Perioperative Evaluation and Risk Stratification of the Elderly Patient Undergoing Vascular Intervention.

The surgical management of elderly patients has become increasingly important as the population ages in the U.S. and globally, and the incidence of cardiovascular risk factors continues to rise.

Coverage of dissociation and related concepts in psychiatric-mental health nursing textbooks.

Purpose: Nurses and nurse educators perceive a lack of knowledge, education, training, and educational materials related to dissociative disorders (DDs) and dissociative symptoms. Additionally, nurses and nurse educators report bias around the teaching of these concepts. Previous research on undergraduate psychopathology textbooks indicated insufficient and inaccurate coverage of dissociation and related concepts, but no such studies had been conducted within the profession of nursing.

Galectin-10 Silencing Reduces Eosinophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps by Inhibiting the p38/MAPK/NF-κB Pathway.

Galectin-10(Gal-10)/CLC(Charcot-Leyden crystal) has been discovered to be related to ECRSwNP characterized by high eosinophilic infiltration. We aimed to investigate the effects of Gal-10 on ECRSwNP. A total of 36 tissue samples were collected, including 11 ECRSwNP samples, 15 non-ECRSwNP samples, and 10 Control samples.

Age-related differences in the step-to-step control of foot placement during prolonged walking.

Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.

Pay-It-Forward 23-Valent Pneumococcal Polysaccharide Vaccination Among Older Adults: Protocol for a Randomized Controlled Trial.

Background: The 23-valent pneumococcal polysaccharide vaccine reduces the risk of pneumonia among adults by 38% to 46%. However, only a few older adults in resource-limited areas of China have received the pneumococcal vaccination. Pay-it-forward is a social innovation that offers participants free or subsidized health services and a community-engaged message, with an opportunity to donate to support subsequent recipients.

Minimally Invasive vs Open Surgery for Thoracolumbar Fractures in Patients With Ankylosing Spinal Diseases: A Meta-Analysis.

Background: Surgical management of thoracolumbar fractures in patients with ankylosing spinal disorders such as ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis remains debated. Although several studies have compared minimally invasive surgery to open fixation of thoracolumbar fractures in this patient population, a meta-analysis compiling the literature on this topic is lacking.

Methods: Following the PRISMA guidelines, PubMed, Cochrane, and Google Scholar (pages 1 to 20) were accessed and explored until October 2024.

Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report.

Purpose: To examine associations between special education, chronic health conditions (CHCs), and college graduation in survivors of childhood cancer and their siblings.

Methods: Childhood Cancer Survivor Study participants included 23,082 5-year survivors (53.7% male; median [IQR] age at diagnosis, 6 [3-13] years; age at evaluation, 31.

An Exploratory Study of the Impact of Hearing Handicap on Listening Fatigue During Health Care Encounters Among Older Adults.

Purpose: This exploratory study examined if hearing handicap in older adults affected listening-related fatigue during health care interactions and explored whether different face mask types worn during the coronavirus disease 2019 (COVID-19) pandemic influenced this association.

Method: A cross-sectional observational study among community-dwelling adults aged 60 years and older receiving care at an academic health care system outpatient audiology or otolaryngology clinics was conducted. Eligible participants completed and returned a mail-in self-reported packet including the Hearing Handicap Inventory for the Elderly (Screener Version; HHIE-S) and the 10-item Vanderbilt Fatigue Scale for Adults (VFS-A-10).

A 5-Step Simplification of the Fisher Anatomical Subunit Cleft Lip Repair.

Unilateral cleft lip repair methods have evolved from straight-line repairs to geometric procedures, rotation-advancement, and contemporary hybrid techniques. The Fisher anatomical subunit repair is a versatile, effective, and highly reproducible technique. It utilizes mathematical precision in design, avoids multi-point closure, minimizes scar burden, and does not compromise horizontal lip length for vertical height in various deformities.

P-Doped Cu-N-C Single-Atom Catalysts Boost Cathodic Electrochemiluminescence of Luminol for MicroRNA-320d Detection.

Compared with efficient anodic luminol electrochemiluminescence (ECL), the disadvantage of cathodic ECL is that luminol cannot be electrochemically oxidized in a direct manner, and the conversion efficiency of dissolved oxygen (DO) as the coreactant to reactive oxygen species (ROS) is poor, which limits its application. Therefore, it is necessary to develop a functional catalyst suitable for the luminol-DO ECL system to directly trigger cathodic ECL. In this study, a coordination microenvironment modulation strategy was proposed.

Different sources and dosages of zinc oxide and copper influence growth performance and intestinal health of post-weaning piglets.

In pig production, weaning is a critical period where piglets face several environmental stressors. This transition leads to a significant growth reduction and can result in digestive disorders, including diarrhea. To formulate a feed that meets zinc (Zn) and copper (Cu) requirements during the weaning period while minimizing their release into the environment, it became evident that a more bioavailable micro-mineral supplement is necessary.

Impact of Intersecting Identities on Student Well-being.

John is a 12-year-old African-American boy with a Specific Learning Disorder in Reading and Generalized Anxiety Disorder who you are seeing in follow-up at your clinic. Last fall, when John was having an escalation of his anxiety symptoms at school, he enacted the behavior intervention plan (BIP) that had been previously established by his educational team of informing his teacher that he needed to leave the classroom. He then paced the hallway outside of his classroom as a method of coping with the anxiety that he was experiencing.

Perioperative Management of Carotid Blowout Syndrome After Head and Neck Cancer Treatment: A Retrospective Case Series.

Background: Carotid blowout syndrome (CBS) is a life-threatening emergency involving the rupture of the carotid arteries and/or branches, often following surgery and radiotherapy for head and neck cancer. Our case series aimed to describe airway management strategies, endovascular and surgical approaches, perioperative resuscitation management, and clinical outcomes in a cohort of patients with CBS at a tertiary referral academic health center.

Methods: We retrospectively identified patients presenting with CBS between 2017 and 2021.

Reproducibility of fixed-node diffusion Monte Carlo across diverse community codes: The case of water-methane dimer.

Fixed-node diffusion quantum Monte Carlo (FN-DMC) is a widely trusted many-body method for solving the Schrödinger equation, known for its reliable predictions of material and molecular properties. Furthermore, its excellent scalability with system complexity and near-perfect utilization of computational power make FN-DMC ideally positioned to leverage new advances in computing to address increasingly complex scientific problems. Even though the method is widely used as a computational gold standard, reproducibility across the numerous FN-DMC code implementations has yet to be demonstrated.

Lanthanum-Induced Gradient Fields in Asymmetric Heterointerface Catalysts for Enhanced Oxygen Electrocatalysis.

Metal-nitrogen-carbon (M-N-C) catalysts display considerable potential as cost-effective alternatives to noble metals in oxygen electrocatalysis. However, uncontrolled atomic migration and random structural rearrangement during pyrolysis often lead to disordered coordination environments and sparse active sites, fundamentally limiting their intrinsic catalytic activities and long-term durability. Herein, a novel strategy is reported for use in directionally regulating atomic migration pathways via the incorporation of a foreign metal (La).

Understanding Radiographic Parameters in Cervical Deformity.

Study Design: Narrative review.

Objective: To synthesize current knowledge on radiographic parameters, classification systems, and compensatory mechanisms essential to the diagnosis and surgical planning of cervical spine deformity (CD) correction.

Summary Of Background Data: CD encompasses a heterogeneous set of conditions associated with neurological impairment and impaired health-related quality of life.

Curvature-Directed Patch Formation on Gold Nanocubes by Thermally Induced Polymer Redistribution.

Patchy nanoparticles (NPs) enable directional interactions and dynamic structural transformations, yet controlling polymeric patch formation with high spatial precision remains a significant challenge. Here, a thermally driven approach is presented to forming polystyrene (PS) patches on low-curvature facets of anisotropic gold nanocubes (NCs) using a single polymer component. Heating in DMF above 90 °C triggers selective desorption of PS chains from high-curvature edges and vertices via Au─S bond dissociation, followed by migration and deposition into rounded patches on flat surfaces.

Electroacupuncture Improves Myocardial Fibrosis in Association With Intestinal Flora and Metabolic Modulation in Mice.

This study investigates the reparative effect of electroacupuncture on myocardial fibrosis (MF) in mice and explores its impact on intestinal flora and metabolism profile. This examines an investigation into the biological mechanisms underlying electroacupuncture's efficacy in treating MF in mice. Twenty-four male Kunming mice (27-34 g) were randomized into three groups: normal control (NC,  = 8), MF model (MF,  = 8), and electroacupuncture treatment (EA,  = 8).

Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023.

Annually, millions of humans and animals suffer from chronic and acute pain, creating welfare and quality of life concerns for both humans and animals who suffer this pain. In developing new therapeutic approaches, the challenge is to accurately measure this pain to ascertain the efficacy of novel therapeutics. Additionally, there is a need to develop new and effective analgesic options that may offer alternatives to using opioids that contribute to the opioid epidemic.

Ethical Behavior Analysis in the Age of Artificial Intelligence (AI): The Importance of Understanding Model Building while Formal AI Literacy Curricula are Developed.

Ethics is fundamentally concerned with claims of "right," "wrong," "good," "bad," and how we might know those claims are accurate. Artificial intelligence (AI) is a term that represents a suite of tools where nonbiological systems process data and information to generate an output considered "intelligent." As with any suite of technologies, choosing the right tool requires the tool user to critically evaluate which tool is best for the task (if one exists).

Retinal Layer Thickness and Volume Measurements in Traumatic Brain Injury.

To assess retinal layer thickness and volume by optical coherence tomography (OCT) in patients with prior traumatic brain injury (TBI). Adults (≥18 years) with prior TBI were prospectively recruited. 512 × 128-mm macular cube scans were obtained using Zeiss Cirrus HD-5000 OCT.

Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.

Background & Aims: Previous studies showed that combination treatment with short interfering RNA JNJ-73763989 (JNJ-3989) ± capsid assembly modulator bersacapavir (JNJ-56136379) and nucleos(t)ide analogs (NAs) was well tolerated by patients with chronic HBV (CHB), with JNJ-3989 dose-dependent reductions in viral markers, including HBsAg. The open-label, single-arm phase IIa PENGUIN study (NCT04667104) evaluated this regimen plus pegylated interferon alpha-2a (PegIFN-α2a) in patients with virologically suppressed CHB.

Methods: Patients who were either HBeAg-positive or -negative virologically suppressed and taking NAs were included; all received JNJ-3989 ± bersacapavir for 24 weeks (some either did not start or discontinued bersacapavir as a result of protocol amendment) with PegIFN-α2a added during the final 12 weeks of treatment.

Case Report: Long-term surgical outcomes in pug dogs with articular facet dysplasia-associated thoracolumbar myelopathies.

Pug dogs are predisposed to thoracolumbar myelopathy associated with vertebral articular process dysplasia, suggesting a biomechanical etiology. While surgery is commonly pursued, long-term outcomes remain poorly defined. This retrospective descriptive case series reports on seven Pug dogs that underwent surgical treatment for thoracolumbar myelopathy and were followed up for at least 7 years postoperatively.

Efficacy of a new biosynthetic bacterial 6-phytase on growth performance, bone mineralization, and nutrient digestibility in nursery and growing pigs.

Two studies were carried out to investigate the effects of a novel bacterial biosynthetic 6-phytase on growth performance, bone mineralization, and apparent total digestibility (ATTD) of phosphorus (P) in weaned piglets and growing pigs. They were carried out on 192 weaned piglets with initial body weight (BW): 9.3 ± 1.