Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extratemporal lobe epilepsy. The advent of optically pumped magnetometers (OPMs) might change this situation thanks to on-scalp MEG. This study aims to investigate the detection/localization accuracy of interictal epileptiform discharges (IEDs) using on-scalp MEG in TLE and the added value of face-OPMs. Eleven patients underwent a 1-h MEG recording with OPMs placed both on the scalp (flexible cap, scalp-OPMs) and on the face (glasseslike structure, face-OPMs). Nine patients underwent cryogenic MEG. IED amplitude and signal-to-noise ratio (SNR) were compared when ≥10 IEDs were detected. A mean of 13 IEDs/patient were detected using on-scalp MEG (mean amplitude = 3.3 pT, mean SNR = 9.4) and localized in the (medial, anterior, basal, lateral, posterior) temporal lobe. Amplitude and SNR were either higher or similar between on-scalp and cryogenic MEG, with neural sources separated by 6-16 mm. In two patients, on-scalp MEG source locations were confirmed by surgical resection cavity or stereoelectroencephalography. Face-OPMs had a clear added value in one patient with anteromedial TLE. On-scalp MEG can detect/localize IEDs in TLE. Face-OPMs may have added value in patients with anterior/medial TLE and increase the spatial coverage of the temporal lobe. This study paves the way for the use of on-scalp MEG in patients with refractory TLE.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/epi.18439 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimal configuration of on-scalp OPMs with fixed channel counts.
Imaging Neurosci (Camb)
May 2025
Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Recent technological developments have brought optically pumped magnetometers (OPMs) within reach of the larger neuroscientific community. The current state-of-the-art consists of whole-head systems that measure the magnetic field at >100 locations. OPM sensors can be constructed to measure the field in either 1, 2, or 3 orientations.
View Article and Find Full Text PDFRefined signal space separation methods for on-scalp MEG systems.
Phys Med Biol
June 2025
Department of Physics, University of Washington, Seattle, WA 98195, United States of America.
The reliability of biomagnetic measurements is improved by data processing techniques like the signal space separation (SSS) method, which transforms multichannel signals into device-independent channels with separate components for internal biomagnetic and external interference signals based on sensor geometry. Newer on-scalp sensors, such as optically-pumped magnetometers (OPMs), have recently been deployed in magnetoencephalography (MEG) systems, bringing a need for refined SSS variants to capture the potentially improved spatial resolution provided by the on-scalp sensors. Standard single-origin SSS may fail to capture the full brain-space when the sensors are on scalp.
View Article and Find Full Text PDFOn-scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy.
Epilepsia
May 2025
Laboratoire de Neuroanatomie et Neuroimagerie Translationnelles, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extratemporal lobe epilepsy. The advent of optically pumped magnetometers (OPMs) might change this situation thanks to on-scalp MEG. This study aims to investigate the detection/localization accuracy of interictal epileptiform discharges (IEDs) using on-scalp MEG in TLE and the added value of face-OPMs.
View Article and Find Full Text PDFAnatomically Veridical On-Scalp Sensor Topographies.
Eur J Neurosci
March 2025
Functional Imaging Laboratory (FIL), Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.
When working with sensor-level data recorded using on-scalp neuroimaging methods such as electroencephalography (EEG), it is common practice to use two-dimensional (2D) representations of sensor positions to aid interpretation. Positioning of sensors relative to anatomy, as in the classic 10-20 system of EEG electrode placement, enables the use of 2D topographies that are familiar to many researchers and clinicians. However, when using another increasingly popular on-scalp neuroimaging method, optically pumped magnetometer-based magnetoencephalography (OP-MEG), bespoke sensor arrays are much more common, and these are not prepared according to any standard principle.
View Article and Find Full Text PDFTri-axial rubidium and helium optically pumped magnetometers for on-scalp magnetoencephalography recording of interictal epileptiform discharges: a case study.
Front Neurosci
November 2023
Laboratoire de Neuroimagerie et Neuroanatomie Translationnelles (LN2T), ULB Neuroscience Institute (UNI), Université libre de Bruxelles, Brussels, Belgium.
Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of tri-axial OPMs [Rb (Rb-OPM) and He gas (He-OPM)] for the detection of interictal epileptiform discharges (IEDs).
View Article and Find Full Text PDF