Advancing insights into psoriasis: from pathogenesis to current and emerging therapies.

Psoriasis is a chronic, immune-mediated skin disease, with Plaque Psoriasis being its most common form. It is characterized by well-defined red plaques with raised white crusts. While its pathogenesis remains complex, involving keratinocytes, inflammatory cells and both adaptive and innate immunity, studies have highlighted an association with genetic predisposition.

Shaping Training Load, Technical-Tactical Behaviour, and Well-Being in Football: A Systematic Review.

Football performance results from the dynamic interaction between physical, tactical, technical, and psychological dimensions-each of which also influences player well-being, recovery, and readiness. However, integrated monitoring approaches remain scarce, particularly in youth and sub-elite contexts. This systematic review screened 341 records from PubMed, Scopus, and Web of Science, with 46 studies meeting the inclusion criteria ( = 1763 players; age range: 13.

Quantification of Weekly External Load in Female Futsal Players: Considering Inter-Day and -Player Variability.

This study aimed to analyze weekly training external load and match demands in female futsal players. Eight players competing in the 2nd Division of Spain, were recruited. Training and match load data, including total, low- medium- high-intensity accelerations (ACC), decelerations (DEC), and changes of direction (COD) were recorded and analyzed considering total effective time.

Analysis of the effects of manipulating the space and number of players in small-sided games on the external load demands of futsal athletes in different age categories.

The study aim was to analyse the effects of manipulating the space and number of players in small-sided games on the external load demands of futsal athletes of different age categories. Fifty-six male futsal players from U15, U17, U19, and adult age categories participated. The study lasted 7 weeks.

Test-retest reliability and criterion validity of three self-report questionnaires for assessing physical activity levels in Brazilian military.

Background: This study aimed to examine the reliability and criterion validity of three physical activity questionnaires in Brazilian military soldiers.

Methods: A convenience sample of 109 male Air Force soldiers (18.86±0.

The Potential of Artificial Intelligence in Pharmaceutical Innovation: From Drug Discovery to Clinical Trials.

Artificial intelligence (AI) is a subfield of computer science focused on developing systems that can execute tasks traditionally associated with human intelligence. AI systems work through algorithms based on rules or instructions that enable the machine to make decisions. With the advancement of science, more sophisticated AI techniques, such as machine learning and deep learning, have been developed, allowing machines to learn from large amounts of data and improve their performance over time.

Identifying Optimal Pitch Training Load in Elite Soccer Players.

Background: There are no data in the literature regarding the optimal pitch training load (PTL) for elite soccer teams during congested seasons.

Objectives: This study had three goals: (1) identify whether there is an adaptation in match physical performance (MPP) in response to PTL throughout a congested season in elite soccer players; (2) identify whether MPP adaptation is specific to the coach's PTL philosophy; and (3) identify the optimal PTL for MPP during a congested season.

Method: Over two seasons, we collected data from 11,658 PTL sessions and 3068 MPP data from 54 elite male soccer players.

Tailored polymeric hydrogels for regenerative medicine and drug delivery: From material design to clinical applications.

Polymeric hydrogels are hydrophilic polymer networks capable of absorbing and retaining large amounts of water or biological fluids, making them highly suitable for biomedical applications. This manuscript presents a comprehensive overview of their fundamental properties, including swelling behavior, biocompatibility, biodegradability, mechanical strength, crosslinking density, and stimuli-responsiveness, which collectively determine their clinical performance. A variety of natural and synthetic polymers are explored in the design of hydrogels, each offering distinct advantages for specific biomedical uses.

Relationship Between Quality of Life, Level of Physical Activity, Physical Fitness, and Body Composition on the Academic Performance of High School Students in an Integrated Educational System.

Adolescence is a critical period for the development of physical and cognitive health. Understanding how lifestyle and physical health parameters relate to academic performance and quality of life may inform school-based interventions. This study aimed to evaluate the relationship between physical activity level (PAL), quality of life (QoL), physical fitness (PF), strength, speed and agility, body composition, and academic performance (AP) in high school students.

Rethinking Pharmaceutical Industry with Quality by Design: Application in Research, Development, Manufacturing, and Quality Assurance.

Quality by Design (QbD) is a transformative and systematic approach to developing top-tier pharmaceutical products, ushering in a departure from traditional trial-and-error methods toward a more science-based, risk-oriented, and holistic strategy. Central to QbD implementation is the meticulous development of formulations and manufacturing processes, consistently fulfilling predefined quality objectives. The core objective of QbD remains unwavering - to guarantee the steadfast alignment of the final pharmaceutical product with predetermined quality attributes, thereby mitigating batch-to-batch variations and potential recalls.

Phenolic Acids from Fruit By-Products as Therapeutic Agents for Metabolic Syndrome: A Review.

The cultivation and processing of fruits generate a wide range of by-products (e.g., pulp, seeds, pomace, leaves, and stems), which are often underutilized despite being rich sources of phenolic compounds with well-documented bioactive properties.

Advancing atherosclerosis treatment: Drug encapsulation nanosystems and synthetic HDL nanoparticles.

Atherosclerosis, characterized by plaque accumulation in arterial walls, remains a leading cause of cardiovascular disease. Current pharmacological treatments often lack efficacy in halting disease progression or addressing systemic complications. Nanotechnology offers promising solutions, including targeted drug delivery, enhanced bioavailability, and the ability to overcome biological barriers.

Unlocking the Potential of (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.

(), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. The unique potential combination of bioactive compounds present in , such as triterpenoids, polysaccharides, and peptides, has inspired interest in leveraging their therapeutic potential In recent years, the emerging field of nanotechnology has opened up new possibilities for using the remarkable properties of at the nanoscale. The main objective of this review is to explore the unique potential of in traditional and innovative therapies, particularly in cancer treatment, and to assess how nanotechnology-based strategies can enhance its therapeutic applications.

Training exercises, match demands, and variability in elite futsal.

Introduction: Understanding the physical demands of different training exercises is crucial for optimizing athlete performance. This study aims to compare high-intensity activities across different training exercises and official match-play scenarios. The analysis focuses on performance variations across training exercises and the variability observed within each format.

The Risk of Pediatric Overweight and Children's Objectively Measured Sedentary Behaviors and Physical Activity by Area of Residence.

: Research considering objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary behaviors (SB) and health outcomes among urban children has produced equivocal findings. Therefore, this study was designed (i) to compare MVPA and SB of urban and non-urban children and (ii) to analyze associations between the risk of overweight and MVPA of children by their degree of urbanization. : The sample comprised 389 children (195 girls) aged 6 to 10 years.

Chemical Characterization and Bioactivities of Sericin Extracted from Silkworm Cocoons from Two Regions of Portugal.

Sericin has been characterized as demonstrating a variety of bioactivities, establishing it as a valuable resource for biomedical and pharmaceutical applications. The diverse biological activities of sericin are likely linked to its unique biochemical composition and properties. This study aimed to assess the effect of origin, seasonality, and amino acid composition on the bioactivity of sericin samples from two Portuguese regions compared to commercial sericin.

The Impact of Parental Behaviors on Children's Lifestyle, Dietary Habits, Screen Time, Sleep Patterns, Mental Health, and BMI: A Scoping Review.

Background And Objectives: Childhood obesity and being overweight are influenced by the family environment, diet, sleep, and mental health, with parents playing a key role in shaping behaviors through routines and practices. Healthy parental habits can encourage positive outcomes, while poor routines and stress often lead to unhealthy weight gain. This study analyzed the impact of parental behaviors on children's lifestyles and habits, as well as the trend and intensity of the effect of these behaviors on different age groups.

The Influence of Game Intervals on Physical Performance Demands in Elite Futsal: Insights from Congested Periods.

The aims of this study were to analyze (1) the external match demands during a congested period (CP) (i.e., three games in eight days) and (2) the differences among games with two- or three-day intervals in professional futsal players.

Intranasal administration of antiseizure drugs using new formulation trends: one step closer to reach clinical trials.

Introduction: Although there are numerous options for epilepsy treatment, its effective control continues unsatisfactory. Thus, search for alternative therapeutic options to improve the efficacy/safety binomial of drugs becomes very attractive to investigate. In this context, intranasal administration of antiseizure drugs formulated on state-of-the-art nanosystems can be a promising strategy.

Low Birth Weight and Related Metabolic Risk Factors, Cardio-Respiratory Fitness and Physical Activity in Adolescents.

Background/objectives: The associations between low birth weight (LBW) and the aggregation of metabolic risk factors (MRF) in youth remain ambiguous. Thus, this study analysed the interrelationship among MRF, LBW, and behavioural factors in adolescents.

Methods: The sample of the present cross-sectional study comprised 491 youth (229 males, 262 females) aged 14-17 years.

The Printed Path to Healing: Advancing Wound Dressings through Additive Manufacturing.

Wound care challenges healthcare systems worldwide as traditional dressings often fall short in addressing the diverse and complex nature of wound healing. Given conventional treatments limitations, innovative alternatives are urgent. Additive manufacturing (AM) has emerged as a distinct and transformative approach for developing advanced wound dressings, offering unprecedented functionality and customization.

The impact of extract on pharmacokinetics of phenytoin in rats.

Epilepsy patients are at a higher risk of developing overweight and obesity. Given the thermogenic properties of (Guarana), this study aimed to evaluate a potential pharmacokinetic interaction between extract and phenytoin in rats. Two pharmacokinetic studies were developed with and phenytoin: a coadministration and a pre-treatment study.

Medication Management in Portuguese Long-Term Care Facilities: A Preliminary Cross-Sectional Study.

Background/objectives: Population ageing has been a pressing global issue for decades. Older adults, especially those residing in long-term care facilities (LTCFs), often experience frailty and polypharmacy, which can lead to negative clinical outcomes. In Portugal, LTCFs provide essential care for individuals aged 65 or older, offering temporary or permanent accommodation.

Editorial for the Special Issue: Pharmacokinetics of Orally Administered Drugs, 2nd Edition.

Oral administration of medicines has been the most common route for drug delivery as it is cost-effective and is convenient for patients [...