Publications by authors named "Paul Okello"

The genus includes some of the most economically and ecologically impactful fungal pathogens affecting global agriculture and human health. Over the past 15 years, rapid advances in molecular biology, genomics, and diagnostic technologies have reshaped our understanding of taxonomy, host-pathogen dynamics, mycotoxin biosynthesis, and disease management. This review synthesizes key developments in these areas, focusing on agriculturally important species complexes such as the species complex (FOSC), species complex (FGSC), and a discussion on emerging lineages such as .

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Background: Healthcare workers (HCWs) often face mental resilience challenges during public health emergencies, including disease outbreaks. On September 20, 2022, the Uganda Ministry of Health declared an outbreak of Sudan virus disease (SVD). We assessed the level and factors associated with workplace resilience among HCWs working at the epicenter of the SVD outbreak in Mubende and Kassanda districts, Uganda.

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Background: On April 7, 2024, the Uganda Ministry of Health was notified of a measles outbreak in Kakumiro District involving death of a suspected case. We investigated to determine the scope of the outbreak, assess risk factors for disease transmission, and recommend evidenced-based interventions.

Methods: We defined a suspected case as onset of fever and maculopapular generalized rash with ≥ 1 of cough, coryza, or conjunctivitis in any resident of Kakumiro District during FebruaryMay 2024.

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  • The study evaluated antimicrobial resistance (AMR) trends in Uganda by analyzing bacterial isolates from clinical samples between 2018-2021 to improve public health responses.
  • A total of 537 isolates were analyzed, with Staphylococcus aureus and Salmonella being the predominant pathogens, showing significant resistance to various antibiotics, particularly sulfonamides and fluoroquinolones.
  • The results indicated fluctuating resistance levels, particularly in methicillin-resistant Staphylococcus aureus and increasing resistance among gram-negative bacteria to antibiotics like tetracycline and ceftriaxone.
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  • Uganda's yellow fever (YF) surveillance system monitored outbreaks from 2017-2022 at seven high-risk sites, assessing attributes like timeliness and data completeness.
  • A total of 3,073 suspected and 15 confirmed YF cases were reported, with significant delays in case confirmation noted (37 days median lag) and varying completeness (76% external, 65% internal).
  • Stakeholders found the system simple and acceptable, contributing to detecting 71% of previous outbreak cases and guiding vaccination efforts, but issues with delays and incomplete data limited its overall efficacy.
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Background: On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25.

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Seedling diseases and root rot, caused by species of , can limit soybean ( L.) production in the United States. Currently, there are few commercially available cultivars resistant to .

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  • * An investigation revealed 25 meningitis cases, including 2 deaths, in the Palorinya Refugee Settlement between December 2022 and May 2023, with most affected being children under 18 years old and none vaccinated against the bacteria.
  • * The outbreak lacked an epidemiological link between cases, prompting recommendations for vaccination of at-risk individuals to control the spread of the infection.
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  • The study evaluates the completeness and timeliness of outpatient department (OPD) health reports in Uganda using data from January 2020 to December 2021.
  • Overall, most regions showed excellent performance with high completeness (99.5% in 2020 and 100% in 2021) and improved timeliness (82.8% in 2020 and 94.9% in 2021), though Kampala and Nakasongola struggled consistently.
  • The findings suggest that while reporting is generally strong, there is a need to support areas that face timeliness issues to enhance overall public health surveillance.
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  • The COVID-19 pandemic highlighted the weaknesses in healthcare facility readiness, particularly in Uganda during the first and second waves of cases in 2020 and 2021.
  • A study evaluated the readiness of 17 referral hospitals and 71 lower-level facilities in Uganda by assessing their management capabilities, resource availability, and preparedness for surges in COVID-19 cases.
  • Results showed that overall readiness was low, with a median score of 39% across all facilities; referral hospitals had a better score (63%), but most lower-level facilities were poorly equipped, lacking critical supplies like medicines and oxygen.
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  • Uganda's 2021 campaign aimed for 100% LLIN ownership and 85% usage, targeting households to provide protection against malaria.
  • A survey across 14 districts revealed that 95% of households owned at least one LLIN, but only 69% slept under one the night before the survey.
  • Factors influencing LLIN ownership included perceptions of LLINs as protective against malaria, while the use of mosquito repellents negatively impacted ownership rates.
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Background: Civil wars in the Great Lakes region resulted in massive displacement of people to neighboring countries including Uganda. With associated disease epidemics related to this conflict, a disease surveillance system was established aiming for timely detection of diseases and rapid response to outbreaks. We describe the evaluation of and lessons learned from the public health surveillance system set up in refugee settlements in Uganda.

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and soybean cyst nematode (SCN) are important pathogens of soybean. Although these pathogens infect soybean roots, there is limited evidence of any interaction between them. The objective of this study was to examine the interaction between SCN and on soybean in the greenhouse.

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On February 22, 2017, Hospital X-Kampala and US CDC-Kenya reported to the Uganda Ministry of Health a respiratory illness in a 46-year-old expatriate of Company A. The patient, Mr. A, was evacuated from Uganda to Kenya and died.

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Background: Compared to the general population in Uganda, fishing communities suffer greater burden of HIV/AIDS. We determined the level of comprehensive knowledge on HIV prevention and its associated factors among fishing communities of Lake Kyoga.

Methods: We conducted secondary analysis of data from the Lake Kyoga Behavioral Survey, a population-based sample survey on behavioral risk factors for HIV, syphilis, and schistosomiasis among adults in fishing communities of Lake Kyoga in 2013.

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Background: A cholera outbreak started on 29 February in Bwikhonge Sub-county, Bulambuli District in Eastern Uganda. Local public health authorities implemented initial control measures. However, in late March, cases sharply increased in Bwikhonge Sub-county.

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The planned upscaling of vector control strategies requires insight into the epidemiological consequences of vector resistance. Therefore, the pyrethroid and DDT resistance status of Anopheles gambiae s.l.

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Malaria transmission intensity has been proposed, based on theoretical models, as an important factor for the spread of falciparum-resistant malaria, but the predictions obtained vary according to the assumptions inherent in the model used. We summarized the available field data on transmission intensity and the prevalence of malaria drug resistance. Resistance to chloroquine and sulphadoxine-pyrimethamine monotherapy was invariably higher where transmission was intense.

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Knowledge of the baseline malaria transmission in a given environment is important to guide malaria control interventions. However, in Uganda, recent information on malaria transmission intensity is lacking. Therefore, a 1-year entomological study was conducted in seven ecologically different sites throughout the country to assess spatial and temporal patterns in malaria transmission intensity.

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