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The kidney plays a vital role in maintaining homeostasis, but lifestyle factors and diseases can lead to kidney failures. Early detection of kidney disease is crucial for effective intervention, often challenging due to unnoticeable symptoms in the initial stages. Computed tomography (CT) imaging aids specialists in detecting various kidney conditions. The research focuses on classifying CT images of cysts, normal states, stones, and tumors using a hyperparameter fine-tuned approach with convolutional neural networks (CNNs), VGG16, ResNet50, CNNAlexnet, and InceptionV3 transfer learning models. It introduces an innovative methodology that integrates finely tuned transfer learning, advanced image processing, and hyperparameter optimization to enhance the accuracy of kidney tumor classification. By applying these sophisticated techniques, the study aims to significantly improve diagnostic precision and reliability in identifying various kidney conditions, ultimately contributing to better patient outcomes in medical imaging. The methodology implements image-processing techniques to enhance classification accuracy. Feature maps are derived through data normalization and augmentation (zoom, rotation, shear, brightness adjustment, horizontal/vertical flip). Watershed segmentation and Otsu's binarization thresholding further refine the feature maps, which are optimized and combined using the relief method. Wide neural network classifiers are employed, achieving the highest accuracy of 99.96% across models. This performance positions the proposed approach as a high-performance solution for automatic and accurate kidney CT image classification, significantly advancing medical imaging and diagnostics. The research addresses the pressing need for early kidney disease detection using an innovative methodology, highlighting the proposed approach's capability to enhance medical imaging and diagnostic capabilities.
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http://dx.doi.org/10.1038/s41598-025-94905-2 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Nephrology Department, Unidade Local de Saúde de Braga, Braga, Portugal.
Introduction: Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) and is widely used in oncology for its anti-angiogenic properties. However, VEGF inhibition may result in significant nephrotoxicity, including thrombotic microangiopathy (TMA). While systemic TMA is well-described, isolated renal-limited TMA remains under recognised.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
September 2025
Department of Primary Health, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali, Republic of Rwanda.
Background: While psychological stress cannot be dissociated from chronic diseases, the extent to which it impacts the management of chronic diseases is poorly understood. This cross-sectional study investigated the prevalence and impact of psychological stress among Rwandan patients with chronic diseases, particularly hypertension, heart failure, malignancies, diabetes, and kidney failure.
Methods: This cross-sectional study was conducted among internal medicine patients receiving treatment for chronic diseases at the University Teaching Hospital of Kigali (n = 81) and the University Teaching Hospital of Butare (CHUB) (n = 78) between May 1 and June 30, 2024.
Front Pediatr
August 2025
Department of Rheumatology and Immunology, Tianjin Children's Hospital (Children's Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China.
Type 1 diabetes mellitus (T1DM) and systemic lupus erythematosus (SLE) are both autoimmune diseases influenced by multiple genetic and environmental factors, but rarely coexist. This case describes a 13-year-old girl with early onset of T1DM who was diagnosed with SLE 12 years later, highlighting diagnostic and therapeutic challenges, particularly in distinguishing kidney involvement and management without exacerbating hyperglycemia. The patient presented with edema of the eyelids and lower limbs.
View Article and Find Full Text PDFCase Rep Pediatr
September 2025
Department of Pediatrics, Nemours Children's Hospital Florida, Orlando, Florida, USA.
We describe the clinical presentation and evaluation of an 11-year-old girl with no reported past medical history, seen by her primary care physician for intermittent knee pain. Outpatient X-rays revealed findings concerning for rickets, prompting further evaluation with blood work. The patient was urgently referred to the emergency department due to abnormal laboratory results and was subsequently found to be in end-stage kidney disease with severe anemia, metabolic acidosis, and significant electrolyte abnormalities.
View Article and Find Full Text PDFMedComm (2020)
September 2025
Immunoglobulin A nephropathy (IgAN), the most prevalent primary glomerulonephritis globally, is characterized by mesangial IgA deposition and heterogeneous clinical trajectories. Historically, management relied on renin-angiotensin system inhibition and empirical immunosuppression, yet high lifetime kidney failure risk persists despite optimized care. This review synthesizes advances in molecular pathogenesis, highlighting how the traditional multi-hit hypothesis-while foundational for targeted therapy development-fails to capture IgAN's recurrent, self-amplifying nature.
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