Relationship between vitamin D deficiency, vitamin D receptor gene variants, & the risk of coronary artery disease among South Indians: A case-control study.

Background & objectives Vitamin D deficiency (VDD) and variations in the vitamin D receptor (VDR) gene are implicated in the pathogenesis of coronary artery disease (CAD). This study investigated the association between VDD, VDR gene variants (ApaI, BsmI, FokI, and TaqI), and CAD risk among South Indians. Methods The case-control study was conducted in 250 CAD patients and 260 matched controls.

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis.

Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD) simulations to evaluate the potential of repurposing terfenadine and domperidone for inhibition of apoptotic gene associations in CRC. Network pharmacology analysis identified 4 principal targets-SLC6A4 (5I6X), DRD2 (7DFP), HTR2A (6WGT), and EGFR (6LUD)-involved in the apoptotic regulatory network.

A study on reflective factors of social media marketing activities and its influence on purchase intention of gen z.

Social Media Marketing Activities (SMMA) are crucial for a brand's identity. Generation Z is called digital natives as they have been exposed to the internet, social networks, and mobile systems from an early age. Driving intent to purchase for this target segment is crucial for brands.

Mutation studies on transmembrane protein sulphate permease for enhanced biohydrogen production in a molecular dynamics simulation approach.

Fossil fuel reserves are rapidly depleting, necessitating the need to find a promising alternative. Hydrogen is a clean and promising energy source with a significant energy yield and water as the only byproduct leading many to view it as a viable source of renewable energy. Despite traditional assessments for the techno-economic feasibility of biohydrogen not supporting its practical implementation, biologically produced hydrogen remains a more environmentally friendly and an efficient energy source.

Prevalence and Risk Factors of Diabetes Mellitus: A Community-Based WHO STEPwise Approach to Surveillance (STEPS) Survey in Rural Haryana, India.

Background: Non-communicable diseases (NCDs), including type 2 diabetes mellitus, are emerging as major health concerns across India. Diabetes, once considered a predominantly urban condition, is increasingly being reported from rural populations as well, reflecting broader lifestyle and epidemiological transitions. National reports highlight a growing prevalence of high blood glucose levels, particularly among adults, with a rising trend in both awareness and disease burden.

Prioritization of phytochemical isolation and characterization against HER2 as a breast cancer target based on chromatographic methods, DFT studies, 3D-QSAR analysis, and molecular docking simulations.

Cancer remains one of the leading causes of death globally. Over the past few decades, significant advancements in cancer diagnostics, prevention, and therapeutics have been achieved. However, developing effective treatments with minimal adverse effects remains the most critical challenge for the medical community.

Pharmacological Potential of Coriander Seeds: A Dual Action Agent Against LPS of (ATCC 27853) and an Epidermoid Carcinoma Cell Line.

Unlabelled: Antimicrobial resistance is gaining a strong foothold in the current healthcare scenario, where skin infections caused by resistant strains of bacteria such as are unresponsive to a majority of antibiotics. In light of this, there is a pressing need to develop novel strategies to control these pathogens. In this study, we aimed to investigate the antibacterial and antiproliferative activities of the bioactive compounds present in the methanolic extract of seeds.

Association of platelet ADP receptor variant rs1371097 with inadequate platelet response to aspirin in Indian patients.

Aim: On-aspirin platelet reactivity, wherein patients show sub-optimal or no response to antiplatelet therapy, occurs in 5-60% of subjects. The genetic etiology of such reactivity in patients with vascular diseases, especially ischemic stroke in the Indian population, is unknown. This study aimed to examine the genetic variations in the pathways of platelet aggregation and aspirin metabolism that could predict aspirin response.

Unlocking effective decision-making and critical thinking in orthopaedics: Insights from a narrative review.

Background: Clinical decision-making and critical thinking are vital in orthopaedic practice, directly impacting patient outcomes. Surgeons often face complex cases requiring both experience and systematic reasoning to ensure the best treatment approach. This review aims to explore the factors influencing decision-making in orthopaedics, focusing on the role of critical thinking in enhancing clinical choices.

A Hypergraph powered approach to Phenotype-driven Gene Prioritization and Rare Disease Prediction.

In the time of advancing medical technology, there is a critical issue concerning the misdiagnosis of diseases. The aim of this research is to significantly reduce the occurrence of misdiagnoses in medical practice by leveraging hypergraphs and genomic data to improve diagnostic accuracy. We have designed and implemented a sophisticated computational framework for phenotype-driven disease prediction that leverages hypergraphs and genomic data to enhance the accuracy of disease identification, leading to more precise and timely treatments for patients.

(Not so) voluntary hospitalization as part of Zolpidem-induced complex sleep behaviour: a case report.

Background: Since its approval 26 years ago, Zolpidem has been implicated in 61 cases of complex sleep behaviours (CSBs) reported to the US FDA. These cases typically describe activities such as eating, walking, cooking or driving while asleep after Zolpidem use. This report describes a unique presentation of Zolpidem-induced CSB.

Evaluation of student's performance on biopsychosocial model-Three-stage assessment using e-learning platform in a distant education program in family medicine.

Introduction: The three-stage assessment, which includes clinical, individual, and contextual assessment, is a person-centred clinical method (biopsychosocial model). This method can help students and clinicians to assess biopsychosocial factors of the patient in a systematic way.

Aim And Objective Of The Study: To assess student performance of 'three-stage assessment-patient centred care method' using a rubric among students enrolled for fellowship in family medicine program.

Generalized spatial modulation for underwater backscatter communication using acoustic metasurfaces.

Design of a long-range, high data-rate and ultra low power underwater communications system is crucial for a variety of applications. However, this task is challenging because of the underwater channel dynamics, propagation characteristics and power constraints. Recently, the concept of acoustic metasurfaces (AMS) has emerged as a promising solution in underwater communications, due to its ability to manipulate wave transmission and reflection.

Linking serum leptin and TSH among metabolic syndrome patients with and without hypothyroidism.

The comparison of thyroid profile and serum leptin levels among patients with metabolic syndrome who did not have hypothyroidism is of interest. Hence, we recruited 40 healthy controls and 80 patients with metabolic syndrome where 40 patients had hypothyroidism and 40 patients are without hypothyroidism. Blood sugar levels, thyroid profiles, lipid profiles and serum leptin levels were measured and compared between the metabolic syndrome and control groups.

Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study.

Unlabelled: Environmental pollutants including diesel soot, have been known to contribute to neurological disorders. Previous studies highlight the neuroprotective effects of strawberry-derived compounds. This work explores the impacts of diesel soot and strawberry extract in movement-related disorders.

Targeted metabolomics in children with autism spectrum disorder with and without developmental regression.

Early diagnosis and intervention in children with autism spectrum disorder (ASD) is crucial. At present, diagnosis of ASD is primarily based on subjective tools. Identifying metabolic biomarkers will aid in early diagnosis of ASD complementing the assessment tools.

Building the Future of Transportation: A Comprehensive Survey on AV Perception, Localization, and Mapping.

Autonomous vehicles (AVs) depend on perception, localization, and mapping to interpret their surroundings and navigate safely. This paper reviews existing methodologies and best practices in these domains, focusing on object detection, object tracking, localization techniques, and environmental mapping strategies. In the perception module, we analyze state-of-the-art object detection frameworks, such as You Only Look Once version 8 (YOLOv8), and object tracking algorithms like ByteTrack and BoT-SORT (Boosted SORT).

Advancing Diabetes Diagnosis in South India Using Artificial Intelligence: A Hub-and-Spoke Model for Early Intervention.

Diabetes mellitus, a non-communicable metabolic disorder, is a significant global health concern, with rising prevalence rates resulting in increased economic burdens on healthcare systems. Early detection and diagnosis are crucial for preventing severe complications. Artificial Intelligence (AI) offers immense potential to revolutionize diabetes management and early detection.

Retraction: High performance flexible supercapacitors based on secondary doped PEDOT-PSS-graphene nanocomposite films for large area solid state devices.

[This retracts the article DOI: 10.1039/D0RA01116A.].

Cubical and spherical directional array-based particle source detection with poisson statistics.

This paper investigates detecting a far-field dynamic particle source using cubical and spherical directional arrays. First, we present a discussion on likelihood ratio test (LRT), generalized LRT (GLRT) and truncated mean test (TMT) in case of a cubical array, considering scenarios with stationary and moving targets. Further, two underlying sub-cases are considered, including the sets of correlated and independent and identically distributed observations.

Effect of fabrication process parameters and graphene reinforcement on mechanical behaviour of additively manufactured AlSi10Mg alloy: A molecular dynamics simulation study.

Context: AlSi10Mg alloy is among the most widely recognised aluminium alloys due to its dimensional stability and exceptional properties for additive manufacturing. However, the alloy's performance can be improved and optimized through appropriate reinforcement and control of the manufacturing process parameters. This work focuses on the impact of process parameters (laser power, scan speed and layer thickness) and graphene reinforcement on the mechanical properties of SLM-fabricated AlSi10Mg alloy.

Fine-tuned deep learning models for early detection and classification of kidney conditions in CT imaging.

The kidney plays a vital role in maintaining homeostasis, but lifestyle factors and diseases can lead to kidney failures. Early detection of kidney disease is crucial for effective intervention, often challenging due to unnoticeable symptoms in the initial stages. Computed tomography (CT) imaging aids specialists in detecting various kidney conditions.