Chitosan-β-glycerophosphate thermogelling microneedles for transdermal contraceptive delivery of levonorgestrel.

This study presents the development of dissolving levonorgestrel-loaded microneedles (LMNs) incorporating a chitosan-β-glycerophosphate thermogelling system for sustained transdermal delivery of levonorgestrel (LNG) as a contraceptive. Polyvinylpyrrolidone K90 and Dextran 40 were included to enhance mechanical strength and controlled drug release. LMNs fabricated using poly dimethyl siloxane moulds exhibited uniform, sharp structures as confirmed by scanning electron microscopy.

Beyond the standard: a comprehensive review of innovative experimental models using Tenebrio molitor larvae.

Insects are considered as an alternative in vivo model for evaluating various biological activities. Among them, larvae stand out as experimental model due to the low economic value during maintenance, in addition to the low demand and easy handling. Tenebrio molitor larvae are receiving attention as alternative methods in determination of efficacy studies.

Amendment of biochar and thiourea-modified biochar to mitigate chromium bioavailability and toxicity by modulating oxidative stress system in Vigna radiata in chromium-contaminated agriculture soil.

Chromium (Cr) contamination in agricultural soil poses a significant threat to crop productivity and human health. However, strategies to reduce Cr bioavailability and transfer within the soil-plant system remain limited. The sole application of biochar or Thiourea has been reported to mitigate Cr-induced toxicity in plants.

Interface Engineering of NiS and Zeolitic Imidazolate Framework-67: Enhancing the Overall Electrochemical Water Splitting.

Recent progress on a metal-free and highly efficient electrocatalyst for the production of oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) during the water electrolysis process makes it highly suitable to produce clean and sustainable renewable hydrogen energy. The electrocatalyst of NiS/ZIF-67 composite prepared by a facile precipitation method and which exhibits excellent catalytic activity for overall OER and HER performances with a small Tafel slope (92.1 and 61.

Insecticidal potential of l-isoleucine, N-allyloxycarbonyl-, dodecyl ester from Actinokineospora fastidiosa against Plutella xylostella.

Insect pests like Plutella xylostella cause significant crop losses, and the overuse of synthetic pesticides has led to resistance and ecological imbalance. This study evaluated the insecticidal properties of 1-isoleucine, N-allyloxycarbonyl-, dodecyl ester, isolated from Actinokineospora fastidiosa. The compound showed strong antifeedant (89.

The soil microbiome enhances sesame growth and oil composition, and soil nutrients under saline conditions.

Soil salinity is a significant abiotic stress that restricts plant growth and agricultural productivity. Plant growth-promoting rhizobacteria (PGPR) offer an eco-friendly and sustainable strategy to mitigate the detrimental effects of salinity by enhancing nutrient availability and promoting plant development. In this study, twelve halophilic bacterial isolates were obtained from saline soils of coastal regions in India and screened for PGPR traits, including siderophore production, indole-3-acetic acid (IAA), hydrogen cyanide (HCN), ammonia production, exopolysaccharide (EPS), cellulase activity, and phosphate solubilization.

Green Synthesis of Copper Oxide Nanoparticles using Dolichandrone falcata (Wall.ex DC.) Seem. Leaf Extract and Assessment of Antioxidant, Antimicrobial, Anti-diabetic and Anticancer Potentials.

Phyto-synthesis of Copper Oxide Nanoparticles (CuO NPs) was carried out using Dolichandrone falcata leaves. The NPs were characterised using Ultraviolet-Visible spectroscopy (UV), UV-Vis diffuse reflectance spectroscopy (UV-DRS), X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and dynamic light scattering (DLS). The synthesised CuO NPs UV-Vis spectra revealed that a high absorption peak at 380 nm with optical band gap was 2.

Phyco-Fabricated Zinc Oxide Nanorods From Dictyota dichotoma Seaweed: A Promising Resource for Environmental and Biomedical Applications.

Nanorods (NRs) have extensive applicability across all scientific disciplines due to their distinctive size, varied shape, and elevated surface-to-volume ratio, which confer distinctive advantages. Nanorod substances are capable of solving nearly any difficulty in sciences. The advancement of nanotechnologies has led to the emergence of metallic or metal oxide nanoparticles as potentially exciting resources.

Eco-Friendly Synthesis of Silver Nanoparticles and Its Larvicidal Property Against Malaria, Filariasis, and Dengue Vectors.

The increasing resistance of mosquitoes to synthetic pesticides necessitates eco-friendly alternatives for vector control. This study presents the green synthesis of silver nanoparticles (Ag-NPs) using Aerva lanata flower extract and evaluates their larvicidal efficacy against Cx. quinquefasciatus, An.

Uranium Concentration in Drinking Water and the Age-dependent Radiation Exposure in Chengalpattu District of Tamil Nadu, India.

The current investigation involved collecting and analyzing groundwater samples from the Chengalpattu district in the state of Tamil Nadu. The content of uranium was determined using an LED fluorimeter. The uranium concentration exhibited a range of 0.

Correction: Biosynthesis of iron oxide nanoparticles (FeONPs) using (L.) Hallier f. leaf extract; Their antibacterial, antioxidant, anti-inflammatory, anticancer activity on against MCF-7 breast cancer cell lines and Photocatalytic degradation.

[This corrects the article DOI: 10.1007/s13205-025-04338-x.].

Stenotrophomonas pavanii AS1 and blue light synergistically enhance kinetin riboside biosynthesis and mercury tolerance in Oryza sativa.

This study delves into the biochemical mechanisms underpinning Stenotrophomonas pavanii AS1 (SPAS1) as a bioremediation candidate for mercury (Hg) reduction. SPAS1 synthesizes kinetin riboside (KR), augmenting the conversion of Hg to elemental Hg. Priming SPAS1 with blue light (BL) boosts Hg tolerance and reduction, likely through upregulated KR biosynthesis.

Synthesis of eggshells-based hydroxyapatite/Acacia nilotica gum-based polymer composite for biomedical applications.

The hydroxyapatite (HAp) with the chemical formula Ca₁₀(PO₄)₆(OH)₂ is derived from the eggshells as a calcium source through the co-precipitation method, has been repurposed into valuable biomaterials with a strong affinity for ion substitution, notably the Sm. Furthermore, the Acacia nilotica gum was utilized for the preparation of a composite, which is excellent in water solubility and composed of both amorphous (96.2 %) and crystalline (3.

Green Synthesis of ZrO Nanoparticles From Gardenia resinifera for Efficient Photocatalytic Methylene Blue Dye Degradation With Antimicrobial and Antioxidant Properties.

This study focuses on the green synthesis of zirconium oxide nanoparticles (ZrO NPs) using Gardenia resinifera leaf extract and evaluates their multifunctional applications. The synthesized ZrO nanoparticles (Gr-ZrO NPs) were characterized through various optical and structural analyses. UV-Vis spectroscopy showed peak absorbance at 294 and 404 nm.

Synergistic effects of imidacloprid on the Perionyx excavatus: Biomarker responses and gene expression profiles.

Imidacloprid, a widely used neonicotinoid insecticide, negatively impacts soil biota and harms the environment with long-term use. In this study, we aimed to evaluate the effects of imidacloprid on Perionyx excavatus, an indigenous earthworm species found in India. To evaluate the toxic effects of imidacloprid on earthworms, avoidance behavior, acute toxicity, chronic toxicity, oxidative damage, and functional gene expression patterns were measured.

Biosynthesis of iron oxide nanoparticles (FeONPs) using (L.) Hallier f. leaf extract; Their antibacterial, antioxidant, anti-inflammatory, anticancer activity on against MCF-7 breast cancer cell lines and Photocatalytic degradation.

The synthesis of iron oxide nanoparticles (FeONPs) by a recently developed green approach is very promising due to its non-toxic and environmentally friendly behavior. In this study, biosynthesis of FeONPs was prepared using leaf extract of plant with ferric chloride solution. They were characterized by UV-vis spectrum show a peak at 293 nm, confirming the presence of FeONPs.

Response surface methodology-based approach for enhanced C-Phycocyanin production from sp. for its potential as natural anticancer drug.

Unlabelled: The present study focuses mainly on the extraction of C-Phycocyanin (CPC) pigment from cyanobacteria, its optimization and evaluation of its radical scavenging and antiproliferative abilities. Optimization of the pigment production was conducted both experimentally and statistically by response surface methodology (RSM). Quadratic models were fitted to the responses obtained from the box-Behnken design (BBD), to examine the interactions among Carbon, Nitrogen, Phosphate, pH and Temperature, and their impact on pigment production.

Halophilic rhizobacteria promote growth, physiology and salinity tolerance in L. grown under salt stress.

Introduction: Salt stress is a major global issue that negatively affects plant growth and physiological processes. Plant growth-promoting rhizobacteria (PGPR) are known to alleviate salt stress and promote plant growth. This study aimed to isolate and characterize salt-tolerant PGPR from salinity-affected soils in Tamil Nadu, India, and assess their potential to enhance growth and salt tolerance in sesame ( L.

antimicrobial resistant pattern, plasmid profile and the survival of isolated from poultry sources.

1. Infections due to spp. significantly contribute to bacterial gastroenteritis worldwide.

Repercussions of the Calpain Cleavage-Related Missense Mutations in the Cytosolic Domains of Human Integrin-β Subunits on the Calpain-Integrin Signaling Axis.

Calpains, calcium-dependent cytosolic cysteine proteases, perform controlled proteolysis of their substrates for various cellular and physiological activities. In different cancers, missense mutations accumulate in the genes coding for the calpain cleavage sites in various calpain substrates termed as the calpain cleavage-related mutations (CCRMs). However, the impact of such CCRMs on the calpain-substrate interaction is yet to be explored.

Developmental and Neuroprotective Effects of α-Terpineol in MPTP-Induced Parkinsonism in Zebrafish Larvae.

Parkinson's disease (PD) is caused by dopaminergic neurodegeneration and α-synuclein aggregation. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), used to replicate PD symptoms, disrupts erythropoiesis, leading to anemia, potentially contributing to dopaminergic neurotoxin-induced developmental toxicity and further investigation into novel therapeutic approaches for reversing PD pathology is strongly advocated. The monoterpene α-terpineol (α-TPN) exhibits several pharmacological effects, including neuroprotection.

Exploring Antibacterial, Antioxidant, Cytotoxic Potential of Oscillatoria sp.-Derived Metabolites and Their Molecular Docking with Estrogen Receptor-α.

Anthropogenic activities have led to the accumulation of carcinogenic toxicants in the food chain, posing severe risks to both human and animal health. Bioactive molecules derived from terrestrial and aquatic systems offer promising solutions to various health challenges. Presently, the cyanobacterial metabolites from ethyl acetate extract of Oscillatoria sp.

Cyanocobalamin-loaded dissolving microneedles for enhanced transdermal delivery: development, characterization, and pharmacokinetic evaluation.

This study demonstrates cyanocobalamin-loaded dissolving microneedles (CNBL-MNs) as a minimally invasive transdermal solution for managing cyanocobalamin (CNBL) deficiency, offering an alternative to intramuscular injections and oral supplements. The CNBL-MNs were developed using biodegradable, water-soluble polymers such as polyvinylpyrrolidone K25, Dextran K40, and chitosan to ensure controlled and gradual release of the CNBL. The formulation's stability and integrity were assessed through FTIR and XRD analyses.

Arsenic Detoxification Using Arsenic-Resistant Bacteria Bacillus cereus SP21 and Bacillus toyonensis SP23: A Laboratory-Scale Study.

Groundwater is the most important source for drinking, cooking and other household purposes. Agriculture is also largely dependent on groundwater. In this study, arsenic was detoxified by microbial oxidation using arsenic-resistant bacteria (ARB) in synthetic water.