Availability, Reading Level, Quality, and Accessibility of Cancer Center Smoking Cessation Materials.

Unlabelled: Smoking cessation following a cancer diagnosis is associated with improved outcomes, including reduced overall mortality. We searched the websites of 64 NCI-designated cancer centers that provide clinical cancer care to adults for webpages about smoking cessation and assessed the quality of the available content. Thirty-five of 64 (55%) websites hosted smoking cessation-focused webpages.

Availability, Reading Level, Quality, and Accessibility of Cancer Center Smoking Cessation Materials.

Smoking cessation following a cancer diagnosis is associated with improved outcomes, including reduced overall mortality. We searched the websites of 64 National Cancer Institute designated cancer centers that provide clinical cancer care to adults for webpages about smoking cessation and assessed the quality of the available content. 35 of 64 (55%) websites hosted smoking cessation-focused webpages.

Multifaceted perspectives of detecting and targeting solid tumors.

Solid tumors are the most prevalent form of cancer. Considerable technological and medical advancements had been achieved for the diagnosis of the disease. However, detection of the disease in an early stage is of utmost importance, still far from reality.

The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.

The Drosophila Id gene extramacrochaetae (emc) is required during Drosophila eye development for proper cell fate specification within the R7 equivalence group. Without emc, R7 cells develop like R1/6 cells, and there are delays and deficits in differentiation of non-neuronal cone cells. Although emc encodes an Inhibitor of DNA-binding (Id) protein that is known to antagonize proneural bHLH protein function, no proneural gene is known for R7 or cone cell fates.

Students' and tutors' experiences of remote 'student-patient' consultations.

Background: Remote consulting has become part of the medical student clinical experience in primary care, but little research exists regarding the impact on learning.

Aim: To describe the experiences of General Practitioner (GP) educators and medical students in using student-led remote consultations as an educational tool.

Method: A qualitative, explorative study conducted at four UK medical schools.

Cross-Feeding and Enzymatic Catabolism for Mannan-Oligosaccharide Utilization by the Butyrate-Producing Gut Bacterium A2-183.

β-Mannan is abundant in the human diet and in hemicellulose derived from softwood. Linear or galactose-substituted β-mannan-oligosaccharides (MOS/GMOSs) derived from β-mannan are considered emerging prebiotics that could stimulate health-associated gut microbiota. However, the underlying mechanisms are not yet resolved.

Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase.

During meiosis, recombination between homologous chromosomes (homologs) generates crossovers that promote proper segregation at the first meiotic division. Recombination is initiated by Spo11-catalyzed DNA double strand breaks (DSBs). 5' end resection of the DSBs creates 3' single strand tails that two recombinases, Rad51 and Dmc1, bind to form presynaptic filaments that search for homology, mediate strand invasion and generate displacement loops (D-loops).

Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification.

Homeobox genes are prominent regulators of neuronal identity, but the extent to which their function has been probed in animal nervous systems remains limited. In the nematode Caenorhabditis elegans, each individual neuron class is defined by the expression of unique combinations of homeobox genes, prompting the question of whether each neuron class indeed requires a homeobox gene for its proper identity specification. We present here progress in addressing this question by extending previous mutant analysis of homeobox gene family members and describing multiple examples of homeobox gene function in different parts of the C.

Fractal Dimension-Based Infection Detection in Chest X-ray Images.

The current ongoing trend of dimension detection of medical images is one of the challenging areas which facilitates several improvements in accurate measuring of clinical imaging based on fractal dimension detection methodologies. For medical diagnosis of any infection, detection of dimension is one of the major challenges due to the fractal shape of the medical object. Significantly improved outcome indicates that the performance of fractal dimension detection techniques is better than that of other state-of-the-art methods to extract diagnostically significant information from clinical image.

Enzymatic Conversion of Different Qualities of Refined Softwood Hemicellulose Recovered from Spent Sulfite Liquor.

Spent sulfite liquor (SSL) from softwood processing is rich in hemicellulose (acetyl galactoglucomannan, AcGGM), lignin, and lignin-derived compounds. We investigated the effect of sequential AcGGM purification on the enzymatic bioconversion of AcGGM. SSL was processed through three consecutive purification steps (membrane filtration, precipitation, and adsorption) to obtain AcGGM with increasing purity.

Rapid Automated Analysis of Skull Base Tumor Specimens Using Intraoperative Optical Imaging and Artificial Intelligence.

Background: Accurate specimen analysis of skull base tumors is essential for providing personalized surgical treatment strategies. Intraoperative specimen interpretation can be challenging because of the wide range of skull base pathologies and lack of intraoperative pathology resources.

Objective: To develop an independent and parallel intraoperative workflow that can provide rapid and accurate skull base tumor specimen analysis using label-free optical imaging and artificial intelligence.

Patient and general public attitudes towards clinical artificial intelligence: a mixed methods systematic review.

Artificial intelligence (AI) promises to change health care, with some studies showing proof of concept of a provider-level performance in various medical specialties. However, there are many barriers to implementing AI, including patient acceptance and understanding of AI. Patients' attitudes toward AI are not well understood.

The Prop1-like homeobox gene specifies the identity of synaptically connected neurons.

Many neuronal identity regulators are expressed in distinct populations of cells in the nervous system, but their function is often analyzed only in specific isolated cellular contexts, thereby potentially leaving overarching themes in gene function undiscovered. We show here that the Prop1-like homeobox gene is expressed in 15 distinct sensory, inter- and motor neuron classes throughout the entire nervous system. Strikingly, all 15 neuron classes expressing are synaptically interconnected, prompting us to investigate whether controls the functional properties of this circuit and perhaps also the assembly of these neurons into functional circuitry.

DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling.

Many cell types display the remarkable ability to alter their cellular phenotype in response to specific external or internal signals. Such phenotypic plasticity is apparent in the nematode Caenorhabditis elegans when adverse environmental conditions trigger entry into the dauer diapause stage. This entry is accompanied by structural, molecular, and functional remodeling of a number of distinct tissue types of the animal, including its nervous system.

TLC bioautography-guided isolation of essential oil components of cinnamon and clove and assessment of their antimicrobial and antioxidant potential in combination.

This study aimed to evaluate possible synergistic interactions on antimicrobial and antioxidant efficacy of clove and cinnamon oil components in combination and characterization of compounds responsible for synergistic interactions using TLC bioautography followed by checkerboard titration, isobologram analysis, and spectrometric characterization. Among the combinations tested, cinnamaldehyde from cinnamon oil and eugenol from clove oil in combination showed a synergistic antimicrobial interaction against foodborne microbes Listeria monocytogenes (fractional inhibitory concentration index (FICI): 0.31), Salmonella typhimurium (FICI: 0.

Expansion microscopy of .

We recently developed expansion microscopy (ExM), which achieves nanoscale-precise imaging of specimens at ~70 nm resolution (with ~4.5x linear expansion) by isotropic swelling of chemically processed, hydrogel-embedded tissue. ExM of is challenged by its cuticle, which is stiff and impermeable to antibodies.

A surface-exposed GH26 β-mannanase from : Structure, role, and phylogenetic analysis of Man26B.

The galactomannan utilization locus (ManPUL) of the human gut bacterium encodes Man26B, a cell-surface-exposed endomannanase whose functional and structural features have been unclear. Our study now places Man26B in context with related enzymes and reveals the structural basis for its specificity. Man26B prefers longer substrates and is less restricted by galactose side-groups than the mannanase Man26A of the same locus.

Plasticity of the Electrical Connectome of C. elegans.

The specific patterns and functional properties of electrical synapses of a nervous system are defined by the neuron-specific complement of electrical synapse constituents. We systematically examined the molecular composition of the electrical connectome of the nematode C. elegans through a genome- and nervous-system-wide analysis of the expression patterns of the invertebrate electrical synapse constituents, the innexins.

The Notch pathway regulates the Second Mitotic Wave cell cycle independently of bHLH proteins.

Notch regulates both neurogenesis and cell cycle activity to coordinate precursor cell generation in the differentiating Drosophila eye. Mosaic analysis with mitotic clones mutant for Notch components was used to identify the pathway of Notch signaling that regulates the cell cycle in the Second Mitotic Wave. Although S phase entry depends on Notch signaling and on the transcription factor Su(H), the transcriptional co-activator Mam and the bHLH repressor genes of the E(spl)-Complex were not essential, although these are Su(H) coactivators and targets during the regulation of neurogenesis.

Nitric oxide sensing by chlorophyll a.

Nitric oxide (NO) acts as a signalling molecule that has direct and indirect regulatory roles in various functional processes in biology, though in plant kingdom its role is relatively unexplored. One reason for this is the fact that sensing of NO is always challenging. There are very few probes that can classify the different NO species.

Precision Diagnosis Of Melanoma And Other Skin Lesions From Digital Images.

Melanoma will affect an estimated 73,000 new cases this year and result in 9,000 deaths, yet precise diagnosis remains a serious problem. Without early detection and preventative care, melanoma can quickly spread to become fatal (Stage IV 5-year survival rate is 20-10%) from a once localized skin lesion (Stage IA 5- year survival rate is 97%). There is no biomarker for melanoma in clinical use, and the current diagnostic criteria for skin lesions remains subjective and imprecise.