Sex differences in performance and pacing in the greatest Quintuple Iron ultra-triathlon race in history: The IUTA World Championship 2024 in France.

Background: Pacing in ultra-triathlon has been investigated by analyzing lap times from Double to Deca Iron ultra-triathlon for World Cup races but not for a World Championship. The present study aimed to investigate pacing in ultra-triathletes competing in the fastest and largest World Championship in Quintuple Iron ultra-triathlon ever held in history.

Methods: A total of 11 female and 24 male finishers who completed the 2024 Quintuple Ultra Triathlon World Championship in Colmar, France, were analyzed.

Continuous Glucose Monitoring During Recreational Diving in Type 1 Diabetes: Navigating Clinical and Technical Uncertainties.

Recreational diving with self-contained underwater breathing devices is gaining popularity worldwide as a sport and leisure activity. People living with type 1 diabetes mellitus (PLT1D) are no exception, although historically diabetes mellitus, especially insulin-treated, has been described as an absolute contra-indication for diving. However, based on observational data collected by the Divers Alert Network, the presence of background diabetes mellitus became only a relative contraindication for those without significant co-morbidities or long-term complications.

Epidemiology of Hypertension in Psoriasis: An Analysis of Trends from 2006 to 2023.

Background: Psoriasis and hypertension (HTN) are known to be closely related. However, at present, no study has systematically examined the epidemiology of this disease pattern on a global scale.

Methods: We examined six databases from their inception until November 1, 2023 and used the Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale to assess the quality of observational studies.

Potential of MRNA vaccines for mpox prevention: current evidence and future directions.

In 2022, the presumption of monkeypox (mpox) to be of limited epidemiology shifted when a global outbreak was announced. Being a member of the Orthopoxvirus genus in the Poxviridae family, it'd been reported in over 82 countries with over 17 000 confirmed cases by July 2022, thus showing its capability for spreading rapidly. As the smallpox vaccine offers 85% cross-immunity against mpox, the outbreak highlighted the attenuation of global immunity against orthopoxviruses after the cessation of vaccination campaigns against smallpox.

Invasive treatment strategies in the ESC guidelines developed in collaboration with EACTS for the management of chronic coronary syndrome: implications for contemporary clinical practice.

Purpose Of Review: To critically appraise the 2024 ESC Guidelines for chronic coronary syndrome (CCS), developed in collaboration with EACTS, emphasizing invasive-treatment recommendations, their underlying rationale and key areas requiring further clarification for clinical implementation.

Recent Findings: The document formally incorporates indications for myocardial revascularization and the criteria for choosing between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) into the single CCS guideline framework. It calls for Heart-Team decisions whenever CABG and PCI are equally recommended and introduces modality-specific criteria based on anatomical complexity, SYNTAX score, and clinically relevant comorbidities.

Crystallographic Engineering of Spin Transport in Antiferromagnetic NiO Thin Films.

In this work, we investigate how the crystallographic growth direction influences spin current transmission in antiferromagnetic (AF) NiO thin films. By manipulating epitaxial growth, we explored the spin transport characteristics in LaSrMnO/NiO/Pt heterostructures grown on top of (001)- and (111)-oriented SrTiO substrates, varying the NiO barrier thickness (t). Spin currents were generated via spin pumping (SP), and detection was done by the inverse spin Hall effect (ISHE).

Maximising biodiversity potential in Europe's mines and quarries: A key role for EU Nature Restoration Regulation targets.

Amid the UN Decade on Ecosystem Restoration and the EU's Nature Restoration Regulation (NRR), which aims to restore degraded areas in the coming decades, post-mining sites must be integrated into biodiversity and ecosystem recovery strategies as key contributors. While mining, quarrying, and other extractive activities have considerable environmental impacts, they also present massive opportunities to create valuable habitats, support biodiversity, guide restoration efforts, and contribute to conservation. A strong foundation of scientific and practical knowledge is already in place, yet implementation gaps persist, and regulatory frameworks remain under-utilised for restoring these degraded areas.

New Anti-HIV Agents Isolated From Two Euphorbia Species.

Four previously unreported tigliane diterpenes (1, 2, 4, and 6), along with two known tiglianes (3 and 5), were isolated from the latex of Euphorbia palustris and Euphorbia lucida. The structures of the isolated compounds were elucidated by spectroscopic techniques. Antiviral activity assays for compounds 1‒4 and 6 against HIV-1 and HIV-2 replication were performed on a CD4 T cell line, MT-4 cells.

Recent Advances in Metal-Organic Framework Nanozyme (MOFzyme)-Based Biosensors for Detecting Food Contaminants.

Ensuring food safety and freshness demands highly sensitive and reliable biosensors for food contaminant detection, where signal probes act as vital elements in this endeavor. Metal-organic framework nanozymes (MOFzymes) have emerged as signal probes owing to their highly tunable porosity, component versatility for modulating enzyme-like activity, and customizable surface modifications. This review systematically encapsulates MOFzyme-based biosensors for the identification of diverse food pollutants.

Factors associated with online information seeking about mental health among high school students in Belgrade, Serbia.

Adolescents may not necessarily have a specific mental health challenge to seek information on mental health. They may be genuinely curious on how to better understand these issues, especially when mental health is being discussed in school, among peers and with parents. The purpose of this study was to examine the frequency and factors associated with online information seeking about mental health among adolescents.

Hypertensive acute heart failure: a critical perspective on definition, epidemiology, pathophysiology, and prognosis-a narrative review: a joint session with the Romanian Society of Cardiology (part II).

Hypertensive acute heart failure (HT-AHF) has historically been recognized as a distinct clinical phenotype of AHF, characterized by acute pulmonary congestion in the context of elevated systolic blood pressure (SBP), typically > 140 mmHg. However, emerging evidence has begun to challenge the diagnostic accuracy, clinical utility, and relevance of this category. A main criticism of HT-AHF is its considerable overlap with other AHF clinical profiles, including acute decompensated heart failure (ADHF) and acute pulmonary oedema (APO).

Managing penicillin resistant pneumococcal meningitis: an international id-iri study.

Penicillin-resistant pneumococcal meningitis (PRPM) is a challenging and fatal infection. We conducted a multicentre international retrospective study to evaluate the clinical features, outcomes, predictors of outcomes antimicrobial efficacy and drug susceptibility in patients with PRPM. The study, conducted through the "Infectious Diseases-International Research Initiative" across 33 centers in 11 countries, analyzed PRPM patients treated between 2019 and 2024 using univariate and multivariate analyses.

Electrostatic Potentials at Nuclei for Atoms From Z = 1 to Z = 54 Using the aHGBSP1-5 Basis Set.

The electrostatic potential at the nucleus of an atom, whether it be in the free state or in a neutral molecule or in an ionic molecular species, is qualitatively a characteristic property of the atom. It changes remarkably little from one molecular environment to another. As has been shown earlier by Politzer, the energies of atoms and molecules can be expressed both rigorously and approximately in terms of the electrostatic potentials at their nuclei.

An expert panel review of endoscopic vein harvesting devices: benefits, limitations, and clinical insights.

Objectives: Endoscopic Vessel Harvesting (EVH) devices are technically complex and the learning curve for novice practitioners can be steep, due to the need for refined hand-eye coordination and device familiarity. Training and mentoring approaches vary widely, as does the experience level of practitioners entering EVH practice.

Methods: This expert review was conducted by 10 international EVH specialists from the UK, USA, and Serbia, each with 18 to 28 years of experience.

Factors influencing the well-being of Central and Eastern European university teachers: the role of physical activity and the sources of stress and resources in the workplace.

Background: While previously a university education career seemed like a predictable, relatively stress-free, flexible, socially recognized profession, this today is no longer the case. Where it once was a job which protected its teachers from all sorts of workplace sources of stress like uncertainty, low work control, it now no longer offers such shielding.

Methods: In our study, based on the Jobs-Demands and Resources Theory, we examined the backgrounds and predictor roles of institutional stress sources and resources, and physical activity as an individual asset, in the wellbeing of teachers.

Pervasive non-random mitochondrial DNA heteroplasmy in the hybrid water frog Pelophylax esculentus.

Background: Heteroplasmy, the presence of more than one type of mitochondrial DNA (mtDNA) within an individual, is an exception to the maternal transmission of mtDNA and has been observed in several animal species. A central question is whether heteroplasmy among individuals and across generations is mainly influenced by genetic drift or by selection.

Results: We quantified heteroplasmy in eight males, eight females and eight unfertilized eggs per female from a natural population of the hybrid frog species Pelophylax esculentus (between P.

Evolving Paradigms and Future Frontiers In Heart Transplantation in the Modern Era: A State-of-Art Focus Review.

Heart transplantation stands at the threshold of a new era shaped by transformative advances across the clinical and scientific continuum. This contemporary review highlights developments with the greatest potential to shift practice and improve patient outcomes. First, evolving strategies in organ preservation and transport- such as ex vivo perfusion and normothermic techniques- are expanding geographic boundaries and optimizing donor heart utilization.

Towards consensus: The need for standardised definitions in Long (post) COVID care in 34 European countries.

Background: The COVID-19 pandemic has significantly impacted global healthcare systems, leading to challenges in managing Long COVID. Variations in definitions and diagnostic criteria across Europe hinder recognition and treatment efforts. This study aims to analyse and compare the definitions of Long COVID used in 34 European countries.

Drug interactions in hospitalized patients: Critical importance of renal disease and drug monitoring based on data from hospital departments of internal medicine in Serbia.

Introduction: Drug-drug interactions (DDIs) have been associated with adverse drug reactions (ADRs) which can cause hospitalization. The aim of this study was to associate potential DDIs (pDDIs) with potential ADRs upon admission to hospital among patients on five internal medicine wards.

Materials And Methods: A cross-sectional study was performed on the cardiology, nephrology, endocrinology, gastroenterology, and geriatrics ward.

Fremanezumab for the treatment of migraine.

Fremanezumab is a monoclonal antibody inhibiting the CGRP signaling leading to migraine prophylaxis. Its efficacy and potential safety concerns are updated here. All available data on fremanezumab were searched in PubMed with emphasis on the mechanisms of action, efficacy, tolerability, and safety.

Asymmetric T-segment binding and gate dynamics govern the final stages of the type IIA topoisomerase catalytic cycle.

Type IIA DNA topoisomerases are molecular nanomachines that alter DNA topology during essential cellular processes. The final steps of their catalytic cycle, after translocation of the transported (T-) segment into the C-gate, are still not fully understood. Here, we performed all-atom molecular dynamics simulations of several conformational states of Saccharomyces cerevisiae topoisomerase IIA, each with a T-segment inserted into the C-gate.