Clinical and Pharmacotherapeutic Profile of Patients with Type 2 Diabetes Mellitus Admitted to a Hospital Emergency Department.

Type 2 diabetes mellitus (T2DM) is closely associated with other pathologies, which may require complex therapeutic approaches. We aim to characterize the clinical and pharmacological profile of T2DM patients admitted to an emergency department. Patients aged ≥65 years and who were already using at least one antidiabetic drug were included in this analysis.

Gastrointestinal disorders potentially associated with Semaglutide: an analysis from the Eudravigilance Database.

Background: Semaglutide is a Glucagon-like peptide-1 receptor agonist used in the second-line treatment of poorly controlled type 2 diabetes and can be used in monotherapy or associated with other oral antidiabetics or even insulin, increasing the effectiveness of the treatment. This work aims to analyze the profile of adverse drug reactions reported for semaglutide in Eudravigilance.

Research Design And Methods: Data on Individual Cases Safety Reports were obtained from the database of the centralized European spontaneous reporting system Eudravigilance by accessing www.

Chemical composition, antioxidant, and antimicrobial activities of six commercial essential oils.

Essential oils (EOs) and their components extracted from medicinal and aromatic plants are used in several areas, such as perfumery and chemical, cosmetic, food, and pharmaceutical industries. Considering the different applications of EOs, this work aimed to screen the composition and the bioactivities properties of the EOs of Foeniculum vulgare, Helichrysum stoechas, Mentha pulegium, Pinus pinaster, Ruta graveolens, and Thymus mastichina. Gas chromatography-mass spectrometry revealed the presence of different compounds in EOs F.

A randomized controlled trial on the effects of "Global Postural Re-education" versus neck specific exercise on pain, disability, postural control, and neuromuscular features in women with chronic non-specific neck pain.

Background: Neck pain is associated with decreased health-related quality of life, decreased work productivity, and increased visits to health care providers.

Aim: The aim of this study was to assess the effectiveness of "Global Postural Re-education" (GPR) versus a neck specific exercise (SE) program on neck pain, disability, cervical range of movement, postural stability, and activity of the superficial cervical flexor muscles.

Design: A parallel-group and single-blinded clinical trial.

Association between the dry-land strength & power and the kick start kinetics in elite male and female swimmers.

The aim of this research was to determine the association between dry-land exercises and the start kinetics in elite swimmers. Fourteen swimmers (eight males and six females) included in a national team took part in this study. A fixed smith-machine was used to measure the maximal full squat strength (Smax).

The Mechanical and Efficiency Constraints When Swimming Front Crawl with the Aquanex System.

The aim of this study was to compare the mechanical and efficiency constraints between free swim and swimming with differential pressure sensors (Aquanex System). These conditions were also analysed to understand the differences between sexes. Thirty young swimmers, 14 boys and 16 girls (12.

Silk Sericin: A Promising Sustainable Biomaterial for Biomedical and Pharmaceutical Applications.

Silk is a natural composite fiber composed mainly of hydrophobic fibroin and hydrophilic sericin, produced by the silkworm In the textile industry, the cocoons of are processed into silk fabric, where the sericin is substantially removed and usually discarded in wastewater. This wastewater pollutes the environment and water sources. However, sericin has been recognized as a potential biomaterial due to its biocompatibility, immunocompatibility, biodegradability, anti-inflammatory, antibacterial, antioxidant and photoprotective properties.

Integrating physical and tactical factors in football using positional data: a systematic review.

Background: Positional data have been used to capture physical and tactical factors in football, however current research is now looking to apply spatiotemporal parameters from an integrative perspective. Thus, the aim of this article was to systematically review the published articles that integrate physical and tactical variables in football using positional data.

Methods And Materials: Following the Preferred Reporting Item for Systematic Reviews and Meta-analyses (PRISMA), a systematic search of relevant English-language articles was performed from earliest record to August 2021.

Reliability of using a pressure sensor system to measure in-water force in young competitive swimmers.

The aim of this study was to analyze the reliability of using a differential pressure system to measure in-water force in young competitive swimmers. Ten boys and five girls (12.38 ± 0.

Employ of Anthocyanins in Nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases.

Anthocyanins are among the best-known phenolic compounds and possess remarkable biological activities, including antioxidant, anti-inflammatory, anticancer, and antidiabetic effects. Despite their therapeutic benefits, they are not widely used as health-promoting agents due to their instability, low absorption, and, thus, low bioavailability and rapid metabolism in the human body. Recent research suggests that the application of nanotechnology could increase their solubility and/or bioavailability, and thus their biological potential.

Anti-Inflammatory and Antimicrobial Activities of Portuguese L. (Sweet Cherry) By-Products Extracts.

The bioactivity of natural by-products in food and pharmaceutical applications is the subject of numerous studies. Cherry production and processing generates large amounts of biowaste, most of which is not used. The recovery of these by-products is essential for promoting the circular economy and to improving sustainability in the food industry.

Insight into the Taxonomic and Functional Diversity of Bacterial Communities Inhabiting Blueberries in Portugal.

is a dwarf shrub of the family with a Palearctic distribution, associated with temperate and cold humid climates. It is widespread on the European continent; on the Iberian Peninsula it is located on Atlantic climate mountains and glacial relicts. In Portugal, we find scattered and interesting populations; however, the majority of them are threatened by climate change and wildfires.

Nanomaterials in Drug Delivery Applications.

The "magic bullet" concept paved the way for nanomaterials' development and innovation [...

Neuromuscular Impact of Acute Hypertrophic Resistance Loading with And Without Blood-Flow Restriction.

Exploring acute neuromuscular fatigue induced by different modalities of resistance exercise would help understand the adaptation subsequent to specific training programs. Therefore, we investigated the acute impact of high-intensity and low-intensity blood flow-restricted resistance exercise on the development of explosive torque throughout the torque-time curve. Seventeen healthy, young participants were included in a randomized, counterbalanced within-subjects design study, in which participants underwent two experimental conditions, separated by a 1-wk period.

FAMMO - Demonstration and evaluation of a framework for the multidisciplinary assessment of organisational maturity on business continuity.

Business Continuity Management (BCM) encompasses effective planning to respond to business interruptions and relaunch business in the short term. This study follows the Design Science Research methodology and proposes a framework to systematise Business Continuity Management and streamline the Business Continuity Plan (BCP) design and implementation. The framework defines metrics providing strategical guidance and assessment of the Business Continuity Management initiatives.

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway.

Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial function and favoring oxidative stress, the mechanisms remain unknown. Sirtuin 1 (SIRT1), peroxisome proliferators-activated receptor γ coactivator 1α (PGC-1α), and sirtuin 3 (SIRT3) are key regulators of mitochondrial function and inducers of antioxidant defenses.

Potentially Inappropriate Medication Prescribing in Older Adults According to EU(7)-Potentially Inappropriate Medication List: A Nationwide Study in Portugal.

Background: Portugal has among the highest rates of dependency among older adults in Europe. Older adults with aging-related comorbidities are prone to the use of potentially inappropriate medication (PIM).

Objective: The aim of this study was to analyze PIM prescriptions in older Portuguese adults, as well as the change rate of PIM prescriptions over time, and assess the geographical variability between the different regions of mainland Portugal.

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa.

A pharmaceutical vehicle based on lyophilized liposomes is proposed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. Liposomes made of egg phosphatidylcholine and cholesterol (7/3 molar ratio) were prepared and lyophilized in the presence of different additive mixtures with mucoadhesive and taste-masking properties. Palatability was assayed on healthy volunteers.

Modeling Gd Complexes for Molecular Dynamics Simulations: Toward a Rational Optimization of MRI Contrast Agents.

The correct parametrization of lanthanide complexes is of the utmost importance for their characterization using computational tools such as molecular dynamics simulations. This allows the optimization of their properties for a wide range of applications, including medical imaging. Here we present a systematic study to establish the best strategies for the correct parametrization of lanthanide complexes using [Gd(DOTA)] as a reference, which is used as a contrast agent in MRI.

Physiological Responses and Technical-Tactical Performance of Youth Basketball Players: A Brief Comparison between 3x3 and 5x5 Basketball.

This study aims to examine youth players' physiological responses and technical-tactical performance when playing simulated 3x3 and 5x5 basketball games. Fifteen well-trained male basketball players (16.6 ± 0.

Single-Step Self-Assembly of Zein-Honey-Chitosan Nanoparticles for Hydrophilic Drug Incorporation by Flash Nanoprecipitation.

Zein- and chitosan-based nanoparticles have been described as promising carrier systems for food, biomedical and pharmaceutical applications. However, the manufacture of size-controlled zein and chitosan particles is challenging. In this study, an adapted anti-solvent nanoprecipitation method was developed.

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties.

Nowadays, it is largely accepted that the daily intake of fruits, vegetables, herbal products and derivatives is an added value in promoting human health, given their capacity to counteract oxidative stress markers and suppress uncontrolled pro-inflammatory responses. Given that, natural-based products seem to be a promising strategy to attenuate, or even mitigate, the development of chronic diseases, such as diabetes, and to boost the immune system. Among fruits, cherries and blueberries are nutrient-dense fruits that have been a target of many studies and interest given their richness in phenolic compounds and notable biological potential.

The Effect of a Resistance Training, Detraining and Retraining Cycle on Postural Stability and Estimated Fall Risk in Institutionalized Older Persons: A 40-Week Intervention.

Physical inactivity and low levels of muscle strength can lead to the early development of sarcopenia and dynapenia, which may increase the number and risk of falls in the elderly population. Meanwhile, exercise programs can stop or even revert the loss of muscle mass, strength, power, and functional capacity and consequently decrease the risk of falls in older adults. However, there is a lack of studies investigating the effect of strengthening programs in octogenarians.