Exploring the functional and structural impacts of high-risk nsSNPs in human and genes associated with premature ovarian failure: an approach.

Premature ovarian failure (POF) is a complex reproductive disorder characterized by the early loss of ovarian function. Two closely related members of the transforming growth factor-β (TGF-β) superfamily, bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been implicated in its pathogenesis. In this study, we investigated the potential pathogenicity of 429 non-synonymous SNPs (nsSNPs) in and 290 nsSNPs in using an integrative bioinformatics approach.

An extremely rare primary non-gestational choriocarcinoma of the vagina: a case report.

Introduction And Importance: Primary non-gestational choriocarcinoma (NGC) of the vagina is an exceedingly rare and aggressive malignancy originating from pluripotent germ cells, with very few cases documented in the literature. Differentiating it from gestational choriocarcinoma is crucial, as NGC exhibits poorer prognosis and reduced chemotherapy responsiveness. This case report highlights a unique presentation of vaginal NGC in a postmenopausal woman, emphasizing diagnostic complexities and therapeutic challenges.

Occurrence and risk assessment of phthalate esters in the Torghabeh River, Northeastern Iran.

Phthalate esters (PAEs), a group of well-known endocrine-disrupting chemicals (EDCs), are extensively used in plastic manufacturing and are recognized for their contribution to environmental pollution and potential adverse health effects. Rivers in urban and recreational areas are increasingly threatened by plastic-derived pollutants, yet there is a lack of data on the occurrence, distribution, and risks of PAEs in such environments in Iran. The Torghabeh River, a popular recreational site near Mashhad, may be particularly vulnerable to phthalate pollution due to tourism, waste discharge, and urban runoff.

Access to pediatric oncology medicine in Iran: a cross-sectional survey in Urmia.

Background: Cancer stands as a significant cause of mortality among children and adolescents, imposing a considerable burden on global healthcare. The World Health Organization (WHO) reports a stark imbalance in the accessibility of cancer medicines between low-income and high-income countries. Due to high prevalence of cancer in Iran and current barriers to access to oncology medicines, this study aims to scrutinize the landscape of pediatric oncology medicine access, considering unique factors such as sanctions and Iran’s economic context.

Desire for childbearing in the view of Iranian parents: A qualitative study.

Background And Aims: Like many other countries, Iran is facing a declining population growth rate. While previous research has primarily focused on childless individuals or parents of only one child, limited attention has been paid to families who, despite already having two or more children, continue to desire larger families. This study examines childbearing motivations among Iranian parents with two or more planned children.

Return to Work in Colorectal Cancer Patients.

Return to work (RTW) significantly impacts the quality of life of cancer survivors and carries substantial economic and social implications. This study investigates the RTW rate among colorectal cancer patients post-surgery. Colorectal cancer patients referred to the Mashhad University of Medical Sciences oncology clinics were enrolled based on inclusion criteria and after obtaining oral consent.

Complementary medicine for post-tonsillectomy pain management in children: a network meta-analysis.

Background: Managing postoperative pain following tonsillectomy presents a significant challenge and often remains suboptimal. This study aimed to compare and rank complementary interventions for alleviating tonsillectomy-related pain in children.

Methods: A comprehensive search was conducted in the databases, including PubMed, Web of Science, Scopus, ClinicalTrials.

Cardiovascular comorbidities in hospitalized patients with hypertrophic cardiomyopathy and factors associated with a higher case-fatality rate.

Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder, with rising hospitalization rates and high comorbidity burden, yet the impact of cardiovascular comorbidities (CVC) on mortality among hospitalized HCM patients remains poorly defined.

Methods: Queried the 2016 to 2020 National Inpatient Sample (NIS) to identify hospitalizations with diagnosed HCM.

Results: Among 278,995 HCM hospitalizations (mean age 64.

Effective Strategies in Disease Control and Prevention: A Systematic Review.

Introduction: Effective disease control and prevention are central to global public health, especially amid increasing chronic diseases, re-emerging infectious threats, and socioeconomic disparities. This systematic review aims to identify and synthesize key strategies that contribute to improved disease management outcomes worldwide.

Methods: This systematic review was conducted using the keywords "disease management," "disease prevention," "public health strategies," "surveillance," "vaccination," "vector control," and "social determinants of health (SDOH)" in electronic databases including PubMed, Scopus, Web of Science, and Google Scholar from 2001 to 2024.

GSTP1 rs1695 Variant and Colorectal Cancer Risk in Women Aged 50+: Insights from Iran's Largest Cohort and Meta-Analysis.

Objective: To evaluate the association between GSTP1 rs1695 A>G polymorphism and colorectal cancer (CRC) risk in an Iranian cohort, and to validate findings through a systematic review and meta-analysis.

Methods: A multicenter case-control study was conducted in Tehran hospitals, including CRC patients and matched controls. Demographic and clinical data were collected, and DNA was extracted from FFPE tissues and blood.

Selenium and Lycopene Ameliorate Methamphetamine-induced Neurotoxicity in Offspring Rats by Suppressing Oxidative Stress, Neuro-inflammation, and Apoptosis.

Methamphetamine (METH) is an illicit drug and sympathetic nervous system stimulant that easily crosses the placenta due to its low molecular weight and high lipid solubility, thus affecting the pregnant mother and fetus. Considering the antioxidant and anti-inflammatory properties of selenium (Se) and lycopene (LYCO), as well as their ability to cross the blood-brain barrier and placental and be secreted into milk, this study aimed to evaluate the combined effects of Se and LYCO on METH-induced neurotoxicity in offspring rats. Thirty pregnant rats were divided into seven groups (n = 3-6), including control, METH (5 mg/kg, ip), METH and Se (2.

FOXC1 and FOXC2 in Osteogenesis: Emerging roles and therapeutic potential in bone regeneration and remodeling.

Bone is a remarkable dynamic tissue, continually undergoing intricate processes of development, repair, and lifelong remodeling, all vital for maintaining skeletal integrity, facilitating injury recovery, and preserving overall health. Mesenchymal stem cells (MSCs) are central to these processes, characterized by their self-renewal capacity, multipotent differentiation (including osteoblasts), and crucial roles in secreting growth factors and remodeling the extracellular matrix. The highly conserved transcription factors FOXC1 and FOXC2 are crucial for correct skeletal development, profoundly influencing both intramembranous and endochondral ossification.

Co-infection of lophomonas blattarum and mycobacterium tuberculosis: Insights from a study in northeastern Iran.

Background: Pulmonary tuberculosis (TB) continues to pose a significant global health challenge, especially in low- and middle-income countries. The immune suppression caused by TB increases susceptibility to secondary infections such as Lophomonas blattarum, a rare protozoan that infects the respiratory tract. Co-infection with Lophomonas can complicate TB treatment due to overlapping symptoms, leading to misdiagnosis or delayed care.

Novel imidazolyl-hydroxamic acid Schiff base scaffold derivatives as histone deacetylase inhibitors: Design, synthesis, and biological assessment.

Histone deacetylases (HDACs) are important therapeutic targets for cancer. A series of new imidazolyl-hydroxamic acid Schiff base scaffold derivatives have been meticulously developed and synthesized with the goal of inhibiting histone deacetylase (HDAC). These compounds are characterized by three units: an imidazolyl as the cap, linked to a 4-amino-benzamido group as a linker and an N-hydroxyl head as metal-binding unit.

Listening to the women's experience of perinatal domestic violence during the COVID-19 pandemic: a qualitative content analysis.

Background: Pregnant women and their fetuses would be a high-risk population and more susceptible to COVID-19 infection. Since the outbreak of COVID-19, quarantine, social distancing and isolation, and the consequences were likely to increase the risk of domestic violence dramatically. This study aimed to explore women's experiences of perinatal domestic violence during the COVID-19 pandemic.

Signaling pathways as the pivotal regulators of cisplatin resistance in tumor cells through SOX2 upregulation.

Chemotherapy is one of the first-line treatment options in cancer patients. Cisplatin (CDDP) is widely used as one of the antineoplastic agents in many cancers. Nevertheless, CDDP resistance is considered as a therapeutic challenge in cancer.

Comparative evaluation of the wear potential of bovine enamel against hybrid and non-hybrid ceramics under abrasive and erosive conditions: An in vitro study.

Background: This in vitro study compared the wear response of natural enamel when opposed to hybrid and conventional dental ceramic materials under both abrasive and erosive conditions.

Methods: Eighty enamel specimens were prepared from bovine central incisors and divided into five groups based on the antagonist material used. Each group consisted of 16 specimens, with antagonists fabricated from four different aesthetic CAD/CAM block materials: VITA Enamic (VE), Lava Ultimate (LU), Lava Plus (LP), and VITA Mark II (VM), alongside natural enamel as a control.

Association between the number of teeth and all-cause mortality rate in the MASHAD Cohort Study.

Background: Previous studies have reported inconsistent results on the relationship between the number of teeth and all-cause mortality. There are several confounding factors in this relationship, especially age. We investigated the relationship between the number of teeth and all-cause mortality among residents in Mashhad, Iran.

Mir-let-7a Differential Expression in Oral Squamous Cell Carcinoma and Oral Lichen Planus: Insights for Early Diagnostic Biomarker Development.

Background: Early detection of oral squamous cell carcinoma (OSCC) is essential for improving treatment outcomes. Oral lichen planus (OLP) is recognized as a premalignant condition that may progress to OSCC. Recently, microRNAs, particularly miR-let-7a, have emerged as promising biomarkers for gene regulation and early disease diagnosis.

Generalized dystonia unraveled: Molecular mechanisms, diagnostic strategies, and treatment paradigms.

Background: Generalized dystonia is a complex and heterogeneous movement disorder characterized by sustained or intermittent muscle contractions that lead to abnormal postures and movements.

Pathophysiology: It primarily arises from dysfunction within basal ganglia circuits and involves a range of underlying pathophysiological mechanisms, including disrupted dopamine synthesis, altered calcium signaling, and impaired stress response pathways. Advances in genetics have identified key causative mutations-most notably in KMT2B, VPS16, EIF2AK2, PRKRA, and AOPEP- that contribute to disease onset and progression, with varying degrees of clinical penetrance.

Fetal and maternal adverse cardiac outcomes in rheumatic diseases: A systematic review.

Background: Autoimmune rheumatic disorders (ARDs) are complex diseases; when experienced during pregnancy, they can be more difficult to manage. Complications vary in severity depending on different factors, including the disease stage and course of treatment.

Methods: A comprehensive electronic search with relevant key words was conducted on PubMed, Scopus, CINAHL, Web of Science, Science Direct, and Google Scholar until 30 August 2024 for systematic review.

Ferroptosis induction by engineered liposomes for enhanced tumor therapy.

Ferroptosis has shown potential therapeutic effects in tumor therapy as an iron-dependent programmed cell death. The induction of ferroptosis is based on lipid peroxidation, the accumulation of iron and reactive oxygen species, and the depletion of glutathione. Nowadays, various nanoparticles are reported for ferroptosis-based therapy.

CCDC82 and neurodevelopment: a novel genetic variant linked to infantile spasms and hypotonia.

Background: Neurodevelopmental disorders (NDDs) are a heterogeneous group of conditions characterized by impairments in motor, cognitive, and behavioral functions. Despite advances in genomic sequencing, the genetic basis of many NDDs remains unexplored. CCDC82 encodes a coiled-coil domain-containing protein with an unknown function in the nervous system.

Short and long-term side effects of the Classic Ketogenic Diet in pediatric epilepsy treatment: A systematic review of clinical trials.

Background/objective: Classic Ketogenic Diet (CKD) is a well-known diet therapy with high fat and low carbohydrates which is used to treat children with medication-resistant epilepsy (MRE). As CKD is a restricted diet, it can cause side effects which are major reason for diet discontinuation. In this study, we aim to systematically identify and categorize these side effects by type and duration to optimize CKD use and increase adherence.