Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa-Impact of Oleogel-S10.

Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel.

Phenotypic plasticity underlies seasonal and latitudinal variation in thermal tolerance in a native bee.

Climate change threatens biodiversity and ecosystem services around the globe. Despite the importance of native bees as pollinators, there is evidence of global declines, and we know very little about how climate shapes their distributions now and into the future. In the current study, we combined large-scale seasonal field sampling and experimental acclimation to examine whether populations of an Australian bee, Exoneura robusta, vary in their capacity to adapt to different climates.

HDL remodeling and enrichment with apoCIII and apoE in Indigenous Australians.

Background: Indigenous Australians have an increased risk of type 2 diabetes mellitus (T2DM) and premature cardiovascular disease. Subpopulations of high-density lipoprotein (HDL) have been associated with increased cardiovascular risk, but HDL composition, size, or function have not been studied in Indigenous Australians.

Methods: The study consisted of 86 non-Indigenous participants, 43 of whom had T2DM, and 75 Indigenous participants, 36 of whom had T2DM.

Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial.

Background: More than 85% of very preterm infants (born <32 weeks' gestation) breathe spontaneously within 1 min of birth, however, more than 60% of infants receive positive pressure ventilation. Face mask application soon after birth might suppress breathing through the trigeminal nerve reflex, causing vocal cord closure and hypoxia. We aimed to investigate whether nasal mask continuous positive airway pressure (nCPAP) would improve CPAP success, reducing the need for positive pressure ventilation and intubation at birth, compared with face mask CPAP (fCPAP).

"Targeting the Glabellar Frown Lines with OnabotulinumtoxinA: In-Silico Evidence Supporting Concentrated, Low-Volume Injection Protocols".

Botulinum Neurotoxin Type A (BoNT-A) remains the cornerstone of glabellar frown line treatment, yet conventional low-dose, high-volume protocols often result in limited durability and imprecise diffusion. This study presents multiscale, in silico framework specifically designed to evaluate high-dose (60-80 Units), low-volume (≤0.045 mL/site) BoNT-A glabellar injection strategies across anatomically realistic conditions.

What do the PHQ-9, the GAD-7 and their variants miss in assessing young people presenting to youth mental health services?

Brief self-report measures offer significant benefits in youth mental health services by providing quick, efficient, and accessible assessment of mental health status. In this study, we describe the psychometric features of the Patient Health Questionnaire-9 (PHQ-9), the Generalised Anxiety Disorder-7 (GAD-7) and their shorter variants in 1063 young people at their first appointment to headspace youth primary care mental health services. Specific aims were to: (i) document the internal consistency, dimensionality, and measurement invariance for sex and age (12-14, 15-17, 18-21, 22-25 years) for the PHQ-9 and GAD-7; (ii) compare the full and shorter variants of the measures; and (iii) determine construct validity by correlating variants with measures of psychological distress, rumination, functioning, and quality of life.

Confining thrombus morphospace through targeted inhibition of platelet mechanosensory signaling.

Background: While current antiplatelets protect against thrombosis, their clinical utility is limited by an elevated risk of bleeding.

Objectives: To understand how structure-function relations in the hemostatic system may be leveraged into improved risk/benefit ratios for antiplatelet therapies.

Methods: We developed a deep learning-based framework to track the activities of large numbers of platelets in vivo, enabling a detailed comparative assessment of the effects of therapeutic interventions on the evolving structural hierarchy of the hemostatic response.

Targeting the zinc metalloprotease gp63 of Leishmania for vaccine design and new drug discovery using immunoinformatics, molecular docking and molecular dynamics simulation studies.

Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., for which there is no vaccine and an urgent need for better drugs. The zinc metalloprotease gp63 of Leishmania has been identified as an antigenic structure for vaccine design and a promising target for new antileishmanial agents.

Nonpharmacological interventions for sleep in people with upper gastrointestinal cancer: A systematic review and meta-analysis.

Context: Sleep problems are common after an upper gastrointestinal (GI) cancer diagnosis. Identifying evidence-based interventions is critical to address sleep problems.

Objectives: This review aimed to summarise evidence on the efficacy of nonpharmacological interventions (NPIs) for sleep in individuals with upper GI cancer and to meta-analyse randomised controlled trials (RCTs).

Analysis of skin immune cells in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

Examination of the immune content in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) lesions reveals the putative role of skin-localised cytotoxic CD8 T cells in disease pathogenesis.

Effect of evolocumab on saphenous vein graft patency after coronary artery bypass surgery (NEWTON-CABG CardioLink-5): an international, randomised, double-blind, placebo-controlled trial.

Background: Saphenous vein graft (SVG) failure remains a substantial challenge after coronary artery bypass graft (CABG). LDL cholesterol (LDL-C) is a causal risk factor for atherosclerosis, but its role in SVG failure is not well established. We evaluated whether early initiation of intensive LDL-C lowering with evolocumab could reduce SVG failure.

Wired to spread: Neural regulation of metastasis.

Neural signaling regulates multiple steps in the metastatic cascade. In this NeuroView, Sloan and Chang suggest that the neural landscape of metastatic microenvironments is highly dynamic and describe opportunities to target peripheral neuroplasticity for personalized anti-metastatic therapeutic interventions.

Cannabis in the wild: Analysis of street cannabis and cannabinoid composition in Australia.

Background: Australia has one of the highest rates of cannabis use globally, yet the concentration of Δ9-tetrahydrocannabinol (THC) of illicit street cannabis has not been formally assessed in over a decade. We aimed to comprehensively profile the concentration of THC, cannabidiol (CBD) and other cannabinoids in contemporary illicit street cannabis in regional Australia, assess variation over time, and examine how the amount of THC relates to consumer's perceived product strength.

Methods: Participants donated two 1-gram samples of cannabis at 3 different timepoints (i.

Nitroreductase-Activated Probes for Monitoring Hypoxia.

Hypoxia, a hallmark of solid tumors, complicates cancer treatment by reducing the efficacy of radiotherapy and chemotherapy. To optimize strategies for hypoxia detection and targeted cancer therapy, this work explores the development of hypoxia-responsive fluorescent probes. In this study, we compared various nitroaromatic groups and both elimination-based and cyclization-based self-immolative designs to study nitroreductase (NTR) activation.

Safety and Efficacy of Perispinal Etanercept for Chronic Stroke: A Randomized Clinical Trial.

Background And Objectives: Stroke is a leading cause of long-term disability. Etanercept, a competitive tumor necrosis factor-α inhibitor, has been proposed as a potential treatment for post-stroke impairments when given through a perispinal subcutaneous injection. We aimed to evaluate the safety and efficacy of perispinal etanercept in patients with chronic stroke.

Observation of the Charge Density Wave Excitonic Order Parameter in Topological Insulator Monolayer WTe.

Strong electron-hole interactions in a semimetal or narrow-gap semiconductor may drive a ground state of condensed excitons. Monolayer WTe has been proposed as a host material for such an exciton condensate, but the order parameter─the key signature of a macroscopic quantum-coherent condensate─has not been observed. Here, we use Fourier-transform scanning tunneling spectroscopy (FT-STS) to study quasiparticle interference (QPI) and periodic modulations of the local density of states (LDOS) in monolayer WTe.

Evaluation of a digital health platform for preventing stroke in the Australian community: Study protocol for a randomized controlled trial - Love Your Brain.

Rationale: One in four people will have a stroke in their lifetime. Over 80% of strokes are preventable through the management of modifiable risk factors. There is a growing demand from the community for information about how to prevent stroke.

HLA-A*02:01 Presents Penicillin-Modified Cysteinylated Peptides for T Cell Recognition.

Background: A subset of patients experience immune-mediated hypersensitivity reactions towards β-lactam antibiotics, with drug-specific T cells implicated as one of the causative factors. The principal mechanism is thought to involve chemical haptenation of self-peptides, resulting in novel peptide drug-adducts that may trigger T cell recognition. Understanding the interactions between the β-lactam drug, the T cell receptor (TCR) and the peptide/human leukocyte antigen (pHLA) complex is critical to gain further mechanistic insights into these hypersensitivity reactions.

Ethical implications of nurse brain drain on undergraduate nursing students.

BackgroundGlobal healthcare worker migration, often termed "brain drain," poses profound ethical challenges for low- and middle-income countries (LMICs) such as Nepal. Although the economic and professional drivers behind nurse migration are relatively well-documented, the ethical implications for nursing students-who witness this dynamic during their formative training-remain insufficiently examined.AimThis study investigated how undergraduate nursing students in Nepal perceive and navigate the ethical dimensions of nurse brain drain.

Re-Visiting the Content Validity of the Manchester Clinical Supervision Scale (MCSS-26).

Clinical supervision is widely regarded as an important part of both pre-graduate and post-registration education and training of healthcare professionals. To ensure comprehensive implementation of effective supervision practices, it is crucial that supervisors, healthcare organisations and researchers have valid and reliable instruments to measure these practices. The Manchester Clinical Supervision Scale (MCSS) is the most widely used instrument for measuring supervision effectiveness in nursing and allied health.

The assessment and management of patients with type 2 myocardial infarction: an international Delphi study.

Aims: Type 2 myocardial infarction due to myocardial oxygen supply-demand imbalance is associated with poor outcomes. There are no guidelines to inform care for these patients. The consensus on the assessment and management of type 2 myocardial infarction is gained.

Iodine-Promoted Ring-Opening -Difunctionalization of Cyclopropanols with Enaminones: A Selective Route to 2,4-Diacylpyrroles.

In this work, we report a novel I-mediated ring-opening -difunctionalization of cyclopropyl alcohols with enaminones for the first time. The selective [3 + 2] annulation instead of [3 + 3] annulation under metal-free conditions enables a straightforward and efficient synthesis of structurally important 2,4-diacylpyrroles. Notably, this methodology dispenses with metal catalysts, proceeds under mild reaction conditions, and features not only simple operation but also suitability for gram-scale preparation and late-stage functionalization of complex bioactive molecules.

Biomimetic semiconducting polymer dots for dual targeted NIR-II phototheranostic and multimodal coordinated immunostimulatory therapy.

Breast cancer is a global health challenge necessitating more precise and effective treatment strategies. In this study, we developed a novel drug-loaded therapeutic nanoplatform, OCPdots@CTe, which integrated near-infrared-II (NIR-II) window phototheranostic for targeted treatment of orthotopic breast tumors. The outer membrane vesicles (OMVs) can stimulate more immune responses based on precise targeting, while chelerythrine (CTe) can induce apoptosis by generating reactive oxygen species (ROS), thereby enhancing the therapeutic effect.