and/or structure can affect the biomechanics of the tissue as well as the intrinsic affinity of elastin for Ca ions.

USPSTF Recommendation Against PSA Screening vs. Stage and Cancer-Specific Mortality in Localized Prostate Cancer.

Background: The USPSTF recommendation against PSA screening (RAPS) in 2012 resulted in unfavorable changes in prostate cancer (PCa) outcomes. However, the effect on cancer-specific mortality (CSM) in localized PCa has not been assessed.

Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2021), we identified patients treated with radiotherapy (RT) or radical prostatectomy (RP) for localized PCa.

Artificial Intelligence Predicts GBA1 Mutated Status in Parkinson's Disease Patients.

Background: GBA1 variants are the major genetic risk factor for Parkinson's Disease (PD) and account for 5-30% of PD cases depending on the population and age at onset of the disease.

Objectives: The aim of this study was to assess whether Artificial Intelligence (AI) could predict GBA1-mutated genotype in PD (GBA1-PD). Particularly, the main objective was to identify a Machine Learning (ML) model capable of accurately providing a pre-test estimate of GBA1-mutated status, relying on the clinical and demographic variables with the highest predictive value.

Caffeine and cardiovascular aging: exploring sex-specific impacts on risk and arrhythmias.

Caffeine is a widely consumed stimulant known for its cardiovascular and metabolic effects. However, its impact on cardiovascular risk, including arrhythmias, in older adults remains underexplored. Emerging evidence highlights sex-specific differences in caffeine metabolism, which may influence its role in cardiovascular health.

Qualitative-archival research on migration is not just preservation.

Qualitative-archival research is not just "preservation": it shows the potential of providing dynamic and interlinked information, including legal frameworks, policy documents, historical context, and original narratives, capable of supporting policies in the long term. Besides this, it is a potential tool to foster the agency of migrants. Morover, qualitative-archival research can be a powerful tool for social innovation, as conducting qualitative research, based on individual and collective narratives, is a necessary basis to non-emergency policies and to social work planning and evaluation.

Pediatric healthcare service utilization after the end of COVID-19 state of emergency in Northern Italy: a 6-year quasi-experimental study using interrupted time-series analysis.

Background: Evidence exists on the major disruptions in pediatric healthcare services occurred during the COVID-19 pandemic, but what happened when all restrictions were lifted is unclear. This study examined trends in pediatric hospital admission and Emergency Department visit rates during the first 12 months following the end of the state of emergency in Italy, compared to pre-pandemic levels.

Methods: We conducted a multicenter, retrospective, quasi-experimental before after study including 11 North Italian hospitals.

Impact of gonadotropin genetic profile and ovarian reserve on controlled ovarian stimulation: data from prospective cohort of the GENOCS trial.

Introduction: Several studies indicate that a specific genotype profile could influence ovarian sensitivity to exogenous gonadotropin. However, most of the previous studies were observational and retrospective and thereby more prone to bias. The aim of this study was to evaluate the impact of gonadotropin single nucleotide polymorphisms (SNPs) on the outcomes of fertilization (IVF) in infertile patients undergoing their first ovarian stimulation (OS) cycle.

Inflammatory bowel disease vs. adverse in-hospital outcomes after radical prostatectomy.

Introduction: The effect of inflammatory bowel disease (IBD) on adverse in-hospital outcomes after radical prostatectomy (RP) for nonmetastatic prostate cancer (PCa) is not well known.

Materials And Methods: Descriptive analyses, propensity score matching and multivariable logistic regression models were used within the National Inpatient Sample (2000-2019) RP patients, after stratification according to Crohn's disease (CD) vs. ulcerative colitis (UC) vs.

Adoptive cellular therapies in non-Hodgkin lymphomas.

Lymphomas are a group of malignant proliferations of B, T or NK-lymphoid cells at different stages of maturation. While they primarily occur in lymph nodes or lymphatic tissues, they can also involve bone marrow, blood, or other organs. Despite advances in treatment, many patients experience relapse, or develop refractory disease, prompting the development of new therapies.

Cancer-specific mortality in secondary bladder cancer after nephroureterectomy for upper tract urothelial carcinoma.

Objective: To examine differences in cancer-specific mortality (CSM) in nonmetastatic upper tract urothelial carcinoma (UTUC) patients with vs. without secondary bladder cancer (BCa) after radical nephroureterectomy (RNU).

Methods: Within the Surveillance, Epidemiology, and End Results database (SEER 2000-2021), T1-T4N0M0 UTUC patients treated with RNU and diagnosed with secondary BCa were identified.

Textbook Outcomes and Minimally Invasive Techniques in Resectable Gallbladder Cancer: A Global Cohort Study.

Introduction: Surgery for resectable gallbladder cancer (GbC) encompasses complex operative management, and evaluating surgical quality through textbook outcome (TO) is crucial. This study aimed to assess TO incidence and impact in a global cohort, identify independent predictors, and evaluate TO rates of minimally invasive (MI) techniques, including robotic (ROB) and laparoscopic (LPS).

Materials And Methods: This cohort study included patients undergoing curative-intent hepatectomy and lymphadenectomy for GbC (T1b-T3) from 2012 to 2023 in 41 hospitals.

No Increase in Blood Pressure Assessed With the 24-h Holter Monitoring in Patients With Episodic Migraine During Early Treatment With Anti-CGRP Monoclonal Antibodies: A Prospective Observational Study (SAFHYPER).

Background: Migraine is associated with an increased cardiovascular risk, including hypertension. Anti-calcitonin gene related peptide (CGRP) monoclonal antibodies (mAbs) are effective preventive treatments, but concerns have been raised about their potential hypertensive effects. Herein, we assess the early changes in blood pressure (BP) during anti-CGRP mAbs treatment in patients with migraine using 24-h Holter monitoring.

Robotic superior mesenteric and portal vein resections in major liver, biliary, and pancreatic surgery.

The robotic approach to liver and pancreatic surgery is expanding worldwide. However, limited data are available on vascular management in these complex procedures. The unique characteristics of the robotic platform may enhance the feasibility of minimally invasive vascular resection and reconstruction.

Update on infection prevention in the ICU.

Purpose Of Review: Healthcare-associated infections (HAIs) remain a critical challenge in intensive care units (ICUs) due to the high prevalence of invasive procedures, vulnerable patient populations, and the increasing threat of antimicrobial-resistant organisms (MDROs). This review synthesizes current evidence on infection prevention and control (IPC) strategies in the ICU setting, highlighting recent findings and innovations in this evolving field, particularly in light of the impact of the COVID-19 pandemic.

Recent Findings: The review outlines ten key IPC strategies for ICUs, categorizing them into horizontal (universal) and vertical (pathogen-specific) approaches.

Structural Flexibility of Hydrated RHO Nanosized Zeolite Synthesized via Green Synthesis Approach at Subfreezing Conditions.

Understanding the structural flexibility of zeolites under cryogenic conditions is essential for optimizing gas separation and storage performance. This study investigates nanosized RHO zeolite synthesized via green synthesis (without organic structural directing agent) upon hydration and cooling to low temperatures (<273 K) using in situ XRPD, in situ FTIR spectroscopy, and DFT simulations. Template-free synthesis is performed at low temperature (363 K), avoiding calcination or postsynthetic activation, yielding highly crystalline nanosized zeolite with minimal energy consumption and no toxic by-products.

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

The transcriptional activity of TEAD4 (transcriptional enhancer associated domain proteins), one of the final effectors of the Hippo pathway, can be dysregulated or mutated in cancer. Consequently, targeting the interaction between TEAD and its co-activator YAP (Yes Associated Protein) to disrupt the YAP:TEAD (Y:T) heterodimer has emerged as a promising anti-cancer strategy. Therefore, in this study, we aimed to identify novel scaffolds targeting the TEAD Interface 3 surface as effective anticancer agents against colorectal and ovarian cancer.

Ancestral Origin and Functional Expression of a Hyaluronic Acid Pathway Complement in Mussels.

Hyaluronic acid (HA) is a key extracellular matrix component of vertebrates, where it mediates cell adhesion, immune regulation, and tissue remodeling through its interaction with specific receptors. Although HA has been detected in a few invertebrate species, the lack of fundamental components of the molecular HA pathway poses relevant objections about its functional role in these species. Mining genomic and transcriptomic data, we considered the conservation of the gene locus encoding for the (XLINK) in marine mussels as well as its expression patterns.

A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto.

The intimate relation between astrocytes and blood vessels was proposed by Camillo Golgi in 1870. Santiago Ramon y Cajal subsequently introduced the idea of astrocytes as regulators of functional hyperaemia accompanying neuronal activity in 1895. In 2003 Giorgio Carmignoto, Micaela Zonta, Tullio Pozzan and their colleagues revealed mechanisms of astrocytic control over vasodilatation.

Microscopic Analysis of Degradation and Breakdown Kinetics in HfO Gate Dielectric after Ions Irradiation.

We combine experiments and simulations to investigate the degradation dynamics and dielectric breakdown (BD) of SiO/HfO gate stacks irradiated with varying doses of 40 MeV carbon ions. The analysis of postirradiation electrical characteristics (current-voltage, -, capacitance-voltage, -, and conductance-voltage, -) reveals that the HfO layer is the most affected by irradiation-induced damage, leading to the formation of defects consistent with oxygen vacancies. Postirradiation constant voltage stress (CVS) experiments reveal an inverse dependence of time to breakdown () and Weibull slopes (β) on the irradiation dose.

Prognosis and biological characteristics of ER-low metastatic breast cancer: results from a multicenter cohort and the TONIC trial.

Purpose: To assess prognosis of ER-low expression and its dynamics in HER2- metastatic breast cancer (BC) and to compare sensitivity to nivolumab between ER-low and triple-negative (TN) BC.

Experimental Design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic BC, and one prospective cohort of 110 patients with ER<10%/HER2- metastatic BC enrolled in the TONIC trial (testing nivolumab). Endpoints were: overall survival (OS) and post-relapse survival (PRS) in the retrospective cohort; progression-free survival (PFS), OS, and clinical benefit rate (CBR) in the TONIC trial.

Diagnosed Patients With Chronic Hepatitis B and Delta Virus in Italy in 2024: An Estimation From a National Real-World Database.

Background And Aims: Hepatitis B (HBV) and Hepatitis Delta virus (HDV) infection have undergone significant changes in Italy over the past few decades, but reliable and updated prevalence of chronic hepatitis B (CHB) and Delta (CHD) data are lacking. The aim of the study was to describe the epidemiology of CHB and CHD in Italy in 2024, based on real-world data.

Methods: The number of patients with a healthcare expenditure exemption for CHB (016.