Integrated profiling of essential metals, phenolic compounds, anti-inflammatory and hydroxyl radical scavenging activities for five medicinal plants.

Medicinal plants are valuable sources of bioactive compounds. In this study, we analyzed the levels of essential metals (Fe, Cu, Zn, Mn) in the leaves of Punica granatum, Teucrium montanum, Chaerophyllum coloratum, Petteria ramentacea, and Menyanthes trifoliata using atomic absorption spectrophotometry. Ethanolic leaf extracts were assessed for anti-inflammatory activity via bovine serum albumin BSA and egg albumin (EgA) denaturation assays and for antioxidant potential by hydroxyl radical scavenging using EPR (Electron Paramagnetic Resonance) spectroscopy.

Effects of glyphosate-based herbicide on oxidative stress and neurotoxicity parameters in newt (Triturus ivanbureschi) larvae under temperature changes predicted by future climate scenarios.

The alarming decline of amphibian populations can largely be attributed to extent use of pesticide and global warming process. Special concerns were raised over the glyphosate-based formulations, one of the most commonly applied herbicides worldwide, due to their potentially detrimental effects on different animal groups. However, researches on the effects of glyphosate in newt species are still scarce.

Unveiling the antimicrobial, biofilm inhibition, and photoprotective potential of Bupleurum falcatum L. for dermatological applications.

L. is known for its therapeutic properties, especially in treating fever, inflammation, and infectious diseases. However, its potential for dermatological applications remains mainly unexplored.

Floristic diversity and assessment of the conservation status of Togo's plant species.

Regular updates of floristic lists are essential for assessing the state of flora, identifying threatened species, and guiding conservation actions. This study aims to provide a comprehensive assessment of the floristic diversity and conservation status of plant species across selected ecological zones in Togo. A total of 121 plots, with areas determined based on the types of vegetation formations, were randomly selected from a systematic grid of points spaced 5 km apart, generated using QGIS 3.

Comparative Analysis of Anthocyanins and Vitamin C Content, Antioxidant Potential, and Antimicrobial Activity of Eight Black Currant (Ribes nigrum L.) Varieties Juices.

This study aimed to compare the juices of eight black currant (Ribes nigrum L.) varieties: Ben Nevis, Ben Lomond, Bona, Čačanska crna, Öyebin, Silmu, Tsema, and Titania. The comparison focused on their dominant anthocyanin content, vitamin C levels, and their antioxidant and antimicrobial properties.

Antithrombotic therapy after coronary artery bypass graft surgery: a Clinical Consensus Statement of the ESC Working Group on Cardiovascular Surgery, the ESC Working Group on Cardiovascular Pharmacotherapy, and the European Association for Cardio-Thoracic Surgery (EACTS).

Antithrombotic therapy is essential after coronary artery bypass graft surgery to reduce ischaemic events and prevent graft occlusion. Although aspirin remains the most commonly used agent, in higher-risk patients, dual antiplatelet therapy or combining antiplatelet therapy with oral anticoagulation may be beneficial, but this increases bleeding risk. The choice of antithrombotic therapy should be tailored to each patient, based on their ischaemic and bleeding risks, and regularly reassessed.

Antithrombotic therapy after coronary artery bypass graft surgery: a Clinical Consensus Statement of the ESC Working Group on Cardiovascular Surgery, the ESC Working Group on Cardiovascular Pharmacotherapy, and the European Association for Cardio-Thoracic Surgery (EACTS).

Antithrombotic therapy is essential after coronary artery bypass graft surgery to reduce ischaemic events and prevent graft occlusion. Although aspirin remains the most commonly used agent, in higher-risk patients, dual antiplatelet therapy or combining antiplatelet therapy with oral anticoagulation may be beneficial, but this increases bleeding risk. The choice of antithrombotic therapy should be tailored to each patient, based on their ischaemic and bleeding risks, and regularly reassessed.

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium-2024.

The 2nd MObility for Vesicle research in Europe (MOVE) Symposium, held in Belgrade-Serbia, from October 8 to 11, 2024, showcased the dynamic and interdisciplinary nature of extracellular vesicles (EVs) research in Europe. Organized by eight National EV Societies under the MOVE initiative, the event gathered over 280 attendees from 28 countries, promoting collaboration and scientific exchange. The symposium featured eight keynote lectures, 48 oral and 126 poster presentations, and sessions dedicated to EV-related tools and industry innovations.

Comparison of potentially toxic elements (PTEs) and organochlorine pesticides (OCPs) levels in Rutilus rutilus (Linnaeus, 1758) sampled from different reservoirs in terms of human health risk due to consumption.

This study evaluates the potential human health risks of environmental pollutant loads carried by consumption of roach (Rutilus rutilus, Linnaeus, 1758), a bioindicator of environmental pollution from the Cyprinidae family in freshwater systems. We analyzed the concentrations of 26 potentially toxic elements (PTEs) in the muscle, gills, and liver, and 18 organochlorine pesticides (OCPs) in the muscle of roach originating from reservoirs (artificial lakes) with different uses (power generation and water supply) and anthropogenic impacts. Elemental concentrations were compared to maximum allowable concentrations and used to calculate pollution indices, including the metal pollution index and liver/muscle Hg index, health risk and benefit indices (target hazard quotient-THQ, target cancer risk-TR, Se:Hg, Na:K, and Ca:Mg ratios), and contributions of selected trace elements and macronutrients in roach meat.

Rationale and design of European microCirculatory Resistance and Absolute Flow Team: The Euro-CRAFT Registry.

Introduction: Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with non-obstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary.

and Characterization of Cytocompatibility and Biocompatibility of a Cross-linked Fish Collagen Wound Membrane.

Background/aim: The aim of the present research is a comprehensive evaluation of a fish-collagen based wound membrane using established and methodologies. A porcine pericardium membrane served as control material.

Materials And Methods: Scanning electron microscopy (SEM) and attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis were initially used to analyze the structure and collagen molecular structure.

Weight loss practices in Chinese national and international-level Sanda athletes.

Background: Sanda is an unarmed combat sport (CS) comprises punching, kicking, throwing, wrestling, and defensive techniques that has increased in popularity. To ensure athletes compete against opponents of similar body size and weight for fairness, Sanda competition is classified according to weight classes. Previous studies revealed that CS athletes tend to intentionally lose weight to gain a competitive advantage over their opponents.

Resurgence of Pertussis in the Autonomous Province of Vojvodina, Serbia: Shifting Seasonality, Age Patterns, and the Need for Booster Immunization.

Background: Despite decades of high childhood vaccination coverage, pertussis has re-emerged in the Autonomous Province of Vojvodina (AP Vojvodina), Serbia. We aimed to describe the temporal, seasonal, and age-specific patterns of pertussis in AP Vojvodina and to analyze trends by vaccination status in order to highlight changes in epidemiology and potential gaps in vaccine-induced protection.

Methods: We retrospectively analyzed 2796 pertussis cases reported between January 1997 and December 2024, examining temporal, seasonal, and age-specific trends, stratifying by vaccination status across four consecutive periods (1997-2003, 2004-2010, 2011-2017, and 2018-2024).

Challenges to the Effectiveness and Immunogenicity of COVID-19 Vaccines: A Narrative Review with a Systematic Approach.

The COVID-19 pandemic accelerated the rapid development and distribution of various vaccine platforms, resulting in a significant reduction in disease severity, hospitalizations, and mortality. However, persistent challenges remain concerning the durability and breadth of vaccine-induced protection, especially in the face of emerging SARS-CoV-2 variants. This review aimed to evaluate the factors influencing the immunogenicity and effectiveness of COVID-19 vaccines to inform future vaccine advancement strategies.

Disseminated Varicella-Zoster Virus Infection with Internal Organ Involvement: A Scoping Review of 156 Cases.

Visceral disseminated varicella-zoster virus infection (VD-VZV) involves the hematogenous spread of VZV from the skin to the internal organs. Though rare, it is potentially life-threatening, predominantly affecting immunocompromised individuals. Diagnosis is often delayed due to nonspecific symptoms mimicking other viral illnesses.

Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol.

The active ingredients of essential plant oils appear as potentially effective antinematodal drugs or substances that can potentiate the action of already-existing anthelmintics. So far, we have verified that, aside from the direct effect on the neuromuscular system of nematodes, some of them can potentiate the effects of drugs that are agonists or antagonists of nematode cholinergic receptors. In this study, the antinematodal effects of geraniol and carvacrol were compared, as well as their interaction in the experimental model , on the contractile properties of neuromuscular preparations and on the ACR-16 nicotinic acetylcholine receptor (nAChR) of expressed in Xenopus leavis oocytes.

Real-World Safety of Vedolizumab in Inflammatory Bowel Disease: A Retrospective Cohort Study Supported by FAERS Signal Analysis.

: Vedolizumab is a gut-selective anti-integrin monoclonal antibody approved for the treatment of inflammatory bowel disease (IBD). While clinical trials have demonstrated a favorable safety profile, real-world studies are essential for identifying rare adverse events (AEs) and evaluating post-marketing safety. This study assessed vedolizumab's safety in a real-world cohort and supported the detection of potential safety signals.

Iron Deficiency and Iron Deficiency Anemia: A Comprehensive Overview of Established and Emerging Concepts.

Iron deficiency (ID) is the most prevalent micronutrient deficiency globally, affecting approximately one in four individuals, with a particularly high burden among children, women of reproductive age, and populations in low- and middle-income countries. It contributes significantly to the global burden of disease, with consequences ranging from impaired cognitive and motor development in children to increased risks during pregnancy, including low birth weight, preterm delivery, and maternal mortality, as well as reduced physical performance and quality of life in adults. ID often precedes iron deficiency anemia (IDA), though clinical and functional impairments-such as cognitive deficits, immune dysfunction, and fatigue-can occur even in the absence of anemia.

Holmium Metal Nanoparticle PbO Anode Formed by Electrodeposition for Efficient Removal of Insecticide Acetamiprid and Improved Oxygen Evolution Reaction.

This work examines the possibility of using a PbO-based electrode doped with the rare-earth metal holmium in the field of oxygen evolution and the development of an efficient method for the degradation of acetamiprid. Acetamiprid is a widely used insecticide and, as such, it very often reaches waterways, where it can cause many problems for wildlife and the environment. X-ray powder diffraction analysis, Raman spectroscopy, and energy-dispersive X-ray spectroscopy results confirmed the structure of Ti/SnO-SbO/Ho-PbO, while the morphology of its surface was investigated by scanning electron microscopy with energy-dispersive X-ray spectroscopy.

Effect of Clear Corneal Incisions via Femtosecond Laser Versus Manual Incisions on Corneal Aberrations in Cataract Surgery.

This study aimed to evaluate whether clear corneal incisions (CCIs) created with the FEMTO LDV Z8 femtosecond laser during cataract surgery are non-inferior to manual CCIs in terms of surgically induced astigmatism (SIA) and higher-order aberrations (HOAs). A total of 78 cataract patients were randomly assigned to two groups: 38 eyes underwent femtosecond laser-assisted cataract surgery (FLACS), and 40 eyes underwent conventional manual cataract surgery (CCS). Preoperative and six-week postoperative SIA, HOAs, and all topographic and refractive data were analysed for both groups.

Differential Exposure to spp. and Spotted Fever Group in Serbia and North Macedonia: A Comparative Study.

Several diseases caused by tick-borne pathogens, including Lyme borreliosis (LB) and spotted fever group rickettsioses, are endemic in the Balkan Peninsula, positioned between Central Europe and the Middle East. This cross-sectional study aimed to assess serological exposure to spp. and spotted fever group (SFGR) among individuals with recent tick bites and healthy controls in two Balkan countries-Serbia and North Macedonia.

From Morphology to Multi-Omics: A New Age of Fusarium Research.

The genus includes some of the most economically and ecologically impactful fungal pathogens affecting global agriculture and human health. Over the past 15 years, rapid advances in molecular biology, genomics, and diagnostic technologies have reshaped our understanding of taxonomy, host-pathogen dynamics, mycotoxin biosynthesis, and disease management. This review synthesizes key developments in these areas, focusing on agriculturally important species complexes such as the species complex (FOSC), species complex (FGSC), and a discussion on emerging lineages such as .