Enhanced Telemedicine Instruction: Simulations Including eStethoscopes for Virtual Cardiac Assessment.

Increased adoption of telemedicine during the COVID-19 pandemic improved care access to rural and underserved patients. This rapid expansion created a pressing need for educational programs focusing on the virtual physical exam. We developed a simulation-based workshop for medical and physician assistant students to teach and evaluate the cardiopulmonary virtual physical exam.

Acute Toxicities of Proton Craniospinal Irradiation in Pediatric Medulloblastoma: A Pediatric Proton/Photon Consortium Registry (PPCR) Study.

Purpose: Medulloblastoma is one of the most common malignant brain tumors in children, and 75% of patients achieve long-term survival. There are limited studies reporting acute toxicity for pediatric patients receiving proton therapy for craniospinal irradiation (CSI) in medulloblastoma, and these are limited by their retrospective nature, modest cohort sizes, and lack of a comparator group.

Materials And Methods: We analyzed data from the Pediatric Proton/Photon Consortium Registry.

Physicochemical differences between wildfire pyrogenic carbon and slow-pyrolysis biochar suggest variations in elemental transport potential.

Wildfires play a crucial role in the carbon cycle. Their contribution to the global carbon cycle is expected to increase with climate change as fire activity, particularly in boreal forests, escalates. As 8-28% of annually produced pyrogenic carbon is transported through riverine systems, its impact on fluvial environmental conditions will likely increase in coming years.

Synteny Enabled Upgrade of the Galapagos Giant Tortoise Genome Improves Inferences of Runs of Homozygosity.

The utility and importance of whole-genome sequences are recognized across various fields, including evolution and conservation. However, for some taxa, like extinct species, using methods to generate contiguous genomes that rely on high-quality DNA is impossible. In such cases, an alternative may be to employ synteny-based methods using a genome from a closely related taxon to generate more complete genomes.

Suffering in silence: Accessing mental health care and repetitive transcranial magnetic stimulation (rTMS) for peripartum depression - A qualitative study.

Peripartum depression (PPD) is a prevalent and serious mental health disorder that is often underdiagnosed and undertreated due to limited effective and safe treatment options. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a non-invasive treatment for PPD, yet awareness among patients is low. This study aims to identify barriers and facilitators to accessing mental health treatment, particularly rTMS, for PPD.

Lateral Gender-Based Violence in 2SLGBTQ+ Communities: The Stifling of Queer Joy Through Intersectional Oppression, "Pitiful" Sexuality Education, and Media (Mis)Representation.

There is a gap in the field of gender-based violence concerning lateral violence within 2SLGBTQ+ communities. This paper helps fill that gap by offering participants' narratives from The Queer Sexual Joy Project, which engaged 100 2SLGBTQ+ youth from Canada and the US, ages 18-35, in focus groups, participatory visual arts-based research, one-on-one interviews, and surveys. The study provides insight into how lateral violence is fueled and expressed through overlapping and intersecting systems of oppression, including fatphobia, transphobia, sexism and misogyny, racism, and ableism.

A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers.

Background: Prevalence estimates of primary biliary cholangitis (PBC) in the United States have evolved with the introduction of newer real-world data capture approaches. Little is known about the geographic distribution of PBC in the United States and the health care provider (HCP) landscape for patients with PBC. This real-world study aimed to estimate the prevalence of PBC in the United States, assess regional variability in its prevalence, and describe HCPs for patients with PBC.

One-Year Changes in Depressive Symptoms and Cognitive Function Among Brazilian Older Adults Attending Primary Care.

: Aging is a global phenomenon closely associated with changes in cognitive function and mental health. These conditions substantially burden public health systems and adversely affect the quality of life of older adults. This study aimed to examine changes in depressive symptoms and cognitive function over a 12-month follow-up period in a cohort of Brazilian older adults attending primary care.

Telehealth and Precision Prevention: Bridging the Gap for Individualised Health Strategies.

Introduction: Precision prevention has shown an upsurge in popularity among epidemiologists in both developed and developing countries in the past decade.

Objectives: Initially practiced in oncology, this approach is increasingly adopted in public health to guard against other common non-communicable diseases (NCDs), such as diabetes and cardiovascular diseases. It aims to tailor preventive measures according to each individual's unique characteristics, such as genomic data, socio-demographic features, environmental factors, and cultural background.

Primary Care EHR data on Social Determinants of Health: Quality and Fitness for Purpose in Precision/Personalised Medicine.

Introduction: Precision and personalised medicine requires comprehensive genetic, epigenetic, lifestyle, social, community and environmental knowledge of the patient. This approach highlights the importance of the social determinants of health (SDoH), described by the World Health Organization (WHO) as 'the non-medical factors that influence health outcomes, the conditions in which people are born, grow, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life such as economic policies and systems, development agendas, social norms, social policies and political systems'.

Methods: This study examined if countries collect SDoH indicators and, if they do, the quality of the data and whether they are fit for clinical and population health purposes.

Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population-Based Study.

Background: Elevated liver biochemistries are associated with increased risk of negative outcomes in patients with primary biliary cholangitis (PBC).

Aims: To evaluate whether longitudinal monitoring of liver biochemistries and fibrosis scores provides additional prognostic value and to assess the relationship between the degree of elevation of multiple biomarkers within different alkaline phosphatase (ALP) strata.

Methods: Adults with PBC were identified from Komodo's Healthcare Map.

Examining Whether Risk Factors Influence Student Perceptions of Campus Sexual Violence.

The present study examined university students' perceptions of a campus sexual violence scenario, and specifically determined whether the presence of known risk factors for sexual perpetration would influence their views of an individual who caused harm. Two hundred and seventy-five student participants read a vignette that either included the present or absence of the following three risk factors: Frequent alcohol use, attitudes supportive of rape, and negative peer influence. The findings indicated that the risk factors did not have a significant relationship with students' risk perceptions, indicating that students' perceptions of risk may not be influenced by the presence of known risk factors.

Measuring Goal Progress Using the Goal-Based Outcome Measure in Youth Wellness Hubs Ontario-An Integrated Youth Services Network.

Background: Goal-based outcomes (GBOs) are a tool for youth-directed care and have been successfully used in a small number of community youth mental health settings. Youth Wellness Hubs Ontario (YWHO) uses GBO data provided by youth to deliver care that amplifies youth voice in decision-making about supports that are important and meaningful to them.

Objective: This article summarizes GBO data from youth receiving clinical and nonclinical services at YWHO hubs to develop a more nuanced understanding of the type of goals set by young people when accessing services.

Transdermal microneedle patch for antioxidants release.

Unlabelled: Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future. Smart and controlled microneedle drug delivery systems remain an emerging research area. One of the objectives of this study was to design an accessible approach of molding microneedles using a beeswax mold.

Role of leaders' positive mindset in mitigating the effects of crises on organizations: The case of Canadian organizations.

Maintaining a positive mindset is important for leadership effectiveness and may even be more important in times of a crisis because such a mindset contributes to organizational survival and resilience. In this study, we examined whether leaders' positive mindset helped to mitigate the harmful effects of the COVID-19 crisis on organizations and if so, how. To address this issue, we conducted an empirical study through LinkedIn with 165 participants working in various organizations in Canada.

Massage Therapy for Ankle Mobility and Spasticity in an Adult with Cerebral Palsy: A Case Report.

Background: Cerebral palsy (CP) refers to a group of permanent neurologic disorders associated with injury to the brain during its development. The most common type of CP is spastic CP. Individuals with spastic CP commonly present with increased deep tendon reflexes, tremors, muscular hypertonicity, and weakness.

Pancreatic Ductal Cell Heterogeneity: Insights into the Potential for β-Cell Regeneration in Diabetes.

Diabetes mellitus is a significant and fast-growing health problem worldwide. Cost, donor shortages, and immune rejection limit current treatment strategies. While considerable progress has been made in creating β-cells in vitro with remarkable morphological and functional resemblance to those in primary pancreatic islets, exploring alternative sources for β-cell replacement is crucial.

Implantable hydrogels as pioneering materials for next-generation brain-computer interfaces.

Use of brain-computer interfaces (BCIs) is rapidly becoming a transformative approach for diagnosing and treating various brain disorders. By facilitating direct communication between the brain and external devices, BCIs have the potential to revolutionize neural activity monitoring, targeted neuromodulation strategies, and the restoration of brain functions. However, BCI technology faces significant challenges in achieving long-term, stable, high-quality recordings and accurately modulating neural activity.

Relationships Among Sex, Sexual Orientation, Dark Triad Traits, Sociosexuality, and Sexual Excitation/Inhibition.

Subclinical narcissism, psychopathy, and Machiavellianism are a cluster of manipulative, callous, and entitled traits known as the Dark Triad (DT). These traits have been repeatedly linked to short-term mating strategies and a tolerance for uncommitted sexual behavior (i.e.

National Evaluation of Emergency Medical Services Clinician Burnout and Workforce-Reducing Factors.

Objectives: Limited recent national data exist measuring burnout levels among emergency medical services (EMS) clinicians and the potential impact of burnout on workforce strength and stability. We aimed to measure current EMS burnout and its association with workforce-reducing factors.

Methods: In April 2022, a random sample of nationally certified EMS clinicians was sent a survey that included the Copenhagen Burnout Inventory (CBI) to assess for burnout in 3 dimensions: personal, work-related, and patient-related.

Pilot Study Exploring the Perspectives of Canadian Clients Who Received Digitally Delivered Psychotherapies Utilized for Trauma-Affected Populations.

The digital delivery of mental health services became increasingly common following the onset of the COVID-19 pandemic. There is still much to learn regarding tailoring interventions for trauma-affected populations (military members, Veterans, public safety personnel). Through the current pilot study, we explored the perceptions of digitally delivered psychotherapies utilized for trauma-affected populations, as reported by Canadian military members, Veterans, and public safety personnel who completed such interventions.

Health System Implementation Is a Non-Linear System of Systems.

Health systems globally are struggling with. common issues such as access, wait times, and the delivery of new models of care such as team-based care. While it has been argued that addressing our health crisis involves better implementation of known solutions, we argue that mindset is an overly simplified representation of health system implementation.

A morphological cell atlas of the freshwater sponge Ephydatia muelleri with key insights from targeted single-cell transcriptomes.

How animal cell types, tissues, and regional body plans arose is a fundamental question in EvoDevo. Many current efforts attempt to link genetic information to the morphology of cells, tissues and regionalization of animal body plans using single-cell sequencing of cell populations. However, a lack of in-depth understanding of the morphology of non-bilaterian animals remains a considerable block to understanding the transitions between bilaterian and non-bilaterian cells and tissues.