Robotic upper urinary tract reconstruction for ureteral stricture: a single-center series.

The surgical approach of ureteral stricture has changed dramatically over the past 15 years with the rise of robotic upper urinary tract reconstruction. This study aimed to evaluate the outcomes of all robotic ureteral reconstructions performed at a single academic center for ureteral stricture and to assess the predictive factors of stricture recurrence. The charts of all patients who underwent robot-assisted ureteral reconstruction between 2013 and 2024 at a single academic center were retrospectively reviewed.

Most Roads Lead to Cushing: Mapping Neurosurgical Training Lineages in the United States.

Objective: Mentorship and training relationships shape the careers and influence of neurosurgeons. Network analysis can reveal structural characteristics and key individuals who support network connectivity and drive the field's development. This endeavor analyzed the US-based neurosurgical training network derived from NeurosurGen.

Trends In Reported Outcomes For Growth Hormone Therapy In Children With Growth Hormone Deficiency.

Objective: To understand the frequency and trends in reported outcomes of safety and effectiveness for recombinant human growth hormone (rhGH) therapy for growth hormone deficiency (GHD) in childhood.

Methods: A systematic review was performed in seven English and Chinese language databases. Eligibility criteria included all studies published between 2003 and 2022, with participants who started rhGH before the age of 16 years for GHD.

Slimming the risks: GLP-1 receptor agonist therapy may reduce in-hospital complications and hospital readmissions rates for hip fractures compared to obese patients not on these medications.

Introduction: To evaluate the impact of prolonged GLP-1 usage on mortality, readmission, incidence of in-hospital complications, and incidence of implant failure following hip fracture surgery across various BMI strata.

Methods: A prospective hip fracture registry (2014-2024) at a single institution was used to identify 58 obese patients on prolonged GLP-1 therapy at the time of injury. These patients (Group A) were matched by age, fracture pattern, and comorbidity burden to BMI-based control cohorts: normal (Group B), overweight (Group C), and obese (Group D).

TNG260 is a Small-Molecule CoREST Inhibitor that Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.

Non-small cell lung cancer (NSCLC) patients with loss of the tumor suppressor gene STK11 are resistant to immune checkpoint therapies like anti-PD-1. Here, we conducted an in vivo CRISPR screen that identified HDAC1 as a target to reverse anti-PD-1 resistance driven by loss of STK11 and developed TNG260, a potent small-molecule inhibitor of the CoREST complex with selectivity exceeding previously generated inhibitors in this class in preclinical studies. Treatment with TNG260 led to increased expression of immunomodulatory genes in STK11-deficient cancer cells.

Tricuspid valve replacement outcomes by baseline tricuspid regurgitation severity: the TRISCEND II trial.

Background And Aims: The TRISCEND II trial demonstrated superior clinical benefits for patients with ≥severe tricuspid regurgitation (TR) treated with the EVOQUE transcatheter tricuspid valve replacement (TTVR) system plus medical therapy versus medical therapy alone. This work reports 1-year and 18-month outcomes in patients stratified by baseline TR severity.

Methods: The multicentre, prospective TRISCEND II trial enrolled 400 patients with symptomatic, ≥severe TR and randomised 2:1 to TTVR (n=267) or control (n=133).

Guidelines From the American Society of Pain and Neuroscience for Using Artificial Intelligence in Interventional Spine and Nerve Treatment.

Introduction: Artificial intelligence (AI) is rapidly evolving and becoming more ubiquitous. Significant advancements have been made in the last few years, driving rapidly increasing adoption. The scale of publications on AI makes it difficult to keep abreast of relevant findings.

Availability, Reading Level, Quality, and Accessibility of Cancer Center Smoking Cessation Materials.

Smoking cessation following a cancer diagnosis is associated with improved outcomes, including reduced overall mortality. We searched the websites of 64 National Cancer Institute designated cancer centers that provide clinical cancer care to adults for webpages about smoking cessation and assessed the quality of the available content. 35 of 64 (55%) websites hosted smoking cessation-focused webpages.

Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.

Neurons stabilize their physiological properties in part by homeostatic compensation between different ion channel conductances. However, little is known about this process in the central brain in vivo. We studied this problem in Kenyon cells, the third-order olfactory neurons in the fruit fly Drosophila that store olfactory associative memories.

Transcatheter Aortic Valve Replacement Waitlist Failure - Correlation with Cardiac Damage Stage.

Background: While waitlists for Transcatheter aortic valve replacement (TAVR) are increasingly growing, universal criteria for prioritizing candidates are lacking, and some patients experience adverse events while awaiting the procedure. Aortic stenosis (AS)-related cardiac damage (CD) staging provides an echocardiographic framework for assessing structural CD in AS patients. We aimed to assess the correlation between CD staging and AS-related adverse events in patients awaiting TAVR.

Robotic Sleeve Gastrectomy Is as Safe as Laparoscopic Sleeve Gastrectomy.

Introduction: Robotic sleeve gastrectomy (RSG) is increasingly used in bariatric surgery, but its safety compared to laparoscopic sleeve gastrectomy (LSG) remains debated.

Methods: We retrospectively reviewed electronic medical records of 927 (575 RSG, 352 LSG) patients at a single academic center from June 2021 to August 2023. The baseline and operative characteristics of the study groups were compared using two-sample t tests, Wilcoxon rank-sum tests, chi-square tests, and Fisher's exact tests.

Safety of Apnea Testing in Pregnant Persons Undergoing Evaluation for Brain Death/Death by Neurologic Criteria.

Brain death, or death by neurologic criteria (BD/DNC), is the permanent loss of brain function, defined by coma with loss of capacity for consciousness and complete brainstem areflexia, including the inability to breathe spontaneously. The 2023 American Academy of Neurology/American Academy of Pediatrics/Child Neurology Society (CNS)/Society for Critical Care Medicine guidelines state that pregnancy is not a contraindication for BD/DNC evaluation. Clinical evaluation of BD/DNC includes an apnea test to demonstrate the absence of spontaneous respiratory effort in response to hypercapnia and acidosis.

Long-Term Follow-Up of Left Atrial Appendage Exclusion: Results of the V-CLIP Multi-Center Post-Market Study.

: Cardiac surgery patients with pre- or post-operative atrial fibrillation are at an increased risk for thromboembolic stroke, often due left atrial appendage (LAA) thrombus. Surgical LAA exclusion (LAAE) can be performed and must be complete to avoid increased thrombus formation. : This prospective, multi-center, post-market study (NCT05101993) evaluated the long-term safety and performance of the epicardial V-shape AtriClip device.

Evaluating Hospital Course Summarization by an Electronic Health Record-Based Large Language Model.

Importance: Hospital course (HC) summarization represents an increasingly onerous discharge summary component for physicians. Literature supports large language models (LLMs) for HC summarization, but whether physicians can effectively partner with electronic health record-embedded LLMs to draft HCs is unknown.

Objectives: To compare the editing effort required by time-constrained resident physicians to improve LLM- vs physician-generated HCs toward a novel 4Cs (complete, concise, cohesive, and confabulation-free) HC.

High-resolution quantitative T mapping of the human brain at 7 T using a multi-echo spin-echo sequence and dictionary-based modeling.

Quantitative mapping offers a unique contrast for detailed brain imaging. At ultra-high field strengths (7 T), the higher signal-to-noise ratio (SNR) enables higher spatial resolution and the delineation of smaller structures. The translation of multi-echo spin-echo-based acquisitions to higher field strength, however, is complicated by inhomogeneities in the radio frequency (RF) transmit field resulting in stronger stimulated echoes and multi-echo refocusing pathways.

Improved myelin water imaging using B correction and data-driven global feature extraction: Application on people with MS.

The predominant technique for quantifying myelin content in the white matter is multicompartment analysis of MRI's Trelaxation times ( analysis). The process of resolving the Tspectrum at each voxel, however, is highly ill-posed and remarkably susceptible to noise and to inhomogeneities of the transmit field ( ). To address these challenges, we employ a preprocessing stage wherein a spatially global data-driven analysis of the tissue is performed to identify a set of mcTconfigurations () that best describe the tissue under investigation, followed by using this basis set to analyze the signal in each voxel.

Dietary Inflammatory Potential and the Risk of Incident Kidney Failure in the Women's Health Initiative.

Key Points: A pro-inflammatory diet was associated with a higher risk of incident kidney failure. Clinical trials should assess the impact of an anti-inflammatory dietary pattern on CKD risk and progression.

Background: Diet affects inflammation and kidney health, but few studies have investigated dietary inflammatory potential in CKD progression, particularly in women.

Exploring the Influence of Dorsal Root Ganglion Stimulation on Sleep Behavior in Patients With Chronic Pain.

Introduction: Chronic pain is associated with sleep disturbances, with >70% of patients reporting clinically significant insomnia. Although dorsal root ganglion stimulation (DRGS) is an established therapy for focal neuropathic pain, its impact on sleep has not been well characterized. This study evaluated changes in patient-reported insomnia after DRGS and examined associations among sleep, pain, and functional outcomes.

Antiphospholipid antibody-related clinical manifestations during childhood versus adulthood: descriptive results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) clinical database and repository.

Objectives: There is a limited number of studies comparing paediatric to adult antiphospholipid syndrome (APS) patients. Our objective was to analyse the characteristics of patients presenting with antiphospholipid antibody (aPL)-related clinical manifestations during childhood versus adulthood.

Methods: We retrieved baseline characteristics from an international registry of persistently aPL-positive adult patients.

Measuring long-term psychiatric outcomes in post-acute autoimmune encephalitis.

Purpose: To compare the performance of different measures of long-term psychiatric outcomes in patients with post-acute autoimmune encephalitis (AE) who may require comprehensive psychiatric evaluation.

Methods: The sensitivity of three self-reported measures of mood and anxiety symptoms (Patient Health Questionnaire [PHQ-9]; Profiles of Mood States-2 [POMS-2]; Generalized Anxiety Disorder 7-item [GAD7]) was compared with a structured clinician-administered tool (Mini Neuropsychiatric Inventory 7.0.

Triceps-sparing versus triceps-splitting approaches for OTA 12A-C and 13A2-3 distal-third humeral shaft fractures have similar 1 year functional outcomes.

Purpose: To compare functional outcomes of distal third humeral shaft fractures (OTA 12A-C and 13A2-3) treated with either triceps-splitting or triceps-sparing surgical approach. Secondarily, the purpose was to compare healing and complication rates between the two surgical approaches.

Method: A retrospective review of a prospectively collected humeral shaft registry was performed from 01/2018-12/2024.