Balancing palliative care needs and medication appropriateness: Initiation and reinitiation of medications at the end of life.

Background: Medications deemed inappropriate and discontinued in the earlier stages of life-limiting disease may become relevant in palliative care context at the end of life. This study aims to determine the incidence of and factors associated with initiation and reinitiation of medications deemed inappropriate according to the STOPPFrail guideline.

Methods: A retrospective cohort study using linked healthcare reimbursement data.

A European Association for Palliative Care White Paper defining an integrative palliative, geriatric, and rehabilitative approach to care and support for older people living with frailty and their family carers: a 28-country Delphi study and recommendations.

Background: A fast-growing number of older people living with frailty experience complex needs throughout their illness trajectory. However, currently, there is no international consensus on optimal care and support to older people living with frailty and their family carers. The European Association for Palliative Care (EAPC) Reference Group on Aging and Palliative Care aimed to develop a White Paper defining an optimal integrative palliative, geriatric, and rehabilitative approach to care and support for this population.

[Medicine's collective memory: a contribution to the debate on gendersensitive medicine].

In this article, we explore how the genderhealth gap has developed from a cultural-historical perspective, through the lens of a general practitioner, health scientist and medical historian. We describe the application of the concept of 'the collective memory' to medicine as a discipline, and show how it shapes medicine's identity. Awareness of the collective memory reveals underlying biases and could result in a sustainable and systematic change in medicine that ultimately improves the health of both women and men.

The emergence of egg intermediaries in the European fertility landscape: the creation of value in reproductive bioeconomies.

With recent growth in both domestic and global private health care markets and increased medical travel by patients, there has been an increase in the existence of medical mediation services. Whilst there is a developing scholarship that considers the brokerage of this travel, less attention has been paid to other forms of medical facilitation. Taking the example of fertility treatment - specifically egg donation - this paper examines how intermediaries develop, how they operate and specifically how they create multiple forms of value within systems of healthcare traditionally based around non-commercial logics.

Soft locality restrictions in negative concord: Evidence from the French future polarity effect.

This paper provides new evidence that syntactic principles that are proposed to explain the (un)grammaticality of a sentence can also hold in sociolinguistic variation. In particular, we argue that two puzzling frequency patterns involving negation in French-the on negative concord and the on future temporal reference-are deeply related and are both derived from the sensitivity of syntactic agreement to "soft" locality constraints. Recent quantitative studies of future temporal reference reveal that, although all negative items are subject to the polarity effect in Laurentian French, does not give rise to the polarity effect in Parisian French.

Master narratives as imperatives: A qualitative study of adolescent identity experiences.

In this study, we explore the influence of culture on adolescent identity formation, using the recently postulated master narrative framework. Most identity research using the framework thus far has departed from specific, a priori defined master narratives and domains. However, considering the rapidly changing and globalized sociocultural landscape, it is vital to consider contemporary developments and investigate what master narratives guide and constrain today's adolescents' identities.

Long-term performance of low-cost free chlorine sensors to monitor on-site water reuse.

Water scarcity increasingly challenges the supply of sufficient quantities of safe water for human consumption. On-site water reuse systems can contribute to mitigating the effects of water scarcity by closing water cycles locally. However, broader adoption of on-site water reuse is constrained by the high cost of water quality monitoring.

What determines quality in palliative sedation? A scoping review identifying elements contributing to palliative sedation quality.

Background: Palliative sedation involves using sedatives to reduce consciousness until death. Though common in end-of-life care, it remains complex and controversial, with unclear quality parameters and limited guidance for improvement. A comprehensive overview of elements that reflect quality in palliative sedation is currently missing.

Sperm and egg donors' views on identity release, donor offspring information and genetic testing.

Purpose: The study intended to find out whether sperm and egg donors hold different views on identifiability, information about donor offspring, genetic testing, and extended carrier screening.

Methods: An online questionnaire was sent to accepted sperm (n = 70) and egg donors (n = 39) from the same gamete bank in the United States 3 years apart (2020 and 2023). Only questions that were identical for both groups were included in the analysis.

Judicial Opinion 132.

Opinion 132 deals with a Request for an Opinion asking the Judicial Commission to assess the nomenclatural status of (Blackall 1989) Chun 1997, a new combination affected by an unusual change in the epithet of its basonym, Blackall 1989. This is done by re-evaluating Opinion 85, which sets a precedent. The reasons and consequences of this earlier Opinion are explained in detail, and corresponding guidelines for orthographic corrections are given, along with further guidance derived from more recently published Judicial Opinions.

The influence of male age and sperm parameters on blastulation and euploidy rates.

Objective: To study the impact of male age and sperm parameters on blastulation and euploidy rates.

Design: Cohort study conducted between July 2017 and August 2023.

Subjects: A total of 47,502 metaphase II oocytes from 5,847 cycles performed with fresh and frozen ejaculated and testicular sperm.

Integrating taxonomic and phenotypic information through FISH-enhanced flow cytometry for microbial community dynamics analysis.

Unlabelled: Flow cytometry is a powerful tool to monitor microbial communities, as it allows tracking both changes in the subpopulations and cell numbers at high throughput and a low sample cost. This information can be combined in a phenotypic fingerprint that can be leveraged for diversity analysis. However, as isogenic individuals can manifest phenotypic diversity, for example, due to differing physiological state and phenotypic plasticity, combining the phenotypic information with taxonomic information adds an extra dimension for describing the dynamics of a microbial community.

Synergistic approaches for combating the pathogen : dynamic constitutional frameworks and pillararene-based self-assembled drug delivery systems.

In this study, we developed dynamic and supramolecular structures to combat the highly resistant pathogen . This Gram-negative ESKAPE pathogen has a strong ability to form biofilms, which raises a key but challenging question: how to discover molecules active on both planktonic bacteria and their biofilms. To achieve this, we introduce two non-covalent ordered systems with antimicrobial and antibiofilm effects based on two distinct types of interactions: dynamic covalent bonding and supramolecular self-assembly.

Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study.

Background And Aims: Atrial fibrillation (AF) is more common with increasing age and older adults have greater prevalence of frailty, multimorbidity and polypharmacy, which may impact clinical outcomes. The present study aims to investigate the relationship between frailty and the risk of hospitalization for AF in older adults, and second, the possible interaction of multimorbidity in this association.

Methods And Results: Data from the Progetto Veneto Anziani (Pro.

In vitro test battery for testing molecular initiating events in chemical-induced cholestasis.

Cholestatic liver injury is a complex adversity leading to the toxic accumulation of.noxious bile salts in the liver and systemic circulation. Cholestasis can be instigated by a plethora of chemicals originating from several applicability domains.

Egg donors' attitudes toward identifiability, offspring information, and genetic testing.

Background: Research on egg donors' perspectives regarding identifiability, donor-conceived offspring, and genetic testing remains limited, as most studies have focused on sperm donors. With the growing demand for donor eggs, understanding egg donors' attitudes is essential for ensuring ethical and effective donor programs. This study aims to address this gap by examining egg donors' views on identity-release and non-identity-release donation, the level of information they wish to receive about donor-conceived offspring, and their perspectives on genetic testing and expanded carrier screening.

On-scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy.

Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extratemporal lobe epilepsy. The advent of optically pumped magnetometers (OPMs) might change this situation thanks to on-scalp MEG. This study aims to investigate the detection/localization accuracy of interictal epileptiform discharges (IEDs) using on-scalp MEG in TLE and the added value of face-OPMs.

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy.

Background: Invariant natural killer T (iNKT) cells and CD8 T cells are key in the immune response against multiple myeloma (MM), a largely incurable blood cancer. Immunization is a promising strategy to activate these T cell populations. To our knowledge, immunization with messenger RNA (mRNA) and the iNKT agonist, α-galactosylceramide (αGC), has not been studied in MM, as knowledge on clinically relevant antigens in preclinical MM models is lacking.

Synergy of Body Composition, Exercise Oncology, and Pharmacokinetics: A Narrative Review of Personalizing Paclitaxel Treatment for Breast Cancer.

Background/objectives: Paclitaxel is a type of small molecule chemotherapy widely used for breast cancer, but its clinical efficacy is often hindered by dose-limiting toxicities such as chemotherapy-induced peripheral neuropathy and neutropenia. Traditional dosing based on body surface area does not account for variations in body composition, which may influence paclitaxel metabolism, toxicity, and treatment outcomes. This review explores the interplay between body composition, physical activity, and paclitaxel pharmacokinetics, emphasizing the potential for personalized dosing strategies.

Collective decision making by embodied neural agents.

Collective decision making using simple social interactions has been studied in many types of multiagent systems, including robot swarms and human social networks. However, existing multiagent studies have rarely modeled the neural dynamics that underlie sensorimotor coordination in embodied biological agents. In this study, we investigated collective decisions that resulted from sensorimotor coordination among agents with simple neural dynamics.

Prefrontal-hippocampal pathways underlying adolescent resilience.

The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents.

Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data.

MK-6194, an interleukin-2 mutein designed to selectively activate regulatory T cells (Tregs), was evaluated for safety, pharmacokinetics (PK), immunogenicity, and pharmacodynamics in healthy participants. In a single ascending dose trial (N = 56), participants received subcutaneous MK-6194 or placebo (3:1 ratio) across dose levels ranging from 1 to 10 mg. In a multiple ascending dose trial (N = 54), participants received subcutaneous MK-6194 or placebo (3:1 ratio) at dose levels ranging from 0.